Abstract:
:Acute nociceptive pain is an undesirable feeling but has a physiological significance as a warning system for living organisms. Conversely, chronic pain is lacking physiological significance, but rather represents a confusion of nerve functions. The neuropathic pain that occurs after peripheral nerve injury (PNI) is perhaps the most important type of chronic pain because it is refractory to available medications and thus remains a heavy clinical burden. In recent decades, studies have shown that spinal microglia play a principal role in the alterations in synaptic functions evoking this pain. It is also clear that the P2X4 receptor (P2X4R), a subtype of ionotropic ATP receptors, is upregulated exclusively in spinal microglia after PNI and plays a key role in evoking neuropathic pain. Neuropathic pain is caused by several conditions associated with activated microglia without nerve damage. 'Microgliopathic pain' is a new concept indicating such abnormal pain related to activated microglia.
journal_name
Open Bioljournal_title
Open biologyauthors
Inoue Kdoi
10.1098/rsob.180154subject
Has Abstractpub_date
2018-11-28 00:00:00issue
11issn
2046-2441pii
rsob.180154journal_volume
8pub_type
杂志文章,评审相关文献
Open Biology文献大全abstract::In mammals, the testis-specific bromodomain and extra terminal (BET) protein BRDT is essential for spermatogenesis. In Drosophila, it was recently reported that the tBRD-1 protein is similarly required for male fertility. Interestingly, however, tBRD-1 has two conserved bromodomains in its N-terminus but it lacks an e...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140145
更新日期:2015-02-01 00:00:00
abstract::Following thymic output, αβ⁺CD4⁺ T cells become activated in the periphery when they encounter peptide-major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages and subsequent expansion and contraction during an appropriate and...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.120157
更新日期:2013-01-23 00:00:00
abstract::Outer membrane phospholipase A (OMPLA) is an enzyme located in the outer membrane of Gram-negative bacteria. OMPLA exhibits broad substrate specificity, and some of its substrates are located in the cellular envelope. Generally, the enzymatic activity can only be induced by perturbation of the cell envelope integrity ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160073
更新日期:2016-09-01 00:00:00
abstract::With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology. As such, they provide a promising system for examining developmental and molecular processes underlying limb morphol...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160252
更新日期:2016-10-01 00:00:00
abstract::Mutation in isocitrate dehydrogenase (IDH) leads to an aberrant function of the enzyme, leading to the production of hydroxyglutarate, as well as changes in cellular metabolism, DNA methylation and histone modification. Previous studies uncovered mutations in IDH1 in several malignancies, with the most frequent mutati...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.180086
更新日期:2018-10-10 00:00:00
abstract::Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, ...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.170104
更新日期:2017-08-01 00:00:00
abstract::'Epichromatin', the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by immunostaining with a specific bivalent mouse monoclonal anti-nucleosome antibody (mAb PL2-6). 'Chromomeres', punctate chromatin particles approximately 200-300 nm in diamet...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.180058
更新日期:2018-06-01 00:00:00
abstract::Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about i...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.120075
更新日期:2012-05-01 00:00:00
abstract::DNA methylation has been investigated for many years, but recent technologies have allowed for single-cell- and single-base-resolution DNA methylation datasets and more accurate assessment of DNA methylation dynamics at the key genomic regions that regulate gene expression in human early embryonic development. In this...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.180131
更新日期:2018-10-31 00:00:00
abstract::Typical centrioles are made of microtubules organized in ninefold symmetry. Most animal somatic cells have two centrioles for normal cell division and function. These centrioles originate from the zygote, but because the oocyte does not provide any centrioles, it is surprising that the zygotes of many animals are thou...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160334
更新日期:2017-03-01 00:00:00
abstract::With the widespread use of avermectins (AVMs) for managing parasitic and agricultural pests, the resistance of worms and insects to AVMs has emerged as a serious threat to human health and agriculture worldwide. The reduced penetration of AVMs is one of the main reasons for the development of the resistance to the che...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150231
更新日期:2016-04-01 00:00:00
abstract::Mycobacterium tuberculosis (Mtb), the aetiological agent of tuberculosis, has evolved to scavenge nutrients from the confined environment of host macrophages with mycobacterial ATP-binding cassette (ABC) transporters playing a key role in nutrient acquisition. Mtb-UspC (Rv2318) is the solute-binding protein of the ess...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160105
更新日期:2016-06-01 00:00:00
abstract::Although systemic or local inflammation, commonly featured by cytokine activation, is implicated in patients with bone loss, the underlying mechanisms are still elusive. As microRNAs (miR), a class of small non-coding RNAs involved in essential physiological processes, have been found in bone cells, we aimed to invest...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150258
更新日期:2016-03-01 00:00:00
abstract::Adult-onset neurodegenerative diseases are among the most difficult human health conditions to model for drug development. Most genetic or toxin-induced cell and animal models cannot faithfully recapitulate pathology in disease-relevant cells, making it excessively challenging to explore the potential mechanisms under...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.180177
更新日期:2019-01-31 00:00:00
abstract::In most animals, the bulk of sperm DNA is packaged with sperm nuclear basic proteins (SNBPs), a diverse group of highly basic chromosomal proteins notably comprising mammalian protamines. The replacement of histones with SNBPs during spermiogenesis allows sperm DNA to reach an extreme level of compaction, but little i...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160207
更新日期:2016-11-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncR...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150262
更新日期:2016-12-01 00:00:00
abstract::Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones. There are numerous homologues and isoforms of Hsp70 that participate in a wide variety of cellular functions. This diversity can facilitate adaption or specialization base...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.200089
更新日期:2020-08-01 00:00:00
abstract::The aim of this study was to analyse the expression pattern and elucidate the mechanistic involvement of long non-coding RNA LINC00467 in hepatocellular carcinoma (HCC). The relative expression of LINC00467 and microRNA (miR)-9-5p was determined by real-time polymerase chain reaction. Cell viability was measured using...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190074
更新日期:2019-09-27 00:00:00
abstract::Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the...
journal_title:Open biology
pub_type: 杂志文章,评审
doi:10.1098/rsob.180109
更新日期:2018-08-01 00:00:00
abstract::Differentiation of columnar epithelial cells involves a dramatic reorganization of the microtubules (MTs) and centrosomal components into an apico-basal array no longer anchored at the centrosome. Instead, the minus-ends of the MTs become anchored at apical non-centrosomal microtubule organizing centres (n-MTOCs). For...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160274
更新日期:2017-02-01 00:00:00
abstract::Pseudomonas aeruginosa are noscomially acquired, opportunistic pathogens that pose a major threat to the health of burns patients and the immunocompromised. We sequenced the genomes of P. aeruginosa isolates RNS_PA1, RNS_PA46 and RNS_PAE05, which displayed resistance to almost all frontline antibiotics, including gent...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.150175
更新日期:2016-03-01 00:00:00
abstract::Gating of AMPA- and kainate-selective ionotropic glutamate receptors can be defined in terms of ligand affinity, efficacy and the rate and extent of desensitization. Crucial insights into all three elements have come from structural studies of the ligand-binding domain (LBD). In particular, binding-cleft closure is as...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.130051
更新日期:2013-05-29 00:00:00
abstract::Most animals have separate sexes. The differential expression of gene products, in particular that of gene regulators, is underlying sexual dimorphism. Analyses of sex-biased expression have focused mostly on protein-coding genes. Several lines of evidence indicate that microRNAs, a class of major gene regulators, are...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.140024
更新日期:2014-04-02 00:00:00
abstract::AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete regions of the nucleoplasm just l...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.160103
更新日期:2016-08-01 00:00:00
abstract::In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is ...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.190244
更新日期:2020-05-01 00:00:00
abstract::The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent...
journal_title:Open biology
pub_type: 共识发展会议,杂志文章
doi:10.1098/rsob.190229
更新日期:2019-12-01 00:00:00
abstract::Redox conditions change in events such as immune and platelet activation, and during viral infection, but the biochemical consequences are not well characterized. There is evidence that some disulfide bonds in membrane proteins are labile while others that are probably structurally important are not exposed at the pro...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.110010
更新日期:2011-11-01 00:00:00
abstract::Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement. Leishmania exhibits both of these flagellum forms and differentiation between these two flagellum form...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.180124
更新日期:2018-11-21 00:00:00
abstract::The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV E6 and E7 oncoproteins. Transcriptomic assay using DNA microarrays revealed that PIR gene expressio...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.170111
更新日期:2017-11-01 00:00:00
abstract::Pigment-Dispersing Factor (PDF) is an important neuropeptide in the brain circadian network of Drosophila and other insects, but its role in bees in which the circadian clock influences complex behaviour is not well understood. We combined high-resolution neuroanatomical characterizations, quantification of PDF levels...
journal_title:Open biology
pub_type: 杂志文章
doi:10.1098/rsob.170224
更新日期:2018-01-01 00:00:00