Abstract:
BACKGROUND:The apolipoprotein (Apo) E gene, and thus its gene product, plays a central and pervasive role in lipid metabolism by serving as a ligand for lipoprotein receptors. Polymorphisms of this gene have been associated with variation in lipid phenotypes in some Caucasian and Asian populations, but not in others. No such study has been carried out in a resident Irish population. AIM:A study was designed to examine the relationship between serum cholesterols and Apo E genotype in a cohort of healthy Irish adults. METHODS:One hundred healthy Irish adults, aged 19-65 years, were recruited from the Cork City area. Two fasting blood samples were collected from each subject. One was assayed for serum cholesterols--total and low-density lipoprotein (LDL), and high-density lipoprotein (HDL)--while the other sample was used for isolation of genomic DNA and determination of Apo E genotype. RESULTS:While the E2 (12%) was the least prevalent, E3 was the most prevalent Apo E genotype (66%) in this group of healthy Irish adults. A significant Apo E gene-dosage effect was evident, whereby individuals with the Apo E2 genotype had a lower level of total cholesterol, E3 had intermediate levels, and E4 had a higher level. Moreover, those with the Apo E4 genotype had a significantly higher level of LDL cholesterol compared to E2 or E3 genotypes. There was no significant difference in mean serum adjusted HDL-cholesterol levels between the three Apo E genotypes. CONCLUSION:These findings suggest that healthy Irish adults with the Apo E4 genotype have higher serum total and LDL-cholesterol levels than those with E2 or E3 Apo E genotypes and therefore may have a higher risk of atherosclerotic coronary artery disease and coronary heart disease in later life.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Sheehan D,Bennett T,Cashman Kdoi
10.1007/BF03170486keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
50-4issue
1eissn
0021-1265issn
1863-4362journal_volume
169pub_type
杂志文章abstract::Advocates of transhiatal oesophagectomy warn of the danger of tracheal injury resulting from the blind dissection of tumours of the upper and middle thirds of the oesophagus when the tumour has invaded the membranous part of the trachea. We report an unusual cause of tracheal injury at transhiatal oesophagectomy due t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02947266
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Wound botulism occurs as a consequence of inoculation of Clostridium botulinum spores into a wound. AIM:To describe such a case of wound botulism. RESULTS:A 23-year-old drug-injecting user presented with bulbar symptoms and progressive signs over a three-day period. The diagnosis of botulism was suspected ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914502
更新日期:2003-07-01 00:00:00
abstract::Height, body weight, the thickness of triceps, biceps, subscapular and supra-iliac skinfolds and the six-minute run-walk test of aerobic endurance were measured on 1163 National school children between the ages of 7 and 13, who were attending rural or urban schools in counties Cork, Galway, Limerick, Mayo, Waterford a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942167
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive illness that is mostly managed in the general practice setting. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines are the international gold standard, and it is important to understand how these are being applied in gene...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1651-7
更新日期:2018-05-01 00:00:00
abstract::It is widely acknowledged that there is interplay between physical and mental health, with causality in both directions. A common theme across countries is the uncertainty surrounding who should act as gatekeeper for physical health matters in psychiatry. Much of the metabolic monitoring is carried out by psychiatrist...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-014-1205-1
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Rubella is caused by the rubella virus, a single-stranded RNA virus of the Togaviridae family. The most severe complications of rubella in adult women occur during pregnancy when infection can lead to miscarriage, stillbirth or congenital rubella syndrome. Antenatal rubella susceptibility screening is no lon...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1722-9
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:We describe a case of Cushing's syndrome due to ectopic ACTH secretion, where the only potential source on conventional imaging was a tiny benign-appearing lung nodule, which failed to take up radiolabelled octreotide. DESIGN AND METHODS:To determine whether the patient might respond to therapeutic administr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0171-x
更新日期:2008-09-01 00:00:00
abstract::Factors which can account for the poor correlation between whole blood and plasma Cyclosporine (CsA) levels in patients on CsA prophylaxis are evaluated. The study took account of the influence of plasma separation procedures, and the sample haematocrit on CsA distribution in the blood of renal transplant patients (n ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02993609
更新日期:1990-09-01 00:00:00
abstract::Supervised machine learning (ML) is a class of algorithms that "learn" from existing input-output pairs, which is gaining popularity in pattern recognition for classification and prediction problems. In this scoping review, we examined the use of supervised ML algorithms for the prediction of long-term allograft survi...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-020-02332-1
更新日期:2020-08-06 00:00:00
abstract:AIM:Scarcity of paediatric cholelithiasis limits the obtainable experience in paediatric laparoscopic cholecystectomy (LPC). We report minilaparotomy cholecystectomy (MLC) in children which may be a useful alternative to LPC avoiding the added cost of disposable laparoscopic equipment. METHODS:Nineteen cases underwent...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0044-8
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Pneumococcal disease, especially in its invasive form, is a significant cause of morbidity and mortality worldwide. However, with the advent of vaccination, invasive disease is potentially avoidable. This study aimed to assess the documentation of pneumococcal vaccination status in elderly patients by health...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-0919-9
更新日期:2013-09-01 00:00:00
abstract::Secondary failure of oral hypoglycaemic agents raises the dilemma of whether to institute therapy with insulin alone, or in combination. We reviewed our experience of combination therapy following secondary failure of oral hypoglycaemic therapy. Seventeen subjects were receiving combination therapy for 6 months or mor...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944248
更新日期:1997-10-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0788-z
更新日期:2012-06-01 00:00:00
abstract::A case of cervical pregnancy resulting in intra abdominal rupture in the first trimester is reported. The clinical features of this rare cause of uterine rupture are outlined. Pathological examination of the uterus showed placenta percreta. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942011
更新日期:1989-01-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-01992-y
更新日期:2019-11-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1919-6
更新日期:2019-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937942
更新日期:1998-04-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02148-8
更新日期:2020-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0503-5
更新日期:2011-09-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0095-x
更新日期:2007-12-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02960724
更新日期:1993-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02177-8
更新日期:2020-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02984636
更新日期:1989-07-01 00:00:00
abstract::Quality of life of out-of-hospital cardiac arrest (OHCA) survivors is believed to be as important as a factor in resuscitation outcome as the survival rate. The aim of this investigation is to assess the quality of life outcomes of survivors of out-of- hospital cardiac arrest in the Munster region. OHCAR was used to i...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02189-4
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Treatment of pilonidal sinus disease is controversial. Many claim policy of marsupialisation and healing by secondary intention. This is demanding in terms of nursing care and time lost from work. AIMS:To examine outcome of excision and primary closure of chronic pilonidal disease on recurrence rate and pat...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0532-0
更新日期:2011-03-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02063-y
更新日期:2020-02-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
doi:10.1007/BF02939577
更新日期:1999-01-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0370-0
更新日期:2011-03-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-020-02402-4
更新日期:2020-10-31 00:00:00
abstract:BACKGROUND:Circumcision is one of the world's most common operations. Series describing a new technique involving the use of fibrin-based glue have become more apparent in the literature. Here we outline the first 100 such cases for 62 children and 38 adults in our practice describing complications and learning curve. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0545-8
更新日期:2011-03-01 00:00:00