Abstract:
:Recent evidence has demonstrated an expanding role of respiratory epithelial cells in immune surveillance and modulation. Studies have been focusing on the earliest events that link epithelial injury to downstream inflammatory responses. Cytokines produced by and released from respiratory epithelial cells are among these early trigger signals. Epithelial-derived cytokines, namely thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, have come to the forefront of recent investigations. Each of these 3 cytokines has been implicated in chronic rhinosinusitis (CRS), asthma, and atopy. Herein we review studies elucidating the roles of epithelial-derived cytokines in the pathobiology of upper airway disease, with particular emphasis on type 2 inflammatory conditions.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Patel NN,Kohanski MA,Maina IW,Workman AD,Herbert DR,Cohen NAdoi
10.1002/alr.22206subject
Has Abstractpub_date
2019-01-01 00:00:00pages
93-99issue
1eissn
2042-6976issn
2042-6984journal_volume
9pub_type
杂志文章,评审abstract:BACKGROUND:Previous studies have shown controversial results of topical amphotericin B (AMB) nasal irrigation for chronic rhinosinusitis (CRS). The purpose of this study was to evaluate the efficacy of 200 μg/mL AMB nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery (FESS). METHODS:Patie...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,随机对照试验
doi:10.1002/alr.22033
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Social determinants of health can have a substantial impact on treatment outcomes. Prior study has shown that socioeconomic status influences the likelihood of improvement in quality-of-life (QOL) following endoscopic sinus surgery (ESS). However, the impact of socioeconomic factors on changes in productivit...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.22374
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Multiple prospective and retrospective studies have reported results from balloon-only procedures and hybrid balloon sinus surgeries through intermediate follow-up periods of up to 1 year. Long-term durability results beyond 2 years are limited. METHODS:One-year results from the original study of standalone...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21024
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Endoscopic repair of anterior skull-base defects has become the gold standard for management of cerebrospinal fluid (CSF) rhinorrhea. Both improved techniques and adjuvant therapies have led to accepted success rates of greater than 90%. As management has evolved, shorter hospitalizations have been required ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21810
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if they are regulated in epitheli...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21516
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Endoscopic Draf 2B and Draf 3 frontal sinusotomies are frequently performed for chronic refractory frontal rhinosinusitis. The purpose of this study was to compare outcomes between Draf 2B and Draf 3 procedures. METHODS:A retrospective cohort study was conducted comparing patients undergoing bilateral Draf ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22032
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The correct use of inhalation devices is essential for successful therapy. We aimed to evaluate the skills in the use of a spacer device with an metered-dose inhaler (MDI) and factors that influence this skill in asthmatic preschool children's caregivers. METHODS:The caregivers of 12-month-old to 72-month-o...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21648
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Patient compliance is critical for successful allergen immunotherapy (AIT). Previous studies suggest that AIT compliance is worse outside of controlled clinical trials, with reported subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) noncompliance at 11% to 50% and 3% to 25%, respectively....
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21699
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The goal of this study was to develop and evaluate the impact of an aviation-style challenge and response sinus surgery-specific checklist on potential safety and equipment issues during sinus surgery at a tertiary academic health center. The secondary goal was to assess the potential impact of use of the ch...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22106
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The endoscopic modified Lothrop procedure (EMLP) is commonly performed in recalcitrant frontal sinusitis, in part to achieve better penetration of medicated irrigations postoperatively. Although EMLP requires a septectomy for exposure, it is unknown whether septectomy size affects delivery of irrigations. In...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22158
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Endoscopic-endonasal skull base surgery (ESBS) provides an important approach to select pathologies. There remains a paucity of data, however, regarding morbidity in patients undergoing ESBS with comorbid acute rhinosinusitis (ARS), a fungal ball (FB), or chronic rhinosinusitis (CRS). METHODS:A retrospectiv...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21476
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Inverted papilloma is a benign sinonasal tumor that arises from a localized attachment site. These attachment sites, however, have not been fully characterized in the literature. The objective of this research was to determine the specific distribution of attachment sites in patients with sinonasal papilloma...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20054
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21056
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Knowledge of our immune system functions is critical for understanding allergic airway disease development as well as for selection of appropriate diagnostic and therapeutic options for patients with respiratory allergies. METHODS:This review explains the current understanding of the basic immunology of the...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21380
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Nitric oxide (NO) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. It is well documented that bacteriostatic and bactericidal effects of NO are concentration-dependent. However, few data exist comparing relative susceptibility of common pathoge...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21966
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Industry outreach promotes awareness of novel technologies. However, concerns have been raised that such relationships may also unduly impact medical decision-making. Our objective in this study was to evaluate industry relationships among practitioners who frequently employ balloon dilation (BD), characteri...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21976
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Olfactory inflammation in chronic rhinosinusitis (CRS) is associated with cytokines that may result in the death of olfactory sensory neurons. The principal signaling molecules involved in the apoptotic pathway are c-Jun N-terminal kinases (JNK). Although the JNK pathway has emerged as a key player in progra...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22053
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Surgical management of the superior turbinate (ST) is required to access the sella in endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenoma. Two common ST management techniques include partial resection of the ST (PRST) and intentional lateralization of the ST (ILST). Given the concentrat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22694
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Treatment options for chronic rhinosinusitis with recurrent polyposis (CRSwNP) after endoscopic sinus surgery (ESS) are limited, and include frequent use of systemic steroids and revision surgery. A bioabsorbable, steroid-eluting implant was studied for its ability to dilate sinuses obstructed by polyps and ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21309
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The pathophysiologic mechanism of allergy is dependent on the action of many redox-sensitive proinflammatory mediators. However, even though redox disturbances are believed to be a hallmark of inflammation, little is known of the effect of redox imbalance to the pathophysiology of allergic rhinitis. We thus ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21145
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22089
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Previous studies have reviewed the safety of preparing and administering allergy injection immunotherapy in a physician's office, and showed no evidence of infectious complications. The current study examines the antimicrobial properties of the common additives used in preparation of multidose immunotherapy ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20105
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Sinonasal squamous cell carcinoma (SNSCC) is the most common malignancy of the paranasal sinuses. Surgery is the mainstay of treatment, yet positive surgical margins (PSM) are common and the prognostic impact on overall survival (OS) is mixed. Given the heterogeneity of impact of PSM on OS within the literat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22415
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:This analysis explores the increasing heterogeneity of trends in allergy management under the premise that the practice of allergy has undergone significant changes in national economics, healthcare delivery, and treatment options from 2007 to 2016. METHODS:Centers for Medicare and Medicaid Services (CMS) d...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22111
更新日期:2018-05-21 00:00:00
abstract:BACKGROUND:Bronchial asthma is one of the most common chronic diseases in childhood, with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming rate. Asthma is a complex genetic disorder with strong environmental influence. It imposes a growing burden on our society in terms of morbidity,...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21557
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Debate still persists on the relation between olfactory bulb volume (OBV) and olfactory function. Many studies suggest that olfactory deprivation decreases the OBV. The aim of this study was to compare the olfactory threshold and OBV of patients with nasal polyps to healthy individuals and to evaluate the im...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21478
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The immunologic mechanisms driving inflammation in the upper airways of patients with chronic rhinosinusitis (CRS) are poorly understood. Previous studies have shown that B cells and immunoglobulin E (IgE) levels are elevated in the nasal tissue of patients with atopic chronic rhinosinusitis without nasal po...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21696
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:This study reviews the published literature related to extramedullary sinonasal plasmacytomas. Clinical presentation, demographics, treatment, and outcomes of this uncommon disease are reported. METHODS:A systematic review of studies for sinonasal plasmacytomas from 1950 to 2012 was conducted. A PubMed data...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21254
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The role of bacteria in the etiopathogenesis of chronic rhinosinusitis (CRS) remains an area of interest. The impact of surgery and factors such as the presence of polyps, asthma, and aspirin sensitivity on the bacterial state are poorly understood. To determine the effect of these factors, this study examin...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21159
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:After endoscopic sinus surgery (ESS), endoscopy is used to gauge surgical success and clinical outcomes. Prior studies have not examined this topic prospectively using validated outcome metrics across multiple institutions. METHODS:A multi-institutional, prospective study of patients with chronic rhinosinus...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21651
更新日期:2016-02-01 00:00:00