Abstract:
:Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the search for compounds that target essential cellular processes to eliminate, for example, tumour cells or pathogens. Research in recent decades has offered many insights into the molecular function of Mps1 and its regulation. In this review, we integrate the latest knowledge regarding the regulation of Mps1 activity and its spatio-temporal distribution, highlight gaps in our understanding of these processes and propose future research avenues to address them.
journal_name
Open Bioljournal_title
Open biologyauthors
Pachis ST,Kops GJPLdoi
10.1098/rsob.180109subject
Has Abstractpub_date
2018-08-01 00:00:00issue
8issn
2046-2441pii
rsob.180109journal_volume
8pub_type
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