Abstract:
BACKGROUND:Patients with viral respiratory infections/viral rhinitis/common colds are often treated with antibiotic; however, there is little information on whether or how bacterial microbiota in the nose and nasopharynx might influence the course of viral illnesses. METHODS:To initiate investigation of possible interaction between viral respiratory illness and microbiota of the nose/nasopharynx, we used microarray technology to examine 100 nasal lavage fluid (NLF) samples for bacterial species and recorded the bacterial titer of culturable bacteria. Rhinovirus illnesses were induced by self-inoculation using the "finger to nose or eye natural transmission route" in 10 otherwise healthy young adults. NLF samples were collected during wellness and at specific time points following experimental rhinovirus inoculation. RESULTS:The rhinovirus infection rate was 70%. There were no consistent changes in the prevalence of different bacterial species determined by microarray and bacterial titer by culture methods during rhinovirus infection. The bacterial profile in NLF samples showed high variability between volunteers but low variability in multiple NLFs obtained before and following infection from the same volunteer. Streptococcus epidermidis/coagulase-negative staphylococcus (CNS) were identified in all 10 subjects. One or more bacterial sinus/otitis pathogens were identified by microarray in 6 of the 10 volunteers. The microarray identified a few bacteria not included in traditional bacterial cultures. CONCLUSION:Our pilot study showed that each of the 10 volunteers had a unique bacterial profile in the nose by microarray analysis and that bacterial load did not change during experimental rhinovirus colds. Larger scale studies are warranted.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Allen EK,Pitkäranta A,Mäki M,Hendley JO,Laakso S,Sale MM,Winther Bdoi
10.1002/alr.21191subject
Has Abstractpub_date
2013-09-01 00:00:00pages
731-9issue
9eissn
2042-6976issn
2042-6984journal_volume
3pub_type
杂志文章abstract:BACKGROUND:Chronic sphenoid rhinosinusitis (CSR) refractory to both medical management and 1 or more sphenoidotomies is a difficult entity to treat. In contrast to the surgical hierarchy that exists for the frontal sinus, there is no systematic approach for addressing persistent disease in the sphenoid. Sphenoid marsup...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20006
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Treatment of recalcitrant chronic rhinosinusitis (CRS) is a challenge with increasing antibiotic resistance, leading to re-emergence of topical therapies. The aim of this study was to assess safety and efficacy of topical colloidal silver solution for the treatment of Staphylococcus aureus biofilms in a shee...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21459
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:There is a lack of population-based, multi-institutional analyses of factors associated with morbidity and mortality following pituitary tumor excision. METHODS:The American College of Surgeons National Surgical Quality Improvement Project files were used to compile information on patients that had undergon...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21641
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:In February 2015, the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) published the Allergic Rhinitis Clinical Practice Guideline (AR-CPG). The objective of this study was to assess otolaryngologists' perception of the accuracy and adherence to the AR-CPG. METHODS:A survey was distribute...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22096
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The etiology of the intense inflammatory response showed by patients with allergic fungal rhinosinusitis (AFRS) remains a mystery. Potential sources of this inflammation may include fungal proteases. Protease-activated receptors (PARs) are components of the innate immune response that are modulated by proteo...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21295
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The role of bacteria in the etiopathogenesis of chronic rhinosinusitis (CRS) remains an area of interest. The impact of surgery and factors such as the presence of polyps, asthma, and aspirin sensitivity on the bacterial state are poorly understood. To determine the effect of these factors, this study examin...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21159
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21056
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:The pathogenic roles of fungus and bacteria in chronic rhinosinusitis (CRS) remain unclear. Recently, we described the bacterial ball, which is distinct from the fungus ball, as an unusual phenotype of bacterial infection. In this study, we investigated the clinical, histopathologic, and immunologic characte...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22410
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Osteitis is a feature of chronic rhinosinusitis (CRS) and often associated with recalcitrant disease. Radiological characteristics of osteitic sinus changes are commonly reported in practice but the clinical and pathologic significance is poorly defined. The objective of this study was to correlate the Kenne...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21113
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The Rhinosinusitis Disability Index (RSDI) consists of multiple subdomains shown to be useful in studying chronic rhinosinusitis (CRS). The objective of this study was to determine if RSDI subdomain scores are associated with selection of treatment modality (endoscopic sinus surgery [ESS] or continued medica...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21656
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Subcutaneous immunotherapy (SCIT) demands a significant time commitment on the part of the patient, especially during the escalation period when weekly visits are required. Many patients refuse or discontinue treatment in spite of the demonstrated clinical efficacy of SCIT. Understanding the factors that aff...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21027
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The objective of the evidence base review was to systematically evaluate the literature to elucidate the potential role of oral antifungal therapy in management of chronic rhinosinusitis (CRS) and its subtypes. METHODS:Articles for inclusion were identified by query of appropriate search terms in the PubMed...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.20088
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Bronchial asthma is one of the most common chronic diseases in childhood, with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming rate. Asthma is a complex genetic disorder with strong environmental influence. It imposes a growing burden on our society in terms of morbidity,...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21557
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericid...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21949
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22089
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The lateral nasal wall (LNW) flap provides vascularized endonasal reconstruction primarily in revision surgery. Although the harvesting technique and reconstructive surface have been reported, the arterial supply to the LNW flap and its clinical implications is not well defined. This study presents anatomica...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22534
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature. METHODS:A systematic literature review was ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21902
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Sufficient clinical data are not available on the effect of hypothyroidism on olfactory function in adults. In this study, we aimed to evaluate the olfactory function of adult patients diagnosed with primary hypothyroidism. METHODS:Forty-five patients aged between 18 and 60 years who were diagnosed with cli...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21565
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Increased frequency of migraine was reported in adults with allergic rhinitis (AR). Although migraine is less common in children than in adults, it can begin in early childhood and persist into adulthood. We conducted this population-based cohort study to investigate the incidence and subsequent risk of migr...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21654
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Patient compliance is critical for successful allergen immunotherapy (AIT). Previous studies suggest that AIT compliance is worse outside of controlled clinical trials, with reported subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) noncompliance at 11% to 50% and 3% to 25%, respectively....
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21699
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Reported revision rates for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) vary significantly. Several investigations examining revision rates for ESS have been limited by duration of follow-up, academic centers, or small surgeon cohorts. The objective of this study was to define the long-te...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22264
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Surgical treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) has evolved over the last decade as rhinologists have increasingly used topical steroid therapies and altered surgical techniques. It is important to understand the changes in success rates of surgery and frequency of revision endosco...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22505
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:The most dramatic complication in endonasal surgery is inadvertent injury to the internal carotid artery (ICA) with massive bleeding. Nasal packing is the favored technique for control; however, this often causes complete carotid occlusion or carotid stenosis, contributing to the morbidity and mortality of t...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20033
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Trefoil factor family (TFF) peptides are mucin-associated secretory products that are produced in the airways and gastrointestinal tract. These peptides appear to play an important role in mucosal healing and epithelial protection and are overexpressed in chronically inflamed gastrointestinal tissues. We hyp...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21334
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Earlier studies have suggested that patients with chronic rhinosinusitis (CRS) report worse sleep quality than population norms. What remains unknown is whether these patients are actually experiencing measurable changes in objective sleep parameters. The goal of this study was to prospectively evaluate obje...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.22212
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Diagnostic strategies employed for cases of cerebrospinal fluid (CSF) rhinorrhea vary widely due to limited evidence-based guidance. METHODS:A systematic review of the literature was performed using PubMed, EMBASE, and Cochrane databases from January 1990 through September 2014, to examine 9 diagnostic and ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21637
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Oral steroids are commonly used in the management of chronic rhinosinusitis (CRS) with and without nasal polyps (CRSwNP and CRSsNP, respectively). Past reports have included evaluation of the evidence for the use of oral steroids in CRS subtypes. However, a review with evidence-based recommendations for all ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21072
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as "sickness behavior." Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21217
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Endoscopic repair of anterior skull-base defects has become the gold standard for management of cerebrospinal fluid (CSF) rhinorrhea. Both improved techniques and adjuvant therapies have led to accepted success rates of greater than 90%. As management has evolved, shorter hospitalizations have been required ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21810
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Most data on sinonasal mucosal melanoma come from small institutional studies, and therefore optimal treatment methods are not well understood. The purpose of this study was to analyze the association between treatment and survival in sinonasal mucosal melanoma. METHODS:Six hundred ninety-five patients diag...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21831
更新日期:2017-01-01 00:00:00