Correlation of the Kennedy Osteitis Score to clinico-histologic features of chronic rhinosinusitis.

Abstract:

BACKGROUND:Osteitis is a feature of chronic rhinosinusitis (CRS) and often associated with recalcitrant disease. Radiological characteristics of osteitic sinus changes are commonly reported in practice but the clinical and pathologic significance is poorly defined. The objective of this study was to correlate the Kennedy Osteitis Score (KOS) to clinico-histologic features of CRS. METHODS:A cross-sectional study of CRS patients undergoing sinus surgery was conducted. Osteitis was scored radiologically using the KOS. Associations between osteitis and histopathology, symptoms, 22-item Sino-Nasal Outcomes Test (SNOT-22), endoscopy, computed tomography (CT) mucosal score, and seromarkers were assessed. Interobserver correlation coefficient was performed. Additionally, the KOS was correlated to an alternate Global Osteitis Score. RESULTS:A total of 88 patients were assessed (45.5% female, age 50.3 ± 13.6 years); 45 (51.1%) patients had osteitis. Patients with KOS >0, had greater endoscopy score (6.1 ± 2.9 vs 4.4 ± 3.6, p = 0.03) and CT score (14.0 ± 6.0 vs 10.1 ± 5.7, p < 0.01) than those without osteitis. There was no difference in symptom score (2.4 ± 1.3 vs 2.4 ± 1.1, p = 0.89) and SNOT-22 (2.0 ± 1.0 vs 1.9 ± 1.1, p = 0.56) in patients with and without osteitis. KOS was higher in patients with tissue eosinophilia >10/high-power field (HPF) (median 3.0 [IQR, 1.0-5.3] vs 0.0 [0.0-4.0], p = 0.03) and serum eosinophilia >0.3 × 10(9) /L (4.0 [2.0-7.0] vs 1.0 [0.0-4.0], p < 0.01). Importantly, this was also true for those without prior surgery. The interobserver correlation coefficient was good (R = 0.86, p < 0.001). There was a significant correlation between the KOS and the Global Osteitis Score (R = 0.93, p < 0.001). CONCLUSION:The KOS is a simple, easy, and reproducible scale in assessing osteitic bones in patients with CRS and can predict measures of severity in eosinophilic rhinosinusitis.

authors

Snidvongs K,McLachlan R,Sacks R,Earls P,Harvey RJ

doi

10.1002/alr.21113

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

369-75

issue

5

eissn

2042-6976

issn

2042-6984

journal_volume

3

pub_type

杂志文章
  • Back-and-forth endoscopic septoplasty: analysis of the technique and outcomes.

    abstract:BACKGROUND:To describe our clinical experience in 218 consecutive patients undergoing endoscopic back-and-forth septoplasty (EBFS), examining surgical indications, technique, and follow-up. METHODS:From January 2005 to November 2008, 218 patients underwent EBFS at the Department of Otorhinolaryngology, San Raffaele Ho...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.20100

    authors: Trimarchi M,Bellini C,Toma S,Bussi M

    更新日期:2012-01-01 00:00:00

  • Longitudinal progression of aspirin-exacerbated respiratory disease: analysis of a national insurance claims database.

    abstract:BACKGROUND:Aspirin-exacerbated respiratory disease (AERD) is a recalcitrant inflammatory disorder defined by asthma, nasal polyposis, and sensitivity to cyclooxygenase-1 inhibitors. The timeline and course of disease progression is unclear. METHODS:The Truven MarketScan Database, a large American health insurance clai...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22412

    authors: Roland LT,Wang H,Mehta CC,Cahill KN,Laidlaw TM,DelGaudio JM,Wise SK,Levy JM

    更新日期:2019-12-01 00:00:00

  • Double-blinded randomized prospective trial of intranasal capsaicin treatment for nonallergic rhinitis.

    abstract:BACKGROUND:Nonallergic rhinitis (NAR) is currently a diagnosis of exclusion with an unclear pathophysiologic mechanism and limited treatment options. In patients diagnosed with NAR based on symptoms, negative skin testing and positive optical rhinometry (ORM), the study's objective was to evaluate the therapeutic actio...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22637

    authors: Zebda D,Jiang ZY,Gibson MM,Pham C,Ahmadi S,Floren S,Yao WC,Citardi MJ,Luong AU

    更新日期:2021-01-01 00:00:00

  • Bacteria in the nose of young adults during wellness and rhinovirus colds: detection by culture and microarray methods in 100 nasal lavage specimens.

    abstract:BACKGROUND:Patients  with  viral respiratory infections/viral rhinitis/common colds are often treated with antibiotic; however, there is little information on whether or how bacterial microbiota in the nose and nasopharynx might influence the course of viral illnesses. METHODS:To initiate investigation of possible int...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21191

    authors: Allen EK,Pitkäranta A,Mäki M,Hendley JO,Laakso S,Sale MM,Winther B

    更新日期:2013-09-01 00:00:00

  • Early postoperative care following endoscopic sinus surgery: an evidence-based review with recommendations.

    abstract:BACKGROUND:Early postoperative care following endoscopic sinus surgery (ESS) has been suggested to minimize avoidable complications and optimize long-term outcomes. Several postoperative care strategies have been proposed but a formal comprehensive evaluation of the evidence has never been performed. The purpose of thi...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.20072

    authors: Rudmik L,Soler ZM,Orlandi RR,Stewart MG,Bhattacharyya N,Kennedy DW,Smith TL

    更新日期:2011-11-01 00:00:00

  • Microwave ablation for the treatment of arterial epistaxis: "how I do it".

    abstract:BACKGROUND:Arterial epistaxis is commonly seen in the rhinology clinic and can have a significant impact on quality of life. Previous studies have explored various therapies to address epistaxis. METHODS:Patients were treated in the outpatient clinic or operating room by microwave ablation (MWA) with a 2450-MHz cooled...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22304

    authors: Lou ZC,Dong Y,Lou ZH

    更新日期:2019-06-01 00:00:00

  • Industry relationships are associated with performing a greater number of sinus balloon dilation procedures.

    abstract:BACKGROUND:Industry outreach promotes awareness of novel technologies. However, concerns have been raised that such relationships may also unduly impact medical decision-making. Our objective in this study was to evaluate industry relationships among practitioners who frequently employ balloon dilation (BD), characteri...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21976

    authors: Eloy JA,Svider PF,Bobian M,Harvey RJ,Gray ST,Baredes S,Folbe AJ

    更新日期:2017-09-01 00:00:00

  • Sinonasal adenoid cystic carcinoma: a population-based analysis of 694 cases.

    abstract:BACKGROUND:Currently, limited literature exists about sinonasal adenoid cystic carcinoma (SNACC). In this study, we analyze the demographics, survival, and treatment efficacy of this rare entity. METHODS:Our study was a retrospective population-based analysis of SNACC in the Surveillance, Epidemiology, and End Results...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21875

    authors: Unsal AA,Chung SY,Zhou AH,Baredes S,Eloy JA

    更新日期:2017-03-01 00:00:00

  • Human papillomavirus infection and biomarkers in sinonasal inverted papillomas: clinical significance and molecular mechanisms.

    abstract:BACKGROUND:The role of human papillomavirus (HPV) in sinonasal inverted papillomas (IPs) is controversial. Determining the prevalence of HPV infection and its impact on the molecular biology of these tumors is critical to characterizing its role in the pathogenesis of IPs. METHODS:A total of 112 paraffin-embedded IPs ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21524

    authors: Scheel A,Lin GC,McHugh JB,Komarck CM,Walline HM,Prince ME,Zacharek MA,Carey TE

    更新日期:2015-08-01 00:00:00

  • Osteitis is a misnomer: a histopathology study in primary chronic rhinosinusitis.

    abstract:BACKGROUND:The histological features of osteitis in chronic rhinosinusitis (CRS) in animal studies induced by bacterial inoculation into maxillary sinuses revealed inflammatory involvement of the underlying bone matrix and/or the Haversian system; however, human studies do not mention these findings. The objective of t...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21291

    authors: Snidvongs K,Earls P,Dalgorf D,Sacks R,Pratt E,Harvey RJ

    更新日期:2014-05-01 00:00:00

  • Characterization of immunoglobulin E plasma cells that are elevated in the upper airway mucosa of nonatopic patients with chronic rhinosinusitis without nasal polyps.

    abstract:BACKGROUND:The immunologic mechanisms driving inflammation in the upper airways of patients with chronic rhinosinusitis (CRS) are poorly understood. Previous studies have shown that B cells and immunoglobulin E (IgE) levels are elevated in the nasal tissue of patients with atopic chronic rhinosinusitis without nasal po...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21696

    authors: Rashan AR,Goshn E,Peterson A,Yang Y,Phillips M,Sahaf B,Herzenberg L,Nayak JV

    更新日期:2016-04-01 00:00:00

  • Chronic rhinosinusitis and sleep: a contemporary review.

    abstract:BACKGROUND:Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as "sickness behavior." Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21217

    authors: Alt JA,Smith TL

    更新日期:2013-11-01 00:00:00

  • Evaluation of olfactory function in adults with primary hypothyroidism.

    abstract:BACKGROUND:Sufficient clinical data are not available on the effect of hypothyroidism on olfactory function in adults. In this study, we aimed to evaluate the olfactory function of adult patients diagnosed with primary hypothyroidism. METHODS:Forty-five patients aged between 18 and 60 years who were diagnosed with cli...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21565

    authors: Günbey E,Karlı R,Gökosmanoğlu F,Düzgün B,Ayhan E,Atmaca H,Ünal R

    更新日期:2015-10-01 00:00:00

  • Determining the best graft-sealant combination for skull base repair using a soft tissue in vitro porcine model.

    abstract:BACKGROUND:The purpose of this work was to compare the absolute breaking strength of various soft tissue skull base (SB) repairs in an in vitro porcine model. METHODS:A burst pressure (BP) testing system was designed using an axial loading force to create increasing hydraulic pressure. Defects measuring 0.5 × 0.5 cm w...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21085

    authors: Fandiño M,Macdonald K,Singh D,Whyne C,Witterick I

    更新日期:2013-03-01 00:00:00

  • Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to tumor necrosis factor alpha inhibitors (TNFαis). The histologic features of CRS caused by TNFαis have yet to be determined and may have important implications in understanding the pathophysiology of...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22462

    authors: Papagiannopoulos P,Devins K,Tong CCL,Yver C,Patel NN,Kuhar HN,Bosso JV,Kohanski MA,Tajudeen BA,Kuan EC,Batra PS,Cohen NA,Kennedy DW,Palmer JN,Montone K,Adappa ND

    更新日期:2020-01-01 00:00:00

  • Prevalence of atopic disease in patients with eosinophilic esophagitis.

    abstract:BACKGROUND:The objective of this work was to evaluate prevalence of eosinophilic esophagitis (EoE) in the United States, and analyze prevalence of atopic disease in patients with EoE. The study design was a retrospective administrative database analysis in U.S.-based outpatient settings. METHODS:A retrospective claims...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21968

    authors: Benninger MS,Strohl M,Holy CE,Hanick AL,Bryson PC

    更新日期:2017-08-01 00:00:00

  • Impact of tobacco smoke on chronic rhinosinusitis: a review of the literature.

    abstract:BACKGROUND:Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). The objectives of this review are to summarize prior studies that describe the correlation between active smoking and secondhand smoke (SHS...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21054

    authors: Reh DD,Higgins TS,Smith TL

    更新日期:2012-09-01 00:00:00

  • Evidence of microbiota dysbiosis in chronic rhinosinusitis.

    abstract:BACKGROUND:Despite considerable research, the pathogenesis of chronic rhinosinusitis (CRS) remains poorly understood. Potential microbial roles in the etiology or progression of CRS have long been hypothesized, yet few specific associations have been identified. In this study we investigate associations between pattern...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21871

    authors: Hoggard M,Biswas K,Zoing M,Wagner Mackenzie B,Taylor MW,Douglas RG

    更新日期:2017-03-01 00:00:00

  • Association between allergic rhinitis and poor sleep parameters in U.S. adults.

    abstract:BACKGROUND:Evidence suggests relationships between allergic rhinitis (AR) and poor sleep parameters, but population-based studies in the United States are lacking. This study investigates the relationship between AR and sleep parameters in a representative sample of U.S. adults. METHODS:Cross-sectional study of 5563 p...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22174

    authors: Roxbury CR,Qiu M,Shargorodsky J,Lin SY

    更新日期:2018-10-01 00:00:00

  • Olfactory loss in chronic rhinosinusitis is associated with neuronal activation of c-Jun N-terminal kinase.

    abstract:BACKGROUND:Olfactory inflammation in chronic rhinosinusitis (CRS) is associated with cytokines that may result in the death of olfactory sensory neurons. The principal signaling molecules involved in the apoptotic pathway are c-Jun N-terminal kinases (JNK). Although the JNK pathway has emerged as a key player in progra...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22053

    authors: Victores AJ,Chen M,Smith A,Lane AP

    更新日期:2018-03-01 00:00:00

  • Identification of chronic rhinosinusitis phenotypes using cluster analysis.

    abstract:BACKGROUND:Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. U...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/alr.21496

    authors: Soler ZM,Hyer JM,Ramakrishnan V,Smith TL,Mace J,Rudmik L,Schlosser RJ

    更新日期:2015-05-01 00:00:00

  • The clinical significance of the pollen calendar of the Western Thrace/northeast Greece region in allergic rhinitis.

    abstract:BACKGROUND:There are major differences in the clinical pattern of allergic rhinitis (AR) patients among countries, reflecting local aerobiological conditions. We analyzed the correlation between airborne pollen concentrations of the Western Thrace/northeast (NE) Greece region with symptoms scores in AR patients. The ab...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21623

    authors: Katotomichelakis M,Nikolaidis C,Makris M,Zhang N,Aggelides X,Constantinidis TC,Bachert C,Danielides V

    更新日期:2015-12-01 00:00:00

  • Long-term revision rates for endoscopic sinus surgery.

    abstract:BACKGROUND:Reported revision rates for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) vary significantly. Several investigations examining revision rates for ESS have been limited by duration of follow-up, academic centers, or small surgeon cohorts. The objective of this study was to define the long-te...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22264

    authors: Smith KA,Orlandi RR,Oakley G,Meeks H,Curtin K,Alt JA

    更新日期:2019-04-01 00:00:00

  • Assessment of skills using a spacer device for a metered-dose inhaler and related independent predictive factors in caregivers of asthmatic preschool children.

    abstract:BACKGROUND:The correct use of inhalation devices is essential for successful therapy. We aimed to evaluate the skills in the use of a spacer device with an metered-dose inhaler (MDI) and factors that influence this skill in asthmatic preschool children's caregivers. METHODS:The caregivers of 12-month-old to 72-month-o...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21648

    authors: Topal E,Celiksoy MH,Catal F,Sinanoglu MS,Karakoc HT,Sancak R,Ozturk F

    更新日期:2016-02-01 00:00:00

  • Comparison of the distribution of intranasal steroid spray using different application techniques.

    abstract:BACKGROUND:Optimizing the intranasal distribution of nasal steroid spray (NS) is important in managing patients with allergic rhinitis (AR). Using a 3-dimensional computational model of the human nose, we found that inspiratory airflow improved particle distribution by 86%. We hence designed a study to determine if the...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21807

    authors: Tay SY,Chao SS,Mark KT,Wang Y

    更新日期:2016-11-01 00:00:00

  • Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.

    abstract:BACKGROUND:Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on pri...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21440

    authors: Chang EH,Tang XX,Shah VS,Launspach JL,Ernst SE,Hilkin B,Karp PH,Abou Alaiwa MH,Graham SM,Hornick DB,Welsh MJ,Stoltz DA,Zabner J

    更新日期:2015-02-01 00:00:00

  • Placebo-controlled assessment of somnolence effect of cetirizine: a meta-analysis.

    abstract:BACKGROUND:It has been found that the most common adverse reaction which occurs more frequently on cetirizine than on placebo is somnolence. However, the somnolence rate varied widely among different studies. The objective of this study was to assess the somnolence effect of cetirizine 10 mg daily compared to placebo i...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,meta分析

    doi:10.1002/alr.21746

    authors: Du Q,Zhou Y

    更新日期:2016-08-01 00:00:00

  • Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database.

    abstract:BACKGROUND:Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy with a propensity for distant metastasis. In this study we describe the incidence and determinants of survival among patients with SNACC between the years 2004 and 2012 using the National Cancer Database (NCDB). METHODS:This was a retrospective...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22255

    authors: Trope M,Triantafillou V,Kohanski MA,Kuan EC,Tong CCL,Patel NN,Maina IW,Carey RM,Workman AD,Palmer JN,Adappa ND,Newman JG,Brant JA

    更新日期:2019-04-01 00:00:00

  • Cadaveric comparison of canine fossa vs transnasal maxillary sinus access.

    abstract:OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.20022

    authors: Feldt BA,McMains KC,Weitzel EK

    更新日期:2011-05-01 00:00:00

  • Ethmoid-to-maxillary opacification ratio: a predictor of postoperative olfaction and outcomes in nasal polyposis?

    abstract:BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22625

    authors: Beswick DM,Smith TL,Mace JC,Alt JA,Farrell NF,Ramakrishnan VR,Schlosser RJ,Soler ZM

    更新日期:2021-01-01 00:00:00