Abstract:
BACKGROUND:The objective of the evidence base review was to systematically evaluate the literature to elucidate the potential role of oral antifungal therapy in management of chronic rhinosinusitis (CRS) and its subtypes. METHODS:Articles for inclusion were identified by query of appropriate search terms in the PubMed database. The articles were reviewed independently by 2 authors and assigned an evidence level. The composite outcome data was reviewed to determine the impact of oral antifungals in CRS. RESULTS:The search yielded 356 abstracts for review, retrieved 60 articles for full review, and incorporated 28 studies in this report. The majority of literature included level 4 (15) and level 5 (12) studies. One study met criteria for level 1 evidence. Most common disease entity studied was allergic fungal rhinosinusitis in 19 series; the most common antifungals reported were itraconazole and ketoconazole in 19 and 6 studies, respectively. Subjective parameters were assessed in 12 (42.8%) studies; overall, 64 (78%) of 82 patients reported symptom resolution or improvement. Objective parameters were reported in 6 (21.4%) studies, including improvement in endoscopic findings (3), CT imaging (3), reduction in oral steroid usage (1), and less revision surgery (2). Median length of follow-up was 14.7 months (3-60). CONCLUSION:The composite data suggests a potential beneficial effect of oral itraconazole and ketoconazole in patients with CRS and its subtypes. However, majority of the studies are uncontrolled case series, confounded by non-validated outcome variables. Randomized controlled trials are required to better elucidate their role in CRS.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Thanasumpun T,Batra PSdoi
10.1002/alr.20088subject
Has Abstractpub_date
2011-09-01 00:00:00pages
382-9issue
5eissn
2042-6976issn
2042-6984journal_volume
1pub_type
杂志文章,评审abstract:BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21056
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:According to epidemiologic studies, fine particulate matter (particulate matter ≤2.5 μm, PM2.5) is closely associated with increases in the incidence and severity of chronic rhinosinusitis (CRS). However, the role of PM2.5 in the pathophysiology of CRS remains largely unknown. In this study, we investigated ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22182
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Lumbar drain (LD) use in the management of cerebrospinal fluid (CSF) rhinorrhea remains controversial. We analyzed the relationship between LD placement and CSF leak recurrence after endoscopic repair. METHODS:A retrospective case series was conducted. Patients who underwent CSF leak repair from 1999 to 201...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21023
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS:An international, multidisciplinary panel of 23 experts in ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22316
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Endoscopic sinus surgery (ESS) enjoys high success rates, but repopulation with pathogenic bacteria is 1 of the hallmarks of poorer outcomes. There are many hypothesized sources of repopulating bacteria; however, this process remains largely unexplored. This study examined changes in the sinus microbiome aft...
journal_title:International forum of allergy & rhinology
pub_type: 临床试验,杂志文章
doi:10.1002/alr.21630
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Previous studies have reviewed the safety of preparing and administering allergy injection immunotherapy in a physician's office, and showed no evidence of infectious complications. The current study examines the antimicrobial properties of the common additives used in preparation of multidose immunotherapy ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20105
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Nasal steroids are a critical part of the management of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after endoscopic sinus surgery (ESS). Increasingly, practitioners are using budesonide respules delivered to the sinonasal cavities, which is an off-label use, in lieu of traditional nas...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,随机对照试验
doi:10.1002/alr.21688
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Subcutaneous immunotherapy (SCIT) demands a significant time commitment on the part of the patient, especially during the escalation period when weekly visits are required. Many patients refuse or discontinue treatment in spite of the demonstrated clinical efficacy of SCIT. Understanding the factors that aff...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21027
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been pro...
journal_title:International forum of allergy & rhinology
pub_type: 共识发展会议,杂志文章
doi:10.1002/alr.22070
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The role of bacteria in the pathogenesis of chronic rhinosinusitis (CRS) remains uncertain. Recent evidence suggests that bacteria are able to establish microcolonies within the underlying mucosa. However, to date there has been no systematic comparison of bacterial community composition and diversity in the...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21600
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The endoscopic modified Lothrop procedure (EMLP) is commonly performed in recalcitrant frontal sinusitis, in part to achieve better penetration of medicated irrigations postoperatively. Although EMLP requires a septectomy for exposure, it is unknown whether septectomy size affects delivery of irrigations. In...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22158
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on pri...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21440
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:This analysis explores the increasing heterogeneity of trends in allergy management under the premise that the practice of allergy has undergone significant changes in national economics, healthcare delivery, and treatment options from 2007 to 2016. METHODS:Centers for Medicare and Medicaid Services (CMS) d...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22111
更新日期:2018-05-21 00:00:00
abstract:BACKGROUND:The purpose of this work was to describe a clinical and radiographic pattern of findings that helps localize the site of spontaneous cerebrospinal fluid (CSF) leaks. METHODS:This study was a retrospective review of CSF leaks treated at the University of Texas Southwestern Medical Center from 2000 to 2009. D...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21048
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Industry outreach promotes awareness of novel technologies. However, concerns have been raised that such relationships may also unduly impact medical decision-making. Our objective in this study was to evaluate industry relationships among practitioners who frequently employ balloon dilation (BD), characteri...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21976
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Patients with refractory chronic rhinosinusitis (RCRS) have persistent symptoms despite best medical therapy. Some evidence suggests continued medical therapy (CMT) is appropriate for patients with RCRS. The primary objective of this study was to evaluate the clinical impact of CMT in patients with RCRS who ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21238
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Olfactory-specific quality of life (QOL) can be measured using the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS), which examines various aspects of olfactory dysfunction. It is unknown if certain factors of the QOD-NS differentially impact QOL. METHODS:Patients with chronic rhinosinusiti...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22112
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Spacers are inserted into the middle meatal space (MMS) following functional endoscopic sinus surgery (FESS) to prevent lateralization of the middle turbinate, scarring, and synechiae. Our objective was to determine if the incidence of postoperative synechiae, facial pain/discomfort, pain during spacer remov...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22119
更新日期:2018-03-30 00:00:00
abstract:BACKGROUND:The purpose of this work was to perform a systematic review regarding ossifying fibroma and its multiple variants of the paranasal sinuses, and to identify any clinical differences between the multiple variants. METHODS:A search of the U.S. National Library of Medicine (PubMed) database was performed for th...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21067
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Interleukin 13 (IL-13) is a pleiotropic cytokine that has been shown to be important in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and other type 2 inflammation-related diseases. Increased IL-13 expression can elicit several pro-inflammatory effects, including eosinophilia, and pat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22630
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Little is known regarding the role of the microbiome of the paranasal sinuses and its contribution to sinus mucosal health and disease. Consequently, we examined the microbiome of chronic rhinosinusitis patients with polyps (CRSwNP) and a control population to provide new insights into the microbiota associa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22297
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Poor sleep quality is common in chronic rhinosinusitis (CRS). Prior studies have demonstrated improvements in patient-reported measures of sleep quality following endoscopic sinus surgery (ESS). The purpose of this study was to evaluate the effect of ESS on objective sleep parameters and identify any associa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22738
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Previous studies have shown controversial results of topical amphotericin B (AMB) nasal irrigation for chronic rhinosinusitis (CRS). The purpose of this study was to evaluate the efficacy of 200 μg/mL AMB nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery (FESS). METHODS:Patie...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,随机对照试验
doi:10.1002/alr.22033
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20022
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Nasopharyngectomy is an accepted treatment for recurrent nasopharyngeal carcinoma following radiation with or without chemotherapy. Traditionally, the nasopharynx has been approached through relatively invasive "open" techniques including transpalatal, maxillary swing, and trans-mandibular-pterygoid approach...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21104
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Olfactory inflammation in chronic rhinosinusitis (CRS) is associated with cytokines that may result in the death of olfactory sensory neurons. The principal signaling molecules involved in the apoptotic pathway are c-Jun N-terminal kinases (JNK). Although the JNK pathway has emerged as a key player in progra...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22053
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Increased frequency of migraine was reported in adults with allergic rhinitis (AR). Although migraine is less common in children than in adults, it can begin in early childhood and persist into adulthood. We conducted this population-based cohort study to investigate the incidence and subsequent risk of migr...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21654
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The incidence of adverse sequelae related to trauma of cranial nerve V2 (V2) and the Vidian nerve (VN) during endoscopic pterygoid recess repair (PRR) of lateral sphenoid encephalocele is insufficiently reported in the medical literature. As part of our quality assessment and improvement program we sought to...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22448
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The treatment of the middle turbinate (MT) during endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) remains a contentious issue with arguments both for and against its resection. The purpose of this study was to examine the clinical impact of partial MT resection (PMTR) during ESS, paying parti...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22127
更新日期:2018-04-06 00:00:00
abstract:BACKGROUND:Surgical management of the superior turbinate (ST) is required to access the sella in endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenoma. Two common ST management techniques include partial resection of the ST (PRST) and intentional lateralization of the ST (ILST). Given the concentrat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22694
更新日期:2020-12-01 00:00:00