Abstract:
:A bioassay method for measuring parathyroid hormone (PTH) and other substances that influence bone metabolism is described. Monolayers of bone cells are culturedin vitro, then treated with the test material. Biological activity is determined by measuring the resulting rise in bone-cell adenosine 3',5'-monophosphate (cAMP).Treatment with PTH (1-500 ng/ml) produced a dose-dependent increase in bone-cell cyclic AMP levels. Treatment with prostaglandin E2 also caused an elevation in bone-cell cyclic AMP level, whereas oestradiol inhibited the effect of PTH. High calcium concentration inhibited the stimulatory effect of PTH on bone-cell cyclic AMP; variations in phosphate and magnesium concentrations were without effect. Biological activity was demonstrated in various unextracted normal and hypercalcaemic sera.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
McPartlin J,Powell Ddoi
10.1007/BF02938966subject
Has Abstractpub_date
1976-12-01 00:00:00pages
319issue
1eissn
0021-1265issn
1863-4362pii
10.1007/BF02938966journal_volume
145pub_type
杂志文章abstract::Susceptibility to metronidazole of 213 clinical strains of H. pylori from dyspeptic patients was determined by a plate dilution method. Seventy two (33.8%) of the strains were resistant to metronidazole (MIC > 8 mg/L), 20 of these were from 24 patients who had received previously metronidazole (83.3%), giving a primar...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942098
更新日期:1993-03-01 00:00:00
abstract::Percutaneous tracheostomy (PCT) facilitates easy, bedside insertion of a tracheostomy tube. The percutaneous approach to tracheostomy is used in some parts of the world. This is the first report of a PCT method, in Ireland. The percutaneous technique appears to have advantages over conventional, surgical tracheostomy....
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02996321
更新日期:1993-10-01 00:00:00
abstract::The establishment of the Dublin Hospitals Initiative and the Efficiency Review Group as first steps in an "action" plan was based on the report in 1989 of the Commission of Health Funding which suggested that "the solution to the problem facing the Irish health services...(lies) primarily...in the way that services ar...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02973395
更新日期:1991-08-01 00:00:00
abstract:INTRODUCTION:The medical elective is a common component of undergraduate medical education in the UK and Ireland. These are often undertaken in varied hospitals and countries across the world, most of which are not related to their parent institutions, in order to explore specialties and regions of interest. However ex...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1919-6
更新日期:2019-08-01 00:00:00
abstract::The aim of this paper is to assess the adequacy of the diet of individuals over 60 yr of age, participating in the 1990 Irish National Nutritional Survey. A nationwide random sample based on the most recently updated electoral register was used. Demographic information was collected. Anthropometric measurements were t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944238
更新日期:1997-10-01 00:00:00
abstract::Advocates of transhiatal oesophagectomy warn of the danger of tracheal injury resulting from the blind dissection of tumours of the upper and middle thirds of the oesophagus when the tumour has invaded the membranous part of the trachea. We report an unusual cause of tracheal injury at transhiatal oesophagectomy due t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02947266
更新日期:1991-03-01 00:00:00
abstract::1. Constrictor responses of the isolated perfused rabbit ear artery to electrical stimulation and to intraluminally applied noradrenaline and histamine have been studied before and after addition to the perfusate of the anticholinesterases neostigmine and physostigmine. 2. Both neostigmine (6×10(-5)-2.4×10(-4) mol/l) ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02939056
更新日期:1975-12-01 00:00:00
abstract:INTRODUCTION:We conducted a study at two main centres for paediatric surgery in the Republic of Ireland, Temple Street Children's University Hospital (TSCUH) and Our Lady's Children's Hospital Crumlin (OLCHC). AIM:The aim of the study was to assess doctors' opinions, frequency and methods of smartphone use in clinical...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1713-x
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Solitary adenomas have been shown to be responsible for almost 90% of cases of primary hyperparathyroidism. AIM:The purpose of this study was to determine the utility of sestamibi scanning pre-operatively to guide minimally invasive video-assisted (MIVA) parathyroidectomy. METHODS:We reviewed 40 patients w...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0075-1
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Despite Ireland's temperate maritime climate, it has the third highest rate of malignant melanoma in the European Union, indicating the need to recognise tanning practices as a risky behaviour, especially amongst those most at risk (the younger population). AIM:To explore the factors associated with deliber...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1389-z
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Nearly half of the Irish population is covered by private health insurance. In recent years, premium inflation has been significantly ahead of overall inflation and has been accelerating. This has contributing to a drop in the numbers insured since the peak in 2008. The fall in the numbers with private healt...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-013-0929-7
更新日期:2013-12-01 00:00:00
abstract::In a prospective study designed to assess the effect of duration of antibiotic therapy on the helicobactericidal and ulcer healing efficacy of bismuth therapy, groups of patients, 10 in each group, with H. pylori-positive duodenal ulcer received a triple therapy regimen consisting of colloidal bismuth subcitrate 120 m...
journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
doi:10.1007/BF02939774
更新日期:1997-01-01 00:00:00
abstract::A case of cervical pregnancy resulting in intra abdominal rupture in the first trimester is reported. The clinical features of this rare cause of uterine rupture are outlined. Pathological examination of the uterus showed placenta percreta. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942011
更新日期:1989-01-01 00:00:00
abstract::Preparing a medical school for institutional review can be a challenging undertaking for any institution requiring an understanding of the international standards being used and adequate preparation and planning (MacCarrick et al. in Med Teach 32(5):e227-e232, 2010). This series examines each of the nine standards dev...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-010-0541-z
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Most femoral neck fractures in younger patients have a different mechanism, treatment, and prognosis from those in elderly patients. AIMS:To evaluate the results of internal fixation of femoral neck fractures in patients aged between 20 and 60 years, and to determine reasons for failure. PATIENTS AND METHO...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168981
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Anal ulceration is uncommon. Patients are typically referred because of severe anal pain, bleeding, discharge, and ulceration. It is important to exclude anal carcinoma, and to consider more unusual causes. METHODS:A 74-year-old lady presented with severe anal pain and ulceration. This was subsequently note...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169175
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:We describe a case of Cushing's syndrome due to ectopic ACTH secretion, where the only potential source on conventional imaging was a tiny benign-appearing lung nodule, which failed to take up radiolabelled octreotide. DESIGN AND METHODS:To determine whether the patient might respond to therapeutic administr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0171-x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Laparoscopic techniques are increasingly used in common surgical procedures. Many of these procedures are used to teach basic surgical trainees (BST) and therefore introduction of these techniques may have implications for training. AIMS:To establish whether the introduction of laparoscopic techniques reduc...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914782
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To investigate whether topical application of hesperin affords protection to Balb/C mice epidermis from UVB-induced cyclobutane pyrimidine dimers (CPDs). METHODS:A DNA damage model of UVB irradiation-induced mice epidermis was established. The immunohistochemical staining and southwestern dot blotting were use...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0503-5
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Secondary prevention therapies, such as angiotension converting enzyme (ACE) inhibitors, beta-blockers and statins, are known to reduce cardiovascular morbidity and mortality. OBJECTIVE:The aim of the study was to examine the prevalence of coronary heart disease (CHD) and the prescribing of secondary preven...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169139
更新日期:2005-07-01 00:00:00
abstract::The Dublin Soft Tissue Sarcoma Panel was established in 1989 with a view to achieving a unified approach to diagnosis and management of soft tissue and visceral sarcomas. This interim report presents data on 265 prospectively-evaluated patients and on a separate retrospective series of 126 patients. The patients in th...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02943260
更新日期:1994-05-01 00:00:00
abstract:PURPOSE:Internal iliac artery (IIA) embolisation is commonly performed prior to endovascular aneurysm repair (EVAR) of aortoiliac aneurysms to prevent type 2 endoleaks via the internal iliac arteries. The safety of this procedure is controversial due to the high incidence of pelvic ischaemic complications. METHODS:We ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1384-4
更新日期:2016-11-01 00:00:00
abstract::The development of the Free Cortisol Index, an indirect measurement of the free or metabolically active portion of circulating cortisol, is described. Patients with non-adrenal disease had FCl values in the same range as normal subjects and in patients with adrenal disease the FCl values moved in the same direction as...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02939036
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND:Of over 20 different scoring systems to evaluate outcome following calcaneal fracture, the Maryland Foot Score has broad current acceptance. A general health survey, the Short Form 36 (SF 36) has also been used. AIMS:The study compared two scoring systems for assessing the outcome of open reduction and inte...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03166916
更新日期:2000-04-01 00:00:00
abstract::The improved survival of cystic fibrosis (CF) patients is partly due to intensive treatment for their chronic infections. Treatment usually includes intravenous and nebulised aminoglycoside antibiotics and they receive a large cumulative dose of these antibiotics over their lifetime. There is little information in the...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02961666
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Perforation of the oesophagus is a life-threatening condition requiring early recognition and repair to prevent mediastinitis and death. Primary closure with mediastinal drainage is recognised as the treatment of choice for patients presenting within 24 hours. Many are frail, however, and unsuitable for majo...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168953
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Vitamin D deficiency in pregnancy has important maternal and fetal implications, with increased risk of developing gestational diabetes, preeclampsia, preterm birth and small for gestational age birthweight. It is recommended that every pregnant woman should take 5 μg (200 IU) of vitamin D per day during pre...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1707-8
更新日期:2018-08-01 00:00:00
abstract::A ten year review (1980-1989) of 59 neonates presenting with congenital diaphragmatic hernia (CDH) to Our Lady's Hospital for Sick Children, the main referral centre for neonatal surgery in Ireland, is presented to determine the outcome and make suggestions for improvements. CDH was more common in males (34M, 25F). Th...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02984671
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been diversely studied. Its role associated with tumor development has attracted attention just in rece...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1297-2
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Programmed cell death, or apoptosis, is a distinct, managed form of cell death. It is fundamentally different from necrosis. It is a genetically controlled, energy-dependent method of cellular deletion without inflammation. In the cardiovascular system, apoptosis occurs as a primary and secondary event in di...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/BF03168827
更新日期:2001-04-01 00:00:00