Hesperidin promotes cyclobutane pyrimidine dimer repair in UVB-exposed mice epidermis.

Abstract:

PURPOSE:To investigate whether topical application of hesperin affords protection to Balb/C mice epidermis from UVB-induced cyclobutane pyrimidine dimers (CPDs). METHODS:A DNA damage model of UVB irradiation-induced mice epidermis was established. The immunohistochemical staining and southwestern dot blotting were used for CPDs detection; western blotting was used for P53 detection. RESULTS:Topical application of hesperidin on Balb/C mice skin significantly decreased the amount of epidermal CPDs 24 and 48 h after 180 mJ/cm(2) of UVB irradiation as compared to untreated mice. UVB-induced p53 expression was more pronounced in hesperidin-treated mice epidermis compared to that of untreated mice. CONCLUSION:Taken together, these results suggest that topical hesperidin application promotes DNA photo-damage repair. Hesperidin is therefore a promising protective substance against UVB radiation.

journal_name

Ir J Med Sci

authors

Jin S,Zhou B,Luo D

doi

10.1007/s11845-010-0503-5

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

709-14

issue

3

eissn

0021-1265

issn

1863-4362

journal_volume

180

pub_type

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