Abstract:
OBJECTIVES:This study is designed to explore the effect of paricalcitol (vitamin D receptor agonist) on pancreatic oxidative stress, inflammatory markers, and adiponectin and glycemic status in diabetic rats. MATERIALS AND METHODS:Forty Sprague-Dawley male rats aged 10-12 weeks (150-250 g) were used in this study. Type 2 diabetes was developed by providing 4 weeks of high-fat-diet feeding before one shot of streptozotocin injection (40 mg/kg i.p.). Four study groups were designed as normal control rats, diabetic control vehicle-treated, diabetic paricalcitol-treated (0.8 μg/kg), and diabetic glibenclamide-treated (0.6 mg/kg) groups with 10 animals in each. After treatment of diabetic rats for 3 months, pancreatic inflammatory and oxidative stress markers, plasma adiponectin, glycemic status parameters, and histopathological pancreatic islet changes were evaluated. RESULTS:Paricalcitol and glibenclamide treatment significantly (P < 0.05) decreased plasma glucose, insulin resistance, and pancreatic malondialdehyde and tumor necrosis factor-α levels. Moreover, they significantly (P < 0.05) increased plasma fasting insulin, C-peptide, adiponectin, pancreatic IL-2, catalase, superoxide dismutase, glutathione peroxidase, and reduced glutathione when contrasted with diabetic control rats. Furthermore, they prevented extensive histopathological damage in the pancreas of diabetic rats. CONCLUSIONS:Paricalcitol reduced pancreatic oxidative stress and inflammatory markers, and improved glycemic status in diabetic rats.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Ali TM,El Esawy B,Elaskary Adoi
10.1007/s11845-017-1635-7subject
Has Abstractpub_date
2018-02-01 00:00:00pages
75-84issue
1eissn
0021-1265issn
1863-4362pii
10.1007/s11845-017-1635-7journal_volume
187pub_type
杂志文章abstract:BACKGROUND:Adults ageing with HIV and on antiretroviral therapy have a greater burden of chronic diseases compared with adults without HIV as reported by Althoff et al. (Curr Opin HIV AIDS 11:527-36, 2016). Therefore, it is important in this clinically stable HIV+ population to monitor and evaluate their risk of chroni...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02063-y
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:To explore the clinical significance of digital tomographic fusion imaging in the diagnosis of avascular disease of the femoral head in adults. METHODS:Eighty-two adult patients with avascular necrosis of the femoral head confirmed by MRI in the department of orthopedics of our hospital were studied retrosp...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02451-9
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:The survey of lifestyles, attitudes and nutrition (SLAN) is a national representative sample of 6,539 adults. AIMS:To report on both global and disease specific measures of self-reported morbidity according to age, gender and medical card status. METHODS:Reported rates of morbidity are given for angina, he...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03170499
更新日期:2002-07-01 00:00:00
abstract::Laparoscopy has been described as being safe and effective in the diagnosis and treatment of Meckel's Diverticulum. We describe the use of laparoscopy in the diagnosis and resection of a Meckel's diverticulum in a 13 year old girl. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942803
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:In Ireland, the paediatric emergency department (PED) is tasked with acute healthcare provision to children and adolescents under 16 years of age. The population > 15 years attending the PED remains undescribed. AIMS:The objective of the study is to describe the presentations of patients > 15 years to the P...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02213-7
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:Fine-needle aspiration biopsy (FNAB) of the thyroid is generally a well-tolerated procedure associated with weak levels of pain. However, pain may be very intense in some patients. The cause for the pain in these patients has not been identified. The hypothesis of this study is that there is a likely relationsh...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1337-y
更新日期:2016-08-01 00:00:00
abstract:AIMS:To assess knowledge of colorectal cancer (CRC) symptoms among outpatient attendees, and to review disease stage, presentation and duration of symptoms in patients diagnosed with CRC. METHODS:A questionnaire survey was used to evaluate knowledge of symptoms of CRC and other malignancies. A review of patients diagn...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167968
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:The European and American colonoscopy guidelines recommend mandatory photodocumentation of caecal intubation to allow retrospective analysis and improve outcomes. We aim to demonstrate whether photodocumentation of caecal intubation improves colonoscopy outcomes. METHODS:We extracted images and procedural d...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02469-z
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:Maternity care in hospitals in the Republic of Ireland is funded by a hybrid of public finance and private health insurance. AIMS:The aim of this longitudinal observational study was to investigate the annual trends in maternity care from 2009 to 2017 during and after the Great Economic Recession. METHODS:...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02415-z
更新日期:2020-10-27 00:00:00
abstract:INTRODUCTION:We report the first case of cancer of the urachal remnant following repair of bladder exstrophy, in a renal transplant recipient. METHOD:A retrospective review of this clinical case and the associated literature were performed. CONCLUSION:This unusual case highlights two very rare entities. Bladder exstr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0310-z
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Although laparoscopic appendectomy (LA) is considered to be minimally invasive compared with open appendectomy (OA), there are few studies showing this in terms of cytokines and oxidative stress markers. AIM:LA and OA techniques have been compared in terms of different conditions such as operation time and ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02317-0
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Increasing prevalence of overweight and obese children in developed countries poses a substantial threat to long-term health. One well-described factor is the amount of time spent watching television, with exposure to food advertising a known influence on food preferences and consumption patterns. AIMS:Foll...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1088-1
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Understanding the impact of a publication by using bibliometric indices becomes an essential activity not only for universities and research institutes but also for individual academicians. This paper aims to provide a brief review of the current bibliometric tools used by authors and editors and proposes an...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-018-1936-5
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats. METHODS:A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg(-1)), middle (30 mg kg(-1)), and high-dose diosgenin (90 mg k...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1309-2
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:During recent years, there has been an exponential demand for joint arthroplasty, which has coincided with the global economic recession. In response, the management of patients following arthroplasty is continuously evolving, with the average inpatient length of stay decreasing from weeks to days, and more ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1641-9
更新日期:2018-02-01 00:00:00
abstract::A ten year review (1980-1989) of 59 neonates presenting with congenital diaphragmatic hernia (CDH) to Our Lady's Hospital for Sick Children, the main referral centre for neonatal surgery in Ireland, is presented to determine the outcome and make suggestions for improvements. CDH was more common in males (34M, 25F). Th...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02984671
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Eclampsia is rare in molar pregnancy. Sudden cortical blindness in eclampsia is an uncommon but very dramatic experience for the patient. Because of its rarity, blindness associated with eclampsia may pose a significant problem for the obstetrician. CASE REPORT:We describe cortical blindness and posterior r...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0370-0
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Tinnitus is a phenomenon that affects approximately 15% of the adult population. A minority of patients will experience chronic bothersome tinnitus that has a detrimental effect on their quality of life. Management of such tinnitus is challenging for healthcare practitioners. Primary care services are the fi...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02222-6
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:This article is a follow-up to an audit performed by the Department of Surgery and published in the Irish Journal of Medical Science in 1996. This audit reviewed all cases of Infantile Hypertrophic Pyloric Stenosis (IHPS) operated on over 22 years up to 1991. AIMS:We aim to demonstrate that radiologic inves...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169126
更新日期:2005-04-01 00:00:00
abstract:INTRODUCTION:Charles Lucas, apothecary, physician and MP, was instrumental in facilitating legislation in Ireland in 1765 that established a nationwide network of hospitals in Ireland. This legislation was unique in contemporary Europe, and by the end of the century, there was a hospital in every county in the country....
journal_title:Irish journal of medical science
pub_type: 传,历史文章,杂志文章
doi:10.1007/s11845-015-1255-z
更新日期:2015-09-01 00:00:00
abstract:INTRODUCTION:Prostate cancer is the most common solid cancer affecting men in Ireland. Transrectal ultrasound (TRUS) biopsies of the prostate are routinely performed to diagnose prostate cancer. They are, in general, a safe procedure but are associated with a significant risk of infective complications ranging from fev...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0774-5
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The numbers of removals of patients from General Practitioner lists in Ireland is increasing and is a cause for some concern. AIMS:To examine the views of both general practitioners and patients toward removals of patients from general practitioner lists. METHODS:Questionnaire survey to general practitione...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0062-6
更新日期:2007-09-01 00:00:00
abstract::Liver failure resulting from deliberate or accidental paracetamol overdose continues to be an important reason for referral to liver transplant centres. Severe hepatic dysfunction often appears 72-96 h after overdose. Liver injury can be prevented by timely administration of the specific antidote, N-acetylcysteine. Un...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0783-4
更新日期:2012-09-01 00:00:00
abstract::The attitudes of a final year of medical students in University College Dublin and their level of satisfaction to their medical training was assessed. Medical students were significantly more dissatisfied with their pre-clinical teaching than clinical teaching and training. The majority of students felt inadequately t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944357
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Ankylosing spondylitis (AS) is characterised by insidious onset lower back pain. Poor symptom recognition results in delays in diagnosis of up to 11 years. Despite the widespread use of anti-tumour necrosis factor alpha (anti-TNFα) therapy, work disability remains a challenging problem in AS. METHODS:A retr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1054-3
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The Fowler-Stephens orchidopexy (FSO) is a well-described treatment for high maldescended testes where the limiting factor for successful placement in the scrotum is short testicular vessels. The operation involves division of these vessels. The testicular blood supply is then dependent on collaterals from t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914517
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is associated with variable predisposing risk factors including preeclampsia and eclampsia since it proposed. However, studies of large case series focusing on pregnancy-related PRES are still limited. We performed a large retrospective study of patients wi...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1567-2
更新日期:2017-08-01 00:00:00
abstract::A case of cervical pregnancy resulting in intra abdominal rupture in the first trimester is reported. The clinical features of this rare cause of uterine rupture are outlined. Pathological examination of the uterus showed placenta percreta. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942011
更新日期:1989-01-01 00:00:00
abstract:AIM:Scarcity of paediatric cholelithiasis limits the obtainable experience in paediatric laparoscopic cholecystectomy (LPC). We report minilaparotomy cholecystectomy (MLC) in children which may be a useful alternative to LPC avoiding the added cost of disposable laparoscopic equipment. METHODS:Nineteen cases underwent...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0044-8
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES AND BACKGROUND:Glasgow coma scale (GCS) is considered an important parameter to predict the clinical outcome in head injury; however, in some cases such as the use of sedative drugs the estimate of GCS would not be precise. Bispectral index (BIS) is an electrophysiological parameter to determine the clinical...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0768-3
更新日期:2012-03-01 00:00:00