The presentation and outcomes of mucosal melanoma in 695 patients.

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to tumor necrosis factor alpha inhibitors (TNFαis). The histologic features of CRS caused by TNFαis have yet to be determined and may have important implications in understanding the pathophysiology of...

journal_title：International forum of allergy & rhinology

authors： Papagiannopoulos P,Devins K,Tong CCL,Yver C,Patel NN,Kuhar HN,Bosso JV,Kohanski MA,Tajudeen BA,Kuan EC,Batra PS,Cohen NA,Kennedy DW,Palmer JN,Montone K,Adappa ND

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Spontaneous cerebrospinal fluid (CSF) rhinorrhea has been associated with elevated intracranial pressure (ICP). As such, ICP reducing measures are commonly employed to optimize repair. Although postoperative acetazolamide use has been described, no data currently exists on the potential for preoperative use....

journal_title：International forum of allergy & rhinology

authors： Tilak AM,Koehn H,Mattos J,Payne SC

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Trefoil factor family (TFF) peptides are mucin-associated secretory products that are produced in the airways and gastrointestinal tract. These peptides appear to play an important role in mucosal healing and epithelial protection and are overexpressed in chronically inflamed gastrointestinal tissues. We hyp...

journal_title：International forum of allergy & rhinology

authors： Li P,Turner JH

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Many asthmatic patients have coexisting allergic rhinitis (AR). This study aims to investigate the compliance of physicians with respiratory medicine specialty (PRMs) to Global Initiative for Asthma (GINA) and Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines during the management of their asthma-...

journal_title：International forum of allergy & rhinology

authors： Su N,Lin J,Liu G,Yin K,Zhou X,Shen H,Chen P,Chen R,Liu C,Wu C,Zhao J,Lin Y

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Optimizing the intranasal distribution of nasal steroid spray (NS) is important in managing patients with allergic rhinitis (AR). Using a 3-dimensional computational model of the human nose, we found that inspiratory airflow improved particle distribution by 86%. We hence designed a study to determine if the...

journal_title：International forum of allergy & rhinology

authors： Tay SY,Chao SS,Mark KT,Wang Y

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Our objectives were to evaluate collaboration with medical students and other nondoctoral authors, and assess whether mentoring such students influences the academic productivity of senior authors. METHODS:Six issues of the Laryngoscope and International Forum of Allergy & Rhinology (IFAR) were examined for...

journal_title：International forum of allergy & rhinology

authors： Svider PF,Husain Q,Mauro KM,Folbe AJ,Baredes S,Eloy JA

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Staphylococcus aureus infection is known to play a role in recalcitrant chronic rhinosinusitis (CRS). However, it is unknown if recurrent S. aureus infections are caused by the same strain or are due to independent acquisitions of different strains. METHODS:Samples were collected from patients with CRS from...

journal_title：International forum of allergy & rhinology

authors： Drilling A,Coombs GW,Tan HL,Pearson JC,Boase S,Psaltis A,Speck P,Vreugde S,Wormald PJ

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Evidence suggests relationships between allergic rhinitis (AR) and poor sleep parameters, but population-based studies in the United States are lacking. This study investigates the relationship between AR and sleep parameters in a representative sample of U.S. adults. METHODS:Cross-sectional study of 5563 p...

journal_title：International forum of allergy & rhinology

authors： Roxbury CR,Qiu M,Shargorodsky J,Lin SY

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Knowledge of our immune system functions is critical for understanding allergic airway disease development as well as for selection of appropriate diagnostic and therapeutic options for patients with respiratory allergies. METHODS:This review explains the current understanding of the basic immunology of the...

journal_title：International forum of allergy & rhinology

authors： Toskala E

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:According to epidemiologic studies, fine particulate matter (particulate matter ≤2.5 μm, PM2.5) is closely associated with increases in the incidence and severity of chronic rhinosinusitis (CRS). However, the role of PM2.5 in the pathophysiology of CRS remains largely unknown. In this study, we investigated ...

journal_title：International forum of allergy & rhinology

authors： Zhao R,Guo Z,Dong W,Deng C,Han Z,Liu J,Wang H,Zhuang G,Zhang R

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:After endoscopic sinus surgery (ESS), endoscopy is used to gauge surgical success and clinical outcomes. Prior studies have not examined this topic prospectively using validated outcome metrics across multiple institutions. METHODS:A multi-institutional, prospective study of patients with chronic rhinosinus...

journal_title：International forum of allergy & rhinology

authors： Schlosser RJ,Storck K,Smith TL,Mace JC,Rudmik L,Shahangian A,Soler ZM

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Over 45 million Americans suffer from recurrent headaches, and an estimated $11.9 million was spent on doctor's visits for rhinogenic pain last year. Sphenopalatine blocks have been described for various facial pain syndromes, but their use and the type of blockade agents remain controversial. The objective ...

journal_title：International forum of allergy & rhinology

authors： Rodman R,Dutton J

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if they are regulated in epitheli...

journal_title：International forum of allergy & rhinology

authors： Yamin M,Holbrook EH,Gray ST,Busaba NY,Lovett B,Hamilos DL

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as "sickness behavior." Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is ...

journal_title：International forum of allergy & rhinology

authors： Alt JA,Smith TL

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Oral steroids are commonly used in the management of chronic rhinosinusitis (CRS) with and without nasal polyps (CRSwNP and CRSsNP, respectively). Past reports have included evaluation of the evidence for the use of oral steroids in CRS subtypes. However, a review with evidence-based recommendations for all ...

journal_title：International forum of allergy & rhinology

authors： Poetker DM,Jakubowski LA,Lal D,Hwang PH,Wright ED,Smith TL

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Endoscopic-endonasal skull base surgery (ESBS) provides an important approach to select pathologies. There remains a paucity of data, however, regarding morbidity in patients undergoing ESBS with comorbid acute rhinosinusitis (ARS), a fungal ball (FB), or chronic rhinosinusitis (CRS). METHODS:A retrospectiv...

journal_title：International forum of allergy & rhinology

authors： Nyquist GG,Friedel ME,Singhal S,Beahm DD,Farrell CJ,Evans JJ,Rosen MR

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Osteitis is a feature of chronic rhinosinusitis (CRS) and often associated with recalcitrant disease. Radiological characteristics of osteitic sinus changes are commonly reported in practice but the clinical and pathologic significance is poorly defined. The objective of this study was to correlate the Kenne...

journal_title：International forum of allergy & rhinology

authors： Snidvongs K,McLachlan R,Sacks R,Earls P,Harvey RJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. The objective of the current study is to assess long-term success of the Draf III mucosal grafting technique. METHODS:Patients undergoing Draf III with mucosal graft...

journal_title：International forum of allergy & rhinology

authors： Illing EA,Cho do Y,Riley KO,Woodworth BA

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The ciprofloxacin-coated sinus stent (CSS) has unique therapeutic potential to deliver antibiotics to the sinuses. The objective of this study is to evaluate the efficacy of the CSS stent in eliminating Pseudomonas aeruginosa infection in a rabbit model of sinusitis. METHODS:A ciprofloxacin-eluting sinus st...

journal_title：International forum of allergy & rhinology

authors： Cho DY,Lim DJ,Mackey C,Skinner D,Weeks C,Gill GS,Hergenrother RW,Swords WE,Woodworth BA

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-9 and IL-17C have been known to play a role in allergic inflammation, yet, their roles in chronic rhinosinusitis (CRS) are not well defined. IL-9 induces changes in epithelial cell gene expression leading to goblet cell metaplasia, whereas IL-17C is functionally distinct in that its expressi...

journal_title：International forum of allergy & rhinology

authors： Olcott CM,Han JK,Cunningham TD,Franzese CB

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The incidence of adverse sequelae related to trauma of cranial nerve V2 (V2) and the Vidian nerve (VN) during endoscopic pterygoid recess repair (PRR) of lateral sphenoid encephalocele is insufficiently reported in the medical literature. As part of our quality assessment and improvement program we sought to...

journal_title：International forum of allergy & rhinology

authors： Chislett SP,Limjuco AP,Solyar AY,Lanza DC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The pathogenic roles of fungus and bacteria in chronic rhinosinusitis (CRS) remain unclear. Recently, we described the bacterial ball, which is distinct from the fungus ball, as an unusual phenotype of bacterial infection. In this study, we investigated the clinical, histopathologic, and immunologic characte...

journal_title：International forum of allergy & rhinology

authors： Kim DK,Wi YC,Shin SJ,Kim KR,Kim DW,Cho SH

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. It is well documented that bacteriostatic and bactericidal effects of NO are concentration-dependent. However, few data exist comparing relative susceptibility of common pathoge...

journal_title：International forum of allergy & rhinology

authors： Workman AD,Carey RM,Kohanski MA,Kennedy DW,Palmer JN,Adappa ND,Cohen NA

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...

journal_title：International forum of allergy & rhinology

authors： Zhang W,Hubin G,Endam LM,Al-Mot S,Filali-Mouhim A,Desrosiers M

更新日期：2012-11-01 00:00:00

abstract：:Early reports have suggested that smell loss may be an early symptom associated with the pandemic known as coronavirus disease 2019 (COVID-19). The possibility that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might cause olfactory dysfunction is certainly plausible. Patients presenting to specialized ...

journal_title：International forum of allergy & rhinology

authors： Soler ZM,Patel ZM,Turner JH,Holbrook EH

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Diagnostic nasal endoscopy is a routine measure of sinonasal inflammation in patients with chronic rhinosinusitis (CRS). Although multiple staging systems have been proposed and evaluated, evidence of association between concurrent symptoms and endoscopic findings remains discordant. The goal of this study i...

journal_title：International forum of allergy & rhinology

authors： DeConde AS,Bodner TE,Mace JC,Alt JA,Rudmik L,Smith TL

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The pathophysiologic mechanism of allergy is dependent on the action of many redox-sensitive proinflammatory mediators. However, even though redox disturbances are believed to be a hallmark of inflammation, little is known of the effect of redox imbalance to the pathophysiology of allergic rhinitis. We thus ...

journal_title：International forum of allergy & rhinology

authors： Guibas GV,Spandou E,Meditskou S,Vyzantiadis TA,Priftis KN,Anogianakis G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Diagnostic strategies employed for cases of cerebrospinal fluid (CSF) rhinorrhea vary widely due to limited evidence-based guidance. METHODS:A systematic review of the literature was performed using PubMed, EMBASE, and Cochrane databases from January 1990 through September 2014, to examine 9 diagnostic and ...

journal_title：International forum of allergy & rhinology

authors： Oakley GM,Alt JA,Schlosser RJ,Harvey RJ,Orlandi RR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Medialization of the middle turbinate (MT) is an effective technique to prevent recurrent rhinosinusitis but could, in theory, reduce olfactory function by interfering the odorants to reach the olfactory mucosae. We performed a prospective randomized double-blind trial under the hypothesis that olfactory fun...

journal_title：International forum of allergy & rhinology

authors： Kim SW,Kim RB,Kang H,Cho HJ,Joo YH,Jeon YJ,Jeon SY

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS:An international, multidisciplinary panel of 23 experts in ...

journal_title：International forum of allergy & rhinology

authors： El Rassi E,Adappa ND,Battaglia P,Castelnuovo P,Dallan I,Freitag SK,Gardner PA,Lenzi R,Lubbe D,Metson R,Moe KS,Muscatello L,Mustak H,Nogueira JF,Palmer JN,Prepageran N,Ramakirshnan VR,Sacks R,Snyderman CH,Stefko ST,

更新日期：2019-07-01 00:00:00