Abstract：
:Diabetes has emerged as a threat to the current world. More than ninety five per cent of all the diabetic population has type 2 diabetes mellitus (T2DM). Aggregates of Amylin hormone, which is co-secreted with insulin from the pancreatic β-cells, inhibit the activities of insulin and glucagon and cause T2DM. Importance of the conformationally restricted peptides for drug design against T2DM has been invigorated by recent FDA approval of Symlin, which is a large conformationally restricted peptide. However, Symlin still has some issues including solubility, oral bioavailability and cost of preparation. Herein, we introduced a novel strategy for conformationally restricted peptide design adopting a minimalistic approach for cost reduction. We have demonstrated efficient inhibition of amyloid formation of Amylin and its disruption by a novel class of conformationally restricted β-sheet breaker hybrid peptidomimetics (BSBHps). We have inserted β, γ and δ -aminobenzoic acid separately into an amyloidogenic peptide sequence, synthesized α/β, α/γ and α/δ hybrid peptidomimetics, respectively. Interestingly, we observed the aggregation inhibitory efficacy of α/β and α/γ BSBHps, but not of α/δ analogues. They also disrupt existing amyloids into non-toxic forms. Results may be useful for newer drug design against T2DM as well as other amyloidoses and understanding amyloidogenesis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Paul A,Kalita S,Kalita S,Sukumar P,Mandal Bdoi
10.1038/srep40095subject
Has Abstractpub_date
2017-01-05 00:00:00pages
40095issn
2045-2322pii
srep40095journal_volume
7pub_type
杂志文章abstract：:Perpendicularly magnetized tunnel junctions (p-MTJs) that contain synthetic antiferromagnetic (SAF) frames show promise as reliable building blocks to meet the demands of perpendicular magnetic anisotropy (PMA)-based spintronic devices. In particular, Co/Pd multilayer-based SAFs have been widely employed due to their ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21324
更新日期：2016-02-18 00:00:00
abstract：:Predicting the occurrence of ventricular tachyarrhythmia (VTA) in advance is a matter of utmost importance for saving the lives of cardiac arrhythmia patients. Machine learning algorithms have been used to predict the occurrence of imminent VTA. In this study, we used a one-dimensional convolutional neural network (1-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63566-8
更新日期：2020-04-21 00:00:00
abstract：:This study was aimed to assess the relationship of intraocular forward scattering, corneal backward scattering, and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) in eyes with granular corneal dystrophy (GCD). We retrospectively examined forty two eyes of 42 consecutive patients w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24677
更新日期：2016-04-18 00:00:00
abstract：:The interaction of osseous tissue with electric fields is an important subject. The electrical stimulation of bone promotes osteogenesis, while bone impedance has been proposed as a measure of osteoporosis, to follow fracture healing, or as a method to improve safety of surgical procedures. However, a deeper understan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26836-0
更新日期：2018-06-05 00:00:00
abstract：:A record 500,000 hectares burned in Portugal during the extreme wildfire season of 2017, with more than 120 human lives lost. Here we analyse the climatic factors responsible for the burned area (BA) from June to October series in Portugal for the period 1980-2017. Superposed onto a substantially stationary trend on B...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50281-2
更新日期：2019-10-10 00:00:00
abstract：:High quality factor (High-Q) and transmission optical devices are required for various applications in the fields of physics and engineering. Critical for these applications is the realization of a structure with high-Q, complete transmission and small volume. A robust high-Q filter with complete transmission by conju...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64076-3
更新日期：2020-04-27 00:00:00
abstract：:Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the material has other bioactivities; for example, it accelerates angiogenesis, has anti-inflammatory properties, and inhibits oxidative stress. We investigated the effects of calcitriol in a random skin flap rat model. "McFarlane f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18945
更新日期：2016-01-06 00:00:00
abstract：:A plasmonic Ag/TiO2 photocatalytic composite was designed by selecting Ag quantum dots (Ag QDs) to act as a surface plasmon resonance (SPR) photosensitizer for driving the visible-light driven photoelectrocatalytic hydrogen evolution. Vertically oriented hierarchical TiO2 nanotube arrays (H-TiO2-NTAs) with macroporous...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10461
更新日期：2015-06-12 00:00:00
abstract：:The G-protein coupled, protease-activated receptor 1 (PAR1) is a membrane protein expressed in astrocytes. Fine astrocytic processes are in tight contact with neurons and blood vessels and shape excitatory synaptic transmission due to their abundant expression of glutamate transporters. PAR1 is proteolytically-activat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43606
更新日期：2017-03-03 00:00:00
abstract：:For accurate micro-scale quantification of a specific protein in biological fluids, immunoaffinity chromatography (IAC) and isoelectric focusing (IEF) were combined in a single fused-silica capillary. The inner wall of the capillary was coated with an anti-E-tag antibody at the inlet side to form an IAC column, and po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39221
更新日期：2016-12-15 00:00:00
abstract：:A method is proposed to drive an ultrafast non-adiabatic dynamics of an ultracold gas trapped in a time-dependent box potential. The resulting state is free from spurious excitations associated with the breakdown of adiabaticity, and preserves the quantum correlations of the initial state up to a scaling factor. The p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00648
更新日期：2012-01-01 00:00:00
abstract：:Anammox is a cost-effective process to treat nitrogenous wastewater. In this work, excitation-emission matrix (EEM) fluorescence spectroscopy was used to characterize the intracellular and extracellular substances of anammox sludge during reactor operation of 276 days. Four main fluorophores were identified from the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39289
更新日期：2017-01-16 00:00:00
abstract：:Marine bacterial strains are of great interest for their ability to produce secondary metabolites with anticancer potentials. Isolation, identification, characterization and anticancer activities of isolated bacteria from El-Hamra Lake, Wadi El-Natrun (Egypt) were the objectives of this study. The isolated bacteria we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70945-8
更新日期：2020-08-21 00:00:00
abstract：:The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV's neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in preclinical models, particular...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00193-w
更新日期：2017-03-21 00:00:00
abstract：:Zircon of crustal origin found in mantle-derived rocks is of great interest because of the information it may provide about crust recycling and mantle dynamics. Consideration of this requires understanding of how mantle temperatures, notably higher than zircon crystallization temperatures, affected the recycled zircon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30934-4
更新日期：2018-08-27 00:00:00
abstract：:Biomarkers of Huntington's disease (HD) in cerebrospinal fluid (CSF) could be of value in elucidating the biology of this genetic neurodegenerative disease, as well as in the development of novel therapeutics. Deranged synaptic and immune function have been reported in HD, and concentrations of the synaptic protein ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21788-x
更新日期：2018-03-09 00:00:00
abstract：:The hip fracture is one major clinical challenge associated with osteoporosis, resulting in heavy socioeconomic burdens and high mortality. Systemic therapies of anti-osteoporosis drugs are expensive, time-consuming and also evoke substantial side effects, which fails to provide early protection from fractures. Accumu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28537
更新日期：2016-06-22 00:00:00
abstract：:We investigated gender differences in the optic nerve head (ONH) microcirculation status in association with obstructive sleep apnea (OSA) by using laser speckle flowgraphy (LSFG). We evaluated 150 men (60.5 ± 11.0 yrs) and 45 women (63.0 ± 10.6 yrs) who underwent overnight polysomnography. The mean blur rate (MBR), m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55470-7
更新日期：2019-12-11 00:00:00
abstract：:Nano-suspensions (NS) exhibit unusual thermophysical behaviors once interparticle aggregations and the shear flows are imposed, which occur ubiquitously in applications but remain poorly understood, because existing theories have not paid these attentions but focused mainly on stationary NS. Here we report the critica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39446
更新日期：2016-12-20 00:00:00
abstract：:A biofilm has a unique structure composed of microorganisms, extracellular polymeric substances (EPSs), etc., and it is layered on a substrate in water. In material science, it is important to detect the biofilm formed on a surface to prevent biofouling. EPSs, the major component of the biofilm, mainly consist of poly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44167-6
更新日期：2019-05-30 00:00:00
abstract：:Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. This is of particular concern in light of the attractiveness of developing SCFA-mediated therapies and considering that SCFAs work as inhibi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37944
更新日期：2016-11-29 00:00:00
abstract：:Our study is major to establish and validate a simple type||diabetes mellitus (T2DM) screening model for identifying high-risk individuals among Chinese adults. A total of 643,439 subjects who participated in the national health examination had been enrolled in this cross-sectional study. After excluding subjects with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68383-7
更新日期：2020-07-14 00:00:00
abstract：:Fear, anxiety, and preference in fish are generally evaluated by video-based behavioural analyses. We previously proposed a system that can measure bioelectrical signals, called ventilatory signals, using a 126-electrode array placed at the bottom of an aquarium and achieved cameraless real-time analysis of motion and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80578-6
更新日期：2021-01-08 00:00:00
abstract：:While Brassica oleracea vegetables have been linked to cancer prevention, the exact mechanism remains unknown. Regulation of gene expression by cross-species microRNAs has been previously reported; however, its link to cancer suppression remains unexplored. In this study we address both issues. We confirm plant microR...
journal_title：Scientific reports
pub_type： 杂志文章,收录出版
doi：10.1038/srep32773
更新日期：2016-09-08 00:00:00
abstract：:Two related models for T cell signalling initiation suggest either that T cell receptor (TCR) engagement leads to its recruitment to ordered membrane domains, often referred to as lipid rafts, where signalling molecules are enriched or that ordered TCR-containing membrane nanodomains coalesce upon TCR engagement. That...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10082
更新日期：2015-05-08 00:00:00
abstract：:Although flowering in rice has been extensively investigated, few studies focused on genetic interactions. Flowering evaluation of two recombinant inbred line (RIL) populations involving photo-insensitive rice cultivars, Bengal and Cypress, and a weedy rice accession, PSRR-1, under natural long-day (LD) conditions, re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20324-1
更新日期：2018-02-01 00:00:00
abstract：:Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41511
更新日期：2017-02-03 00:00:00
abstract：:We isolated a novel bacterial strain from a prokaryotic consortium associated to the psychrophilic marine ciliate Euplotes focardii, endemic of the Antarctic coastal seawater. The 16S rDNA sequencing and the phylogenetic analysis revealed the close evolutionary relationship to the Antarctic marine bacterium Marinomona...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66878-x
更新日期：2020-06-23 00:00:00
abstract：:Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20608-6
更新日期：2018-02-13 00:00:00
abstract：:The annotation of protein function is a vital step to elucidate the essence of life at a molecular level, and it is also meritorious in biomedical and pharmaceutical industry. Developments of sequencing technology result in constant expansion of the gap between the number of the known sequences and their functions. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37179
更新日期：2016-11-16 00:00:00
