Or47b plays a role in Drosophila males' preference for younger mates.

Abstract:

:Reproductive behaviour is important for animals to keep their species existing on Earth. A key question is how to generate more and healthier progenies by choosing optimal mates. In Drosophila melanogaster, males use multiple sensory cues, including vision, olfaction and gustation, to achieve reproductive success. These sensory inputs are important, yet not all these different modalities are simultaneously required for courtship behaviour to occur. Moreover, the roles of these sensory inputs for male courtship choice remain largely unknown. Here, we demonstrate that males court younger females with greater preference and that olfactory inputs are indispensable for this male courtship choice. Specifically, the olfactory receptor Or47b is required for males to discriminate younger female mates from older ones. In combination with our previous work indicating that gustatory perception is necessary for this preference behaviour, our current study demonstrates the requirement of both olfaction and gustation in Drosophila males' courtship preference, thus providing new insights into the role of sensory cues in reproductive behaviour and success.

journal_name

Open Biol

journal_title

Open biology

authors

Zhuang L,Sun Y,Hu M,Wu C,La X,Chen X,Feng Y,Wang X,Hu Y,Xue L

doi

10.1098/rsob.160086

subject

Has Abstract

pub_date

2016-06-01 00:00:00

issue

6

issn

2046-2441

pii

rsob.160086

journal_volume

6

pub_type

杂志文章
  • Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for?

    abstract::Following thymic output, αβ⁺CD4⁺ T cells become activated in the periphery when they encounter peptide-major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages and subsequent expansion and contraction during an appropriate and...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.120157

    authors: Coomes SM,Pelly VS,Wilson MS

    更新日期:2013-01-23 00:00:00

  • Deubiquitylation of deubiquitylases.

    abstract::Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. In contrast to the plethora of research being conducted on the ability of DUBs to counter the degradation of cellular proteins or auto-ubiquitylated E3 ligases, very little is known about the m...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170016

    authors: Haq S,Ramakrishna S

    更新日期:2017-06-01 00:00:00

  • Pigment-Dispersing Factor-expressing neurons convey circadian information in the honey bee brain.

    abstract::Pigment-Dispersing Factor (PDF) is an important neuropeptide in the brain circadian network of Drosophila and other insects, but its role in bees in which the circadian clock influences complex behaviour is not well understood. We combined high-resolution neuroanatomical characterizations, quantification of PDF levels...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170224

    authors: Beer K,Kolbe E,Kahana NB,Yayon N,Weiss R,Menegazzi P,Bloch G,Helfrich-Förster C

    更新日期:2018-01-01 00:00:00

  • Drosophila as a model system to unravel the layers of innate immunity to infection.

    abstract::Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about i...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.120075

    authors: Kounatidis I,Ligoxygakis P

    更新日期:2012-05-01 00:00:00

  • A state-of-the-art perspective on microgliopathic pain.

    abstract::Acute nociceptive pain is an undesirable feeling but has a physiological significance as a warning system for living organisms. Conversely, chronic pain is lacking physiological significance, but rather represents a confusion of nerve functions. The neuropathic pain that occurs after peripheral nerve injury (PNI) is p...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180154

    authors: Inoue K

    更新日期:2018-11-28 00:00:00

  • IDH1 mutation promotes lung cancer cell proliferation through methylation of Fibulin-5.

    abstract::Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification. Previous studies uncovered mutations in IDH1 in several malignancies, with the most frequent mutati...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.180086

    authors: Yan B,Hu Y,Ma T,Wang Y

    更新日期:2018-10-10 00:00:00

  • An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease.

    abstract::Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200116

    authors: Banack SA,Dunlop RA,Cox PA

    更新日期:2020-06-01 00:00:00

  • Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars.

    abstract::Mycobacterium tuberculosis (Mtb), the aetiological agent of tuberculosis, has evolved to scavenge nutrients from the confined environment of host macrophages with mycobacterial ATP-binding cassette (ABC) transporters playing a key role in nutrient acquisition. Mtb-UspC (Rv2318) is the solute-binding protein of the ess...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160105

    authors: Fullam E,Prokes I,Fütterer K,Besra GS

    更新日期:2016-06-01 00:00:00

  • Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.

    abstract::Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental stress. This disruption mechanism was largely explained through nsP3-m...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160078

    authors: Schulte T,Liu L,Panas MD,Thaa B,Dickson N,Götte B,Achour A,McInerney GM

    更新日期:2016-07-01 00:00:00

  • Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update.

    abstract::Cancer cells undergo many different alterations during their transformation, including genetic and epigenetic events. The controlled division of healthy cells can be impaired through the downregulation of tumour suppressor genes. Here, we provide an update of the mechanisms in which epigenetically altered coding and n...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170152

    authors: Llinàs-Arias P,Esteller M

    更新日期:2017-09-01 00:00:00

  • Establishment and function of chromatin modification at enhancers.

    abstract::How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell fates by selectively activating unique subsets of their genome. This is achieved, in part, by enhancers-genetic elements that can increase transcription of both ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200255

    authors: Tafessu A,Banaszynski LA

    更新日期:2020-10-01 00:00:00

  • Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells.

    abstract::Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncR...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.150262

    authors: Lin CY,Kleinbrink EL,Dachet F,Cai J,Ju D,Goldstone A,Wood EJ,Liu K,Jia H,Goustin AS,Kosir MA,Thepsuwan P,Lipovich L

    更新日期:2016-12-01 00:00:00

  • Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrations.

    abstract::Understanding gene regulation requires knowledge of changes in transcription factor (TF) activities. Simultaneous direct measurement of numerous TF activities is currently impossible. Nevertheless, statistical approaches to infer TF activities have yielded non-trivial and verifiable predictions for individual TFs. Her...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.120091

    authors: Rolfe MD,Ocone A,Stapleton MR,Hall S,Trotter EW,Poole RK,Sanguinetti G,Green J,SysMO-SUMO Consortium.

    更新日期:2012-07-01 00:00:00

  • Glareosin: a novel sexually dimorphic urinary lipocalin in the bank vole, Myodes glareolus.

    abstract::The urine of bank voles (Myodes glareolus) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleu...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170135

    authors: Loxley GM,Unsworth J,Turton MJ,Jebb A,Lilley KS,Simpson DM,Rigden DJ,Hurst JL,Beynon RJ

    更新日期:2017-09-01 00:00:00

  • Biochemical evidence for diverse strategies in the inner kinetochore.

    abstract::The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore. However, recent efforts towards biochemical reconstitution of diverse kinetochore...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.200284

    authors: Hamilton GE,Davis TN

    更新日期:2020-11-01 00:00:00

  • Mutational analysis of dimeric linkers in peri- and cytoplasmic domains of histidine kinase DctB reveals their functional roles in signal transduction.

    abstract::Membrane-associated histidine kinases (HKs) in two-component systems respond to environmental stimuli by autophosphorylation and phospho-transfer. HK typically contains a periplasmic sensor domain that regulates the cytoplasmic kinase domain through a conserved cytoplasmic linker. How signal is transduced from the lig...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.140023

    authors: Liu J,Yang J,Wen J,Yang Y,Wei X,Zhang X,Wang YP

    更新日期:2014-06-01 00:00:00

  • Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease.

    abstract::Adult-onset neurodegenerative diseases are among the most difficult human health conditions to model for drug development. Most genetic or toxin-induced cell and animal models cannot faithfully recapitulate pathology in disease-relevant cells, making it excessively challenging to explore the potential mechanisms under...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.180177

    authors: Wu YY,Chiu FL,Yeh CS,Kuo HC

    更新日期:2019-01-31 00:00:00

  • The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.

    abstract::AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the nucleoplasm just l...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160103

    authors: Burla R,Carcuro M,Torre ML,Fratini F,Crescenzi M,D'Apice MR,Spitalieri P,Raffa GD,Astrologo L,Lattanzi G,Cundari E,Raimondo D,Biroccio A,Gatti M,Saggio I

    更新日期:2016-08-01 00:00:00

  • TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin.

    abstract::Although systemic or local inflammation, commonly featured by cytokine activation, is implicated in patients with bone loss, the underlying mechanisms are still elusive. As microRNAs (miR), a class of small non-coding RNAs involved in essential physiological processes, have been found in bone cells, we aimed to invest...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.150258

    authors: Wang N,Zhou Z,Wu T,Liu W,Yin P,Pan C,Yu X

    更新日期:2016-03-01 00:00:00

  • The outer membrane phospholipase A is essential for membrane integrity and type III secretion in Shigella flexneri.

    abstract::Outer membrane phospholipase A (OMPLA) is an enzyme located in the outer membrane of Gram-negative bacteria. OMPLA exhibits broad substrate specificity, and some of its substrates are located in the cellular envelope. Generally, the enzymatic activity can only be induced by perturbation of the cell envelope integrity ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160073

    authors: Wang X,Jiang F,Zheng J,Chen L,Dong J,Sun L,Zhu Y,Liu B,Yang J,Yang G,Jin Q

    更新日期:2016-09-01 00:00:00

  • Adult Drosophila muscle morphometry through microCT reveals dynamics during ageing.

    abstract::Indirect flight muscles (IFMs) in adult Drosophila provide the key power stroke for wing beating. They also serve as a valuable model for studying muscle development. An age-dependent decline in Drosophila free flight has been documented, but its relation to gross muscle structure has not yet been explored satisfactor...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190087

    authors: Chaturvedi D,Prabhakar S,Aggarwal A,Atreya KB,VijayRaghavan K

    更新日期:2019-06-28 00:00:00

  • Expression of a hindlimb-determining factor Pitx1 in the forelimb of the lizard Pogona vitticeps during morphogenesis.

    abstract::With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology. As such, they provide a promising system for examining developmental and molecular processes underlying limb morphol...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.160252

    authors: Melville J,Hunjan S,McLean F,Mantziou G,Boysen K,Parry LJ

    更新日期:2016-10-01 00:00:00

  • AMP-activated protein kinase: a therapeutic target in intestinal diseases.

    abstract::Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, ...

    journal_title:Open biology

    pub_type: 杂志文章,评审

    doi:10.1098/rsob.170104

    authors: Sun X,Zhu MJ

    更新日期:2017-08-01 00:00:00

  • Short linear motif acquisition, exon formation and alternative splicing determine a pathway to diversity for NCoR-family co-repressors.

    abstract::Vertebrate NCoR-family co-repressors play central roles in the timing of embryo and stem cell differentiation by repressing the activity of a range of transcription factors. They interact with nuclear receptors using short linear motifs (SLiMs) termed co-repressor for nuclear receptor (CoRNR) boxes. Here, we identify ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.150063

    authors: Short S,Peterkin T,Guille M,Patient R,Sharpe C

    更新日期:2015-08-01 00:00:00

  • Regulation of neurite growth by tumour necrosis superfamily member RANKL.

    abstract::RANKL (receptor-activator of NF-κB ligand, TNFSF11) is a member of the TNF superfamily that regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands. While RANKL and its membrane bound receptor RANK (TNFRSF11A) are expressed in the adult central nervous system and have been implicat...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.120150

    authors: Gutierrez H,Kisiswa L,O'Keeffe GW,Smithen MJ,Wyatt S,Davies AM

    更新日期:2013-01-08 00:00:00

  • Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.

    abstract::The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL in its conserved STAN motif has been shown to promote its interaction with Sas6. However, S...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170247

    authors: Dzhindzhev NS,Tzolovsky G,Lipinszki Z,Abdelaziz M,Debski J,Dadlez M,Glover DM

    更新日期:2017-12-01 00:00:00

  • Understanding the mammalian TRAP complex function(s).

    abstract::In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is ...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.190244

    authors: Russo A

    更新日期:2020-05-01 00:00:00

  • Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells.

    abstract::The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expressio...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.170111

    authors: Carrillo D,Muñoz JP,Huerta H,Leal G,Corvalán A,León O,Calaf GM,Urzúa U,Boccardo E,Tapia JC,Aguayo F

    更新日期:2017-11-01 00:00:00

  • A vitamin B₁₂ transporter in Mycobacterium tuberculosis.

    abstract::Vitamin B₁₂-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B₁₂ in vitro, it is uncertain whether the organism is able to scavenge B₁₂ during host infection. This quest...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.120175

    authors: Gopinath K,Venclovas C,Ioerger TR,Sacchettini JC,McKinney JD,Mizrahi V,Warner DF

    更新日期:2013-02-13 00:00:00

  • Dependency relationships between IFT-dependent flagellum elongation and cell morphogenesis in Leishmania.

    abstract::Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement. Leishmania exhibits both of these flagellum forms and differentiation between these two flagellum form...

    journal_title:Open biology

    pub_type: 杂志文章

    doi:10.1098/rsob.180124

    authors: Sunter JD,Moreira-Leite F,Gull K

    更新日期:2018-11-21 00:00:00