Abstract:
BACKGROUND:Chronic rhinosinusitis (CRS) in aspirin-exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation for which a multidisciplinary consensus on patient management has not been reached. Several medical interventions have been investigated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence-based approach for the multidisciplinary management of CRS in AERD. METHODS:A systematic review of the literature was performed and the guidelines for development of an evidence-based review with recommendations were followed. Study inclusion criteria included: adult population >18 years old; CRS based on published diagnostic criteria, and a presumptive diagnosis of AERD. We focused on reporting higher-quality studies (level 2 or higher) when available, but reported lower-quality studies if the topic contained insufficient evidence. Treatment recommendations were based on American Academy of Otolaryngology (AAO) guidelines, with defined grades of evidence and evaluation of research quality and risk/benefits associated with each treatment. RESULTS:This review identified and evaluated the literature on 3 treatment strategies for CRS in AERD: dietary salicylate avoidance, leukotriene modification, and desensitization with daily aspirin therapy. CONCLUSION:Based on the available evidence, dietary salicylate avoidance and leukotriene-modifying drugs are options following appropriate treatment with nasal corticosteroids and saline irrigation. Desensitization with daily aspirin therapy is recommended following revision endoscopic sinus surgery (ESS).
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Levy JM,Rudmik L,Peters AT,Wise SK,Rotenberg BW,Smith TLdoi
10.1002/alr.21826subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1273-1283issue
12eissn
2042-6976issn
2042-6984journal_volume
6pub_type
杂志文章,评审abstract:BACKGROUND:Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify asthma susce...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21725
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The surgical significance of the lingual process of the sphenoid bone (LPSB) has not been sufficiently addressed. The purpose of this study was to describe the anatomical details of the LPSB in relation to the quadrangular space. Moreover, the incidence of the LPSB and its correlation with the pneumatization...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22594
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Early postoperative care following endoscopic sinus surgery (ESS) has been suggested to minimize avoidable complications and optimize long-term outcomes. Several postoperative care strategies have been proposed but a formal comprehensive evaluation of the evidence has never been performed. The purpose of thi...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.20072
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is strongly associated with comorbid asthma. This study compares early-onset and late-onset asthma in a CRS population using patient-reported and clinical characteristics. METHODS:At enrollment into a clinical registry, CRS patients completed the 22-item Sino-Nasal Outcome Test ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22064
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology is poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were associated with sleep dysfunction severity or altered the improvement in sleep dysfunction follow...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22678
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Treatment options for chronic rhinosinusitis with recurrent polyposis (CRSwNP) after endoscopic sinus surgery (ESS) are limited, and include frequent use of systemic steroids and revision surgery. A bioabsorbable, steroid-eluting implant was studied for its ability to dilate sinuses obstructed by polyps and ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21309
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:We have previously demonstrated that persistent symptoms following functional endoscopic sinus surgery for chronic rhinosinusitis (CRS) is associated with Gram-negative bacterial carriage. Mechanisms for this remain unknown. We wished to determine whether Gram-negative carriage in patients with CRS with nasa...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21481
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Nasopharyngectomy is an accepted treatment for recurrent nasopharyngeal carcinoma following radiation with or without chemotherapy. Traditionally, the nasopharynx has been approached through relatively invasive "open" techniques including transpalatal, maxillary swing, and trans-mandibular-pterygoid approach...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21104
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Frontal sinus cerebrospinal fluid (CSF) leaks have traditionally been repaired via open procedures (eg, osteoplastic flap or cranialization). Advancements in instrumentation, technique, and experience have improved the feasibility of repairing frontal sinus skull-base defects using an endoscopic approach. Th...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21019
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericid...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21949
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Requests from researchers for olfactory mucosal biopsies are increasing as a result of advances in the fields of neuroscience and stem cell biology. Published studies report variable rates of success in obtaining true olfactory tissue, often below 50%. In cases where biopsies are not obtained carefully and c...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21711
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:This analysis explores the increasing heterogeneity of trends in allergy management under the premise that the practice of allergy has undergone significant changes in national economics, healthcare delivery, and treatment options from 2007 to 2016. METHODS:Centers for Medicare and Medicaid Services (CMS) d...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22111
更新日期:2018-05-21 00:00:00
abstract:BACKGROUND:Surgical treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) has evolved over the last decade as rhinologists have increasingly used topical steroid therapies and altered surgical techniques. It is important to understand the changes in success rates of surgery and frequency of revision endosco...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22505
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is an inflammatory disease process characterized by different phenotypes and histopathology profiles. Race and access to care have been implicated in CRS disease severity. Structural histopathology reporting may aid in delineating the inflammatory burden responsible for this effe...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22295
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22625
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:Anatomic limitations complicate complete eradication of debris from the maxillary sinus using an exclusively transnasal (TN) endoscopic technique. Creation of a canine fossa trephination (CFT) permits a more direct approach than removal via the maxillary ostium. METHODS:Microdebrider eradication of debris co...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.20022
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to tumor necrosis factor alpha inhibitors (TNFαis). The histologic features of CRS caused by TNFαis have yet to be determined and may have important implications in understanding the pathophysiology of...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.22462
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. U...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21496
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Fibroblasts are implicated in tissue remodeling and recruitment of inflammatory cells in chronic rhinosinusitis (CRS). Populations of fibroblasts remain unquantified in CRS subtypes. The objectives of this study were to measure fibroblast populations in subtypes of CRS, and to investigate the association bet...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21636
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The role of bacteria in the pathogenesis of chronic rhinosinusitis (CRS) remains uncertain. Recent evidence suggests that bacteria are able to establish microcolonies within the underlying mucosa. However, to date there has been no systematic comparison of bacterial community composition and diversity in the...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21600
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Endoscopic sinus surgery (ESS) enjoys high success rates, but repopulation with pathogenic bacteria is 1 of the hallmarks of poorer outcomes. There are many hypothesized sources of repopulating bacteria; however, this process remains largely unexplored. This study examined changes in the sinus microbiome aft...
journal_title:International forum of allergy & rhinology
pub_type: 临床试验,杂志文章
doi:10.1002/alr.21630
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The management of chronic rhinosinusitis with nasal polyposis (CRSwNP) becomes unclear when patients require multiple courses of corticosteroids to maintain quality of life. Repeated courses of corticosteroids carry increased risks to patients. Although endoscopic sinus surgery (ESS) is an effective therapeu...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21377
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Subcutaneous immunotherapy (SCIT) demands a significant time commitment on the part of the patient, especially during the escalation period when weekly visits are required. Many patients refuse or discontinue treatment in spite of the demonstrated clinical efficacy of SCIT. Understanding the factors that aff...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21027
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Antibiotics are commonly used in the management of both acute rhinosinusitis and acute exacerbations of chronic rhinosinusitis. With their common use, they have become the leading medication for litigation. It is crucial for the provider to be familiar with potential complications and the medico-legal ramifi...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21433
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Diagnostic nasal endoscopy is a routine measure of sinonasal inflammation in patients with chronic rhinosinusitis (CRS). Although multiple staging systems have been proposed and evaluated, evidence of association between concurrent symptoms and endoscopic findings remains discordant. The goal of this study i...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21683
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). The objectives of this review are to summarize prior studies that describe the correlation between active smoking and secondhand smoke (SHS...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.21054
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The objective of the evidence base review was to systematically evaluate the literature to elucidate the potential role of oral antifungal therapy in management of chronic rhinosinusitis (CRS) and its subtypes. METHODS:Articles for inclusion were identified by query of appropriate search terms in the PubMed...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.20088
更新日期:2011-09-01 00:00:00
abstract::Early reports have suggested that smell loss may be an early symptom associated with the pandemic known as coronavirus disease 2019 (COVID-19). The possibility that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might cause olfactory dysfunction is certainly plausible. Patients presenting to specialized ...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
doi:10.1002/alr.22578
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The histological features of osteitis in chronic rhinosinusitis (CRS) in animal studies induced by bacterial inoculation into maxillary sinuses revealed inflammatory involvement of the underlying bone matrix and/or the Haversian system; however, human studies do not mention these findings. The objective of t...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21291
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The role that bacterial biofilms might play in recalcitrant forms of chronic rhinosinusitis (CRS) is increasingly being recognized. However, the detection of bacteria existing in this form, using standard culture, is limited by their unique metabolically inactive properties. All current biofilm diagnostic mo...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21115
更新日期:2013-02-01 00:00:00