Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response.

abstract：:Aberrant tumour necrosis factor (TNF) signalling is a hallmark of many inflammatory diseases including rheumatoid arthritis (RA), irritable bowel disease and lupus. Maladaptive TNF signalling can lead to hyper active downstream nuclear factor (NF)-κβ signalling in turn amplifying a cell's inflammatory response and exa...

journal_title：Open biology

authors： Totzke J,Scarneo SA,Yang KW,Haystead TAJ

更新日期：2020-09-01 00:00:00

abstract：:Ubiquitination is a versatile post-translational modification that regulates a multitude of cellular processes. Its versatility is based on the ability of ubiquitin to form multiple types of polyubiquitin chains, which are recognized by specific ubiquitin receptors to induce the required cellular response. Linear ubiq...

journal_title：Open biology

authors： Rittinger K,Ikeda F

更新日期：2017-04-01 00:00:00

abstract：:Vitamin B₁₂-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B₁₂ in vitro, it is uncertain whether the organism is able to scavenge B₁₂ during host infection. This quest...

journal_title：Open biology

authors： Gopinath K,Venclovas C,Ioerger TR,Sacchettini JC,McKinney JD,Mizrahi V,Warner DF

更新日期：2013-02-13 00:00:00

abstract：:Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still understood about the biological responses of the lens to low-dose ionizing ...

journal_title：Open biology

authors： Markiewicz E,Barnard S,Haines J,Coster M,van Geel O,Wu W,Richards S,Ainsbury E,Rothkamm K,Bouffler S,Quinlan RA

更新日期：2015-04-01 00:00:00

abstract：:At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus. The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side ch...

journal_title：Open biology

authors： Kinoshita T

更新日期：2020-03-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra and accumulation of ubiquitinated proteins in aggregates called Lewy bodies. Several mutated genes have been found in familial PD patients, including SNCA (α-synuclein), PARK2 (parkin), PINK...

journal_title：Open biology

authors： Im E,Yoo L,Hyun M,Shin WH,Chung KC

更新日期：2016-08-01 00:00:00

abstract：:Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or ...

journal_title：Open biology

authors： Cha J,Sun X,Bartos A,Fenelon J,Lefèvre P,Daikoku T,Shaw G,Maxson R,Murphy BD,Renfree MB,Dey SK

更新日期：2013-04-24 00:00:00

abstract：:Membrane-associated histidine kinases (HKs) in two-component systems respond to environmental stimuli by autophosphorylation and phospho-transfer. HK typically contains a periplasmic sensor domain that regulates the cytoplasmic kinase domain through a conserved cytoplasmic linker. How signal is transduced from the lig...

journal_title：Open biology

authors： Liu J,Yang J,Wen J,Yang Y,Wei X,Zhang X,Wang YP

更新日期：2014-06-01 00:00:00

abstract：:Current ageing theories are far from satisfactory because of the many determinants involved in ageing. The well-known rate-of-living theory assumes that the product (lifetime energy expenditure, LEE) of maximum lifespan (MLS) and mass-specific basal metabolic rate (msBMR) is approximately constant. Although this theor...

journal_title：Open biology

authors： Kitazoe Y,Hasegawa M,Tanaka M,Futami M,Futami J

更新日期：2017-10-01 00:00:00

abstract：:RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to knock down a targeted gene's expression. However, in other species,...

journal_title：Open biology

authors： Tayler A,Heschuk D,Giesbrecht D,Park JY,Whyard S

更新日期：2019-12-01 00:00:00

abstract：:The conserved Hedgehog (HH) signals control animal development, adult stem cell maintenance and oncogenesis. In Drosophila, the HH co-receptor Patched (PTC) controls both HH gradient formation and signalling. PTC is post-translationally downregulated by HH, which promotes its endocytosis and destabilization, but the m...

journal_title：Open biology

authors： Brigui A,Hofmann L,Argüelles C,Sanial M,Holmgren RA,Plessis A

更新日期：2015-10-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncR...

journal_title：Open biology

authors： Lin CY,Kleinbrink EL,Dachet F,Cai J,Ju D,Goldstone A,Wood EJ,Liu K,Jia H,Goustin AS,Kosir MA,Thepsuwan P,Lipovich L

更新日期：2016-12-01 00:00:00

abstract：:Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between transformed cells and their progenitors. We report that tumour cells ...

journal_title：Open biology

authors： Uriostegui-Arcos M,Aguayo-Ortiz R,Valencia-Morales MDP,Melchy-Pérez E,Rosenstein Y,Dominguez L,Zurita M

更新日期：2020-06-01 00:00:00

abstract：:Outer membrane phospholipase A (OMPLA) is an enzyme located in the outer membrane of Gram-negative bacteria. OMPLA exhibits broad substrate specificity, and some of its substrates are located in the cellular envelope. Generally, the enzymatic activity can only be induced by perturbation of the cell envelope integrity ...

journal_title：Open biology

authors： Wang X,Jiang F,Zheng J,Chen L,Dong J,Sun L,Zhu Y,Liu B,Yang J,Yang G,Jin Q

更新日期：2016-09-01 00:00:00

abstract：:The range of biological outcomes generated by many signalling proteins in development and homeostasis is increased by their interactions with glycosaminoglycans, particularly heparan sulfate (HS). This interaction controls the localization and movement of these signalling proteins, but whether such control depends on ...

journal_title：Open biology

authors： Sun C,Marcello M,Li Y,Mason D,Lévy R,Fernig DG

更新日期：2016-03-01 00:00:00

abstract：:Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as regulators of cellular events by their ability to form microdoma...

journal_title：Open biology

authors： Olsen ASB,Færgeman NJ

更新日期：2017-05-01 00:00:00

abstract：:Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic target of rapamycin com...

journal_title：Open biology

authors： Liu W,Wang Z,Yang J,Wang Y,Li K,Huang B,Yan B,Wang T,Li M,Zou Z,Yang J,Xiao G,Cui ZK,Liu A,Bai X

更新日期：2019-05-31 00:00:00

abstract：:The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL in its conserved STAN motif has been shown to promote its interaction with Sas6. However, S...

journal_title：Open biology

authors： Dzhindzhev NS,Tzolovsky G,Lipinszki Z,Abdelaziz M,Debski J,Dadlez M,Glover DM

更新日期：2017-12-01 00:00:00

abstract：:Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous sources of somatic mutations found in multiple human cancers. Wh...

journal_title：Open biology

authors： Granadillo Rodríguez M,Flath B,Chelico L

更新日期：2020-12-01 00:00:00

abstract：:Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We ...

journal_title：Open biology

authors： Banack SA,Dunlop RA,Cox PA

更新日期：2020-06-01 00:00:00

abstract：:Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries and thus prevent silencing of expressed genes. Here we show that lo...

journal_title：Open biology

authors： Verrier L,Taglini F,Barrales RR,Webb S,Urano T,Braun S,Bayne EH

更新日期：2015-05-01 00:00:00

abstract：:In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the correspondin...

journal_title：Open biology

authors： Urano D,Chen JG,Botella JR,Jones AM

更新日期：2013-03-27 00:00:00

abstract：:The genus Caulobacter is found in a variety of habitats and is known for its ability to thrive in low-nutrient conditions. K31 is a novel Caulobacter isolate that has the ability to tolerate copper and chlorophenols, and can grow at 4 ° C with a doubling time of 40 h. K31 contains a 5.5 Mb chromosome that codes for mo...

journal_title：Open biology

authors： Ash K,Brown T,Watford T,Scott LE,Stephens C,Ely B

更新日期：2014-10-01 00:00:00

abstract：:How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell fates by selectively activating unique subsets of their genome. This is achieved, in part, by enhancers-genetic elements that can increase transcription of both ...

journal_title：Open biology

authors： Tafessu A,Banaszynski LA

更新日期：2020-10-01 00:00:00

abstract：:Indirect flight muscles (IFMs) in adult Drosophila provide the key power stroke for wing beating. They also serve as a valuable model for studying muscle development. An age-dependent decline in Drosophila free flight has been documented, but its relation to gross muscle structure has not yet been explored satisfactor...

journal_title：Open biology

authors： Chaturvedi D,Prabhakar S,Aggarwal A,Atreya KB,VijayRaghavan K

更新日期：2019-06-28 00:00:00

abstract：:With the widespread use of avermectins (AVMs) for managing parasitic and agricultural pests, the resistance of worms and insects to AVMs has emerged as a serious threat to human health and agriculture worldwide. The reduced penetration of AVMs is one of the main reasons for the development of the resistance to the che...

journal_title：Open biology

authors： Chen LP,Wang P,Sun YJ,Wu YJ

更新日期：2016-04-01 00:00:00

abstract：:Synaptic vesicle exocytosis relies on the tethering of release ready vesicles close to voltage-gated Ca2+ channels and specific lipids at the future site of fusion. This enables rapid and efficient neurotransmitter secretion during presynaptic depolarization by an action potential. Extensive research has revealed that...

journal_title：Open biology

authors： Held RG,Kaeser PS

更新日期：2018-02-01 00:00:00

abstract：:The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore. However, recent efforts towards biochemical reconstitution of diverse kinetochore...

journal_title：Open biology

authors： Hamilton GE,Davis TN

更新日期：2020-11-01 00:00:00

abstract：:Genomic regions with repeated sequences are unstable and prone to rapid DNA diversification. However, the role of tandem repeats within the coding region is not fully characterized. Here, we have identified a new hypervariable C-type lectin gene family with different numbers of tandem repeats (Rlecs; R means repeat) i...

journal_title：Open biology

authors： Huang Y,Huang X,Zhou X,Wang J,Zhang R,Ma F,Wang K,Zhang Z,Dai X,Cao X,Zhang C,Han K,Ren Q

更新日期：2020-09-01 00:00:00

abstract：:Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is achieved by mechanisms that adapt the number of mitochondria to that required for energy production and for the supply of metabolic intermediates necessary to su...

journal_title：Open biology

authors： Groenewoud MJ,Zwartkruis FJ

更新日期：2013-12-18 00:00:00