Abstract:
:The improved survival of cystic fibrosis (CF) patients is partly due to intensive treatment for their chronic infections. Treatment usually includes intravenous and nebulised aminoglycoside antibiotics and they receive a large cumulative dose of these antibiotics over their lifetime. There is little information in the literature on the prevalence of ototoxicity due to aminoglycoside in these patients. We performed pure tone audiometry on 43 CF patients aged 14-42 years. Seven (16%) had bilateral sensorineural hearing loss (SNHL) for high frequency sounds, consistent with aminoglycoside induced ototoxicity. However, only 2 of these patients had documented toxic serum levels in the past. The identification of bilateral SNHL in one in six adult CF patients is a cause for concern. It may be that the high cumulative dose of aminoglycosides received by these patients may be causing inner ear injury in the absence of specific episodes of toxic serum levels.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Mulherin D,Fahy J,Grant W,Keogan M,Kavanagh B,FitzGerald Mdoi
10.1007/BF02961666subject
Has Abstractpub_date
1991-06-01 00:00:00pages
173-5issue
6eissn
0021-1265issn
1863-4362journal_volume
160pub_type
杂志文章abstract:BACKGROUND:Of over 20 different scoring systems to evaluate outcome following calcaneal fracture, the Maryland Foot Score has broad current acceptance. A general health survey, the Short Form 36 (SF 36) has also been used. AIMS:The study compared two scoring systems for assessing the outcome of open reduction and inte...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03166916
更新日期:2000-04-01 00:00:00
abstract::Two-hundred and eleven Irish GPs responded to a questionnaire survey of their experience and management of acute myocardial infarction (MI) and their attitudes to the use of thrombolytic therapy Three-quarters of the respondents felt they dealt with three or more MIs per year; most felt that the majority of MIs were i...
journal_title:Irish journal of medical science
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02984671
更新日期:1992-01-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
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更新日期:1995-10-01 00:00:00
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更新日期:2007-12-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:1976-12-01 00:00:00
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journal_title:Irish journal of medical science
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更新日期:2007-07-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944357
更新日期:1999-10-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0169-4
更新日期:2009-09-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1384-4
更新日期:2016-11-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02016-5
更新日期:2019-11-01 00:00:00
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journal_title:Irish journal of medical science
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doi:10.1007/s11845-008-0240-1
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journal_title:Irish journal of medical science
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更新日期:2016-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
abstract::Nineteen patients underwent one stage surgical management of infected hip prostheses over a five year period. Thirteen were male and six were female. The mean age was 64 years (Range 49-82). The mean time interval between primary and revision surgery was 26 months (Range 6 months-16 years). One stage re-implantation w...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942793
更新日期:1996-01-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 传,历史文章,杂志文章,评审
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更新日期:2018-11-01 00:00:00
abstract::DNA, extracted from tumours arising in 29 paediatric patients [14 neuroblastoma, 9 Wilms tumour (nephroblastoma), 6 miscellaneous] was investigated for evidence of N-myc amplification, using pNb-1, a recombinant plasmid containing a 1.0 Kb fragment homologous to the 5' end of the human N-myc gene. Within the neuroblas...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937236
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Most femoral neck fractures in younger patients have a different mechanism, treatment, and prognosis from those in elderly patients. AIMS:To evaluate the results of internal fixation of femoral neck fractures in patients aged between 20 and 60 years, and to determine reasons for failure. PATIENTS AND METHO...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168981
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Congenital cytomegalovirus (CMV) infection is the most important infectious cause of central nervous system disease and hearing loss in children. AIMS:In this study, we aimed to investigate the role of maternal screening in early diagnosis of congenital infection in highly immune populations. METHODS:A tot...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1149-5
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula. The modification of diet in renal disease (MDRD) equation is now routinely available to estimate GFR (eGFR). METHODS:We performe...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0250-z
更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00