Abstract:
:Liver failure resulting from deliberate or accidental paracetamol overdose continues to be an important reason for referral to liver transplant centres. Severe hepatic dysfunction often appears 72-96 h after overdose. Liver injury can be prevented by timely administration of the specific antidote, N-acetylcysteine. Unfortunately, administration of N-acetylcysteine is frequently delayed due to late presentation or late administration. While N-acetylcysteine works best if given within 8 h of overdose, it is beneficial at any time period and should always be given if there is concern about significant overdose, irrespective of interval from time of ingestion. Early discussion with liver transplant unit is suggested if there is any doubt or evidence of liver failure.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Iqbal M,Cash WJ,Sarwar S,McCormick PAdoi
10.1007/s11845-011-0783-4subject
Has Abstractpub_date
2012-09-01 00:00:00pages
439-43issue
3eissn
0021-1265issn
1863-4362journal_volume
181pub_type
杂志文章abstract::von Willebrand's disease (vWD) is the commonest inherited bleeding disorder in man with an estimated incidence of 1 per thousand of the population. Acquired von Willebrand's disease (AvWD) is rare with less than 70 cases reported. AvWD is usually associated with autoimmune or clonal proliferation disorders and whilst ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937942
更新日期:1998-04-01 00:00:00
abstract::The management of patients with suspected post laparotomy intra-abdominal sepsis poses a major therapeutic challenge to clinicians. The mortality is high and the optimal interventional modality remains ill-defined. We define the incidence, diagnostic methodology, pre- and postoperative findings and outcome of patients...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944195
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes. METHODS:A 79-year-old lady presented with frequent episodes of torsade de pointes following commencement of clari...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0057-3
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Pre-pubertal varicocele can result in hypotrophy of testes, progressive deterioration of Sertoli cells and spermatogonia cell number, decrease in seminiferous diameter and cause to sperm damage. AIMS:Because of detrimental time-dependent effects of varicocele, this study describes the effects of varicocele ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1167-3
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Childhood obesity is associated with increased risk of adult obesity, cardiovascular disease, diabetes and cancer. Appropriate techniques for assessment of childhood adiposity are required to identify children at risk. The aim of this review was to examine core clinical measurements and more technical tool...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-014-1124-1
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The numbers of removals of patients from General Practitioner lists in Ireland is increasing and is a cause for some concern. AIMS:To examine the views of both general practitioners and patients toward removals of patients from general practitioner lists. METHODS:Questionnaire survey to general practitione...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0062-6
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Injuries to the cervical spine (C-spine) are among the most serious in rugby and are well documented. Front-row players are particularly at risk due to repetitive high-intensity collisions in the scrum. AIM:This study evaluates degenerative changes of the C-spine and associated symptomatology in front-row r...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0432-3
更新日期:2010-06-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The presentation of Table 1 was incorrectly captured. The Publisher regrets that it introduced errors to Table 1 during the typesetting of the article. The original article has been corrected. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11845-017-1719-4
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive illness that is mostly managed in the general practice setting. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines are the international gold standard, and it is important to understand how these are being applied in gene...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1651-7
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Pneumococcal disease, especially in its invasive form, is a significant cause of morbidity and mortality worldwide. However, with the advent of vaccination, invasive disease is potentially avoidable. This study aimed to assess the documentation of pneumococcal vaccination status in elderly patients by health...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-0919-9
更新日期:2013-09-01 00:00:00
abstract::The establishment of the Dublin Hospitals Initiative and the Efficiency Review Group as first steps in an "action" plan was based on the report in 1989 of the Commission of Health Funding which suggested that "the solution to the problem facing the Irish health services...(lies) primarily...in the way that services ar...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02973395
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Rubella is caused by the rubella virus, a single-stranded RNA virus of the Togaviridae family. The most severe complications of rubella in adult women occur during pregnancy when infection can lead to miscarriage, stillbirth or congenital rubella syndrome. Antenatal rubella susceptibility screening is no lon...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1722-9
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:This article is a follow-up to an audit performed by the Department of Surgery and published in the Irish Journal of Medical Science in 1996. This audit reviewed all cases of Infantile Hypertrophic Pyloric Stenosis (IHPS) operated on over 22 years up to 1991. AIMS:We aim to demonstrate that radiologic inves...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169126
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Anal ulceration is uncommon. Patients are typically referred because of severe anal pain, bleeding, discharge, and ulceration. It is important to exclude anal carcinoma, and to consider more unusual causes. METHODS:A 74-year-old lady presented with severe anal pain and ulceration. This was subsequently note...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169175
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:In patients presenting with rapidly progressive dementia, prion disease may enter the differential diagnosis. The commonest malignancies masquerading as prion disease are primary CNS lymphoma and intravascular large B-cell lymphoma, both rare and difficult to diagnose without brain biopsy. CASE PRESENTATION...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1653-5
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Sport-related concussion (SRC) is a potential issue within Gaelic Football. Therefore, it is essential that concussion management guidelines are adhered to. HYPOTHESIS/PURPOSE:The aim of this study is to determine if potential concussive events (PCEs) in the Gaelic Athletic Association (GAA) National Footba...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02390-5
更新日期:2020-09-30 00:00:00
abstract:BACKGROUND AND AIMS:Assess the association between the Society for Vascular Surgery/American Association for Vascular Surgery (SVS/AVSS) (Rutherford et al., J Vasc Surg 26: 517-38, 1997; Chaikof et al., J Vasc Surg 35:1061-6, 2002) medical comorbidity scoring scheme (MCS), and the global scoring system (GS) and major m...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02160-y
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:The "National Integrated Medical Imaging System" or NIMIS went live in 2011 and allows the movement of patient radiology imaging throughout the Irish health system. At the time of its launch, NIMIS was not only going to allow the filmless passage of patient radiology imaging but it was also envisaged that ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1900-4
更新日期:2019-05-01 00:00:00
abstract:INTRODUCTION:Prostate cancer cells can switch from an androgen-dependent state to an androgen-independent state after a continuous androgen ablation therapy. However, the molecular mechanisms underlying this switch are still unclear. Therefore, we explored the change in androgen receptor (AR)-related gene expression du...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0714-4
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:We report the first case of cancer of the urachal remnant following repair of bladder exstrophy, in a renal transplant recipient. METHOD:A retrospective review of this clinical case and the associated literature were performed. CONCLUSION:This unusual case highlights two very rare entities. Bladder exstr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0310-z
更新日期:2011-12-01 00:00:00
abstract:AIM:Scarcity of paediatric cholelithiasis limits the obtainable experience in paediatric laparoscopic cholecystectomy (LPC). We report minilaparotomy cholecystectomy (MLC) in children which may be a useful alternative to LPC avoiding the added cost of disposable laparoscopic equipment. METHODS:Nineteen cases underwent...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0044-8
更新日期:2007-07-01 00:00:00
abstract::A new investigative modality, cervicography, has been advocated for cervical screening. In the first 51 patients referred for colposcopy because of an abnormal cervicogram, none had invasive cancer and 75% had preinvasive cancer. The cervicogram appears superior to cytology but inferior to colposcopy in the detection ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937249
更新日期:1990-02-01 00:00:00
abstract::Previous studies have shown that up to 40 per cent of patients have symptoms after cholecystectomy or laparoscopic cholecystectomy (LC). There are concerns, however, that these symptoms reflect those of the general population and are not a specific post-operative phenomenon. Abdominal symptoms of 212 patients followin...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937544
更新日期:1998-01-01 00:00:00
abstract::A bioassay method for measuring parathyroid hormone (PTH) and other substances that influence bone metabolism is described. Monolayers of bone cells are culturedin vitro, then treated with the test material. Biological activity is determined by measuring the resulting rise in bone-cell adenosine 3',5'-monophosphate (c...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02938966
更新日期:1976-12-01 00:00:00
abstract::Nineteen patients underwent one stage surgical management of infected hip prostheses over a five year period. Thirteen were male and six were female. The mean age was 64 years (Range 49-82). The mean time interval between primary and revision surgery was 26 months (Range 6 months-16 years). One stage re-implantation w...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942793
更新日期:1996-01-01 00:00:00
abstract::The aim of this paper is to assess the adequacy of the diet of individuals over 60 yr of age, participating in the 1990 Irish National Nutritional Survey. A nationwide random sample based on the most recently updated electoral register was used. Demographic information was collected. Anthropometric measurements were t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944238
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Cell-based tissue engineering has emerged as a potential therapy for intervertebral disc degeneration. However, propagating and maintaining high quantity and quality of the seed cells remains a challenge. AIMS:To investigate the feasibility of culturing human disc cells using a microcarrier bioreactor syste...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0537-8
更新日期:2010-12-01 00:00:00
abstract::STRIPS of bovine tracheal smooth muscle were subjected to changes in the gas tensions of the Krebs solution bathing them. Contractions were produced by 50 Hz sine-wave electrical field stimulation, either in single bursts, or repetitively throughout the experiment.Hypoxia (Po2 99, 55 or 22 mm Hg, pH 7.4) decreased the...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02939006
更新日期:1975-12-01 00:00:00
abstract::Factors which can account for the poor correlation between whole blood and plasma Cyclosporine (CsA) levels in patients on CsA prophylaxis are evaluated. The study took account of the influence of plasma separation procedures, and the sample haematocrit on CsA distribution in the blood of renal transplant patients (n ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02993609
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:The clinical spectrum of adult coeliac disease (ACD) is varied with limited Irish data. AIMS AND OBJECTIVES:The aim of this study was to analyse the presenting symptoms, associated conditions and complications in a consecutive series of patients with ACD. METHODS:Data were obtained from database on patient...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0788-z
更新日期:2012-06-01 00:00:00