Wnt signalling in the development of axon, dendrites and synapses.

Abstract:

:Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the morphogenesis and body patterning during the development of metazoan species. In recent years, mounting evidence has revealed important functions of Wnt signalling in diverse aspects of neural development, including neuronal polarization, guidance and branching of the axon and dendrites, as well as synapse formation and its structural remodelling. In contrast to Wnt signalling in cell proliferation and differentiation, which mostly acts through β-catenin-dependent pathways, Wnts engage a diverse array of non-transcriptional cascades in neuronal development, such as the planar cell polarity, cytoskeletal or calcium signalling pathways. In this review, we summarize recent advances in the mechanisms of Wnt signalling in the development of axon, dendrite and synapse formation.

journal_name

Open Biol

journal_title

Open biology

authors

He CW,Liao CP,Pan CL

doi

10.1098/rsob.180116

subject

Has Abstract

pub_date

2018-10-03 00:00:00

issue

10

issn

2046-2441

pii

rsob.180116

journal_volume

8

pub_type

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