Comparison of intranasal fluticasone spray, budesonide atomizer, and budesonide respules in patients with chronic rhinosinusitis with polyposis after endoscopic sinus surgery.

Abstract:

BACKGROUND:Nasal steroids are a critical part of the management of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after endoscopic sinus surgery (ESS). Increasingly, practitioners are using budesonide respules delivered to the sinonasal cavities, which is an off-label use, in lieu of traditional nasal steroids. There has been little research comparing budesonide with traditional nasal steroids and the most effective delivery method of budesonide. METHODS:A randomized controlled trial was performed on patients after ESS for CRSwNP in a tertiary care center. Patients were randomized into 1 of 3 groups: group A received fluticasone nasal spray twice daily; group B received budesonide respules via a mucosal atomization device (MAD) twice daily; and group C received budesonide respules instilled via the vertex-to-floor (VF) position twice daily. Primary endpoints were 22-item Sino-Nasal Outcome Test (SNOT-22) and Lund-Kennedy scores at 6 months. RESULTS:Thirty-two patients were enrolled in the study, 23 of whom completed the 6-month trial. There were no significant differences among groups A, B, and C with respect to age, gender, asthma, aspirin sensitivity, or previous ESS. Group B had a statistically significant greater reduction in SNOT-22 and Lund-Kennedy scores at the primary endpoint of 6 months compared to groups A and C. Group C had the next greatest reduction, which was statistically significant, followed by group A. CONCLUSION:Patients treated with budesonide after ESS for CRSwNP had greater improvement in SNOT-22 and Lund-Kennedy scores compared to fluticasone at 6 months. The data supports the use of budesonide respules, particularly with a MAD, over fluticasone for CRSwNP patients after ESS.

authors

Neubauer PD,Schwam ZG,Manes RP

doi

10.1002/alr.21688

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

233-7

issue

3

eissn

2042-6976

issn

2042-6984

journal_volume

6

pub_type

杂志文章,随机对照试验
  • International consensus statement on allergy and rhinology: allergic rhinitis-executive summary.

    abstract:BACKGROUND:The available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been pro...

    journal_title:International forum of allergy & rhinology

    pub_type: 共识发展会议,杂志文章

    doi:10.1002/alr.22070

    authors: Wise SK,Lin SY,Toskala E

    更新日期:2018-02-01 00:00:00

  • The bacteriology of chronic rhinosinusitis and the pre-eminence of Staphylococcus aureus in revision patients.

    abstract:BACKGROUND:The role of bacteria in the etiopathogenesis of chronic rhinosinusitis (CRS) remains an area of interest. The impact of surgery and factors such as the presence of polyps, asthma, and aspirin sensitivity on the bacterial state are poorly understood. To determine the effect of these factors, this study examin...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21159

    authors: Cleland EJ,Bassiouni A,Wormald PJ

    更新日期:2013-08-01 00:00:00

  • Profibrotic transforming growth factor beta 1 and activin A are increased in nasal polyp tissue and induced in nasal polyp epithelium by cigarette smoke and Toll-like receptor 3 ligation.

    abstract:BACKGROUND:The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if they are regulated in epitheli...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21516

    authors: Yamin M,Holbrook EH,Gray ST,Busaba NY,Lovett B,Hamilos DL

    更新日期:2015-07-01 00:00:00

  • Asthma risk factors.

    abstract:BACKGROUND:Bronchial asthma is one of the most common chronic diseases in childhood, with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming rate. Asthma is a complex genetic disorder with strong environmental influence. It imposes a growing burden on our society in terms of morbidity,...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21557

    authors: Toskala E,Kennedy DW

    更新日期:2015-09-01 00:00:00

  • Size of septectomy does not affect distribution of nasal irrigation after endoscopic modified Lothrop procedure.

    abstract:BACKGROUND:The endoscopic modified Lothrop procedure (EMLP) is commonly performed in recalcitrant frontal sinusitis, in part to achieve better penetration of medicated irrigations postoperatively. Although EMLP requires a septectomy for exposure, it is unknown whether septectomy size affects delivery of irrigations. In...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22158

    authors: Roxbury CR,Tang D,Shah J,McBride J,Woodard TD,Sindwani R

    更新日期:2018-10-01 00:00:00

  • Influence of the location of nasal polyps on olfactory airflow and olfaction.

    abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22089

    authors: Nishijima H,Kondo K,Yamamoto T,Nomura T,Kikuta S,Shimizu Y,Mizushima Y,Yamasoba T

    更新日期:2018-06-01 00:00:00

  • What rhinologists and allergists should know about the medico-legal implications of antibiotic use: a review of the literature.

    abstract:BACKGROUND:Antibiotics are commonly used in the management of both acute rhinosinusitis and acute exacerbations of chronic rhinosinusitis. With their common use, they have become the leading medication for litigation. It is crucial for the provider to be familiar with potential complications and the medico-legal ramifi...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21433

    authors: Poetker DM,Smith TL

    更新日期:2015-02-01 00:00:00

  • Predictors of 30-day morbidity and mortality in transnasal microscopic pituitary tumor excision.

    abstract:BACKGROUND:There is a lack of population-based, multi-institutional analyses of factors associated with morbidity and mortality following pituitary tumor excision. METHODS:The American College of Surgeons National Surgical Quality Improvement Project files were used to compile information on patients that had undergon...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21641

    authors: Lawrence LA,Baker AB,Nguyen SA,Karnezis TT,Soler ZM,Schlosser RJ

    更新日期:2016-02-01 00:00:00

  • A phase 3 trial of mometasone furoate sinus implants for chronic sinusitis with recurrent nasal polyps.

    abstract:BACKGROUND:Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/alr.22084

    authors: Kern RC,Stolovitzky JP,Silvers SL,Singh A,Lee JT,Yen DM,Iloreta AMC Jr,Langford FPJ,Karanfilov B,Matheny KE,Stambaugh JW,Gawlicka AK,RESOLVE II study investigators.

    更新日期:2018-04-01 00:00:00

  • Does bilateral inferior turbinate reduction affect long-term quality-of-life outcomes in patients undergoing endoscopic sinus surgery?

    abstract:BACKGROUND:The objective of this study was to evaluate the impact of bilateral inferior turbinate reduction (BITR) on patient-reported quality of life (QOL) following endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). METHODS:This was a prospective cohort study. Patients with CRS, who were recruited from...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22300

    authors: Scangas GA,Bleier BS,Husain Q,Holbrook EH,Gray ST,Metson R

    更新日期:2019-06-01 00:00:00

  • Distant pseudomeningoceles of the ventral skull base: a report of 2 cases.

    abstract:BACKGROUND:The objective of this case series was to report what is to the best of our knowledge the first reports of nasopharyngeal and soft palate pseudomeningoceles tracking submucosally from the sphenoid sinus. METHODS:Analysis of cases through medical records. RESULTS:Two cases of middle-aged male patients presen...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21242

    authors: Lieberman SM,Ojo RB,Casiano RR

    更新日期:2013-12-01 00:00:00

  • Effect of elderly status on postoperative complications in patients with sinonasal cancer.

    abstract:BACKGROUND:Elderly patients with multiple comorbidities may be at higher risk of postoperative complications. With an increasingly aging population, more data assessing for predisposing factors are needed in this at-risk group. In this study, we analyzed the effect of elderly status on relative comorbidities and compli...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22239

    authors: Bashjawish B,Patel S,Kılıç S,Svider PF,Hsueh WD,Liu JK,Baredes S,Eloy JA

    更新日期:2019-02-01 00:00:00

  • Desloratadine-montelukast combination improves quality of life and decreases nasal obstruction in patients with perennial allergic rhinitis.

    abstract:BACKGROUND:The effects of desloratadine-montelukast combination on quality of life (QoL) and nasal airflow of patients with perennial allergic rhinitis (PAR) has not been reported. The objective of this work was investigate the efficacy of desloratadine-montelukast combination on nasal obstruction and health-related qu...

    journal_title:International forum of allergy & rhinology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/alr.21185

    authors: Cingi C,Oghan F,Eskiizmir G,Yaz A,Ural A,Erdogmus N

    更新日期:2013-10-01 00:00:00

  • Assessment of skills using a spacer device for a metered-dose inhaler and related independent predictive factors in caregivers of asthmatic preschool children.

    abstract:BACKGROUND:The correct use of inhalation devices is essential for successful therapy. We aimed to evaluate the skills in the use of a spacer device with an metered-dose inhaler (MDI) and factors that influence this skill in asthmatic preschool children's caregivers. METHODS:The caregivers of 12-month-old to 72-month-o...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21648

    authors: Topal E,Celiksoy MH,Catal F,Sinanoglu MS,Karakoc HT,Sancak R,Ozturk F

    更新日期:2016-02-01 00:00:00

  • Evolving patterns in the diagnosis and management of allergy-mediated disorders.

    abstract:BACKGROUND:This analysis explores the increasing heterogeneity of trends in allergy management under the premise that the practice of allergy has undergone significant changes in national economics, healthcare delivery, and treatment options from 2007 to 2016. METHODS:Centers for Medicare and Medicaid Services (CMS) d...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22111

    authors: Arianpour K,Svider PF,Yuhan B,Hooda Z,Eloy JA,Folbe AJ

    更新日期:2018-05-21 00:00:00

  • Steroid-eluting sinus implant for in-office treatment of recurrent nasal polyposis: a prospective, multicenter study.

    abstract:BACKGROUND:Treatment options for chronic rhinosinusitis with recurrent polyposis (CRSwNP) after endoscopic sinus surgery (ESS) are limited, and include frequent use of systemic steroids and revision surgery. A bioabsorbable, steroid-eluting implant was studied for its ability to dilate sinuses obstructed by polyps and ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/alr.21309

    authors: Lavigne F,Miller SK,Gould AR,Lanier BJ,Romett JL

    更新日期:2014-05-01 00:00:00

  • Impact of continued medical therapy in patients with refractory chronic rhinosinusitis.

    abstract:BACKGROUND:Patients with refractory chronic rhinosinusitis (RCRS) have persistent symptoms despite best medical therapy. Some evidence suggests continued medical therapy (CMT) is appropriate for patients with RCRS. The primary objective of this study was to evaluate the clinical impact of CMT in patients with RCRS who ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21238

    authors: Smith KA,Rudmik L

    更新日期:2014-01-01 00:00:00

  • Early postoperative care following endoscopic sinus surgery: an evidence-based review with recommendations.

    abstract:BACKGROUND:Early postoperative care following endoscopic sinus surgery (ESS) has been suggested to minimize avoidable complications and optimize long-term outcomes. Several postoperative care strategies have been proposed but a formal comprehensive evaluation of the evidence has never been performed. The purpose of thi...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.20072

    authors: Rudmik L,Soler ZM,Orlandi RR,Stewart MG,Bhattacharyya N,Kennedy DW,Smith TL

    更新日期:2011-11-01 00:00:00

  • Characterization of a novel, papain-inducible murine model of eosinophilic rhinosinusitis.

    abstract:BACKGROUND:Eosinophilic chronic rhinosinusitis (ECRS) is a disease characterized by eosinophilic inflammatory infiltrate and a local type 2 cytokine milieu. Current animal models fail to recapitulate many of the innate and adaptive immunologic hallmarks of the disease, thus hindering the development of effective therap...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22072

    authors: Tharakan A,Dobzanski A,London NR Jr,Khalil SM,Surya N,Lane AP,Ramanathan M Jr

    更新日期:2018-04-01 00:00:00

  • Impact of mentoring medical students on scholarly productivity.

    abstract:BACKGROUND:Our objectives were to evaluate collaboration with medical students and other nondoctoral authors, and assess whether mentoring such students influences the academic productivity of senior authors. METHODS:Six issues of the Laryngoscope and International Forum of Allergy & Rhinology (IFAR) were examined for...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21247

    authors: Svider PF,Husain Q,Mauro KM,Folbe AJ,Baredes S,Eloy JA

    更新日期:2014-02-01 00:00:00

  • Sniffin' Sticks and olfactory system imaging in patients with Kallmann syndrome.

    abstract:BACKGROUND:The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21550

    authors: Ottaviano G,Cantone E,D'Errico A,Salvalaggio A,Citton V,Scarpa B,Favaro A,Sinisi AA,Liuzzi R,Bonanni G,Di Salle F,Elefante A,Manara R,Staffieri A,Martini A,Brunetti A

    更新日期:2015-09-01 00:00:00

  • Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to tumor necrosis factor alpha inhibitors (TNFαis). The histologic features of CRS caused by TNFαis have yet to be determined and may have important implications in understanding the pathophysiology of...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22462

    authors: Papagiannopoulos P,Devins K,Tong CCL,Yver C,Patel NN,Kuhar HN,Bosso JV,Kohanski MA,Tajudeen BA,Kuan EC,Batra PS,Cohen NA,Kennedy DW,Palmer JN,Montone K,Adappa ND

    更新日期:2020-01-01 00:00:00

  • Management of sinonasal chondrosarcoma: a systematic review of 161 patients.

    abstract:BACKGROUND:This study reviews the published literature related to management of sinonasal chondrosarcoma. Clinical presentation, demographics, radiographic diagnosis, treatment, and management outcomes of this uncommon disease are reported. METHODS:A systematic review of studies for sinonasal chondrosarcoma from 1950 ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章,评审

    doi:10.1002/alr.21162

    authors: Khan MN,Husain Q,Kanumuri VV,Boghani Z,Patel CR,Liu JK,Eloy JA

    更新日期:2013-08-01 00:00:00

  • Interleukin 13 (IL-13) alters hypoxia-associated genes and upregulates CD73.

    abstract:BACKGROUND:Interleukin 13 (IL-13) is a pleiotropic cytokine that has been shown to be important in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and other type 2 inflammation-related diseases. Increased IL-13 expression can elicit several pro-inflammatory effects, including eosinophilia, and pat...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22630

    authors: Khalil SM,Bernstein I,Kulaga H,Gour N,Rowan N,Lajoie S,Lane AP

    更新日期:2020-09-01 00:00:00

  • The impact of culturable bacterial community on histopathology in chronic rhinosinusitis.

    abstract:BACKGROUND:The influence of the microbial community on inflammatory subtype in chronic rhinosinusitis (CRS) has been proposed. Superantigen mechanisms potentially create a T helper 2 (Th-2)/eosinophilic dominated inflammation as a product of local flora rather than an intrinsic mucosal process. The associations between...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21220

    authors: Rom D,Snidvongs K,Sacks PL,Dalgorf D,Pratt E,Earls P,Sacks R,Harvey RJ

    更新日期:2014-01-01 00:00:00

  • Development of the international orbital Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system.

    abstract:BACKGROUND:Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS:An international, multidisciplinary panel of 23 experts in ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22316

    authors: El Rassi E,Adappa ND,Battaglia P,Castelnuovo P,Dallan I,Freitag SK,Gardner PA,Lenzi R,Lubbe D,Metson R,Moe KS,Muscatello L,Mustak H,Nogueira JF,Palmer JN,Prepageran N,Ramakirshnan VR,Sacks R,Snyderman CH,Stefko ST,

    更新日期:2019-07-01 00:00:00

  • Surgical management of rhinosinusitis in endoscopic-endonasal skull-base surgery.

    abstract:BACKGROUND:Endoscopic-endonasal skull base surgery (ESBS) provides an important approach to select pathologies. There remains a paucity of data, however, regarding morbidity in patients undergoing ESBS with comorbid acute rhinosinusitis (ARS), a fungal ball (FB), or chronic rhinosinusitis (CRS). METHODS:A retrospectiv...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21476

    authors: Nyquist GG,Friedel ME,Singhal S,Beahm DD,Farrell CJ,Evans JJ,Rosen MR

    更新日期:2015-04-01 00:00:00

  • Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.

    abstract:BACKGROUND:Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. The objective of this work was to determine if increasing CF transmembrane conductance regulator (CFTR) activity by ivacaftor could treat CF sinus disease and assess its effect on pri...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21440

    authors: Chang EH,Tang XX,Shah VS,Launspach JL,Ernst SE,Hilkin B,Karp PH,Abou Alaiwa MH,Graham SM,Hornick DB,Welsh MJ,Stoltz DA,Zabner J

    更新日期:2015-02-01 00:00:00

  • Asthma onset pattern and patient outcomes in a chronic rhinosinusitis population.

    abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is strongly associated with comorbid asthma. This study compares early-onset and late-onset asthma in a CRS population using patient-reported and clinical characteristics. METHODS:At enrollment into a clinical registry, CRS patients completed the 22-item Sino-Nasal Outcome Test ...

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.22064

    authors: John Staniorski C,Price CPE,Weibman AR,Welch KC,Conley DB,Shintani-Smith S,Stevens WW,Peters AT,Grammer L,Lidder AK,Schleimer RP,Kern RC,Tan BK

    更新日期:2018-04-01 00:00:00

  • Immunotherapy compliance: comparison of subcutaneous versus sublingual immunotherapy.

    abstract:BACKGROUND:Patient compliance is critical for successful allergen immunotherapy (AIT). Previous studies suggest that AIT compliance is worse outside of controlled clinical trials, with reported subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) noncompliance at 11% to 50% and 3% to 25%, respectively....

    journal_title:International forum of allergy & rhinology

    pub_type: 杂志文章

    doi:10.1002/alr.21699

    authors: Leader BA,Rotella M,Stillman L,DelGaudio JM,Patel ZM,Wise SK

    更新日期:2016-05-01 00:00:00