Abstract：
:STRIPS of bovine tracheal smooth muscle were subjected to changes in the gas tensions of the Krebs solution bathing them. Contractions were produced by 50 Hz sine-wave electrical field stimulation, either in single bursts, or repetitively throughout the experiment.Hypoxia (Po2 99, 55 or 22 mm Hg, pH 7.4) decreased the response to single bursts of stimuli by 22-56 per cent (P<0.01). Hypoxia also reduced the resting tension by 72 per cent (P<0.005). All changes due to altered gas tensions were, at least partially, reversible by returning the tissue to standard conditions.Hypercapnic acidosis (Pco2 140-150 mm Hg, pH 6.7-7.0) reduced the response to single bursts of stimuli by 6 per cent (P<0.01) and reduced the response to repetitive bursts of stimuli by 16 per cent (P<0.01). Acapnic alkalosis (Pco2 0 mm Hg, pH 7.9) did not significantly alter the response to repetitive stimulation.It is concluded that hypoxia, and to a lesser extent hypercapnia, can directly modify tone in the airways, and may contribute to regulation of airflow in the tracheobronchial tree.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Crouch CN,Kirkpatrick CTdoi
10.1007/BF02939006subject
Has Abstractpub_date
1975-12-01 00:00:00pages
157issue
1eissn
0021-1265issn
1863-4362pii
10.1007/BF02939006journal_volume
144pub_type
杂志文章abstract：INTRODUCTION:Compression fracture of the vertebrae is common, often the result of falls from height and motor vehicle accidents in the younger age groups. It can occur following minor trauma in the elderly and in those with osteoporosis. MATERIALS AND METHODS:We present an interesting case of compression fracture of t...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0434-1
更新日期：2010-09-01 00:00:00
abstract：INTRODUCTION:We describe a case report and technique for using an ultrasound scanner and a linear transducer to guide serratus posterior superior (SPS) muscle injection. A 43-year-old female presented with chronic pain centered under the right upper portion of her scapula impacting her activities of daily living. METH...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-015-1336-z
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Cardiac arrest due to ischaemia is frequently the first manifestation of cardiovascular disease. We sought to describe the characteristics and outcomes of patients admitted to the Intensive Care Unit (ICU) with a diagnosis of cardiac arrest secondary to acute coronary syndrome (ACS). METHODS:We performed a ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-016-1422-x
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:The incidence and prevalence of childhood chronic disease is increasing worldwide. Obesity, poor diet and lifestyle may be more prevalent in children with a chronic disease than in their healthier contemporaries. The Growing Up in Ireland (GUI) study is a nationally representative cohort study of children li...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1814-1
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The intravenous infusion of atrial (ANP) and brain (BNP) natriuretic peptides have been shown to increase urinary albumin excretion in type 1 diabetes. AIMS:To measure plasma ANP and BNP concentrations in patients with type 1 diabetes and to examine the parameters associated with elevated plasma concentrati...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169149
更新日期：2005-07-01 00:00:00
abstract：INTRODUCTION:Optimisation of patient comfort during flexible bronchoscopy is achieved with the use of intravenous sedation and vocal anaesthesia. METHODS:The effect of transcricoid lignocaine injection was investigated with regards to ease of procedure and frequency of cough. A single-blinded study was carried out and...
journal_title：Irish journal of medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11845-014-1099-y
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:A relationship may exist between body iron stores, endothelial dysfunction and overall cardiovascular risk. AIMS:To compare vascular compliance, biochemical endothelial function and antioxidant status between patients with homozygous hereditary haemochromatosis and healthy controls. METHODS:Haemochromatosi...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1010-2
更新日期：2014-06-01 00:00:00
abstract：:Anxiety, depression, self-esteem, behavioural deviance and prosocial behaviour were studied in children attending a normal school in a disadvantaged urban area, using self-rated and teacher-rated questionnaires. The prevalence of depression was rated as 5%. 15% described frequent suicidal thoughts. 40% scored as behav...
journal_title：Irish journal of medical science
pub_type： 临床试验,杂志文章
doi：10.1007/BF02943055
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND AND AIMS:Coeliac disease (CD) is more common in those with type 1 diabetes mellitus (T1DM) and may be asymptomatic despite the presence of intestinal histological changes. Optimal screening practice guidelines differ internationally. We undertook a retrospective audit to determine the efficacy of current scr...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1831-0
更新日期：2019-02-01 00:00:00
abstract：:Secondary failure of oral hypoglycaemic agents raises the dilemma of whether to institute therapy with insulin alone, or in combination. We reviewed our experience of combination therapy following secondary failure of oral hypoglycaemic therapy. Seventeen subjects were receiving combination therapy for 6 months or mor...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02944248
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to analyze neuropathic pain (NeP) and its therapy in patients with Guillain-Barré syndrome (GBS) during a 6-month follow-up period. METHOD:This longitudinal multicenter study included 69 newly diagnosed adult GBS patients. NeP diagnosis was based on the criteria of Finnerup and conf...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02395-0
更新日期：2020-10-15 00:00:00
abstract：:Isolated third cranial nerve palsy is usually due to vascular causes like posterior communicating artery aneurysm and it is rare in neurocysticercosis. Third cranial nerve palsy in neurocysticercosis is usually caused by supratentorial or sub-arachnoid lesions with accompanying hydrocephalus or meningitis. We report a...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0308-6
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Secondary prevention therapies, such as angiotension converting enzyme (ACE) inhibitors, beta-blockers and statins, are known to reduce cardiovascular morbidity and mortality. OBJECTIVE:The aim of the study was to examine the prevalence of coronary heart disease (CHD) and the prescribing of secondary preven...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169139
更新日期：2005-07-01 00:00:00
abstract：:Ninety-nine inguinal herniorrhaphies were performed under local anaesthetic blockade between 1980 and 1988. This represents 32% of this surgical teams herniorrhaphy operations. A follow-up interview was possible in 82 patients. Satisfaction was expressed by 77 patient (94%) although six of the interviewed patients (7....
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02942128
更新日期：1994-06-01 00:00:00
abstract：:One hundred and forty-nine renal transplant patients attending 2 centres in Dublin were examined. Twelve patients (8.1%) were found to have cutaneous malignancy while dysplastic lesions (premalignant and/or malignant) were identified in 34 (22.8%). The prevalence of cutaneous malignancy in this study is substantially ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02983762
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:This study was to investigate the value of 10 serum inflammatory cytokines for predicting clinical response to celecoxib in ankylosing spondylitis (AS) patients. METHODS:Totally, 103 active AS patients who underwent celecoxib treatment for 12 weeks were enrolled. Then, pre-treatment serum TNF-α, IL-1β, IL-6...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02366-5
更新日期：2020-09-21 00:00:00
abstract：INTRODUCTION:Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02386-1
更新日期：2020-10-17 00:00:00
abstract：BACKGROUND:This article is a follow-up to an audit performed by the Department of Surgery and published in the Irish Journal of Medical Science in 1996. This audit reviewed all cases of Infantile Hypertrophic Pyloric Stenosis (IHPS) operated on over 22 years up to 1991. AIMS:We aim to demonstrate that radiologic inves...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169126
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:With the increasing incidence of breast cancer in patients over 70 years, there is interest in the best therapeutic approach. AIMS:To review the management of breast cancer in elderly women and to identify the factors involved in the decision to treat patients with tamoxifen as first line therapy. PATIENTS...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03168937
更新日期：2002-01-01 00:00:00
abstract：INTRODUCTION:Bibliometrics is the statistical analysis of written publications. Bibliometric analyses have been performed across a range of biomedical disciplines. The aim of this study was to provide a comprehensive qualitative and quantitative analysis of Irish urology and nephrology research and to analyse how this ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-016-1485-8
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Medication discrepancies at the time of hospital discharge are common and can result in error, patient/carer inconvenience or patient harm. Providing accurate medication information to the next care provider is necessary to prevent adverse events. AIMS:To investigate the quality and consistency of medicatio...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0142-2
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVES:The European and American colonoscopy guidelines recommend mandatory photodocumentation of caecal intubation to allow retrospective analysis and improve outcomes. We aim to demonstrate whether photodocumentation of caecal intubation improves colonoscopy outcomes. METHODS:We extracted images and procedural d...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02469-z
更新日期：2021-01-20 00:00:00
abstract：AIMS:To assess knowledge of colorectal cancer (CRC) symptoms among outpatient attendees, and to review disease stage, presentation and duration of symptoms in patients diagnosed with CRC. METHODS:A questionnaire survey was used to evaluate knowledge of symptoms of CRC and other malignancies. A review of patients diagn...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03167968
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes. METHODS:A 79-year-old lady presented with frequent episodes of torsade de pointes following commencement of clari...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-007-0057-3
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVES:This study is designed to explore the effect of paricalcitol (vitamin D receptor agonist) on pancreatic oxidative stress, inflammatory markers, and adiponectin and glycemic status in diabetic rats. MATERIALS AND METHODS:Forty Sprague-Dawley male rats aged 10-12 weeks (150-250 g) were used in this study. Typ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1635-7
更新日期：2018-02-01 00:00:00
abstract：:Menorrhagia affects 20-30% of healthy women, many of whom undergo hysterectomy. In recent years, transcervical resection of the endometrium (TCRE) has become an alternative surgical option. This observational study assesses patient satisfaction following TCRE. The case notes of 55 patients who had a TCRE in the Coombe...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02940244
更新日期：1996-07-01 00:00:00
abstract：:Reproductive surrogacy can be altruistic or commercial, each with complex ethical considerations that are complicated by heterogeneity in governing laws across jurisdictions. Surrogacy in Ireland is relatively new and largely unregulated, so this review aims to elucidate its current regulatory status and associated et...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-020-02402-4
更新日期：2020-10-31 00:00:00
abstract：AIMS:To evaluate the potential role of key DNA repair proteins in the sensitivity of normal human fibroblasts to ionising radiations. METHODS:Radiosensitivity of six human fibroblast strains established from skin biopsies of women who had undergone conservative breast surgery and received a curative breast conserving ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-010-0554-7
更新日期：2011-09-01 00:00:00
abstract：:Preparing a medical school for institutional review can be a challenging undertaking for any institution requiring an understanding of the international standards being used and adequate preparation and planning (MacCarrick et al. in Med Teach 32(5):e227-e232, 2010). This series examines each of the nine standards dev...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-010-0541-z
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Wound botulism occurs as a consequence of inoculation of Clostridium botulinum spores into a wound. AIM:To describe such a case of wound botulism. RESULTS:A 23-year-old drug-injecting user presented with bulbar symptoms and progressive signs over a three-day period. The diagnosis of botulism was suspected ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02914502
更新日期：2003-07-01 00:00:00
