Abstract:
BACKGROUND:Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METHODS:On ClinicalTrials.gov, the following terms were searched: allergen immunotherapy OR allergy immunotherapy. Variables, including completion status, dates, design, study population, funder, location, and allergen were recorded. The NIH Research Portfolio Online Reporting Tools (RePORTER) system was also used to gather relevant variables. RESULTS:A total of 372 clinical trials met inclusion criteria. The proportion of industry-funded clinical trials has declined over 15 years. There has been a slow decline in pollen allergy immunotherapy research, with an increase in both food and animal allergy immunotherapy research. Otolaryngologists comprised only 6.4% of clinical trials principal investigators (PIs). There was a total adjusted NIH funding of $74,986,125 for the 118 total funding years. CONCLUSION:Despite an immense interest in allergen immunotherapy, this analysis demonstrates that otolaryngologists represented a small proportion of PIs leading associated clinical trials and basic science inquiry. The proportion of trials with industry sponsorship has declined considerably in recent decades. These trends could help direct future resource allocation for allergen immunotherapy.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Ramsey T,Lai W,Svider PF,Hojjat H,Eloy JA,Folbe AJdoi
10.1002/alr.22016subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1127-1134issue
12eissn
2042-6976issn
2042-6984journal_volume
7pub_type
杂志文章abstract:BACKGROUND:The association between sinonasal microbiome and clinical outcomes of patients with chronic rhinosinusitis (CRS) is unclear. We performed a systematic review of prior studies evaluating the CRS microbiome in relation to clinical outcomes. METHODS:Computerized searches of PubMed/Medline, Cochrane, and EMBASE...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22524
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Little is known about the use of allergy and asthma medications in older adults. This study aimed to assess the prevalence of use of these medications in older adults and evaluate predictors of their use. METHODS:Cross-sectional study using data from the National Social Life, Health, and Aging Project (NSHA...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21856
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The Rhinosinusitis Disability Index (RSDI) consists of multiple subdomains shown to be useful in studying chronic rhinosinusitis (CRS). The objective of this study was to determine if RSDI subdomain scores are associated with selection of treatment modality (endoscopic sinus surgery [ESS] or continued medica...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21656
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:This study reviews the published literature related to management of sinonasal chondrosarcoma. Clinical presentation, demographics, radiographic diagnosis, treatment, and management outcomes of this uncommon disease are reported. METHODS:A systematic review of studies for sinonasal chondrosarcoma from 1950 ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21162
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Bronchial asthma is one of the most common chronic diseases in childhood, with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming rate. Asthma is a complex genetic disorder with strong environmental influence. It imposes a growing burden on our society in terms of morbidity,...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21557
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Many asthmatic patients have coexisting allergic rhinitis (AR). This study aims to investigate the compliance of physicians with respiratory medicine specialty (PRMs) to Global Initiative for Asthma (GINA) and Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines during the management of their asthma-...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21449
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) has been defined as inflammation of the paranasal sinuses lasting at least 12 weeks with corresponding 2 or more "cardinal symptoms" that include: (1) nasal obstruction; (2) thick nasal discharge; (3) facial pain/pressure; and (4) reduction or loss of sense of smell. Although pri...
journal_title:International forum of allergy & rhinology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/alr.21410
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on pri...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21440
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The objective of this work was to better understand variations in perioperative management in endoscopic endonasal skull-base surgery (EESBS) and to identify trends in management based upon the practice patterns of North American Skull Base Society (NASBS) members. METHODS:A 29-question survey evaluating pe...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22066
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. U...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21496
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Osteitis is a feature of chronic rhinosinusitis (CRS) and often associated with recalcitrant disease. Radiological characteristics of osteitic sinus changes are commonly reported in practice but the clinical and pathologic significance is poorly defined. The objective of this study was to correlate the Kenne...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21113
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:It has been found that the most common adverse reaction which occurs more frequently on cetirizine than on placebo is somnolence. However, the somnolence rate varied widely among different studies. The objective of this study was to assess the somnolence effect of cetirizine 10 mg daily compared to placebo i...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,meta分析
doi:10.1002/alr.21746
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Nasopharyngectomy is an accepted treatment for recurrent nasopharyngeal carcinoma following radiation with or without chemotherapy. Traditionally, the nasopharynx has been approached through relatively invasive "open" techniques including transpalatal, maxillary swing, and trans-mandibular-pterygoid approach...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21104
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:The purpose of this work was to perform a systematic review regarding ossifying fibroma and its multiple variants of the paranasal sinuses, and to identify any clinical differences between the multiple variants. METHODS:A search of the U.S. National Library of Medicine (PubMed) database was performed for th...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21067
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Knowledge of our immune system functions is critical for understanding allergic airway disease development as well as for selection of appropriate diagnostic and therapeutic options for patients with respiratory allergies. METHODS:This review explains the current understanding of the basic immunology of the...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21380
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The purpose of this work was to compare the absolute breaking strength of various soft tissue skull base (SB) repairs in an in vitro porcine model. METHODS:A burst pressure (BP) testing system was designed using an axial loading force to create increasing hydraulic pressure. Defects measuring 0.5 × 0.5 cm w...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21085
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:The role that bacterial biofilms might play in recalcitrant forms of chronic rhinosinusitis (CRS) is increasingly being recognized. However, the detection of bacteria existing in this form, using standard culture, is limited by their unique metabolically inactive properties. All current biofilm diagnostic mo...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21115
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Multiple prospective and retrospective studies have reported results from balloon-only procedures and hybrid balloon sinus surgeries through intermediate follow-up periods of up to 1 year. Long-term durability results beyond 2 years are limited. METHODS:One-year results from the original study of standalone...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21024
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Olfactory-specific quality of life (QOL) can be measured using the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS), which examines various aspects of olfactory dysfunction. It is unknown if certain factors of the QOD-NS differentially impact QOL. METHODS:Patients with chronic rhinosinusiti...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22112
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20022
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Industry outreach promotes awareness of novel technologies. However, concerns have been raised that such relationships may also unduly impact medical decision-making. Our objective in this study was to evaluate industry relationships among practitioners who frequently employ balloon dilation (BD), characteri...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21976
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Trefoil factor family (TFF) peptides are mucin-associated secretory products that are produced in the airways and gastrointestinal tract. These peptides appear to play an important role in mucosal healing and epithelial protection and are overexpressed in chronically inflamed gastrointestinal tissues. We hyp...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21334
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Most data on sinonasal mucosal melanoma come from small institutional studies, and therefore optimal treatment methods are not well understood. The purpose of this study was to analyze the association between treatment and survival in sinonasal mucosal melanoma. METHODS:Six hundred ninety-five patients diag...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21831
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Our objectives were to evaluate collaboration with medical students and other nondoctoral authors, and assess whether mentoring such students influences the academic productivity of senior authors. METHODS:Six issues of the Laryngoscope and International Forum of Allergy & Rhinology (IFAR) were examined for...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21247
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify asthma susce...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21725
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS:An international, multidisciplinary panel of 23 experts in ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22316
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Spontaneous cerebrospinal fluid (CSF) rhinorrhea has been associated with elevated intracranial pressure (ICP). As such, ICP reducing measures are commonly employed to optimize repair. Although postoperative acetazolamide use has been described, no data currently exists on the potential for preoperative use....
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22245
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:To describe our clinical experience in 218 consecutive patients undergoing endoscopic back-and-forth septoplasty (EBFS), examining surgical indications, technique, and follow-up. METHODS:From January 2005 to November 2008, 218 patients underwent EBFS at the Department of Otorhinolaryngology, San Raffaele Ho...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20100
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The goal of this study was to develop and evaluate the impact of an aviation-style challenge and response sinus surgery-specific checklist on potential safety and equipment issues during sinus surgery at a tertiary academic health center. The secondary goal was to assess the potential impact of use of the ch...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22106
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Earlier studies have suggested that patients with chronic rhinosinusitis (CRS) report worse sleep quality than population norms. What remains unknown is whether these patients are actually experiencing measurable changes in objective sleep parameters. The goal of this study was to prospectively evaluate obje...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.22212
更新日期:2019-01-01 00:00:00