Abstract:
BACKGROUND:The most dramatic complication in endonasal surgery is inadvertent injury to the internal carotid artery (ICA) with massive bleeding. Nasal packing is the favored technique for control; however, this often causes complete carotid occlusion or carotid stenosis, contributing to the morbidity and mortality of the patient. The aim of this study is to compare the efficacy of endoscopically applied hemostatic techniques that maintain vascular flow in an animal model of carotid artery injury. METHODS:A total of 20 sheep underwent ICA dissection/isolation followed by the placement of the artery within a modified "sinus model otorhino neuro trainer" (SIMONT) model. A standardized 4-mm carotid artery injury was created endoscopically. Randomization of sheep to receive 1 of 5 hemostatic techniques was performed (Floseal, oxidized regenerated cellulose, Chitosan gel, muscle patch, or the U-Clip anastomotic device). Specific outcome measures were time to hemostasis, duration of time mean arterial pressure (MAP) was >55 mmHg, blood loss, and survival time. RESULTS:Muscle patch hemostasis and the U-Clip anastomotic device were significantly more effective at achieving primary hemostasis rapidly, reducing total blood loss, and increasing survival time and time MAP was >55 mmHg more than Floseal, oxidized regenerated cellulose, and Chitosan gel (p < 0.05). Additionally, all muscle patch-treated and U-Clip device-treated sheep achieved primary hemostasis and reached the endpoint of observation, while maintaining vascular patency. Floseal and oxidized regenerated cellulose failed to achieve hemostasis in any animal, with all animals exsanguinating prematurely. CONCLUSION:In the sheep model of endoscopic ICA injury, the muscle patch and U-Clip anastomotic device significantly improved survival, reduced blood loss, and achieved primary hemostasis while maintaining vascular patency.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Valentine R,Boase S,Jervis-Bardy J,Dones Cabral JD,Robinson S,Wormald PJdoi
10.1002/alr.20033subject
Has Abstractpub_date
2011-03-01 00:00:00pages
118-22issue
2eissn
2042-6976issn
2042-6984journal_volume
1pub_type
杂志文章abstract:BACKGROUND:Chronic rhinosinusitis (CRS) in aspirin-exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation for which a multidisciplinary consensus on patient management has not been reached. Several medical interventions have been investigated, but a formal comprehensive evaluati...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21826
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare 2010 access to, usage of, and attitudes toward image-guided surgery (IGS) for endoscopic sinus surgery and anterior skull-base surgery to those in 2005. METHODS:A mail survey of American Rhinologic Society (ARS) members was performed in January 2010. Results were compare...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20107
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to tumor necrosis factor alpha inhibitors (TNFαis). The histologic features of CRS caused by TNFαis have yet to be determined and may have important implications in understanding the pathophysiology of...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22462
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22625
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to identify and evaluate adverse clinical outcomes following office-based sclerotherapy using sodium tetradecyl sulfate (STS) for epistaxis due to hereditary hemorrhagic telangiectasias (HHT or Osler-Weber-Rendu). METHODS:A retrospective chart review of 36 adult patients treated wi...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21287
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a local inflammatory process driven by eosinophils. Mucosal eosinophil count (MEC) has previously been demonstrated to be a reliable indicator of disease severity. We aim to evaluate use of MEC in guiding medical management of CRS after functional endoscopic sinus surgery (FES...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22517
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Treatment of recalcitrant chronic rhinosinusitis (CRS) is a challenge with increasing antibiotic resistance, leading to re-emergence of topical therapies. The aim of this study was to assess safety and efficacy of topical colloidal silver solution for the treatment of Staphylococcus aureus biofilms in a shee...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21459
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is strongly associated with comorbid asthma. This study compares early-onset and late-onset asthma in a CRS population using patient-reported and clinical characteristics. METHODS:At enrollment into a clinical registry, CRS patients completed the 22-item Sino-Nasal Outcome Test ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22064
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Aspirin-exacerbated respiratory disease (AERD) is a recalcitrant inflammatory disorder defined by asthma, nasal polyposis, and sensitivity to cyclooxygenase-1 inhibitors. The timeline and course of disease progression is unclear. METHODS:The Truven MarketScan Database, a large American health insurance clai...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22412
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis (AR) and asthma patients. METHODS:In total, 327 patients with diagnoses of persistent AR or mild-to-...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/alr.21468
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Frontal sinus cerebrospinal fluid (CSF) leaks have traditionally been repaired via open procedures (eg, osteoplastic flap or cranialization). Advancements in instrumentation, technique, and experience have improved the feasibility of repairing frontal sinus skull-base defects using an endoscopic approach. Th...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21019
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. U...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21496
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:A genetic basis to chronic rhinosinusitis (CRS) is postulated, but remains elusive. We have recently identified low levels of circulating CD8 lymphocytes as a frequent finding in difficult-to-treat or refractory CRS. In major histocompatibility complex 1 class 1 (MHC1) deficiency, low circulating levels of C...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21174
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:According to epidemiologic studies, fine particulate matter (particulate matter ≤2.5 μm, PM2.5) is closely associated with increases in the incidence and severity of chronic rhinosinusitis (CRS). However, the role of PM2.5 in the pathophysiology of CRS remains largely unknown. In this study, we investigated ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22182
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Reported revision rates for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) vary significantly. Several investigations examining revision rates for ESS have been limited by duration of follow-up, academic centers, or small surgeon cohorts. The objective of this study was to define the long-te...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22264
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22089
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Sinonasal squamous cell carcinoma (SNSCC) is the most common malignancy of the paranasal sinuses. Surgery is the mainstay of treatment, yet positive surgical margins (PSM) are common and the prognostic impact on overall survival (OS) is mixed. Given the heterogeneity of impact of PSM on OS within the literat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22415
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Surgical treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) has evolved over the last decade as rhinologists have increasingly used topical steroid therapies and altered surgical techniques. It is important to understand the changes in success rates of surgery and frequency of revision endosco...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22505
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:We have previously demonstrated that persistent symptoms following functional endoscopic sinus surgery for chronic rhinosinusitis (CRS) is associated with Gram-negative bacterial carriage. Mechanisms for this remain unknown. We wished to determine whether Gram-negative carriage in patients with CRS with nasa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21481
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:After endoscopic sinus surgery (ESS), endoscopy is used to gauge surgical success and clinical outcomes. Prior studies have not examined this topic prospectively using validated outcome metrics across multiple institutions. METHODS:A multi-institutional, prospective study of patients with chronic rhinosinus...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
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更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether anterior rhinoscopy (AR), nasal endoscopy (NE) and paranasal sinus computed tomography (PNS CT) can predict other sinonasal obstructive pathologies in the setting of nasal septal deviation (NSD), and to evaluate the impact of preoperative PNS CT on the decision ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21545
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a common condition encountered in primary care medicine and is estimated to affect 12.5% of the United States population. This study aims to compare methods of assessing health utility in CRS. METHODS:A cross-sectional sample of CRS patients (n = 137) were interviewed using d...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21556
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20022
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Arterial epistaxis is commonly seen in the rhinology clinic and can have a significant impact on quality of life. Previous studies have explored various therapies to address epistaxis. METHODS:Patients were treated in the outpatient clinic or operating room by microwave ablation (MWA) with a 2450-MHz cooled...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22304
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-9 and IL-17C have been known to play a role in allergic inflammation, yet, their roles in chronic rhinosinusitis (CRS) are not well defined. IL-9 induces changes in epithelial cell gene expression leading to goblet cell metaplasia, whereas IL-17C is functionally distinct in that its expressi...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21745
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Social determinants of health can have a substantial impact on treatment outcomes. Prior study has shown that socioeconomic status influences the likelihood of improvement in quality-of-life (QOL) following endoscopic sinus surgery (ESS). However, the impact of socioeconomic factors on changes in productivit...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.22374
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Spacers are inserted into the middle meatal space (MMS) following functional endoscopic sinus surgery (FESS) to prevent lateralization of the middle turbinate, scarring, and synechiae. Our objective was to determine if the incidence of postoperative synechiae, facial pain/discomfort, pain during spacer remov...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22119
更新日期:2018-03-30 00:00:00
abstract:BACKGROUND:Requests from researchers for olfactory mucosal biopsies are increasing as a result of advances in the fields of neuroscience and stem cell biology. Published studies report variable rates of success in obtaining true olfactory tissue, often below 50%. In cases where biopsies are not obtained carefully and c...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21711
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Olfactory-specific quality of life (QOL) can be measured using the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS), which examines various aspects of olfactory dysfunction. It is unknown if certain factors of the QOD-NS differentially impact QOL. METHODS:Patients with chronic rhinosinusiti...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22112
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Olfaction is one of the important senses for humans. Systemic glucocorticoids are the most commonly used medications for olfactory loss because of their strong anti-inflammatory effects. However, their effect on olfactory function is still controversial and the precise mechanism is not clear. To gain a globa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21586
更新日期:2015-10-01 00:00:00