Abstract:
PURPOSE:To investigate whether topical application of hesperin affords protection to Balb/C mice epidermis from UVB-induced cyclobutane pyrimidine dimers (CPDs). METHODS:A DNA damage model of UVB irradiation-induced mice epidermis was established. The immunohistochemical staining and southwestern dot blotting were used for CPDs detection; western blotting was used for P53 detection. RESULTS:Topical application of hesperidin on Balb/C mice skin significantly decreased the amount of epidermal CPDs 24 and 48 h after 180 mJ/cm(2) of UVB irradiation as compared to untreated mice. UVB-induced p53 expression was more pronounced in hesperidin-treated mice epidermis compared to that of untreated mice. CONCLUSION:Taken together, these results suggest that topical hesperidin application promotes DNA photo-damage repair. Hesperidin is therefore a promising protective substance against UVB radiation.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Jin S,Zhou B,Luo Ddoi
10.1007/s11845-010-0503-5subject
Has Abstractpub_date
2011-09-01 00:00:00pages
709-14issue
3eissn
0021-1265issn
1863-4362journal_volume
180pub_type
杂志文章abstract:BACKGROUND:Among many factors predisposing to monosymptomatic enuresis (MNE) disturbances in urinary electrolites excretion play an important role. Because of many controversies in this field there is a need to debate the role of hypercalciuria in MNE. The aim of our study was to determine the urinary calcium in childr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1217-x
更新日期:2015-12-01 00:00:00
abstract::Susceptibility to metronidazole of 213 clinical strains of H. pylori from dyspeptic patients was determined by a plate dilution method. Seventy two (33.8%) of the strains were resistant to metronidazole (MIC > 8 mg/L), 20 of these were from 24 patients who had received previously metronidazole (83.3%), giving a primar...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942098
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Electroanatomical mapping systems (EMS) reduce fluoroscopy dose for the ablation. Higher costs and longer procedure times are the drawbacks associated with EMS. Our objective was to validate the efficiency of the EMS. OBJECTIVE:To demonstrate that using EMS is more efficient and as secure as the traditional...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02247-x
更新日期:2021-02-01 00:00:00
abstract::Over a four year period, 20 segments in 16 patients were treated by lengthening by callotasis or chondrodiastasis. The indications for treatment were leg length discrepancy in 13 patients and short stature in three. Patients with leg length discrepancy were all treated by femoral lengthening; the mean length gained wa...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02960724
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Cardiac arrest due to ischaemia is frequently the first manifestation of cardiovascular disease. We sought to describe the characteristics and outcomes of patients admitted to the Intensive Care Unit (ICU) with a diagnosis of cardiac arrest secondary to acute coronary syndrome (ACS). METHODS:We performed a ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-016-1422-x
更新日期:2017-02-01 00:00:00
abstract::Hepatic haemangiosarcoma is a rare condition although there are known carcinogens in 25%. This case reports hepatic haemangiosarcoma in a 59 year old man with psoriasis and Crohn's disease who had previously received combined treatment with psoralen and UVA light. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/BF02942382
更新日期:1992-12-01 00:00:00
abstract:INTRODUCTION:Emergency laparotomy (EL) is a commonly performed operation with increased morbidity and mortality. Currently, there is a lack of published outcomes following emergency laparotomy within an Irish population. The aim of this study was to assess our outcomes and compare these to predefined outcomes from NELA...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1759-4
更新日期:2018-11-01 00:00:00
abstract::A questionnaire survey was carried out to estimate activity levels in a sample of 784 men and women aged 35 to 64 years in County Kilkenny, Ireland. Men were more likely to have sedentary, heavy or very heavy work activity while the majority of women had moderate activity during an average day. Only a small minority o...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02950440
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:We report the first case of cancer of the urachal remnant following repair of bladder exstrophy, in a renal transplant recipient. METHOD:A retrospective review of this clinical case and the associated literature were performed. CONCLUSION:This unusual case highlights two very rare entities. Bladder exstr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0310-z
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Despite Ireland's temperate maritime climate, it has the third highest rate of malignant melanoma in the European Union, indicating the need to recognise tanning practices as a risky behaviour, especially amongst those most at risk (the younger population). AIM:To explore the factors associated with deliber...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1389-z
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:During recent years, there has been an exponential demand for joint arthroplasty, which has coincided with the global economic recession. In response, the management of patients following arthroplasty is continuously evolving, with the average inpatient length of stay decreasing from weeks to days, and more ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1641-9
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:In patients presenting with rapidly progressive dementia, prion disease may enter the differential diagnosis. The commonest malignancies masquerading as prion disease are primary CNS lymphoma and intravascular large B-cell lymphoma, both rare and difficult to diagnose without brain biopsy. CASE PRESENTATION...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1653-5
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Understanding the impact of a publication by using bibliometric indices becomes an essential activity not only for universities and research institutes but also for individual academicians. This paper aims to provide a brief review of the current bibliometric tools used by authors and editors and proposes an...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-018-1936-5
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:'Slaintecare' aims to address complex patient care needs in an integrated fashion with an emphasis on patient-centred, patient-empowered community care.Currently there is a lack of knowledge of the impact of rare disease management in primary care and of the information tools required by general practitioner...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02168-4
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To describe the shared care and outcomes of patients with periocular skin tumours who underwent Mohs micrographic surgery (MMS) performed by dermatologists, followed by oculoplastic reconstruction undertaken by ophthalmologists at two teaching and one private hospital in Ireland. RESEARCH DESIGN AND METHODS:...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1296-3
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:The purpose of this study is to introduce peer teaching of communication skills to first-year anaesthesia trainees in Ireland and to evaluate their perception of this teaching modality. METHODS:Seventy-nine first-year anaesthesia trainees participated in a novel peer-led communication skills programme over a 2...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1637-5
更新日期:2018-02-01 00:00:00
abstract::Early Warning Systems (EWS) track the physiological parameters of individual patients and trigger a response when the parameter threshold has been reached. The use of early warning scores in adult hospital medicine has been shown to be beneficial in facilitating the early recognition of the deteriorating patient, ther...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-019-02028-1
更新日期:2020-02-01 00:00:00
abstract:AIM:The aim of this study was to investigate the microbiology of secondary bacterial peritonitis due to appendicitis and the appropriateness of current antimicrobial practice in one institution. METHODS:A 14-year retrospective single-centre study of 69 consecutive paediatric patients (age 1-14 years) with appendicitis...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1055-2
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The apolipoprotein (Apo) E gene, and thus its gene product, plays a central and pervasive role in lipid metabolism by serving as a ligand for lipoprotein receptors. Polymorphisms of this gene have been associated with variation in lipid phenotypes in some Caucasian and Asian populations, but not in others. N...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03170486
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:Surgical site infection (SSI) is one of the main causes of postoperative morbidity and mortality. Appendectomy for acute appendicitis is one of the most commonly performed surgical interventions worldwide. The use of ring retractors to protect the wound edge from contaminated intra-abdominal contents may b...
journal_title:Irish journal of medical science
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11845-015-1381-7
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:The medical elective is a common component of undergraduate medical education in the UK and Ireland. These are often undertaken in varied hospitals and countries across the world, most of which are not related to their parent institutions, in order to explore specialties and regions of interest. However ex...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1919-6
更新日期:2019-08-01 00:00:00
abstract::The Dublin Soft Tissue Sarcoma Panel was established in 1989 with a view to achieving a unified approach to diagnosis and management of soft tissue and visceral sarcomas. This interim report presents data on 265 prospectively-evaluated patients and on a separate retrospective series of 126 patients. The patients in th...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02943260
更新日期:1994-05-01 00:00:00
abstract:AIM:This study aimed to investigate the impact of the 2014 safety warnings on use of domperidone, on subsequent prescribing patterns in Ireland. METHODS:The Irish HSE-PCRS pharmacy claims database was used to identify the study cohort (aged 18+), prescribed domperidone from Jan 2014 to Oct 2015. Dosage was available f...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1657-1
更新日期:2018-05-01 00:00:00
abstract::Reproductive surrogacy can be altruistic or commercial, each with complex ethical considerations that are complicated by heterogeneity in governing laws across jurisdictions. Surrogacy in Ireland is relatively new and largely unregulated, so this review aims to elucidate its current regulatory status and associated et...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-020-02402-4
更新日期:2020-10-31 00:00:00
abstract:OBJECTIVE:Evaluate condylar, ramal, and condylar plus ramal vertical mandibular asymmetry in patients with unilateral posterior crossbite (UPCB) and in patients with unilateral cleft lip and palate (UCLP) compared with subjects having normal occlusion. DESIGN:This cross-sectional study evaluated panoramic radiographs ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1020-0
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The clinical efficacy of adenotonsillectomy is under debate with falling tonsillectomy rates in the UK and Ireland. In 2010, an NHS commissioned randomised controlled trial recommended medical management, leading to some Primary Care Trusts refusing to commission any tonsillectomies at all. With the HSE cutt...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-016-1398-6
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Increasing prevalence of overweight and obese children in developed countries poses a substantial threat to long-term health. One well-described factor is the amount of time spent watching television, with exposure to food advertising a known influence on food preferences and consumption patterns. AIMS:Foll...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1088-1
更新日期:2015-03-01 00:00:00
abstract::We report a case of primary aldosteronism in pregnancy that was treated surgically by removal of the adenoma in the 2nd trimester. Only a few cases have been reported in the English literature due to the rarity of the condition. Primary aldosteronism follows a variable course in pregnancy. In the majority of cases the...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/BF02967204
更新日期:1995-10-01 00:00:00
abstract:INTRODUCTION:Rapid Access Prostate Clinics (RAPC) were introduced in Ireland by the National Cancer Control Programme bringing about expedited referral pathways and increased detection rates of prostate cancer. Lower Gleason (G) grade at diagnosis due to RAPC has been previously reported but grade at prostatectomy has ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1583-2
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Anal ulceration is uncommon. Patients are typically referred because of severe anal pain, bleeding, discharge, and ulceration. It is important to exclude anal carcinoma, and to consider more unusual causes. METHODS:A 74-year-old lady presented with severe anal pain and ulceration. This was subsequently note...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169175
更新日期:2006-07-01 00:00:00