Role of Toll-like receptor 9 signaling on activation of nasal polyp-derived fibroblasts and its association with nasal polypogenesis.

abstract：BACKGROUND:The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. The objective of the current study is to assess long-term success of the Draf III mucosal grafting technique. METHODS:Patients undergoing Draf III with mucosal graft...

journal_title：International forum of allergy & rhinology

authors： Illing EA,Cho do Y,Riley KO,Woodworth BA

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic rhinosinusitis, nasal polyps, asthma, and respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). In addition to sensitivity to aspirin and NSAIDs, the majority of patients with AERD have bee...

journal_title：International forum of allergy & rhinology

authors： Glicksman JT,Parasher AK,Doghramji L,Brauer D,Waldram J,Walters K,Bulva J,Palmer JN,Adappa ND,White AA,Bosso JV

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Olfactory dysfunction is 1 of the hallmark symptoms of chronic rhinosinusitis (CRS). Eosinophilic inflammation has been implicated as a potential causative factor. However, prior studies have been limited by retrospective study designs, concomitant use of systemic corticosteroids, and other confounding facto...

journal_title：International forum of allergy & rhinology

authors： Hauser LJ,Chandra RK,Li P,Turner JH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The histological features of osteitis in chronic rhinosinusitis (CRS) in animal studies induced by bacterial inoculation into maxillary sinuses revealed inflammatory involvement of the underlying bone matrix and/or the Haversian system; however, human studies do not mention these findings. The objective of t...

journal_title：International forum of allergy & rhinology

authors： Snidvongs K,Earls P,Dalgorf D,Sacks R,Pratt E,Harvey RJ

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature. METHODS:A systematic literature review was ...

journal_title：International forum of allergy & rhinology

authors： Hodzic Z,Rowan NR,Kashiwazaki R,Willson TJ,Wang EW,Lee SE

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:It has been found that the most common adverse reaction which occurs more frequently on cetirizine than on placebo is somnolence. However, the somnolence rate varied widely among different studies. The objective of this study was to assess the somnolence effect of cetirizine 10 mg daily compared to placebo i...

journal_title：International forum of allergy & rhinology

authors： Du Q,Zhou Y

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Medialization of the middle turbinate (MT) is an effective technique to prevent recurrent rhinosinusitis but could, in theory, reduce olfactory function by interfering the odorants to reach the olfactory mucosae. We performed a prospective randomized double-blind trial under the hypothesis that olfactory fun...

journal_title：International forum of allergy & rhinology

authors： Kim SW,Kim RB,Kang H,Cho HJ,Joo YH,Jeon YJ,Jeon SY

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been pro...

journal_title：International forum of allergy & rhinology

authors： Wise SK,Lin SY,Toskala E

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on pri...

journal_title：International forum of allergy & rhinology

authors： Chang EH,Tang XX,Shah VS,Launspach JL,Ernst SE,Hilkin B,Karp PH,Abou Alaiwa MH,Graham SM,Hornick DB,Welsh MJ,Stoltz DA,Zabner J

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:There are major differences in the clinical pattern of allergic rhinitis (AR) patients among countries, reflecting local aerobiological conditions. We analyzed the correlation between airborne pollen concentrations of the Western Thrace/northeast (NE) Greece region with symptoms scores in AR patients. The ab...

journal_title：International forum of allergy & rhinology

authors： Katotomichelakis M,Nikolaidis C,Makris M,Zhang N,Aggelides X,Constantinidis TC,Bachert C,Danielides V

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Arterial epistaxis is commonly seen in the rhinology clinic and can have a significant impact on quality of life. Previous studies have explored various therapies to address epistaxis. METHODS:Patients were treated in the outpatient clinic or operating room by microwave ablation (MWA) with a 2450-MHz cooled...

journal_title：International forum of allergy & rhinology

authors： Lou ZC,Dong Y,Lou ZH

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:This analysis explores the increasing heterogeneity of trends in allergy management under the premise that the practice of allergy has undergone significant changes in national economics, healthcare delivery, and treatment options from 2007 to 2016. METHODS:Centers for Medicare and Medicaid Services (CMS) d...

journal_title：International forum of allergy & rhinology

authors： Arianpour K,Svider PF,Yuhan B,Hooda Z,Eloy JA,Folbe AJ

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:The role of human papillomavirus (HPV) in sinonasal inverted papillomas (IPs) is controversial. Determining the prevalence of HPV infection and its impact on the molecular biology of these tumors is critical to characterizing its role in the pathogenesis of IPs. METHODS:A total of 112 paraffin-embedded IPs ...

journal_title：International forum of allergy & rhinology

authors： Scheel A,Lin GC,McHugh JB,Komarck CM,Walline HM,Prince ME,Zacharek MA,Carey TE

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) is a chronic systemic allergic disease with an association reported between allergy and anxiety. The objective of the current study was therefore to investigate and retrospectively evaluate the factors that may possibly induce state and trait anxiety among patients with AR and vasomoto...

journal_title：International forum of allergy & rhinology

authors： Xi L,Cao F,Zhang Y,Zhang L

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The surgical significance of the lingual process of the sphenoid bone (LPSB) has not been sufficiently addressed. The purpose of this study was to describe the anatomical details of the LPSB in relation to the quadrangular space. Moreover, the incidence of the LPSB and its correlation with the pneumatization...

journal_title：International forum of allergy & rhinology

authors： Li L,London NR Jr,Chen X,Prevedello DM,Carrau RL

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Chronic sphenoid rhinosinusitis (CSR) refractory to both medical management and 1 or more sphenoidotomies is a difficult entity to treat. In contrast to the surgical hierarchy that exists for the frontal sinus, there is no systematic approach for addressing persistent disease in the sphenoid. Sphenoid marsup...

journal_title：International forum of allergy & rhinology

authors： Leight WD,Leopold DA

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Fibroblasts are implicated in tissue remodeling and recruitment of inflammatory cells in chronic rhinosinusitis (CRS). Populations of fibroblasts remain unquantified in CRS subtypes. The objectives of this study were to measure fibroblast populations in subtypes of CRS, and to investigate the association bet...

journal_title：International forum of allergy & rhinology

authors： Carroll WW,O'Connell BP,Schlosser RJ,Gudis DA,Karnezis TT,Lawrence LA,Soler ZM,Mulligan JK

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Asthma is a chronic inflammatory disease of the lower airway that is commonly encountered by the otolaryngologist. This article provides information on how to recognize patients with asthma and discuss issues related to diagnosis, treatment, and continued management within the context of current guidelines. ...

journal_title：International forum of allergy & rhinology

authors： Reisacher WR

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as "sickness behavior." Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is ...

journal_title：International forum of allergy & rhinology

authors： Alt JA,Smith TL

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Early postoperative care following endoscopic sinus surgery (ESS) has been suggested to minimize avoidable complications and optimize long-term outcomes. Several postoperative care strategies have been proposed but a formal comprehensive evaluation of the evidence has never been performed. The purpose of thi...

journal_title：International forum of allergy & rhinology

authors： Rudmik L,Soler ZM,Orlandi RR,Stewart MG,Bhattacharyya N,Kennedy DW,Smith TL

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Previous studies have reviewed the safety of preparing and administering allergy injection immunotherapy in a physician's office, and showed no evidence of infectious complications. The current study examines the antimicrobial properties of the common additives used in preparation of multidose immunotherapy ...

journal_title：International forum of allergy & rhinology

authors： Gilbert KC,Sundareshan V,Bass RM,Lin SY

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Olfactory inflammation in chronic rhinosinusitis (CRS) is associated with cytokines that may result in the death of olfactory sensory neurons. The principal signaling molecules involved in the apoptotic pathway are c-Jun N-terminal kinases (JNK). Although the JNK pathway has emerged as a key player in progra...

journal_title：International forum of allergy & rhinology

authors： Victores AJ,Chen M,Smith A,Lane AP

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...

journal_title：International forum of allergy & rhinology

authors： Nishijima H,Kondo K,Yamamoto T,Nomura T,Kikuta S,Shimizu Y,Mizushima Y,Yamasoba T

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Variants of squamous cell carcinoma (SCC) make up 15% of all cases of SCC of the upper aerodigestive tract. There are 5 main histologic variants of SCC in the head and neck region: verrucous (VSCC), papillary (PSCC), spindle cell (sarcomatoid) (SCSC), basaloid (BSCC), and adenosquamous (ASC). Conventional si...

journal_title：International forum of allergy & rhinology

authors： Vazquez A,Khan MN,Blake DM,Patel TD,Baredes S,Eloy JA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Osteitis is a feature of chronic rhinosinusitis (CRS) and often associated with recalcitrant disease. Radiological characteristics of osteitic sinus changes are commonly reported in practice but the clinical and pathologic significance is poorly defined. The objective of this study was to correlate the Kenne...

journal_title：International forum of allergy & rhinology

authors： Snidvongs K,McLachlan R,Sacks R,Earls P,Harvey RJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Olfaction is one of the important senses for humans. Systemic glucocorticoids are the most commonly used medications for olfactory loss because of their strong anti-inflammatory effects. However, their effect on olfactory function is still controversial and the precise mechanism is not clear. To gain a globa...

journal_title：International forum of allergy & rhinology

authors： Tian J,Pinto JM,Xin Y,Zhang H,Li L,Sun Z,Wei Y

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-9 and IL-17C have been known to play a role in allergic inflammation, yet, their roles in chronic rhinosinusitis (CRS) are not well defined. IL-9 induces changes in epithelial cell gene expression leading to goblet cell metaplasia, whereas IL-17C is functionally distinct in that its expressi...

journal_title：International forum of allergy & rhinology

authors： Olcott CM,Han JK,Cunningham TD,Franzese CB

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Sufficient clinical data are not available on the effect of hypothyroidism on olfactory function in adults. In this study, we aimed to evaluate the olfactory function of adult patients diagnosed with primary hypothyroidism. METHODS:Forty-five patients aged between 18 and 60 years who were diagnosed with cli...

journal_title：International forum of allergy & rhinology

authors： Günbey E,Karlı R,Gökosmanoğlu F,Düzgün B,Ayhan E,Atmaca H,Ünal R

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Previous studies have shown controversial results of topical amphotericin B (AMB) nasal irrigation for chronic rhinosinusitis (CRS). The purpose of this study was to evaluate the efficacy of 200 μg/mL AMB nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery (FESS). METHODS:Patie...

journal_title：International forum of allergy & rhinology

authors： Jiang RS,Twu CW,Liang KL

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...

journal_title：International forum of allergy & rhinology

authors： Feldt BA,McMains KC,Weitzel EK

更新日期：2011-05-01 00:00:00