Abstract:
BACKGROUND:Debate still persists on the relation between olfactory bulb volume (OBV) and olfactory function. Many studies suggest that olfactory deprivation decreases the OBV. The aim of this study was to compare the olfactory threshold and OBV of patients with nasal polyps to healthy individuals and to evaluate the impact of functional endoscopic sinus surgery (FESS) on OBV and olfactory threshold. METHODS:A longitudinal study was carried out in Tehran between 2011 and 2012. Twenty-two patients with nasal polyps were compared with 37 healthy individuals. Olfactory threshold test and magnetic resonance imaging (MRI) were performed on all participants. Twenty-two patients in case group were followed for 6 months after FESS. OBV and olfactory threshold were measured after 6 months. RESULTS:There was no significant difference between the age, gender, and OBV of the 2 groups. However, the difference between olfactory threshold was significant (p = 0.005). The olfactory threshold showed no significant relation with OBV (p > 0.05). The correlation between Lund-Mackay score and the mean total OBV and left OBV was significant (r = -0.15, p = 0.045; r = -0.22, p = 0.047; respectively). The decrease in olfactory threshold measured after FESS was statistically significant. Right, left, and total OBV significantly increased after FESS. CONCLUSION:The results of our study show that FESS has a significant impact on OBV increment and olfactory threshold decrement. The olfactory bulb is a plastic structure and improvement in peripheral olfactory function results in increase in OBV. However, further studies are mandated, in order to establish this result.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Sadeghi M,Amali A,Ezabadi SR,Motiee-Langroudi M,Farshchi S,Mokhtari Zdoi
10.1002/alr.21478subject
Has Abstractpub_date
2015-04-01 00:00:00pages
356-60issue
4eissn
2042-6976issn
2042-6984journal_volume
5pub_type
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journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
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