Olfactory loss in chronic rhinosinusitis is associated with neuronal activation of c-Jun N-terminal kinase.

abstract：BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...

journal_title：International forum of allergy & rhinology

authors： Zhang W,Hubin G,Endam LM,Al-Mot S,Filali-Mouhim A,Desrosiers M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The endoscopic modified Lothrop procedure (EMLP) is used to manage ongoing refractory frontal sinusitis after failed previous endoscopic sinus surgery (ESS), but this approach has a significant restenosis rate. We evaluated the potential benefits of mucosal grafts and pedicled flaps on the opening of the new...

journal_title：International forum of allergy & rhinology

authors： Wang YP,Shen PH,Hsieh LC,Wormald PJ

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Inverted papilloma is a benign sinonasal tumor that arises from a localized attachment site. These attachment sites, however, have not been fully characterized in the literature. The objective of this research was to determine the specific distribution of attachment sites in patients with sinonasal papilloma...

journal_title：International forum of allergy & rhinology

authors： Schneyer MS,Milam BM,Payne SC

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Patients  with  viral respiratory infections/viral rhinitis/common colds are often treated with antibiotic; however, there is little information on whether or how bacterial microbiota in the nose and nasopharynx might influence the course of viral illnesses. METHODS:To initiate investigation of possible int...

journal_title：International forum of allergy & rhinology

authors： Allen EK,Pitkäranta A,Mäki M,Hendley JO,Laakso S,Sale MM,Winther B

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to tumor necrosis factor alpha inhibitors (TNFαis). The histologic features of CRS caused by TNFαis have yet to be determined and may have important implications in understanding the pathophysiology of...

journal_title：International forum of allergy & rhinology

authors： Papagiannopoulos P,Devins K,Tong CCL,Yver C,Patel NN,Kuhar HN,Bosso JV,Kohanski MA,Tajudeen BA,Kuan EC,Batra PS,Cohen NA,Kennedy DW,Palmer JN,Montone K,Adappa ND

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericid...

journal_title：International forum of allergy & rhinology

authors： Carey RM,Workman AD,Hatten KM,Siebert AP,Brooks SG,Chen B,Adappa ND,Palmer JN,Kennedy DW,Lee RJ,Cohen NA

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Interleukin 13 (IL-13) is a pleiotropic cytokine that has been shown to be important in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and other type 2 inflammation-related diseases. Increased IL-13 expression can elicit several pro-inflammatory effects, including eosinophilia, and pat...

journal_title：International forum of allergy & rhinology

authors： Khalil SM,Bernstein I,Kulaga H,Gour N,Rowan N,Lajoie S,Lane AP

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology is poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were associated with sleep dysfunction severity or altered the improvement in sleep dysfunction follow...

journal_title：International forum of allergy & rhinology

authors： Farrell NF,Mace JC,Sauer DA,Thomas AJ,Geltzeiler M,Detwiller KY,Alt JA,Smith TL

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:Multiple prospective and retrospective studies have reported results from balloon-only procedures and hybrid balloon sinus surgeries through intermediate follow-up periods of up to 1 year. Long-term durability results beyond 2 years are limited. METHODS:One-year results from the original study of standalone...

journal_title：International forum of allergy & rhinology

authors： Stankiewicz J,Truitt T,Atkins J,Winegar B,Cink P,Raviv J,Henderson D,Tami T

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...

journal_title：International forum of allergy & rhinology

authors： Beswick DM,Smith TL,Mace JC,Alt JA,Farrell NF,Ramakrishnan VR,Schlosser RJ,Soler ZM

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Despite considerable research, the pathogenesis of chronic rhinosinusitis (CRS) remains poorly understood. Potential microbial roles in the etiology or progression of CRS have long been hypothesized, yet few specific associations have been identified. In this study we investigate associations between pattern...

journal_title：International forum of allergy & rhinology

authors： Hoggard M,Biswas K,Zoing M,Wagner Mackenzie B,Taylor MW,Douglas RG

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:This study reviews the published literature related to management of sinonasal chondrosarcoma. Clinical presentation, demographics, radiographic diagnosis, treatment, and management outcomes of this uncommon disease are reported. METHODS:A systematic review of studies for sinonasal chondrosarcoma from 1950 ...

journal_title：International forum of allergy & rhinology

authors： Khan MN,Husain Q,Kanumuri VV,Boghani Z,Patel CR,Liu JK,Eloy JA

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The objective of this case series was to report what is to the best of our knowledge the first reports of nasopharyngeal and soft palate pseudomeningoceles tracking submucosally from the sphenoid sinus. METHODS:Analysis of cases through medical records. RESULTS:Two cases of middle-aged male patients presen...

journal_title：International forum of allergy & rhinology

authors： Lieberman SM,Ojo RB,Casiano RR

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Cystic fibrosis (CF) is caused by a misfunctional CF transmembrane conductance regulator (CFTR) protein, which is believed to contributes to the regulation of the airway surface liquid (ASL) pH. This study investigated acid and base secretion in freshly excised human nasal tissues from CF patients homozygous...

journal_title：International forum of allergy & rhinology

authors： Cho DY,Hwang PH,Illek B,Fischer H

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Olfactory dysfunction is 1 of the hallmark symptoms of chronic rhinosinusitis (CRS). Eosinophilic inflammation has been implicated as a potential causative factor. However, prior studies have been limited by retrospective study designs, concomitant use of systemic corticosteroids, and other confounding facto...

journal_title：International forum of allergy & rhinology

authors： Hauser LJ,Chandra RK,Li P,Turner JH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Endoscopic repair of anterior skull-base defects has become the gold standard for management of cerebrospinal fluid (CSF) rhinorrhea. Both improved techniques and adjuvant therapies have led to accepted success rates of greater than 90%. As management has evolved, shorter hospitalizations have been required ...

journal_title：International forum of allergy & rhinology

authors： Adams AS,Francis DO,Russell PT

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Nasal polyposis is characterized by persistent inflammation but the pathogenesis is complex and still debatable. Autophagy has been associated with many human health problems including chronic inflammatory airway diseases. Whether autophagy plays a role in nasal polyps and could be a therapeutic target is co...

journal_title：International forum of allergy & rhinology

authors： Chen JY,Hour TC,Yang SF,Chien CY,Chen HR,Tsai KL,Ko JY,Wang LF

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Inadequate efficacy of current intranasal steroids in chronic rhinosinusitis (CRS) is attributable to ineffective and/or inconsistent drug delivery to target anatomic sites. A new exhalation delivery system with fluticasone (EDS-FLU) may improve outcomes by significantly increasing superior/posterior cortico...

journal_title：International forum of allergy & rhinology

authors： Palmer JN,Jacobson KW,Messina JC,Kosik-Gonzalez C,Djupesland PG,Mahmoud RA

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Arterial epistaxis is commonly seen in the rhinology clinic and can have a significant impact on quality of life. Previous studies have explored various therapies to address epistaxis. METHODS:Patients were treated in the outpatient clinic or operating room by microwave ablation (MWA) with a 2450-MHz cooled...

journal_title：International forum of allergy & rhinology

authors： Lou ZC,Dong Y,Lou ZH

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). The objectives of this review are to summarize prior studies that describe the correlation between active smoking and secondhand smoke (SHS...

journal_title：International forum of allergy & rhinology

authors： Reh DD,Higgins TS,Smith TL

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Patients with eosinophilic chronic rhinosinusitis (ECRS) have been shown to have greater disease severity and poorer treatment outcomes after sinus surgery. Although the inflammatory pattern of ECRS is essential to diagnosing this subtype, there is currently no consensus for diagnosis. Our aim in this study ...

journal_title：International forum of allergy & rhinology

authors： McHugh T,Snidvongs K,Xie M,Banglawala S,Sommer D

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:The effects of desloratadine-montelukast combination on quality of life (QoL) and nasal airflow of patients with perennial allergic rhinitis (PAR) has not been reported. The objective of this work was investigate the efficacy of desloratadine-montelukast combination on nasal obstruction and health-related qu...

journal_title：International forum of allergy & rhinology

authors： Cingi C,Oghan F,Eskiizmir G,Yaz A,Ural A,Erdogmus N

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent...

journal_title：International forum of allergy & rhinology

authors： Kern RC,Stolovitzky JP,Silvers SL,Singh A,Lee JT,Yen DM,Iloreta AMC Jr,Langford FPJ,Karanfilov B,Matheny KE,Stambaugh JW,Gawlicka AK,RESOLVE II study investigators.

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The objective of the evidence base review was to systematically evaluate the literature to elucidate the potential role of oral antifungal therapy in management of chronic rhinosinusitis (CRS) and its subtypes. METHODS:Articles for inclusion were identified by query of appropriate search terms in the PubMed...

journal_title：International forum of allergy & rhinology

authors： Thanasumpun T,Batra PS

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Previous studies have shown controversial results of topical amphotericin B (AMB) nasal irrigation for chronic rhinosinusitis (CRS). The purpose of this study was to evaluate the efficacy of 200 μg/mL AMB nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery (FESS). METHODS:Patie...

journal_title：International forum of allergy & rhinology

authors： Jiang RS,Twu CW,Liang KL

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The incidence of adverse sequelae related to trauma of cranial nerve V2 (V2) and the Vidian nerve (VN) during endoscopic pterygoid recess repair (PRR) of lateral sphenoid encephalocele is insufficiently reported in the medical literature. As part of our quality assessment and improvement program we sought to...

journal_title：International forum of allergy & rhinology

authors： Chislett SP,Limjuco AP,Solyar AY,Lanza DC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Insufficiency of the nasal valve is increasingly being recognized as a cause of nasal airway obstruction. The condition is associated with many symptoms, including nasal congestion, sleep disturbance, snoring, and an overall decline in quality of life (QoL). An in-office, minimally invasive radiofrequency tr...

journal_title：International forum of allergy & rhinology

authors： Ephrat M,Jacobowitz O,Driver M

更新日期：2020-08-09 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) has been defined as inflammation of the paranasal sinuses lasting at least 12 weeks with corresponding 2 or more "cardinal symptoms" that include: (1) nasal obstruction; (2) thick nasal discharge; (3) facial pain/pressure; and (4) reduction or loss of sense of smell. Although pri...

journal_title：International forum of allergy & rhinology

authors： DeConde AS,Mace JC,Alt JA,Soler ZM,Orlandi RR,Smith TL

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Industry outreach promotes awareness of novel technologies. However, concerns have been raised that such relationships may also unduly impact medical decision-making. Our objective in this study was to evaluate industry relationships among practitioners who frequently employ balloon dilation (BD), characteri...

journal_title：International forum of allergy & rhinology

authors： Eloy JA,Svider PF,Bobian M,Harvey RJ,Gray ST,Baredes S,Folbe AJ

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Staphylococcus aureus infection is known to play a role in recalcitrant chronic rhinosinusitis (CRS). However, it is unknown if recurrent S. aureus infections are caused by the same strain or are due to independent acquisitions of different strains. METHODS:Samples were collected from patients with CRS from...

journal_title：International forum of allergy & rhinology

authors： Drilling A,Coombs GW,Tan HL,Pearson JC,Boase S,Psaltis A,Speck P,Vreugde S,Wormald PJ

更新日期：2014-12-01 00:00:00