Abstract:
BACKGROUND:The ciprofloxacin-coated sinus stent (CSS) has unique therapeutic potential to deliver antibiotics to the sinuses. The objective of this study is to evaluate the efficacy of the CSS stent in eliminating Pseudomonas aeruginosa infection in a rabbit model of sinusitis. METHODS:A ciprofloxacin-eluting sinus stent was created by coating ciprofloxacin/Eudragit RS100 on biodegradable poly-D/L-lactic acid (2 mg). After analyzing in-vitro inhibition of P aeruginosa (PAO-1 strain) biofilm formation, a total of 8 stents (4 shams, 4 CSSs) were placed unilaterally in rabbit maxillary sinuses via dorsal sinusotomy after inducing infection for 1 week with PAO-1. Animals were assessed 2 weeks after stent insertion with nasal endoscopy, sinus culture, computed tomography (CT) scan, histopathology, and scanning electron microscopy (SEM). RESULTS:PAO-1 biofilm formation was significantly reduced in vitro with exposure to the CSS (p < 0.0001). Insertion of the stent in PAO-1-infected rabbits for 2 weeks resulted in significant improvement in sinusitis according to endoscopy scoring (p < 0.0001) and CT scoring (p < 0.002). Histology and SEM revealed marked improvement in the structure of the mucosa and submucosa with no detection of biofilm structures in the CSS cohort. CONCLUSION:Although this study had a small sample size, we identified robust therapeutic efficacy of the CSS by reducing bacterial load and biofilm formation of P aeruginosa in a preclinical model of sinusitis after placement for 2 weeks.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Cho DY,Lim DJ,Mackey C,Skinner D,Weeks C,Gill GS,Hergenrother RW,Swords WE,Woodworth BAdoi
10.1002/alr.22081subject
Has Abstractpub_date
2018-04-01 00:00:00pages
482-489issue
4eissn
2042-6976issn
2042-6984journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a local inflammatory process driven by eosinophils. Mucosal eosinophil count (MEC) has previously been demonstrated to be a reliable indicator of disease severity. We aim to evaluate use of MEC in guiding medical management of CRS after functional endoscopic sinus surgery (FES...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22517
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Endoscopic-endonasal skull base surgery (ESBS) provides an important approach to select pathologies. There remains a paucity of data, however, regarding morbidity in patients undergoing ESBS with comorbid acute rhinosinusitis (ARS), a fungal ball (FB), or chronic rhinosinusitis (CRS). METHODS:A retrospectiv...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21476
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether anterior rhinoscopy (AR), nasal endoscopy (NE) and paranasal sinus computed tomography (PNS CT) can predict other sinonasal obstructive pathologies in the setting of nasal septal deviation (NSD), and to evaluate the impact of preoperative PNS CT on the decision ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21545
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Antibiotics are commonly used in the management of both acute rhinosinusitis and acute exacerbations of chronic rhinosinusitis. With their common use, they have become the leading medication for litigation. It is crucial for the provider to be familiar with potential complications and the medico-legal ramifi...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21433
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Optimizing the intranasal distribution of nasal steroid spray (NS) is important in managing patients with allergic rhinitis (AR). Using a 3-dimensional computational model of the human nose, we found that inspiratory airflow improved particle distribution by 86%. We hence designed a study to determine if the...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21807
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The histological features of osteitis in chronic rhinosinusitis (CRS) in animal studies induced by bacterial inoculation into maxillary sinuses revealed inflammatory involvement of the underlying bone matrix and/or the Haversian system; however, human studies do not mention these findings. The objective of t...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21291
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The influence of the microbial community on inflammatory subtype in chronic rhinosinusitis (CRS) has been proposed. Superantigen mechanisms potentially create a T helper 2 (Th-2)/eosinophilic dominated inflammation as a product of local flora rather than an intrinsic mucosal process. The associations between...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21220
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Patients with refractory chronic rhinosinusitis (RCRS) have persistent symptoms despite best medical therapy. Some evidence suggests continued medical therapy (CMT) is appropriate for patients with RCRS. The primary objective of this study was to evaluate the clinical impact of CMT in patients with RCRS who ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21238
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The purpose of this work was to describe a clinical and radiographic pattern of findings that helps localize the site of spontaneous cerebrospinal fluid (CSF) leaks. METHODS:This study was a retrospective review of CSF leaks treated at the University of Texas Southwestern Medical Center from 2000 to 2009. D...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21048
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22089
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Povidone-iodine (PVP-I) is well known as an antiseptic and exhibits extensive activity against various pathogens. However, due to its uniquely unpleasant nature, it cannot be used locally to deactivate various sinonasal pathogens. Therefore, we developed a PVP-I composite that blocks the unpleasant odor of P...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22568
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The incidence of adverse sequelae related to trauma of cranial nerve V2 (V2) and the Vidian nerve (VN) during endoscopic pterygoid recess repair (PRR) of lateral sphenoid encephalocele is insufficiently reported in the medical literature. As part of our quality assessment and improvement program we sought to...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22448
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The effects of desloratadine-montelukast combination on quality of life (QoL) and nasal airflow of patients with perennial allergic rhinitis (PAR) has not been reported. The objective of this work was investigate the efficacy of desloratadine-montelukast combination on nasal obstruction and health-related qu...
journal_title:International forum of allergy & rhinology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/alr.21185
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22625
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Nasal polyposis is characterized by persistent inflammation and remodeling in sinonasal mucosa. Toll-like receptor 9 (TLR9) is a DNA receptor of the innate immune system that plays a pivotal role in fibrosis and inflammatory responses. The aim of this study is to explore the expression, activity, and potenti...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22155
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Osteitis is a feature of chronic rhinosinusitis (CRS) and often associated with recalcitrant disease. Radiological characteristics of osteitic sinus changes are commonly reported in practice but the clinical and pathologic significance is poorly defined. The objective of this study was to correlate the Kenne...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21113
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METH...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22016
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Bronchial asthma is one of the most common chronic diseases in childhood, with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming rate. Asthma is a complex genetic disorder with strong environmental influence. It imposes a growing burden on our society in terms of morbidity,...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21557
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Our objectives were to evaluate collaboration with medical students and other nondoctoral authors, and assess whether mentoring such students influences the academic productivity of senior authors. METHODS:Six issues of the Laryngoscope and International Forum of Allergy & Rhinology (IFAR) were examined for...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21247
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The objective of this work was to evaluate prevalence of eosinophilic esophagitis (EoE) in the United States, and analyze prevalence of atopic disease in patients with EoE. The study design was a retrospective administrative database analysis in U.S.-based outpatient settings. METHODS:A retrospective claims...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21968
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-9 and IL-17C have been known to play a role in allergic inflammation, yet, their roles in chronic rhinosinusitis (CRS) are not well defined. IL-9 induces changes in epithelial cell gene expression leading to goblet cell metaplasia, whereas IL-17C is functionally distinct in that its expressi...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21745
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a common condition encountered in primary care medicine and is estimated to affect 12.5% of the United States population. This study aims to compare methods of assessing health utility in CRS. METHODS:A cross-sectional sample of CRS patients (n = 137) were interviewed using d...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21556
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Diagnostic nasal endoscopy is a routine measure of sinonasal inflammation in patients with chronic rhinosinusitis (CRS). Although multiple staging systems have been proposed and evaluated, evidence of association between concurrent symptoms and endoscopic findings remains discordant. The goal of this study i...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21683
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The role of bacteria in the pathogenesis of chronic rhinosinusitis (CRS) remains uncertain. Recent evidence suggests that bacteria are able to establish microcolonies within the underlying mucosa. However, to date there has been no systematic comparison of bacterial community composition and diversity in the...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21600
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Sinonasal squamous cell carcinoma (SNSCC) is the most common malignancy of the paranasal sinuses. Surgery is the mainstay of treatment, yet positive surgical margins (PSM) are common and the prognostic impact on overall survival (OS) is mixed. Given the heterogeneity of impact of PSM on OS within the literat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22415
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) is prolonged inflammation of the sinonasal mucosa. Interleukin-32 (IL-32) is involved in the pathogenesis of chronic lung inflammatory diseases. The aim of study is to compare the expression level of IL-32 in normal nasal mucosa and CRSwNP and to investigate ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21792
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Evidence suggests relationships between allergic rhinitis (AR) and poor sleep parameters, but population-based studies in the United States are lacking. This study investigates the relationship between AR and sleep parameters in a representative sample of U.S. adults. METHODS:Cross-sectional study of 5563 p...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22174
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy with a propensity for distant metastasis. In this study we describe the incidence and determinants of survival among patients with SNACC between the years 2004 and 2012 using the National Cancer Database (NCDB). METHODS:This was a retrospective...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22255
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Over 45 million Americans suffer from recurrent headaches, and an estimated $11.9 million was spent on doctor's visits for rhinogenic pain last year. Sphenopalatine blocks have been described for various facial pain syndromes, but their use and the type of blockade agents remain controversial. The objective ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21035
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Reported revision rates for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) vary significantly. Several investigations examining revision rates for ESS have been limited by duration of follow-up, academic centers, or small surgeon cohorts. The objective of this study was to define the long-te...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22264
更新日期:2019-04-01 00:00:00