When do the risks of repeated courses of corticosteroids exceed the risks of surgery?

abstract：BACKGROUND:Endoscopic sinus surgery (ESS) enjoys high success rates, but repopulation with pathogenic bacteria is 1 of the hallmarks of poorer outcomes. There are many hypothesized sources of repopulating bacteria; however, this process remains largely unexplored. This study examined changes in the sinus microbiome aft...

journal_title：International forum of allergy & rhinology

authors： Hauser LJ,Ir D,Kingdom TT,Robertson CE,Frank DN,Ramakrishnan VR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical ...

journal_title：International forum of allergy & rhinology

authors： Ottaviano G,Cantone E,D'Errico A,Salvalaggio A,Citton V,Scarpa B,Favaro A,Sinisi AA,Liuzzi R,Bonanni G,Di Salle F,Elefante A,Manara R,Staffieri A,Martini A,Brunetti A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) a...

journal_title：International forum of allergy & rhinology

authors： Nishijima H,Kondo K,Yamamoto T,Nomura T,Kikuta S,Shimizu Y,Mizushima Y,Yamasoba T

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:There are major differences in the clinical pattern of allergic rhinitis (AR) patients among countries, reflecting local aerobiological conditions. We analyzed the correlation between airborne pollen concentrations of the Western Thrace/northeast (NE) Greece region with symptoms scores in AR patients. The ab...

journal_title：International forum of allergy & rhinology

authors： Katotomichelakis M,Nikolaidis C,Makris M,Zhang N,Aggelides X,Constantinidis TC,Bachert C,Danielides V

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) has been defined as inflammation of the paranasal sinuses lasting at least 12 weeks with corresponding 2 or more "cardinal symptoms" that include: (1) nasal obstruction; (2) thick nasal discharge; (3) facial pain/pressure; and (4) reduction or loss of sense of smell. Although pri...

journal_title：International forum of allergy & rhinology

authors： DeConde AS,Mace JC,Alt JA,Soler ZM,Orlandi RR,Smith TL

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The role of bacteria in the etiopathogenesis of chronic rhinosinusitis (CRS) remains an area of interest. The impact of surgery and factors such as the presence of polyps, asthma, and aspirin sensitivity on the bacterial state are poorly understood. To determine the effect of these factors, this study examin...

journal_title：International forum of allergy & rhinology

authors： Cleland EJ,Bassiouni A,Wormald PJ

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The most dramatic complication in endonasal surgery is inadvertent injury to the internal carotid artery (ICA) with massive bleeding. Nasal packing is the favored technique for control; however, this often causes complete carotid occlusion or carotid stenosis, contributing to the morbidity and mortality of t...

journal_title：International forum of allergy & rhinology

authors： Valentine R,Boase S,Jervis-Bardy J,Dones Cabral JD,Robinson S,Wormald PJ

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Patients  with  viral respiratory infections/viral rhinitis/common colds are often treated with antibiotic; however, there is little information on whether or how bacterial microbiota in the nose and nasopharynx might influence the course of viral illnesses. METHODS:To initiate investigation of possible int...

journal_title：International forum of allergy & rhinology

authors： Allen EK,Pitkäranta A,Mäki M,Hendley JO,Laakso S,Sale MM,Winther B

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:In February 2015, the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) published the Allergic Rhinitis Clinical Practice Guideline (AR-CPG). The objective of this study was to assess otolaryngologists' perception of the accuracy and adherence to the AR-CPG. METHODS:A survey was distribute...

journal_title：International forum of allergy & rhinology

authors： Honeybrook A,Ellison M,Puscas L,Raynor E

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Increased frequency of migraine was reported in adults with allergic rhinitis (AR). Although migraine is less common in children than in adults, it can begin in early childhood and persist into adulthood. We conducted this population-based cohort study to investigate the incidence and subsequent risk of migr...

journal_title：International forum of allergy & rhinology

authors： Wang IC,Tsai JD,Lin CL,Shen TC,Li TC,Wei CC

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Nasal polyposis is characterized by persistent inflammation and remodeling in sinonasal mucosa. Toll-like receptor 9 (TLR9) is a DNA receptor of the innate immune system that plays a pivotal role in fibrosis and inflammatory responses. The aim of this study is to explore the expression, activity, and potenti...

journal_title：International forum of allergy & rhinology

authors： Park SK,Jin SY,Yeon SH,Lee SB,Xu J,Yoon YH,Rha KS,Kim YM

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Surgical treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) has evolved over the last decade as rhinologists have increasingly used topical steroid therapies and altered surgical techniques. It is important to understand the changes in success rates of surgery and frequency of revision endosco...

journal_title：International forum of allergy & rhinology

authors： Loftus CA,Soler ZM,Desiato VM,Koochakzadeh S,Yoo F,Storck KA,Schlosser RJ

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The incidence of adverse sequelae related to trauma of cranial nerve V2 (V2) and the Vidian nerve (VN) during endoscopic pterygoid recess repair (PRR) of lateral sphenoid encephalocele is insufficiently reported in the medical literature. As part of our quality assessment and improvement program we sought to...

journal_title：International forum of allergy & rhinology

authors： Chislett SP,Limjuco AP,Solyar AY,Lanza DC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Industry outreach promotes awareness of novel technologies. However, concerns have been raised that such relationships may also unduly impact medical decision-making. Our objective in this study was to evaluate industry relationships among practitioners who frequently employ balloon dilation (BD), characteri...

journal_title：International forum of allergy & rhinology

authors： Eloy JA,Svider PF,Bobian M,Harvey RJ,Gray ST,Baredes S,Folbe AJ

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Olfactory-specific quality of life (QOL) can be measured using the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS), which examines various aspects of olfactory dysfunction. It is unknown if certain factors of the QOD-NS differentially impact QOL. METHODS:Patients with chronic rhinosinusiti...

journal_title：International forum of allergy & rhinology

authors： Mattos JL,Schlosser RJ,DeConde AS,Hyer M,Mace JC,Smith TL,Soler ZM

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...

journal_title：International forum of allergy & rhinology

authors： Beswick DM,Smith TL,Mace JC,Alt JA,Farrell NF,Ramakrishnan VR,Schlosser RJ,Soler ZM

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Social determinants of health can have a substantial impact on treatment outcomes. Prior study has shown that socioeconomic status influences the likelihood of improvement in quality-of-life (QOL) following endoscopic sinus surgery (ESS). However, the impact of socioeconomic factors on changes in productivit...

journal_title：International forum of allergy & rhinology

authors： Beswick DM,Mace JC,Soler ZM,Rudmik L,Alt JA,Smith KA,Detwiller KY,Ramakrishnan VR,Smith TL

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS:An international, multidisciplinary panel of 23 experts in ...

journal_title：International forum of allergy & rhinology

authors： El Rassi E,Adappa ND,Battaglia P,Castelnuovo P,Dallan I,Freitag SK,Gardner PA,Lenzi R,Lubbe D,Metson R,Moe KS,Muscatello L,Mustak H,Nogueira JF,Palmer JN,Prepageran N,Ramakirshnan VR,Sacks R,Snyderman CH,Stefko ST,

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Despite considerable research, the pathogenesis of chronic rhinosinusitis (CRS) remains poorly understood. Potential microbial roles in the etiology or progression of CRS have long been hypothesized, yet few specific associations have been identified. In this study we investigate associations between pattern...

journal_title：International forum of allergy & rhinology

authors： Hoggard M,Biswas K,Zoing M,Wagner Mackenzie B,Taylor MW,Douglas RG

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been pro...

journal_title：International forum of allergy & rhinology

authors： Wise SK,Lin SY,Toskala E

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. U...

journal_title：International forum of allergy & rhinology

authors： Soler ZM,Hyer JM,Ramakrishnan V,Smith TL,Mace J,Rudmik L,Schlosser RJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as "sickness behavior." Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is ...

journal_title：International forum of allergy & rhinology

authors： Alt JA,Smith TL

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Bronchial asthma is one of the most common chronic diseases in childhood, with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming rate. Asthma is a complex genetic disorder with strong environmental influence. It imposes a growing burden on our society in terms of morbidity,...

journal_title：International forum of allergy & rhinology

authors： Toskala E,Kennedy DW

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Cystic fibrosis (CF) is caused by a misfunctional CF transmembrane conductance regulator (CFTR) protein, which is believed to contributes to the regulation of the airway surface liquid (ASL) pH. This study investigated acid and base secretion in freshly excised human nasal tissues from CF patients homozygous...

journal_title：International forum of allergy & rhinology

authors： Cho DY,Hwang PH,Illek B,Fischer H

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Previous studies have consistently shown that females with chronic rhinosinusitis (CRS) have a greater CRS symptom burden than males with CRS. Our objective was to determine whether differential disease perception could explain this phenomenon. METHODS:A total of 500 participants (239 males, 261 females) wi...

journal_title：International forum of allergy & rhinology

authors： Phillips KM,Bergmark RW,Hoehle LP,Shu ET,Caradonna DS,Gray ST,Sedaghat AR

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...

journal_title：International forum of allergy & rhinology

authors： Zhang W,Hubin G,Endam LM,Al-Mot S,Filali-Mouhim A,Desrosiers M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:A genetic basis to chronic rhinosinusitis (CRS) is postulated, but remains elusive. We have recently identified low levels of circulating CD8 lymphocytes as a frequent finding in difficult-to-treat or refractory CRS. In major histocompatibility complex 1 class 1 (MHC1) deficiency, low circulating levels of C...

journal_title：International forum of allergy & rhinology

authors： Alromaih S,Mfuna-Endam L,Bosse Y,Filali-Mouhim A,Desrosiers M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent...

journal_title：International forum of allergy & rhinology

authors： Kern RC,Stolovitzky JP,Silvers SL,Singh A,Lee JT,Yen DM,Iloreta AMC Jr,Langford FPJ,Karanfilov B,Matheny KE,Stambaugh JW,Gawlicka AK,RESOLVE II study investigators.

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Asthma is a chronic inflammatory disease of the lower airway that is commonly encountered by the otolaryngologist. This article provides information on how to recognize patients with asthma and discuss issues related to diagnosis, treatment, and continued management within the context of current guidelines. ...

journal_title：International forum of allergy & rhinology

authors： Reisacher WR

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The pathophysiologic mechanism of allergy is dependent on the action of many redox-sensitive proinflammatory mediators. However, even though redox disturbances are believed to be a hallmark of inflammation, little is known of the effect of redox imbalance to the pathophysiology of allergic rhinitis. We thus ...

journal_title：International forum of allergy & rhinology

authors： Guibas GV,Spandou E,Meditskou S,Vyzantiadis TA,Priftis KN,Anogianakis G

更新日期：2013-07-01 00:00:00