Preoperative management of spontaneous cerebrospinal fluid rhinorrhea with acetazolamide.

Abstract:

BACKGROUND:Spontaneous cerebrospinal fluid (CSF) rhinorrhea has been associated with elevated intracranial pressure (ICP). As such, ICP reducing measures are commonly employed to optimize repair. Although postoperative acetazolamide use has been described, no data currently exists on the potential for preoperative use. METHODS:A retrospective review was performed including patients treated for anterior spontaneous CSF leaks by a single surgeon over a 6-year period during which acetazolamide therapy (250 mg twice daily) was employed before considering surgical repair. The primary endpoint was whether the patient went on to require surgical repair. RESULTS:A total of 16 patients were identified who were pretreated with acetazolamide. Leak sites were noted as cribriform (5/16), sphenoid (8/16), ethmoid (1/16), multiple (1/16), and indeterminate (1/16). Five patients had resolution of their rhinorrhea without surgery (31.3%). Mean follow-up for these nonsurgical patients was 470 days (range, 64 to 857 days). There were no differences in the patients' age or site of leak between surgical and nonsurgical patients (p = 0.65, p = 0.52, respectively). Nonsurgical patients had a lower body mass index (BMI) than surgical patients (p = 0.04). CONCLUSION:This is the first study to report the use of acetazolamide therapy as a primary treatment option for spontaneous CSF rhinorrhea. This therapy enabled surgery to be avoided in 31.3% of patients. This would indicate that in the absence of other contraindications for delaying repair, a trial of acetazolamide therapy could be considered as an initial option in the management of isolated spontaneous CSF rhinorrhea.

authors

Tilak AM,Koehn H,Mattos J,Payne SC

doi

10.1002/alr.22245

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

265-269

issue

3

eissn

2042-6976

issn

2042-6984

journal_volume

9

pub_type

杂志文章
  • Asthma onset pattern and patient outcomes in a chronic rhinosinusitis population.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is strongly associated with comorbid asthma. This study compares early-onset and late-onset asthma in a CRS population using patient-reported and clinical characteristics. METHODS:At enrollment into a clinical registry, CRS patients completed the 22-item Sino-Nasal Outcome Test ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22064

    authors: John Staniorski C,Price CPE,Weibman AR,Welch KC,Conley DB,Shintani-Smith S,Stevens WW,Peters AT,Grammer L,Lidder AK,Schleimer RP,Kern RC,Tan BK

    更新日期:2018-04-01 00:00:00

  • Complications from office sclerotherapy for epistaxis due to hereditary hemorrhagic telangiectasia (HHT or Osler-Weber-Rendu).

    abstract:BACKGROUND:The aim of this study was to identify and evaluate adverse clinical outcomes following office-based sclerotherapy using sodium tetradecyl sulfate (STS) for epistaxis due to hereditary hemorrhagic telangiectasias (HHT or Osler-Weber-Rendu). METHODS:A retrospective chart review of 36 adult patients treated wi...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21287

    authors: Hanks JE,Hunter D,Goding GS Jr,Boyer HC

    更新日期:2014-05-01 00:00:00

  • Immunotherapy compliance: comparison of subcutaneous versus sublingual immunotherapy.

    abstract:BACKGROUND:Patient compliance is critical for successful allergen immunotherapy (AIT). Previous studies suggest that AIT compliance is worse outside of controlled clinical trials, with reported subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) noncompliance at 11% to 50% and 3% to 25%, respectively....

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21699

    authors: Leader BA,Rotella M,Stillman L,DelGaudio JM,Patel ZM,Wise SK

    更新日期:2016-05-01 00:00:00

  • Surgical management of rhinosinusitis in endoscopic-endonasal skull-base surgery.

    abstract:BACKGROUND:Endoscopic-endonasal skull base surgery (ESBS) provides an important approach to select pathologies. There remains a paucity of data, however, regarding morbidity in patients undergoing ESBS with comorbid acute rhinosinusitis (ARS), a fungal ball (FB), or chronic rhinosinusitis (CRS). METHODS:A retrospectiv...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21476

    authors: Nyquist GG,Friedel ME,Singhal S,Beahm DD,Farrell CJ,Evans JJ,Rosen MR

    更新日期:2015-04-01 00:00:00

  • Toll-like receptor 4-mediated expression of interleukin-32 via the c-Jun N-terminal kinase/protein kinase B/cyclic adenosine monophosphate response element binding protein pathway in chronic rhinosinusitis with nasal polyps.

    abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) is prolonged inflammation of the sinonasal mucosa. Interleukin-32 (IL-32) is involved in the pathogenesis of chronic lung inflammatory diseases. The aim of study is to compare the expression level of IL-32 in normal nasal mucosa and CRSwNP and to investigate ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21792

    authors: Cho JS,Kim JA,Park JH,Park IH,Han IH,Lee HM

    更新日期:2016-10-01 00:00:00

  • Evaluation of the olfactory bulb volume and olfactory threshold in patients with nasal polyps and impact of functional endoscopic sinus surgery: a longitudinal study.

    abstract:BACKGROUND:Debate still persists on the relation between olfactory bulb volume (OBV) and olfactory function. Many studies suggest that olfactory deprivation decreases the OBV. The aim of this study was to compare the olfactory threshold and OBV of patients with nasal polyps to healthy individuals and to evaluate the im...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21478

    authors: Sadeghi M,Amali A,Ezabadi SR,Motiee-Langroudi M,Farshchi S,Mokhtari Z

    更新日期:2015-04-01 00:00:00

  • Development of the international orbital Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system.

    abstract:BACKGROUND:Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS:An international, multidisciplinary panel of 23 experts in ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22316

    authors: El Rassi E,Adappa ND,Battaglia P,Castelnuovo P,Dallan I,Freitag SK,Gardner PA,Lenzi R,Lubbe D,Metson R,Moe KS,Muscatello L,Mustak H,Nogueira JF,Palmer JN,Prepageran N,Ramakirshnan VR,Sacks R,Snyderman CH,Stefko ST,

    更新日期:2019-07-01 00:00:00

  • Safety and Perioperative Adverse Events in Pediatric Endoscopic Sinus Surgery: An ACS-NSQIP-P Analysis.

    abstract:INTRODUCTION:This study describes safety outcomes of pediatric endoscopic sinus surgery (ESS) to identify risk factors for 30-day postoperative adverse events using the National Surgical Quality Improvement Program-Pediatric (NSQIP-P) database. METHODS:We performed a retrospective cohort study involving patients in th...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21954

    authors: Roxbury CR,Li L,Rhee D,Jatana KR,Shah RK,Boss EF

    更新日期:2017-08-01 00:00:00

  • Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database.

    abstract:BACKGROUND:Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy with a propensity for distant metastasis. In this study we describe the incidence and determinants of survival among patients with SNACC between the years 2004 and 2012 using the National Cancer Database (NCDB). METHODS:This was a retrospective...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22255

    authors: Trope M,Triantafillou V,Kohanski MA,Kuan EC,Tong CCL,Patel NN,Maina IW,Carey RM,Workman AD,Palmer JN,Adappa ND,Newman JG,Brant JA

    更新日期:2019-04-01 00:00:00

  • Association of the sinonasal bacterial microbiome with clinical outcomes in chronic rhinosinusitis: a systematic review.

    abstract:BACKGROUND:The association between sinonasal microbiome and clinical outcomes of patients with chronic rhinosinusitis (CRS) is unclear. We performed a systematic review of prior studies evaluating the CRS microbiome in relation to clinical outcomes. METHODS:Computerized searches of PubMed/Medline, Cochrane, and EMBASE...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22524

    authors: Wang JC,Moore CA,Epperson MV,Sedaghat AR

    更新日期:2020-04-01 00:00:00

  • Influence of a medialized middle turbinate on olfactory function: a prospective randomized double-blind study.

    abstract:BACKGROUND:Medialization of the middle turbinate (MT) is an effective technique to prevent recurrent rhinosinusitis but could, in theory, reduce olfactory function by interfering the odorants to reach the olfactory mucosae. We performed a prospective randomized double-blind trial under the hypothesis that olfactory fun...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/alr.22279

    authors: Kim SW,Kim RB,Kang H,Cho HJ,Joo YH,Jeon YJ,Jeon SY

    更新日期:2019-05-01 00:00:00

  • Placebo-controlled assessment of somnolence effect of cetirizine: a meta-analysis.

    abstract:BACKGROUND:It has been found that the most common adverse reaction which occurs more frequently on cetirizine than on placebo is somnolence. However, the somnolence rate varied widely among different studies. The objective of this study was to assess the somnolence effect of cetirizine 10 mg daily compared to placebo i...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,meta分析

    doi:10.1002/alr.21746

    authors: Du Q,Zhou Y

    更新日期:2016-08-01 00:00:00

  • Sinonasal squamous cell carcinoma and the prognostic implications of its histologic variants: a population-based study.

    abstract:BACKGROUND:Variants of squamous cell carcinoma (SCC) make up 15% of all cases of SCC of the upper aerodigestive tract. There are 5 main histologic variants of SCC in the head and neck region: verrucous (VSCC), papillary (PSCC), spindle cell (sarcomatoid) (SCSC), basaloid (BSCC), and adenosquamous (ASC). Conventional si...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21418

    authors: Vazquez A,Khan MN,Blake DM,Patel TD,Baredes S,Eloy JA

    更新日期:2015-01-01 00:00:00

  • The clinical significance of the pollen calendar of the Western Thrace/northeast Greece region in allergic rhinitis.

    abstract:BACKGROUND:There are major differences in the clinical pattern of allergic rhinitis (AR) patients among countries, reflecting local aerobiological conditions. We analyzed the correlation between airborne pollen concentrations of the Western Thrace/northeast (NE) Greece region with symptoms scores in AR patients. The ab...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21623

    authors: Katotomichelakis M,Nikolaidis C,Makris M,Zhang N,Aggelides X,Constantinidis TC,Bachert C,Danielides V

    更新日期:2015-12-01 00:00:00

  • Management of sinonasal chondrosarcoma: a systematic review of 161 patients.

    abstract:BACKGROUND:This study reviews the published literature related to management of sinonasal chondrosarcoma. Clinical presentation, demographics, radiographic diagnosis, treatment, and management outcomes of this uncommon disease are reported. METHODS:A systematic review of studies for sinonasal chondrosarcoma from 1950 ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21162

    authors: Khan MN,Husain Q,Kanumuri VV,Boghani Z,Patel CR,Liu JK,Eloy JA

    更新日期:2013-08-01 00:00:00

  • Asthma with allergic rhinitis management in China: a nationwide survey of respiratory specialists at tertiary hospitals.

    abstract:BACKGROUND:Many asthmatic patients have coexisting allergic rhinitis (AR). This study aims to investigate the compliance of physicians with respiratory medicine specialty (PRMs) to Global Initiative for Asthma (GINA) and Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines during the management of their asthma-...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21449

    authors: Su N,Lin J,Liu G,Yin K,Zhou X,Shen H,Chen P,Chen R,Liu C,Wu C,Zhao J,Lin Y

    更新日期:2015-03-01 00:00:00

  • Activation of the rat olfactory bulb by direct ventral stimulation after nerve transection.

    abstract:BACKGROUND:The aim of this study was to demonstrate how direct electrical stimulation can activate the olfactory bulb after denervation of the olfactory nerve input. METHODS:Sprague-Dawley rats (n = 5) were anesthetized and olfactory bulbs exposed. Olfactory nerves were transected by passing a Teflon blade between the...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22133

    authors: Coelho DH,Socolovsky LD,Costanzo RM

    更新日期:2018-05-02 00:00:00

  • Microwave ablation for the treatment of arterial epistaxis: "how I do it".

    abstract:BACKGROUND:Arterial epistaxis is commonly seen in the rhinology clinic and can have a significant impact on quality of life. Previous studies have explored various therapies to address epistaxis. METHODS:Patients were treated in the outpatient clinic or operating room by microwave ablation (MWA) with a 2450-MHz cooled...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22304

    authors: Lou ZC,Dong Y,Lou ZH

    更新日期:2019-06-01 00:00:00

  • What rhinologists and allergists should know about the medico-legal implications of antibiotic use: a review of the literature.

    abstract:BACKGROUND:Antibiotics are commonly used in the management of both acute rhinosinusitis and acute exacerbations of chronic rhinosinusitis. With their common use, they have become the leading medication for litigation. It is crucial for the provider to be familiar with potential complications and the medico-legal ramifi...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21433

    authors: Poetker DM,Smith TL

    更新日期:2015-02-01 00:00:00

  • Impact of margin status on survival after surgery for sinonasal squamous cell carcinoma.

    abstract:BACKGROUND:Sinonasal squamous cell carcinoma (SNSCC) is the most common malignancy of the paranasal sinuses. Surgery is the mainstay of treatment, yet positive surgical margins (PSM) are common and the prognostic impact on overall survival (OS) is mixed. Given the heterogeneity of impact of PSM on OS within the literat...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22415

    authors: Jafari A,Shen SA,Qualliotine JR,Orosco RK,Califano JA,DeConde AS

    更新日期:2019-10-01 00:00:00

  • Cousins, siblings, or copies: the genomics of recurrent Staphylococcus aureus infections in chronic rhinosinusitis.

    abstract:BACKGROUND:Staphylococcus aureus infection is known to play a role in recalcitrant chronic rhinosinusitis (CRS). However, it is unknown if recurrent S. aureus infections are caused by the same strain or are due to independent acquisitions of different strains. METHODS:Samples were collected from patients with CRS from...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21423

    authors: Drilling A,Coombs GW,Tan HL,Pearson JC,Boase S,Psaltis A,Speck P,Vreugde S,Wormald PJ

    更新日期:2014-12-01 00:00:00

  • Endoscopic endonasal anatomy of the nasopharynx in a cadaver model.

    abstract:BACKGROUND:Nasopharyngectomy is an accepted treatment for recurrent nasopharyngeal carcinoma following radiation with or without chemotherapy. Traditionally, the nasopharynx has been approached through relatively invasive "open" techniques including transpalatal, maxillary swing, and trans-mandibular-pterygoid approach...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21104

    authors: Becker AM,Hwang PH

    更新日期:2013-04-01 00:00:00

  • Distant pseudomeningoceles of the ventral skull base: a report of 2 cases.

    abstract:BACKGROUND:The objective of this case series was to report what is to the best of our knowledge the first reports of nasopharyngeal and soft palate pseudomeningoceles tracking submucosally from the sphenoid sinus. METHODS:Analysis of cases through medical records. RESULTS:Two cases of middle-aged male patients presen...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21242

    authors: Lieberman SM,Ojo RB,Casiano RR

    更新日期:2013-12-01 00:00:00

  • Determining the best graft-sealant combination for skull base repair using a soft tissue in vitro porcine model.

    abstract:BACKGROUND:The purpose of this work was to compare the absolute breaking strength of various soft tissue skull base (SB) repairs in an in vitro porcine model. METHODS:A burst pressure (BP) testing system was designed using an axial loading force to create increasing hydraulic pressure. Defects measuring 0.5 × 0.5 cm w...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21085

    authors: Fandiño M,Macdonald K,Singh D,Whyne C,Witterick I

    更新日期:2013-03-01 00:00:00

  • Endoscopic neural blockade for rhinogenic headache and facial pain: 2011 update.

    abstract:BACKGROUND:Over 45 million Americans suffer from recurrent headaches, and an estimated $11.9 million was spent on doctor's visits for rhinogenic pain last year. Sphenopalatine blocks have been described for various facial pain syndromes, but their use and the type of blockade agents remain controversial. The objective ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21035

    authors: Rodman R,Dutton J

    更新日期:2012-07-01 00:00:00

  • Chronic rhinosinusitis without nasal polyps is associated with increased expression of trefoil factor family peptides.

    abstract:BACKGROUND:Trefoil factor family (TFF) peptides are mucin-associated secretory products that are produced in the airways and gastrointestinal tract. These peptides appear to play an important role in mucosal healing and epithelial protection and are overexpressed in chronically inflamed gastrointestinal tissues. We hyp...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21334

    authors: Li P,Turner JH

    更新日期:2014-07-01 00:00:00

  • Characterization of immunoglobulin E plasma cells that are elevated in the upper airway mucosa of nonatopic patients with chronic rhinosinusitis without nasal polyps.

    abstract:BACKGROUND:The immunologic mechanisms driving inflammation in the upper airways of patients with chronic rhinosinusitis (CRS) are poorly understood. Previous studies have shown that B cells and immunoglobulin E (IgE) levels are elevated in the nasal tissue of patients with atopic chronic rhinosinusitis without nasal po...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21696

    authors: Rashan AR,Goshn E,Peterson A,Yang Y,Phillips M,Sahaf B,Herzenberg L,Nayak JV

    更新日期:2016-04-01 00:00:00

  • Ethmoid-to-maxillary opacification ratio: a predictor of postoperative olfaction and outcomes in nasal polyposis?

    abstract:BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22625

    authors: Beswick DM,Smith TL,Mace JC,Alt JA,Farrell NF,Ramakrishnan VR,Schlosser RJ,Soler ZM

    更新日期:2021-01-01 00:00:00

  • Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis.

    abstract:BACKGROUND:Allergic rhinitis (AR) is a chronic systemic allergic disease with an association reported between allergy and anxiety. The objective of the current study was therefore to investigate and retrospectively evaluate the factors that may possibly induce state and trait anxiety among patients with AR and vasomoto...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21802

    authors: Xi L,Cao F,Zhang Y,Zhang L

    更新日期:2016-11-01 00:00:00

  • Investigation of change in cardinal symptoms of chronic rhinosinusitis after surgical or ongoing medical management.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) has been defined as inflammation of the paranasal sinuses lasting at least 12 weeks with corresponding 2 or more "cardinal symptoms" that include: (1) nasal obstruction; (2) thick nasal discharge; (3) facial pain/pressure; and (4) reduction or loss of sense of smell. Although pri...

    journal_title:International forum of allergy & rhinology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/alr.21410

    authors: DeConde AS,Mace JC,Alt JA,Soler ZM,Orlandi RR,Smith TL

    更新日期:2015-01-01 00:00:00