International consensus statement on allergy and rhinology: allergic rhinitis-executive summary.

abstract：BACKGROUND:Optimizing the intranasal distribution of nasal steroid spray (NS) is important in managing patients with allergic rhinitis (AR). Using a 3-dimensional computational model of the human nose, we found that inspiratory airflow improved particle distribution by 86%. We hence designed a study to determine if the...

journal_title：International forum of allergy & rhinology

authors： Tay SY,Chao SS,Mark KT,Wang Y

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology is poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were associated with sleep dysfunction severity or altered the improvement in sleep dysfunction follow...

journal_title：International forum of allergy & rhinology

authors： Farrell NF,Mace JC,Sauer DA,Thomas AJ,Geltzeiler M,Detwiller KY,Alt JA,Smith TL

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:Previous studies have consistently shown that females with chronic rhinosinusitis (CRS) have a greater CRS symptom burden than males with CRS. Our objective was to determine whether differential disease perception could explain this phenomenon. METHODS:A total of 500 participants (239 males, 261 females) wi...

journal_title：International forum of allergy & rhinology

authors： Phillips KM,Bergmark RW,Hoehle LP,Shu ET,Caradonna DS,Gray ST,Sedaghat AR

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to demonstrate how direct electrical stimulation can activate the olfactory bulb after denervation of the olfactory nerve input. METHODS:Sprague-Dawley rats (n = 5) were anesthetized and olfactory bulbs exposed. Olfactory nerves were transected by passing a Teflon blade between the...

journal_title：International forum of allergy & rhinology

authors： Coelho DH,Socolovsky LD,Costanzo RM

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Knowledge of our immune system functions is critical for understanding allergic airway disease development as well as for selection of appropriate diagnostic and therapeutic options for patients with respiratory allergies. METHODS:This review explains the current understanding of the basic immunology of the...

journal_title：International forum of allergy & rhinology

authors： Toskala E

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:As part of this primer, this article is intended to introduce new and emerging therapies for treating asthma. METHODS:A PubMed search was performed for the years 2013 through 2015 for asthma review, asthma treatment, asthma therapy, and asthma new. Subset searches were additionally performed as suggested by...

journal_title：International forum of allergy & rhinology

authors： Calhoun KH

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Multiple prospective and retrospective studies have reported results from balloon-only procedures and hybrid balloon sinus surgeries through intermediate follow-up periods of up to 1 year. Long-term durability results beyond 2 years are limited. METHODS:One-year results from the original study of standalone...

journal_title：International forum of allergy & rhinology

authors： Stankiewicz J,Truitt T,Atkins J,Winegar B,Cink P,Raviv J,Henderson D,Tami T

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Debate still persists on the relation between olfactory bulb volume (OBV) and olfactory function. Many studies suggest that olfactory deprivation decreases the OBV. The aim of this study was to compare the olfactory threshold and OBV of patients with nasal polyps to healthy individuals and to evaluate the im...

journal_title：International forum of allergy & rhinology

authors： Sadeghi M,Amali A,Ezabadi SR,Motiee-Langroudi M,Farshchi S,Mokhtari Z

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Lumbar drain (LD) use in the management of cerebrospinal fluid (CSF) rhinorrhea remains controversial. We analyzed the relationship between LD placement and CSF leak recurrence after endoscopic repair. METHODS:A retrospective case series was conducted. Patients who underwent CSF leak repair from 1999 to 201...

journal_title：International forum of allergy & rhinology

authors： Caballero N,Bhalla V,Stankiewicz JA,Welch KC

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Previous studies have reviewed the safety of preparing and administering allergy injection immunotherapy in a physician's office, and showed no evidence of infectious complications. The current study examines the antimicrobial properties of the common additives used in preparation of multidose immunotherapy ...

journal_title：International forum of allergy & rhinology

authors： Gilbert KC,Sundareshan V,Bass RM,Lin SY

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) in aspirin-exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation for which a multidisciplinary consensus on patient management has not been reached. Several medical interventions have been investigated, but a formal comprehensive evaluati...

journal_title：International forum of allergy & rhinology

authors： Levy JM,Rudmik L,Peters AT,Wise SK,Rotenberg BW,Smith TL

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The pathophysiologic mechanism of allergy is dependent on the action of many redox-sensitive proinflammatory mediators. However, even though redox disturbances are believed to be a hallmark of inflammation, little is known of the effect of redox imbalance to the pathophysiology of allergic rhinitis. We thus ...

journal_title：International forum of allergy & rhinology

authors： Guibas GV,Spandou E,Meditskou S,Vyzantiadis TA,Priftis KN,Anogianakis G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:To describe our clinical experience in 218 consecutive patients undergoing endoscopic back-and-forth septoplasty (EBFS), examining surgical indications, technique, and follow-up. METHODS:From January 2005 to November 2008, 218 patients underwent EBFS at the Department of Otorhinolaryngology, San Raffaele Ho...

journal_title：International forum of allergy & rhinology

authors： Trimarchi M,Bellini C,Toma S,Bussi M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Variants of squamous cell carcinoma (SCC) make up 15% of all cases of SCC of the upper aerodigestive tract. There are 5 main histologic variants of SCC in the head and neck region: verrucous (VSCC), papillary (PSCC), spindle cell (sarcomatoid) (SCSC), basaloid (BSCC), and adenosquamous (ASC). Conventional si...

journal_title：International forum of allergy & rhinology

authors： Vazquez A,Khan MN,Blake DM,Patel TD,Baredes S,Eloy JA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Olfactory dysfunction is 1 of the hallmark symptoms of chronic rhinosinusitis (CRS). Eosinophilic inflammation has been implicated as a potential causative factor. However, prior studies have been limited by retrospective study designs, concomitant use of systemic corticosteroids, and other confounding facto...

journal_title：International forum of allergy & rhinology

authors： Hauser LJ,Chandra RK,Li P,Turner JH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:In lower airway disease such as asthma, epithelial cells have been shown to be potent regulators of dendritic cell (DC) functions. However, it is unclear how human sinonasal epithelial cells (HSNECs) from patients with sinusitis regulate DC functions. Therefore, in these studies we investigated the ability o...

journal_title：International forum of allergy & rhinology

authors： Mulligan JK,Mulligan RM,Atkinson C,Schlosser RJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Interleukin 13 (IL-13) is a pleiotropic cytokine that has been shown to be important in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and other type 2 inflammation-related diseases. Increased IL-13 expression can elicit several pro-inflammatory effects, including eosinophilia, and pat...

journal_title：International forum of allergy & rhinology

authors： Khalil SM,Bernstein I,Kulaga H,Gour N,Rowan N,Lajoie S,Lane AP

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The objective of the evidence base review was to systematically evaluate the literature to elucidate the potential role of oral antifungal therapy in management of chronic rhinosinusitis (CRS) and its subtypes. METHODS:Articles for inclusion were identified by query of appropriate search terms in the PubMed...

journal_title：International forum of allergy & rhinology

authors： Thanasumpun T,Batra PS

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNP) is prolonged inflammation of the sinonasal mucosa. Interleukin-32 (IL-32) is involved in the pathogenesis of chronic lung inflammatory diseases. The aim of study is to compare the expression level of IL-32 in normal nasal mucosa and CRSwNP and to investigate ...

journal_title：International forum of allergy & rhinology

authors： Cho JS,Kim JA,Park JH,Park IH,Han IH,Lee HM

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Subcutaneous immunotherapy (SCIT) demands a significant time commitment on the part of the patient, especially during the escalation period when weekly visits are required. Many patients refuse or discontinue treatment in spite of the demonstrated clinical efficacy of SCIT. Understanding the factors that aff...

journal_title：International forum of allergy & rhinology

authors： Jourdy DN,Reisacher WR

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if they are regulated in epitheli...

journal_title：International forum of allergy & rhinology

authors： Yamin M,Holbrook EH,Gray ST,Busaba NY,Lovett B,Hamilos DL

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericid...

journal_title：International forum of allergy & rhinology

authors： Carey RM,Workman AD,Hatten KM,Siebert AP,Brooks SG,Chen B,Adappa ND,Palmer JN,Kennedy DW,Lee RJ,Cohen NA

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The treatment of the middle turbinate (MT) during endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) remains a contentious issue with arguments both for and against its resection. The purpose of this study was to examine the clinical impact of partial MT resection (PMTR) during ESS, paying parti...

journal_title：International forum of allergy & rhinology

authors： Tan NC,Goggin R,Psaltis AJ,Wormald PJ

更新日期：2018-04-06 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) has been defined as inflammation of the paranasal sinuses lasting at least 12 weeks with corresponding 2 or more "cardinal symptoms" that include: (1) nasal obstruction; (2) thick nasal discharge; (3) facial pain/pressure; and (4) reduction or loss of sense of smell. Although pri...

journal_title：International forum of allergy & rhinology

authors： DeConde AS,Mace JC,Alt JA,Soler ZM,Orlandi RR,Smith TL

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The objective of this case series was to report what is to the best of our knowledge the first reports of nasopharyngeal and soft palate pseudomeningoceles tracking submucosally from the sphenoid sinus. METHODS:Analysis of cases through medical records. RESULTS:Two cases of middle-aged male patients presen...

journal_title：International forum of allergy & rhinology

authors： Lieberman SM,Ojo RB,Casiano RR

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid-to-maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populat...

journal_title：International forum of allergy & rhinology

authors： Beswick DM,Smith TL,Mace JC,Alt JA,Farrell NF,Ramakrishnan VR,Schlosser RJ,Soler ZM

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed. METHODS:An international, multidisciplinary panel of 23 experts in ...

journal_title：International forum of allergy & rhinology

authors： El Rassi E,Adappa ND,Battaglia P,Castelnuovo P,Dallan I,Freitag SK,Gardner PA,Lenzi R,Lubbe D,Metson R,Moe KS,Muscatello L,Mustak H,Nogueira JF,Palmer JN,Prepageran N,Ramakirshnan VR,Sacks R,Snyderman CH,Stefko ST,

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The role of human papillomavirus (HPV) in sinonasal inverted papillomas (IPs) is controversial. Determining the prevalence of HPV infection and its impact on the molecular biology of these tumors is critical to characterizing its role in the pathogenesis of IPs. METHODS:A total of 112 paraffin-embedded IPs ...

journal_title：International forum of allergy & rhinology

authors： Scheel A,Lin GC,McHugh JB,Komarck CM,Walline HM,Prince ME,Zacharek MA,Carey TE

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Nasal steroids are a critical part of the management of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after endoscopic sinus surgery (ESS). Increasingly, practitioners are using budesonide respules delivered to the sinonasal cavities, which is an off-label use, in lieu of traditional nas...

journal_title：International forum of allergy & rhinology

authors： Neubauer PD,Schwam ZG,Manes RP

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Endoscopic sinus surgery (ESS) enjoys high success rates, but repopulation with pathogenic bacteria is 1 of the hallmarks of poorer outcomes. There are many hypothesized sources of repopulating bacteria; however, this process remains largely unexplored. This study examined changes in the sinus microbiome aft...

journal_title：International forum of allergy & rhinology

authors： Hauser LJ,Ir D,Kingdom TT,Robertson CE,Frank DN,Ramakrishnan VR

更新日期：2016-01-01 00:00:00