Abstract：
BACKGROUND:Endoscopic repair of anterior skull-base defects has become the gold standard for management of cerebrospinal fluid (CSF) rhinorrhea. Both improved techniques and adjuvant therapies have led to accepted success rates of greater than 90%. As management has evolved, shorter hospitalizations have been required and the goal of this study is to analyze the outcomes of patients repaired on an outpatient basis vs those managed as inpatients postoperatively. METHODS:Patients undergoing endoscopic repair of CSF rhinorrhea between 2004 and 2014 were identified by review of medical records. Demographic and clinical data were collected and compared between patients having surgery with and without postoperative admission. Patients managed with lumbar drains were not included. Statistical analyses were preformed to determine if any differences in patient demographics and outcomes existed. RESULTS:A total of 86 patients were identified; 39 of 86 patients (45.3%) underwent outpatient surgery; 47 patients were admitted postoperatively with a mean hospital stay of 1.66 days with a median and mode of 1 day. No statistically significant differences were found between leak location, etiology, rates of recurrence, or complications. The outpatient group was found to have a greater proportion of small defects <1 cm2 (p = 0.003). Repair technique was also significantly different between groups (p = 0.001). CONCLUSION:Endoscopic management of CSF rhinorrhea is a safe method of treatment with reliable success rates. Our retrospective analysis revealed comparable outcomes in patients treated with and without postoperative hospital admission, and supports the idea that outpatient management may be reasonable in certain patients, especially those with defects <1 cm2 .
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Adams AS,Francis DO,Russell PTdoi
10.1002/alr.21810subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1126-1130issue
11eissn
2042-6976issn
2042-6984journal_volume
6pub_type
杂志文章abstract：BACKGROUND:Inadequate efficacy of current intranasal steroids in chronic rhinosinusitis (CRS) is attributable to ineffective and/or inconsistent drug delivery to target anatomic sites. A new exhalation delivery system with fluticasone (EDS-FLU) may improve outcomes by significantly increasing superior/posterior cortico...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.22141
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. The objective of the current study is to assess long-term success of the Draf III mucosal grafting technique. METHODS:Patients undergoing Draf III with mucosal graft...
journal_title：International forum of allergy & rhinology
pub_type： 临床试验,杂志文章
doi：10.1002/alr.21708
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on pri...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21440
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:There are major differences in the clinical pattern of allergic rhinitis (AR) patients among countries, reflecting local aerobiological conditions. We analyzed the correlation between airborne pollen concentrations of the Western Thrace/northeast (NE) Greece region with symptoms scores in AR patients. The ab...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21623
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical ...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21550
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:The treatment of the middle turbinate (MT) during endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) remains a contentious issue with arguments both for and against its resection. The purpose of this study was to examine the clinical impact of partial MT resection (PMTR) during ESS, paying parti...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.22127
更新日期：2018-04-06 00:00:00
abstract：BACKGROUND:We have previously demonstrated that persistent symptoms following functional endoscopic sinus surgery for chronic rhinosinusitis (CRS) is associated with Gram-negative bacterial carriage. Mechanisms for this remain unknown. We wished to determine whether Gram-negative carriage in patients with CRS with nasa...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21481
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:As part of this primer, this article is intended to introduce new and emerging therapies for treating asthma. METHODS:A PubMed search was performed for the years 2013 through 2015 for asthma review, asthma treatment, asthma therapy, and asthma new. Subset searches were additionally performed as suggested by...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章,评审
doi：10.1002/alr.21611
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Nitric oxide (NO) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. It is well documented that bacteriostatic and bactericidal effects of NO are concentration-dependent. However, few data exist comparing relative susceptibility of common pathoge...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21966
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Despite considerable research, the pathogenesis of chronic rhinosinusitis (CRS) remains poorly understood. Potential microbial roles in the etiology or progression of CRS have long been hypothesized, yet few specific associations have been identified. In this study we investigate associations between pattern...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21871
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:The surgical significance of the lingual process of the sphenoid bone (LPSB) has not been sufficiently addressed. The purpose of this study was to describe the anatomical details of the LPSB in relation to the quadrangular space. Moreover, the incidence of the LPSB and its correlation with the pneumatization...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.22594
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Odontogenic sinusitis (OS) presents a therapeutic dilemma. Evidence is lacking whether dental treatment alone is sufficient or whether patients will eventually require endoscopic sinus surgery (ESS). Our aim was to identify predictors of OS patients undergoing ESS. METHODS:Retrospective review performed of ...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21736
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Spontaneous cerebrospinal fluid (CSF) rhinorrhea has been associated with elevated intracranial pressure (ICP). As such, ICP reducing measures are commonly employed to optimize repair. Although postoperative acetazolamide use has been described, no data currently exists on the potential for preoperative use....
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.22245
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Cystic fibrosis (CF) is caused by a misfunctional CF transmembrane conductance regulator (CFTR) protein, which is believed to contributes to the regulation of the airway surface liquid (ASL) pH. This study investigated acid and base secretion in freshly excised human nasal tissues from CF patients homozygous...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.20028
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to identify and evaluate adverse clinical outcomes following office-based sclerotherapy using sodium tetradecyl sulfate (STS) for epistaxis due to hereditary hemorrhagic telangiectasias (HHT or Osler-Weber-Rendu). METHODS:A retrospective chart review of 36 adult patients treated wi...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21287
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Treatment options for chronic rhinosinusitis with recurrent polyposis (CRSwNP) after endoscopic sinus surgery (ESS) are limited, and include frequent use of systemic steroids and revision surgery. A bioabsorbable, steroid-eluting implant was studied for its ability to dilate sinuses obstructed by polyps and ...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章,多中心研究
doi：10.1002/alr.21309
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. U...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章,多中心研究
doi：10.1002/alr.21496
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is an inflammatory disease process characterized by different phenotypes and histopathology profiles. Race and access to care have been implicated in CRS disease severity. Structural histopathology reporting may aid in delineating the inflammatory burden responsible for this effe...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.22295
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as "sickness behavior." Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is ...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章,评审
doi：10.1002/alr.21217
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Nasal steroids are a critical part of the management of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after endoscopic sinus surgery (ESS). Increasingly, practitioners are using budesonide respules delivered to the sinonasal cavities, which is an off-label use, in lieu of traditional nas...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章,随机对照试验
doi：10.1002/alr.21688
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:After endoscopic sinus surgery (ESS), endoscopy is used to gauge surgical success and clinical outcomes. Prior studies have not examined this topic prospectively using validated outcome metrics across multiple institutions. METHODS:A multi-institutional, prospective study of patients with chronic rhinosinus...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章,多中心研究
doi：10.1002/alr.21651
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:The influence of the microbial community on inflammatory subtype in chronic rhinosinusitis (CRS) has been proposed. Superantigen mechanisms potentially create a T helper 2 (Th-2)/eosinophilic dominated inflammation as a product of local flora rather than an intrinsic mucosal process. The associations between...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21220
更新日期：2014-01-01 00:00:00
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journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.22133
更新日期：2018-05-02 00:00:00
abstract：BACKGROUND:Treatment of recalcitrant chronic rhinosinusitis (CRS) is a challenge with increasing antibiotic resistance, leading to re-emergence of topical therapies. The aim of this study was to assess safety and efficacy of topical colloidal silver solution for the treatment of Staphylococcus aureus biofilms in a shee...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21459
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.20022
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Asthma is a chronic inflammatory disease of the lower airway that is commonly encountered by the otolaryngologist. This article provides information on how to recognize patients with asthma and discuss issues related to diagnosis, treatment, and continued management within the context of current guidelines. ...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章,评审
doi：10.1002/alr.21386
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Most data on sinonasal mucosal melanoma come from small institutional studies, and therefore optimal treatment methods are not well understood. The purpose of this study was to analyze the association between treatment and survival in sinonasal mucosal melanoma. METHODS:Six hundred ninety-five patients diag...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21831
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:The role of human papillomavirus (HPV) in sinonasal inverted papillomas (IPs) is controversial. Determining the prevalence of HPV infection and its impact on the molecular biology of these tumors is critical to characterizing its role in the pathogenesis of IPs. METHODS:A total of 112 paraffin-embedded IPs ...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21524
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Techniques for inferior turbinate reduction vary from complete turbinectomy to limited cauterization. Surgical methods differ on the degree of tissue reduction and reliance on surgical tissue removal vs tissue ablation. The outcome and morbidity from 3 different turbinate techniques are compared. METHODS:A ...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章,随机对照试验
doi：10.1002/alr.21574
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Lumbar drain (LD) use in the management of cerebrospinal fluid (CSF) rhinorrhea remains controversial. We analyzed the relationship between LD placement and CSF leak recurrence after endoscopic repair. METHODS:A retrospective case series was conducted. Patients who underwent CSF leak repair from 1999 to 201...
journal_title：International forum of allergy & rhinology
pub_type： 杂志文章
doi：10.1002/alr.21023
更新日期：2012-05-01 00:00:00
