A novel finding on computed tomography in the diagnosis and localization of cerebrospinal fluid leaks without a clear bony defect.

Abstract:

BACKGROUND:The purpose of this work was to describe a clinical and radiographic pattern of findings that helps localize the site of spontaneous cerebrospinal fluid (CSF) leaks. METHODS:This study was a retrospective review of CSF leaks treated at the University of Texas Southwestern Medical Center from 2000 to 2009. Data collected included demographics, nature of presentation, imaging findings, intraoperative location of skull-base defect, and clinical follow-up. RESULTS:Forty-six patients' charts were reviewed. Among these patients, 15 did not show a bony skull-base defect on high-resolution computed tomography (CT) scan. They did, however, each show a small area of opacification in the olfactory cleft. In each case, this area of opacification correlated with the site of the CSF leak. Intrathecal fluorescein was not used, except in 2 instances. Successful repair was noted in all patients on follow-up, without evidence of recurrence at the repair site. CONCLUSION:In the absence of a clearly identifiable bony skull-base defect, opacification of the olfactory cleft is a localizing sign in some cases of spontaneous CSF rhinorrhea. Such a finding should direct endoscopic repair, and may serve as the only marker for the specific leak site.

authors

Manes RP,Ryan MW,Marple BF

doi

10.1002/alr.21048

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

402-4

issue

5

eissn

2042-6976

issn

2042-6984

journal_volume

2

pub_type

杂志文章
  • Immunotherapy compliance: comparison of subcutaneous versus sublingual immunotherapy.

    abstract:BACKGROUND:Patient compliance is critical for successful allergen immunotherapy (AIT). Previous studies suggest that AIT compliance is worse outside of controlled clinical trials, with reported subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) noncompliance at 11% to 50% and 3% to 25%, respectively....

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21699

    authors: Leader BA,Rotella M,Stillman L,DelGaudio JM,Patel ZM,Wise SK

    更新日期:2016-05-01 00:00:00

  • A primer on viral-associated olfactory loss in the era of COVID-19.

    abstract::Early reports have suggested that smell loss may be an early symptom associated with the pandemic known as coronavirus disease 2019 (COVID-19). The possibility that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might cause olfactory dysfunction is certainly plausible. Patients presenting to specialized ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.22578

    authors: Soler ZM,Patel ZM,Turner JH,Holbrook EH

    更新日期:2020-07-01 00:00:00

  • Free mucosal grafts and anterior pedicled flaps to prevent ostium restenosis after endoscopic modified Lothrop (frontal drillout) procedure: a randomized, controlled study.

    abstract:BACKGROUND:The endoscopic modified Lothrop procedure (EMLP) is used to manage ongoing refractory frontal sinusitis after failed previous endoscopic sinus surgery (ESS), but this approach has a significant restenosis rate. We evaluated the potential benefits of mucosal grafts and pedicled flaps on the opening of the new...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/alr.22416

    authors: Wang YP,Shen PH,Hsieh LC,Wormald PJ

    更新日期:2019-11-01 00:00:00

  • Role of tissue eosinophils in chronic rhinosinusitis-associated olfactory loss.

    abstract:BACKGROUND:Olfactory dysfunction is 1 of the hallmark symptoms of chronic rhinosinusitis (CRS). Eosinophilic inflammation has been implicated as a potential causative factor. However, prior studies have been limited by retrospective study designs, concomitant use of systemic corticosteroids, and other confounding facto...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21994

    authors: Hauser LJ,Chandra RK,Li P,Turner JH

    更新日期:2017-10-01 00:00:00

  • Expression of the extracellular matrix gene periostin is increased in chronic rhinosinusitis and decreases following successful endoscopic sinus surgery.

    abstract:BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21056

    authors: Zhang W,Hubin G,Endam LM,Al-Mot S,Filali-Mouhim A,Desrosiers M

    更新日期:2012-11-01 00:00:00

  • Is preoperative paranasal sinus computed tomography necessary for every patient undergoing septoplasty?

    abstract:BACKGROUND:The aim of this study was to determine whether anterior rhinoscopy (AR), nasal endoscopy (NE) and paranasal sinus computed tomography (PNS CT) can predict other sinonasal obstructive pathologies in the setting of nasal septal deviation (NSD), and to evaluate the impact of preoperative PNS CT on the decision ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21545

    authors: Günbey E,Günbey HP,Uygun S,Karabulut H,Cingi C

    更新日期:2015-09-01 00:00:00

  • Draf III mucosal graft technique: long-term results.

    abstract:BACKGROUND:The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. The objective of the current study is to assess long-term success of the Draf III mucosal grafting technique. METHODS:Patients undergoing Draf III with mucosal graft...

    journal_title:International forum of allergy & rhinology

    pub_type: 临床试验,杂志文章

    doi:10.1002/alr.21708

    authors: Illing EA,Cho do Y,Riley KO,Woodworth BA

    更新日期:2016-05-01 00:00:00

  • Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes.

    abstract:BACKGROUND:Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericid...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21949

    authors: Carey RM,Workman AD,Hatten KM,Siebert AP,Brooks SG,Chen B,Adappa ND,Palmer JN,Kennedy DW,Lee RJ,Cohen NA

    更新日期:2017-07-01 00:00:00

  • Predictors of 30-day morbidity and mortality in transnasal microscopic pituitary tumor excision.

    abstract:BACKGROUND:There is a lack of population-based, multi-institutional analyses of factors associated with morbidity and mortality following pituitary tumor excision. METHODS:The American College of Surgeons National Surgical Quality Improvement Project files were used to compile information on patients that had undergon...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21641

    authors: Lawrence LA,Baker AB,Nguyen SA,Karnezis TT,Soler ZM,Schlosser RJ

    更新日期:2016-02-01 00:00:00

  • A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.

    abstract:BACKGROUND:Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature. METHODS:A systematic literature review was ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21902

    authors: Hodzic Z,Rowan NR,Kashiwazaki R,Willson TJ,Wang EW,Lee SE

    更新日期:2017-05-01 00:00:00

  • Influence of the location of nasal polyps on olfactory airflow and olfaction.

    abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22089

    authors: Nishijima H,Kondo K,Yamamoto T,Nomura T,Kikuta S,Shimizu Y,Mizushima Y,Yamasoba T

    更新日期:2018-06-01 00:00:00

  • Objective sleep measures after endoscopic sinus surgery in patients with chronic rhinosinusitis.

    abstract:BACKGROUND:Poor sleep quality is common in chronic rhinosinusitis (CRS). Prior studies have demonstrated improvements in patient-reported measures of sleep quality following endoscopic sinus surgery (ESS). The purpose of this study was to evaluate the effect of ESS on objective sleep parameters and identify any associa...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22738

    authors: Little RE,Alt JA,Ramakrishnan VR,Platt MP,Schlosser RJ,Storck KA,Soler ZM

    更新日期:2020-11-23 00:00:00

  • Severity of nasal obstruction can predict the anxiety status of patients with allergic rhinitis but not patients with vasomotor rhinitis.

    abstract:BACKGROUND:Allergic rhinitis (AR) is a chronic systemic allergic disease with an association reported between allergy and anxiety. The objective of the current study was therefore to investigate and retrospectively evaluate the factors that may possibly induce state and trait anxiety among patients with AR and vasomoto...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21802

    authors: Xi L,Cao F,Zhang Y,Zhang L

    更新日期:2016-11-01 00:00:00

  • Back-and-forth endoscopic septoplasty: analysis of the technique and outcomes.

    abstract:BACKGROUND:To describe our clinical experience in 218 consecutive patients undergoing endoscopic back-and-forth septoplasty (EBFS), examining surgical indications, technique, and follow-up. METHODS:From January 2005 to November 2008, 218 patients underwent EBFS at the Department of Otorhinolaryngology, San Raffaele Ho...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.20100

    authors: Trimarchi M,Bellini C,Toma S,Bussi M

    更新日期:2012-01-01 00:00:00

  • Contemporary management of chronic rhinosinusitis with nasal polyposis in aspirin-exacerbated respiratory disease: an evidence-based review with recommendations.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) in aspirin-exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation for which a multidisciplinary consensus on patient management has not been reached. Several medical interventions have been investigated, but a formal comprehensive evaluati...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21826

    authors: Levy JM,Rudmik L,Peters AT,Wise SK,Rotenberg BW,Smith TL

    更新日期:2016-12-01 00:00:00

  • Effects of povidone-iodine composite on the elimination of bacterial biofilm.

    abstract:BACKGROUND:Povidone-iodine (PVP-I) is well known as an antiseptic and exhibits extensive activity against various pathogens. However, due to its uniquely unpleasant nature, it cannot be used locally to deactivate various sinonasal pathogens. Therefore, we developed a PVP-I composite that blocks the unpleasant odor of P...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22568

    authors: Jeronimo LP,Choi MR,Yeon SH,Park SK,Yoon YH,Choi SH,Kim HJ,Jang IT,Park JK,Rha KS,Kim YM

    更新日期:2020-07-01 00:00:00

  • Impact of mentoring medical students on scholarly productivity.

    abstract:BACKGROUND:Our objectives were to evaluate collaboration with medical students and other nondoctoral authors, and assess whether mentoring such students influences the academic productivity of senior authors. METHODS:Six issues of the Laryngoscope and International Forum of Allergy & Rhinology (IFAR) were examined for...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21247

    authors: Svider PF,Husain Q,Mauro KM,Folbe AJ,Baredes S,Eloy JA

    更新日期:2014-02-01 00:00:00

  • A challenge-response endoscopic sinus surgery specific checklist as an add-on to standard surgical checklist: an evaluation of potential safety and quality improvement issues.

    abstract:BACKGROUND:The goal of this study was to develop and evaluate the impact of an aviation-style challenge and response sinus surgery-specific checklist on potential safety and equipment issues during sinus surgery at a tertiary academic health center. The secondary goal was to assess the potential impact of use of the ch...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22106

    authors: Sommer DD,Arbab-Tafti S,Farrokhyar F,Tewfik M,Vescan A,Witterick IJ,Rotenberg B,Chandra R,Weitzel EK,Wright E,Ramakrishna J

    更新日期:2018-07-01 00:00:00

  • International consensus statement on allergy and rhinology: allergic rhinitis-executive summary.

    abstract:BACKGROUND:The available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been pro...

    journal_title:International forum of allergy & rhinology

    pub_type: 共识发展会议,杂志文章

    doi:10.1002/alr.22070

    authors: Wise SK,Lin SY,Toskala E

    更新日期:2018-02-01 00:00:00

  • Acid and base secretion in freshly excised nasal tissue from cystic fibrosis patients with ΔF508 mutation.

    abstract:BACKGROUND:Cystic fibrosis (CF) is caused by a misfunctional CF transmembrane conductance regulator (CFTR) protein, which is believed to contributes to the regulation of the airway surface liquid (ASL) pH. This study investigated acid and base secretion in freshly excised human nasal tissues from CF patients homozygous...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.20028

    authors: Cho DY,Hwang PH,Illek B,Fischer H

    更新日期:2011-03-01 00:00:00

  • Cadaveric comparison of canine fossa vs transnasal maxillary sinus access.

    abstract:OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.20022

    authors: Feldt BA,McMains KC,Weitzel EK

    更新日期:2011-05-01 00:00:00

  • Effect of elderly status on postoperative complications in patients with sinonasal cancer.

    abstract:BACKGROUND:Elderly patients with multiple comorbidities may be at higher risk of postoperative complications. With an increasingly aging population, more data assessing for predisposing factors are needed in this at-risk group. In this study, we analyzed the effect of elderly status on relative comorbidities and compli...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22239

    authors: Bashjawish B,Patel S,Kılıç S,Svider PF,Hsueh WD,Liu JK,Baredes S,Eloy JA

    更新日期:2019-02-01 00:00:00

  • Office-based olfactory mucosa biopsies.

    abstract:BACKGROUND:Requests from researchers for olfactory mucosal biopsies are increasing as a result of advances in the fields of neuroscience and stem cell biology. Published studies report variable rates of success in obtaining true olfactory tissue, often below 50%. In cases where biopsies are not obtained carefully and c...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21711

    authors: Holbrook EH,Rebeiz L,Schwob JE

    更新日期:2016-06-01 00:00:00

  • Impact of postoperative endoscopy upon clinical outcomes after endoscopic sinus surgery.

    abstract:BACKGROUND:After endoscopic sinus surgery (ESS), endoscopy is used to gauge surgical success and clinical outcomes. Prior studies have not examined this topic prospectively using validated outcome metrics across multiple institutions. METHODS:A multi-institutional, prospective study of patients with chronic rhinosinus...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/alr.21651

    authors: Schlosser RJ,Storck K,Smith TL,Mace JC,Rudmik L,Shahangian A,Soler ZM

    更新日期:2016-02-01 00:00:00

  • Dexamethasone affects mouse olfactory mucosa gene expression and attenuates genes related to neurite outgrowth.

    abstract:BACKGROUND:Olfaction is one of the important senses for humans. Systemic glucocorticoids are the most commonly used medications for olfactory loss because of their strong anti-inflammatory effects. However, their effect on olfactory function is still controversial and the precise mechanism is not clear. To gain a globa...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21586

    authors: Tian J,Pinto JM,Xin Y,Zhang H,Li L,Sun Z,Wei Y

    更新日期:2015-10-01 00:00:00

  • Human papillomavirus infection and biomarkers in sinonasal inverted papillomas: clinical significance and molecular mechanisms.

    abstract:BACKGROUND:The role of human papillomavirus (HPV) in sinonasal inverted papillomas (IPs) is controversial. Determining the prevalence of HPV infection and its impact on the molecular biology of these tumors is critical to characterizing its role in the pathogenesis of IPs. METHODS:A total of 112 paraffin-embedded IPs ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21524

    authors: Scheel A,Lin GC,McHugh JB,Komarck CM,Walline HM,Prince ME,Zacharek MA,Carey TE

    更新日期:2015-08-01 00:00:00

  • Perioperative management in endoscopic endonasal skull-base surgery: a survey of the North American Skull Base Society.

    abstract:BACKGROUND:The objective of this work was to better understand variations in perioperative management in endoscopic endonasal skull-base surgery (EESBS) and to identify trends in management based upon the practice patterns of North American Skull Base Society (NASBS) members. METHODS:A 29-question survey evaluating pe...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22066

    authors: Roxbury CR,Lobo BC,Kshettry VR,D'Anza B,Woodard TD,Recinos PF,Snyderman CH,Sindwani R

    更新日期:2018-05-01 00:00:00

  • Role of Toll-like receptor 9 signaling on activation of nasal polyp-derived fibroblasts and its association with nasal polypogenesis.

    abstract:BACKGROUND:Nasal polyposis is characterized by persistent inflammation and remodeling in sinonasal mucosa. Toll-like receptor 9 (TLR9) is a DNA receptor of the innate immune system that plays a pivotal role in fibrosis and inflammatory responses. The aim of this study is to explore the expression, activity, and potenti...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22155

    authors: Park SK,Jin SY,Yeon SH,Lee SB,Xu J,Yoon YH,Rha KS,Kim YM

    更新日期:2018-09-01 00:00:00

  • Development of a clinically relevant endoscopic grading system for chronic rhinosinusitis using canonical correlation analysis.

    abstract:BACKGROUND:Diagnostic nasal endoscopy is a routine measure of sinonasal inflammation in patients with chronic rhinosinusitis (CRS). Although multiple staging systems have been proposed and evaluated, evidence of association between concurrent symptoms and endoscopic findings remains discordant. The goal of this study i...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21683

    authors: DeConde AS,Bodner TE,Mace JC,Alt JA,Rudmik L,Smith TL

    更新日期:2016-05-01 00:00:00

  • Comparing the efficacy of Silastic and gloved-Merocel middle meatal spacers for functional endoscopic sinus surgery: a randomized controlled trial.

    abstract:BACKGROUND:Spacers are inserted into the middle meatal space (MMS) following functional endoscopic sinus surgery (FESS) to prevent lateralization of the middle turbinate, scarring, and synechiae. Our objective was to determine if the incidence of postoperative synechiae, facial pain/discomfort, pain during spacer remov...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22119

    authors: Manji J,Habib AR,Macias-Valle L,Finkelstein A,Alsaleh S,Dadgostar A,Al-Asousi F,Okpaleke C,Javer AR

    更新日期:2018-03-30 00:00:00