Abstract:
BACKGROUND:Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as "sickness behavior." Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is known about the underlying etiology and pathophysiology. This narrative review aims to further organize and present the current knowledge associating sleep and CRS. METHODS:A literature search was conducted of the OVID MEDLINE database using key search words including: "chronic rhinosinusitis," "sleep," "sleep disorders," and "sleep dysfunction." Additional keywords "nasal obstruction," "nasal polyp," and "fatigue" were identified and used to further delineate relevant articles. RESULTS:The articles that specifically addressed sleep and CRS were dissected and presented as follows: (1) chronic rhinosinusitis and sleep; (2) chronic rhinosinusitis and fatigue; (3) chronic rhinosinusitis, nasal obstruction, and sleep; and (4) pathophysiology of sleep in chronic rhinosinusitis (cytokines in both sleep and chronic rhinosinusitis and their association to the neuroimmune biology of chronic rhinosinusitis). CONCLUSION:Patients with CRS have sleep dysfunction that is associated with their disease severity and overall quality of life. The etiology of sleep dysfunction in CRS is most likely multifactorial. Increasing evidence suggests sleep dysfunction in patients with CRS is partly due to the inflammatory disease process, and sleep physiology in patients with CRS may be actively regulated by the inflammatory component of the disease.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Alt JA,Smith TLdoi
10.1002/alr.21217subject
Has Abstractpub_date
2013-11-01 00:00:00pages
941-9issue
11eissn
2042-6976issn
2042-6984journal_volume
3pub_type
杂志文章,评审abstract:BACKGROUND:The histological features of osteitis in chronic rhinosinusitis (CRS) in animal studies induced by bacterial inoculation into maxillary sinuses revealed inflammatory involvement of the underlying bone matrix and/or the Haversian system; however, human studies do not mention these findings. The objective of t...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21291
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Fibroblasts are implicated in tissue remodeling and recruitment of inflammatory cells in chronic rhinosinusitis (CRS). Populations of fibroblasts remain unquantified in CRS subtypes. The objectives of this study were to measure fibroblast populations in subtypes of CRS, and to investigate the association bet...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21636
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Nonallergic rhinitis (NAR) is currently a diagnosis of exclusion with an unclear pathophysiologic mechanism and limited treatment options. In patients diagnosed with NAR based on symptoms, negative skin testing and positive optical rhinometry (ORM), the study's objective was to evaluate the therapeutic actio...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22637
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:There is a lack of population-based, multi-institutional analyses of factors associated with morbidity and mortality following pituitary tumor excision. METHODS:The American College of Surgeons National Surgical Quality Improvement Project files were used to compile information on patients that had undergon...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21641
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). The objectives of this review are to summarize prior studies that describe the correlation between active smoking and secondhand smoke (SHS...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21054
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Allergic rhinitis (AR) is a chronic systemic allergic disease with an association reported between allergy and anxiety. The objective of the current study was therefore to investigate and retrospectively evaluate the factors that may possibly induce state and trait anxiety among patients with AR and vasomoto...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21802
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Increased frequency of migraine was reported in adults with allergic rhinitis (AR). Although migraine is less common in children than in adults, it can begin in early childhood and persist into adulthood. We conducted this population-based cohort study to investigate the incidence and subsequent risk of migr...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21654
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if they are regulated in epitheli...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21516
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a common condition encountered in primary care medicine and is estimated to affect 12.5% of the United States population. This study aims to compare methods of assessing health utility in CRS. METHODS:A cross-sectional sample of CRS patients (n = 137) were interviewed using d...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21556
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Despite considerable research, the pathogenesis of chronic rhinosinusitis (CRS) remains poorly understood. Potential microbial roles in the etiology or progression of CRS have long been hypothesized, yet few specific associations have been identified. In this study we investigate associations between pattern...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21871
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:After endoscopic sinus surgery (ESS), endoscopy is used to gauge surgical success and clinical outcomes. Prior studies have not examined this topic prospectively using validated outcome metrics across multiple institutions. METHODS:A multi-institutional, prospective study of patients with chronic rhinosinus...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21651
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Patient compliance is critical for successful allergen immunotherapy (AIT). Previous studies suggest that AIT compliance is worse outside of controlled clinical trials, with reported subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) noncompliance at 11% to 50% and 3% to 25%, respectively....
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21699
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Techniques for inferior turbinate reduction vary from complete turbinectomy to limited cauterization. Surgical methods differ on the degree of tissue reduction and reliance on surgical tissue removal vs tissue ablation. The outcome and morbidity from 3 different turbinate techniques are compared. METHODS:A ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,随机对照试验
doi:10.1002/alr.21574
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The objective of the evidence base review was to systematically evaluate the literature to elucidate the potential role of oral antifungal therapy in management of chronic rhinosinusitis (CRS) and its subtypes. METHODS:Articles for inclusion were identified by query of appropriate search terms in the PubMed...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.20088
更新日期:2011-09-01 00:00:00
abstract::Recent evidence has demonstrated an expanding role of respiratory epithelial cells in immune surveillance and modulation. Studies have been focusing on the earliest events that link epithelial injury to downstream inflammatory responses. Cytokines produced by and released from respiratory epithelial cells are among th...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.22206
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Osteitis is a feature of chronic rhinosinusitis (CRS) and often associated with recalcitrant disease. Radiological characteristics of osteitic sinus changes are commonly reported in practice but the clinical and pathologic significance is poorly defined. The objective of this study was to correlate the Kenne...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21113
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Arterial epistaxis is commonly seen in the rhinology clinic and can have a significant impact on quality of life. Previous studies have explored various therapies to address epistaxis. METHODS:Patients were treated in the outpatient clinic or operating room by microwave ablation (MWA) with a 2450-MHz cooled...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22304
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic rhinosinusitis, nasal polyps, asthma, and respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). In addition to sensitivity to aspirin and NSAIDs, the majority of patients with AERD have bee...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.22168
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericid...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21949
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Chronic sphenoid rhinosinusitis (CSR) refractory to both medical management and 1 or more sphenoidotomies is a difficult entity to treat. In contrast to the surgical hierarchy that exists for the frontal sinus, there is no systematic approach for addressing persistent disease in the sphenoid. Sphenoid marsup...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20006
更新日期:2011-01-01 00:00:00
abstract::Early reports have suggested that smell loss may be an early symptom associated with the pandemic known as coronavirus disease 2019 (COVID-19). The possibility that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might cause olfactory dysfunction is certainly plausible. Patients presenting to specialized ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.22578
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The effects of desloratadine-montelukast combination on quality of life (QoL) and nasal airflow of patients with perennial allergic rhinitis (PAR) has not been reported. The objective of this work was investigate the efficacy of desloratadine-montelukast combination on nasal obstruction and health-related qu...
journal_title:International forum of allergy & rhinology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/alr.21185
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:This study reviews the published literature related to extramedullary sinonasal plasmacytomas. Clinical presentation, demographics, treatment, and outcomes of this uncommon disease are reported. METHODS:A systematic review of studies for sinonasal plasmacytomas from 1950 to 2012 was conducted. A PubMed data...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21254
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Evidence suggests relationships between allergic rhinitis (AR) and poor sleep parameters, but population-based studies in the United States are lacking. This study investigates the relationship between AR and sleep parameters in a representative sample of U.S. adults. METHODS:Cross-sectional study of 5563 p...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22174
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Treatment options for chronic rhinosinusitis with recurrent polyposis (CRSwNP) after endoscopic sinus surgery (ESS) are limited, and include frequent use of systemic steroids and revision surgery. A bioabsorbable, steroid-eluting implant was studied for its ability to dilate sinuses obstructed by polyps and ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21309
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS:An international, multidisciplinary panel of 23 experts in ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22316
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The objective of this case series was to report what is to the best of our knowledge the first reports of nasopharyngeal and soft palate pseudomeningoceles tracking submucosally from the sphenoid sinus. METHODS:Analysis of cases through medical records. RESULTS:Two cases of middle-aged male patients presen...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21242
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The Rhinosinusitis Disability Index (RSDI) consists of multiple subdomains shown to be useful in studying chronic rhinosinusitis (CRS). The objective of this study was to determine if RSDI subdomain scores are associated with selection of treatment modality (endoscopic sinus surgery [ESS] or continued medica...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21656
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The role that bacterial biofilms might play in recalcitrant forms of chronic rhinosinusitis (CRS) is increasingly being recognized. However, the detection of bacteria existing in this form, using standard culture, is limited by their unique metabolically inactive properties. All current biofilm diagnostic mo...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21115
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Little is known regarding the role of the microbiome of the paranasal sinuses and its contribution to sinus mucosal health and disease. Consequently, we examined the microbiome of chronic rhinosinusitis patients with polyps (CRSwNP) and a control population to provide new insights into the microbiota associa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22297
更新日期:2019-06-01 00:00:00