Abstract:
BACKGROUND:Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericidal antimicrobial peptides (AMPs) in neighboring ciliated epithelial cells. We hypothesized that there is patient variability in the amount of bacterial killing induced by different concentrations of denatonium and that the differences correlate with CRS clinical outcomes. METHODS:Bacterial growth inhibition was quantified after mixing bacteria with airway surface liquid (ASL) collected from denatonium-stimulated sinonasal air-liquid interface (ALI) cultures. Patient ASL bacterial killing at 0.1 mM denatonium and baseline characteristics and sinus surgery outcomes were compared between these populations. RESULTS:There is variability in the degree of denatonium-induced bacterial killing between patients. In CRS with nasal polyps (CRSwNP), patients with increased bacterial killing after stimulation with low levels of denatonium undergo significantly more functional endoscopic sinus surgeries (FESSs) (p = 0.037) and have worse 6-month post-FESS 22-item Sino-Nasal Outcome Test (SNOT-22) scores (p = 0.012). CONCLUSION:Bacterial killing after stimulation with low levels of denatonium correlates with number of prior FESS and postoperative SNOT-22 scores in CRSwNP. Some symptoms of CRS in patients with hyperresponsiveness to low levels of denatonium may be due to increased airway immune activity or inherent disease severity.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Carey RM,Workman AD,Hatten KM,Siebert AP,Brooks SG,Chen B,Adappa ND,Palmer JN,Kennedy DW,Lee RJ,Cohen NAdoi
10.1002/alr.21949subject
Has Abstractpub_date
2017-07-01 00:00:00pages
699-704issue
7eissn
2042-6976issn
2042-6984journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Eosinophilic chronic rhinosinusitis (ECRS) is a disease characterized by eosinophilic inflammatory infiltrate and a local type 2 cytokine milieu. Current animal models fail to recapitulate many of the innate and adaptive immunologic hallmarks of the disease, thus hindering the development of effective therap...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22072
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:A genetic basis to chronic rhinosinusitis (CRS) is postulated, but remains elusive. We have recently identified low levels of circulating CD8 lymphocytes as a frequent finding in difficult-to-treat or refractory CRS. In major histocompatibility complex 1 class 1 (MHC1) deficiency, low circulating levels of C...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21174
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) in aspirin-exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation for which a multidisciplinary consensus on patient management has not been reached. Several medical interventions have been investigated, but a formal comprehensive evaluati...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Nasal steroids are a critical part of the management of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after endoscopic sinus surgery (ESS). Increasingly, practitioners are using budesonide respules delivered to the sinonasal cavities, which is an off-label use, in lieu of traditional nas...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,随机对照试验
doi:10.1002/alr.21688
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-9 and IL-17C have been known to play a role in allergic inflammation, yet, their roles in chronic rhinosinusitis (CRS) are not well defined. IL-9 induces changes in epithelial cell gene expression leading to goblet cell metaplasia, whereas IL-17C is functionally distinct in that its expressi...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21745
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Most data on sinonasal mucosal melanoma come from small institutional studies, and therefore optimal treatment methods are not well understood. The purpose of this study was to analyze the association between treatment and survival in sinonasal mucosal melanoma. METHODS:Six hundred ninety-five patients diag...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been pro...
journal_title:International forum of allergy & rhinology
pub_type: 共识发展会议,杂志文章
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更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). The objectives of this review are to summarize prior studies that describe the correlation between active smoking and secondhand smoke (SHS...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21054
更新日期:2012-09-01 00:00:00
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journal_title:International forum of allergy & rhinology
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更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:This study reviews the published literature related to management of sinonasal chondrosarcoma. Clinical presentation, demographics, radiographic diagnosis, treatment, and management outcomes of this uncommon disease are reported. METHODS:A systematic review of studies for sinonasal chondrosarcoma from 1950 ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Earlier studies have suggested that patients with chronic rhinosinusitis (CRS) report worse sleep quality than population norms. What remains unknown is whether these patients are actually experiencing measurable changes in objective sleep parameters. The goal of this study was to prospectively evaluate obje...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
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更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Social determinants of health can have a substantial impact on treatment outcomes. Prior study has shown that socioeconomic status influences the likelihood of improvement in quality-of-life (QOL) following endoscopic sinus surgery (ESS). However, the impact of socioeconomic factors on changes in productivit...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
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更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) has been defined as inflammation of the paranasal sinuses lasting at least 12 weeks with corresponding 2 or more "cardinal symptoms" that include: (1) nasal obstruction; (2) thick nasal discharge; (3) facial pain/pressure; and (4) reduction or loss of sense of smell. Although pri...
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Elderly patients with multiple comorbidities may be at higher risk of postoperative complications. With an increasingly aging population, more data assessing for predisposing factors are needed in this at-risk group. In this study, we analyzed the effect of elderly status on relative comorbidities and compli...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22239
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22089
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Osteitis is a feature of chronic rhinosinusitis (CRS) and often associated with recalcitrant disease. Radiological characteristics of osteitic sinus changes are commonly reported in practice but the clinical and pathologic significance is poorly defined. The objective of this study was to correlate the Kenne...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21113
更新日期:2013-05-01 00:00:00
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journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
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更新日期:2014-05-01 00:00:00
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更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Debate still persists on the relation between olfactory bulb volume (OBV) and olfactory function. Many studies suggest that olfactory deprivation decreases the OBV. The aim of this study was to compare the olfactory threshold and OBV of patients with nasal polyps to healthy individuals and to evaluate the im...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21478
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a common condition encountered in primary care medicine and is estimated to affect 12.5% of the United States population. This study aims to compare methods of assessing health utility in CRS. METHODS:A cross-sectional sample of CRS patients (n = 137) were interviewed using d...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21556
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. The objective of the current study is to assess long-term success of the Draf III mucosal grafting technique. METHODS:Patients undergoing Draf III with mucosal graft...
journal_title:International forum of allergy & rhinology
pub_type: 临床试验,杂志文章
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更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:We have previously demonstrated that persistent symptoms following functional endoscopic sinus surgery for chronic rhinosinusitis (CRS) is associated with Gram-negative bacterial carriage. Mechanisms for this remain unknown. We wished to determine whether Gram-negative carriage in patients with CRS with nasa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Lumbar drain (LD) use in the management of cerebrospinal fluid (CSF) rhinorrhea remains controversial. We analyzed the relationship between LD placement and CSF leak recurrence after endoscopic repair. METHODS:A retrospective case series was conducted. Patients who underwent CSF leak repair from 1999 to 201...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21023
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Endoscopic Draf 2B and Draf 3 frontal sinusotomies are frequently performed for chronic refractory frontal rhinosinusitis. The purpose of this study was to compare outcomes between Draf 2B and Draf 3 procedures. METHODS:A retrospective cohort study was conducted comparing patients undergoing bilateral Draf ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00