Abstract:
:Pigment-Dispersing Factor (PDF) is an important neuropeptide in the brain circadian network of Drosophila and other insects, but its role in bees in which the circadian clock influences complex behaviour is not well understood. We combined high-resolution neuroanatomical characterizations, quantification of PDF levels over the day and brain injections of synthetic PDF peptide to study the role of PDF in the honey bee Apis mellifera We show that PDF co-localizes with the clock protein Period (PER) in a cluster of laterally located neurons and that the widespread arborizations of these PER/PDF neurons are in close vicinity to other PER-positive cells (neurons and glia). PDF-immunostaining intensity oscillates in a diurnal and circadian manner with possible influences for age or worker task on synchrony of oscillations in different brain areas. Finally, PDF injection into the area between optic lobes and the central brain at the end of the subjective day produced a consistent trend of phase-delayed circadian rhythms in locomotor activity. Altogether, these results are consistent with the hypothesis that PDF is a neuromodulator that conveys circadian information from pacemaker cells to brain centres involved in diverse functions including locomotion, time memory and sun-compass orientation.
journal_name
Open Bioljournal_title
Open biologyauthors
Beer K,Kolbe E,Kahana NB,Yayon N,Weiss R,Menegazzi P,Bloch G,Helfrich-Förster Cdoi
10.1098/rsob.170224subject
Has Abstractpub_date
2018-01-01 00:00:00issue
1issn
2046-2441pii
rsob.170224journal_volume
8pub_type
杂志文章相关文献
Open Biology文献大全abstract::Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.180109
更新日期:2018-08-01 00:00:00
abstract::Intercalation allows cells to exchange positions in a spatially oriented manner in an array of diverse processes, spanning convergent extension in embryonic gastrulation to the formation of tubular organs. However, given the co-occurrence of cell intercalation and changes in cell shape, it is sometimes difficult to as...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200329
更新日期:2020-11-01 00:00:00
abstract::The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleu...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.170135
更新日期:2017-09-01 00:00:00
abstract::Leucocytes form the principal cellular components of immunity and inflammation, existing as multiple subsets defined by distinct phenotypic and functional profiles. To date, this has most notably been documented for lymphocytes and monocytes. In contrast, as neutrophils are traditionally considered, to be short-lived,...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.120134
更新日期:2012-11-01 00:00:00
abstract::Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to understand why cells promote the formation of protein foci. Comparison ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140221
更新日期:2015-02-01 00:00:00
abstract::Parkinson's disease (PD) is characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra and accumulation of ubiquitinated proteins in aggregates called Lewy bodies. Several mutated genes have been found in familial PD patients, including SNCA (α-synuclein), PARK2 (parkin), PINK...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160193
更新日期:2016-08-01 00:00:00
abstract::Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries and thus prevent silencing of expressed genes. Here we show that lo...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150045
更新日期:2015-05-01 00:00:00
abstract::Wnt/β-catenin signalling controls development and adult tissue homeostasis and causes cancer when inappropriately activated. In unstimulated cells, an Axin1-centred multi-protein complex phosphorylates the transcriptional co-activator β-catenin, marking it for degradation. Wnt signalling antagonizes β-catenin proteoly...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140120
更新日期:2014-11-01 00:00:00
abstract::Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is achieved by mechanisms that adapt the number of mitochondria to that required for energy production and for the supply of metabolic intermediates necessary to su...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.130185
更新日期:2013-12-18 00:00:00
abstract::The aim of this study was to analyse the expression pattern and elucidate the mechanistic involvement of long non-coding RNA LINC00467 in hepatocellular carcinoma (HCC). The relative expression of LINC00467 and microRNA (miR)-9-5p was determined by real-time polymerase chain reaction. Cell viability was measured using...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190074
更新日期:2019-09-27 00:00:00
abstract::Although systemic or local inflammation, commonly featured by cytokine activation, is implicated in patients with bone loss, the underlying mechanisms are still elusive. As microRNAs (miR), a class of small non-coding RNAs involved in essential physiological processes, have been found in bone cells, we aimed to invest...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150258
更新日期:2016-03-01 00:00:00
abstract::In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190244
更新日期:2020-05-01 00:00:00
abstract::Tn5 transposase is a bacterial enzyme that integrates a DNA fragment into genomic DNA, and is used as a tool for detecting nucleosome-free regions of genomic DNA in eukaryotes. However, in chromatin, the DNA targeting by Tn5 transposase has remained unclear. In the present study, we reconstituted well-positioned 601 d...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190116
更新日期:2019-08-30 00:00:00
abstract::Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycobacteria cell wall and in the storage lipids inside the cell. In order ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160277
更新日期:2017-02-01 00:00:00
abstract::Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic target of rapamycin com...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.180262
更新日期:2019-05-31 00:00:00
abstract::AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the nucleoplasm just l...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160103
更新日期:2016-08-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncR...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150262
更新日期:2016-12-01 00:00:00
abstract::Current ageing theories are far from satisfactory because of the many determinants involved in ageing. The well-known rate-of-living theory assumes that the product (lifetime energy expenditure, LEE) of maximum lifespan (MLS) and mass-specific basal metabolic rate (msBMR) is approximately constant. Although this theor...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.170083
更新日期:2017-10-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the oncoproteins that drive cancer progression. Its actions depend upon its essential ATPase, an activity fortuitously inhibited with a very high degree of selectivity by nat...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.120138
更新日期:2012-12-12 00:00:00
abstract::The structures of F-ATPases have been determined predominantly with mitochondrial enzymes, but hitherto no F-ATPase has been crystallized intact. A high-resolution model of the bovine enzyme built up from separate sub-structures determined by X-ray crystallography contains about 85% of the entire complex, but it lacks...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150119
更新日期:2015-09-01 00:00:00
abstract::The innate immune response is the first line of defence against infection. Germ-line-encoded receptors recognize conserved molecular motifs from both exogenous and endogenous sources. Receptor activation results in the initiation of a pro-inflammatory immune response that enables the resolution of infection. Understan...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.120015
更新日期:2012-04-01 00:00:00
abstract::In mammals, the testis-specific bromodomain and extra terminal (BET) protein BRDT is essential for spermatogenesis. In Drosophila, it was recently reported that the tBRD-1 protein is similarly required for male fertility. Interestingly, however, tBRD-1 has two conserved bromodomains in its N-terminus but it lacks an e...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140145
更新日期:2015-02-01 00:00:00
abstract::With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology. As such, they provide a promising system for examining developmental and molecular processes underlying limb morphol...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160252
更新日期:2016-10-01 00:00:00
abstract::Outer membrane phospholipase A (OMPLA) is an enzyme located in the outer membrane of Gram-negative bacteria. OMPLA exhibits broad substrate specificity, and some of its substrates are located in the cellular envelope. Generally, the enzymatic activity can only be induced by perturbation of the cell envelope integrity ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160073
更新日期:2016-09-01 00:00:00
abstract::Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.130035
更新日期:2013-04-24 00:00:00
abstract::Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous sources of somatic mutations found in multiple human cancers. Wh...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200188
更新日期:2020-12-01 00:00:00
abstract::Ubiquitination is a versatile post-translational modification that regulates a multitude of cellular processes. Its versatility is based on the ability of ubiquitin to form multiple types of polyubiquitin chains, which are recognized by specific ubiquitin receptors to induce the required cellular response. Linear ubiq...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170026
更新日期:2017-04-01 00:00:00
abstract::Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as regulators of cellular events by their ability to form microdoma...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170069
更新日期:2017-05-01 00:00:00
abstract::How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell fates by selectively activating unique subsets of their genome. This is achieved, in part, by enhancers-genetic elements that can increase transcription of both ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200255
更新日期:2020-10-01 00:00:00
abstract::Somatostatin (SS) and allatostatin-C (ASTC) are structurally and evolutionarily related neuropeptides that act as inhibitory regulators of physiological processes in mammals and insects, respectively. Here, we report the first molecular and functional characterization of SS/ASTC-type signalling in a deuterostome inver...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200172
更新日期:2020-09-01 00:00:00