Factor V Leiden: prevalence and thromboembolic complications after total hip replacement in Ireland.

Abstract:

BACKGROUND:The Factor V Leiden (FVL) mutation is the commonest genetic abnormality associated with venous thromboembolism. AIMS:To determine the prevalence of the FVL mutation in Irish patients undergoing total hip replacement and whether it has an increased risk of deep venous thrombosis or pulmonary embolism (DVT/PE). METHODS:Prospective screening of 113 patients over 2 years. All had prophylaxis against thrombosis. Symptomatic DVT and PE were diagnosed with venography and ventilation-perfusion scans, respectively. RESULTS:The prevalence of the FVL mutation was 2%. Six patients (5.3%) developed a DVT/PE. Half of these had a history of venous thromboembolism (resulting in a higher risk of post operative DVT/PE (P = 0.04, Fischer's exact test) but none had the FVL mutation. Of the remaining 107 patients not developing DVT/PE, 2 had the FVL mutation (heterozygotes). CONCLUSIONS:The prevalence of the FVL mutation was 2% but was not a risk factor for acute symptomatic DVT/PE.

journal_name

Ir J Med Sci

authors

Bowler DJ,Bale E,O'Byrne J

doi

10.1007/s11845-007-0095-x

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

273-7

issue

4

eissn

0021-1265

issn

1863-4362

journal_volume

176

pub_type

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