Abstract:
OBJECTIVE:To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats. METHODS:A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg(-1)), middle (30 mg kg(-1)), and high-dose diosgenin (90 mg kg(-1))-treated groups. The osteoporosis rats model was induced by retinoic acid. The BMD and physical parameters of femoral including length, wet weight, and dry weight in each group were measured. The hematoxylin-eosin staining was used for bone histomorphology analysis. Besides, the bone calcium (Ca) and phosphorus (P) contents were measured. In order to detect the biochemical index in different treatment groups, the serum tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), estradiol, and osteocalcin were compared among different groups. RESULTS:The osteoporosis rat model was successfully induced by retinoic acid. Compared with the model group, the lessening of femoral length and weight and the loss of BMD were significantly improved in diosgenin groups. Both contents of Ca and P were much more increased when induced by retinoic acid (p < 0.05). The estradiol and osteocalcin levels in the middle and high-dose treatment groups were significantly higher than that of the model group, while the ALP and TRAP levels were much lower than the model group (p < 0.05). CONCLUSION:Diosgenin can prevent the loss of bone in experimental rats. The mechanism may be that it improves the level of estrogenic hormone of estradiol and inhibits the high bone turnover.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Zhao S,Niu F,Xu CY,Liu Y,Ye L,Bi GB,Chen L,Tian G,Nie THdoi
10.1007/s11845-015-1309-2subject
Has Abstractpub_date
2016-08-01 00:00:00pages
581-587issue
3eissn
0021-1265issn
1863-4362pii
10.1007/s11845-015-1309-2journal_volume
185pub_type
杂志文章abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive illness that is mostly managed in the general practice setting. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines are the international gold standard, and it is important to understand how these are being applied in gene...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1651-7
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:This study is designed to explore the effect of paricalcitol (vitamin D receptor agonist) on pancreatic oxidative stress, inflammatory markers, and adiponectin and glycemic status in diabetic rats. MATERIALS AND METHODS:Forty Sprague-Dawley male rats aged 10-12 weeks (150-250 g) were used in this study. Typ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1635-7
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Increasing prevalence of overweight and obese children in developed countries poses a substantial threat to long-term health. One well-described factor is the amount of time spent watching television, with exposure to food advertising a known influence on food preferences and consumption patterns. AIMS:Foll...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1088-1
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Hereditary pancreatitis is an important cause of chronic pancreatitis, which may result in endocrine and exocrine failure. This may necessitate simultaneous pancreas and kidney transplant (SPK). Bladder drainage of the exocrine secretions may cause problems. AIM:To report one such case and its surgical corr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02915290
更新日期:2003-10-01 00:00:00
abstract::Menorrhagia affects 20-30% of healthy women, many of whom undergo hysterectomy. In recent years, transcervical resection of the endometrium (TCRE) has become an alternative surgical option. This observational study assesses patient satisfaction following TCRE. The case notes of 55 patients who had a TCRE in the Coombe...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02940244
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Anal ulceration is uncommon. Patients are typically referred because of severe anal pain, bleeding, discharge, and ulceration. It is important to exclude anal carcinoma, and to consider more unusual causes. METHODS:A 74-year-old lady presented with severe anal pain and ulceration. This was subsequently note...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169175
更新日期:2006-07-01 00:00:00
abstract:AIMS:To evaluate the potential role of key DNA repair proteins in the sensitivity of normal human fibroblasts to ionising radiations. METHODS:Radiosensitivity of six human fibroblast strains established from skin biopsies of women who had undergone conservative breast surgery and received a curative breast conserving ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0554-7
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:This is a retrospective review of the Rotunda Hospital Emergency Room (ER) documentation with respect to attendances for a 4-month period (August-November) in both 2009 and 2012. The aim was to quantify the workload and assess the quality of care offered to patients attending the ER over the two time perio...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1185-1
更新日期:2014-12-01 00:00:00
abstract::An unusual case of a well-documented granulomatous hepatitis in secondary syphilis in a 47-year-old male is presented. This hepatic pathology in secondary syphilis is summarised, and a review of the literature regarding syphilitic granulomatous hepatitis presented. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/BF02937251
更新日期:1990-02-01 00:00:00
abstract:INTRODUCTION:The case report is the cornerstone of both medical teaching and writing. However, during recent years the value of the case report has been questioned, so much so that it has been abandoned by many journals. The aim of this study was to assess case reports published by the Irish Journal of Medical Science ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-010-0649-1
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The intravenous infusion of atrial (ANP) and brain (BNP) natriuretic peptides have been shown to increase urinary albumin excretion in type 1 diabetes. AIMS:To measure plasma ANP and BNP concentrations in patients with type 1 diabetes and to examine the parameters associated with elevated plasma concentrati...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169149
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Gaming is a growing area and there are conflicting reports on its harms and benefits. There is also increasing interest in the use of gaming clinically. AIMS:This research aims to enhance our understanding of video and smartphone game use, and perceptions, among outpatients attending an Irish general adult ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02016-5
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Cell-based tissue engineering has emerged as a potential therapy for intervertebral disc degeneration. However, propagating and maintaining high quantity and quality of the seed cells remains a challenge. AIMS:To investigate the feasibility of culturing human disc cells using a microcarrier bioreactor syste...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0537-8
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Although laparoscopic appendectomy (LA) is considered to be minimally invasive compared with open appendectomy (OA), there are few studies showing this in terms of cytokines and oxidative stress markers. AIM:LA and OA techniques have been compared in terms of different conditions such as operation time and ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02317-0
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Adults ageing with HIV and on antiretroviral therapy have a greater burden of chronic diseases compared with adults without HIV as reported by Althoff et al. (Curr Opin HIV AIDS 11:527-36, 2016). Therefore, it is important in this clinically stable HIV+ population to monitor and evaluate their risk of chroni...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02063-y
更新日期:2020-02-01 00:00:00
abstract::We report a rare case of iatrogenic tracheal tear during a three-stage oesophagectomy in a 76-year-old woman and review current literature. The tear occurred due to trauma from a double lumen endotracheal tube. We used a novel technique of repairing the tear, which extended to the carina, avoiding a second thoracotomy...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0169-4
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To analyze the capability of four-dimensional surface rendering mode ultrasound (4D SRM USG) in the detection of fetal abnormalities, and also compare it with 2D USG. MATERIALS AND METHODS:A total of 1,379 pregnant women were enrolled in the study, and they all underwent 2D USG screening. In the same session...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1184-2
更新日期:2015-09-01 00:00:00
abstract::Elective and emergent coronary interventions via transradial access (TRA) are been used increasingly as they carry a reduced risk of complications. Percutaneous coronary intervention via TRA may lead to radial artery spasms (RAS) that may result in prolonged procedure time, cross-over of access site, and other complic...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-020-02203-9
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Attitudes have been shown to be important determinants of the quality and efficacy of medical care. There is little research on the education about, and assessment of, attitudes in undergraduate medical education. AIM:To describe the design and delivery of an attitude awareness workshop, and the associated ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03170282
更新日期:2002-10-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The presentation of Table 1 was incorrectly captured. The Publisher regrets that it introduced errors to Table 1 during the typesetting of the article. The original article has been corrected. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11845-017-1719-4
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Whether developments in palliative care have impacted on where cancer patients die is unknown. We investigated time trends in place of death for colorectal cancer. METHODS:Details were abstracted on 10,175 colorectal cancer deaths during 1994-2004. Time trends were analysed by joinpoint regression. RESULTS...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0607-y
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:A relationship may exist between body iron stores, endothelial dysfunction and overall cardiovascular risk. AIMS:To compare vascular compliance, biochemical endothelial function and antioxidant status between patients with homozygous hereditary haemochromatosis and healthy controls. METHODS:Haemochromatosi...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1010-2
更新日期:2014-06-01 00:00:00
abstract::Isolated third cranial nerve palsy is usually due to vascular causes like posterior communicating artery aneurysm and it is rare in neurocysticercosis. Third cranial nerve palsy in neurocysticercosis is usually caused by supratentorial or sub-arachnoid lesions with accompanying hydrocephalus or meningitis. We report a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0308-6
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The majority of patients presenting with oesophageal cancer have symptoms for more than three months and advanced disease at presentation. Most appear unaware of the significance of dysphagia as a symptom. Cancer awareness programmes focus on symptoms such as lumps and bleeding. AIM:To sample the level of p...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167788
更新日期:2001-10-01 00:00:00
abstract::Anxiety, depression, self-esteem, behavioural deviance and prosocial behaviour were studied in children attending a normal school in a disadvantaged urban area, using self-rated and teacher-rated questionnaires. The prevalence of depression was rated as 5%. 15% described frequent suicidal thoughts. 40% scored as behav...
journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
doi:10.1007/BF02943055
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:The management of patients with chronic pain is challenging. The aim of treatment is alleviation of symptoms in an attempt to increase functional capacity. Interventional procedures, such as chemical neurolysis are adopted when other techniques fail to provide adequate pain control. RESULTS:An 82-year-old m...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0312-x
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02386-1
更新日期:2020-10-17 00:00:00
abstract:BACKGROUND:Non-attendance at outpatient clinics is common and costly. AIMS:This study aimed to determine if sending SMS ('short message service' or text message) reminders to patients before appointments reduced non-attendance. METHODS:We collected outpatient data at Ballyfermot and Lucan Community Adult Mental Healt...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1710-0
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:There is no agreeing if rescue therapy can avoid short-term colectomy in patients treated for severe steroid-refractory ulcerative colitis. AIMS:The aim of our study was to identify predictors of response to infliximab and cyclosporine A. METHODS:In this cross-sectional study, 49 patients with severe ulcer...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1666-0
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Circumcision is one of the world's most common operations. Series describing a new technique involving the use of fibrin-based glue have become more apparent in the literature. Here we outline the first 100 such cases for 62 children and 38 adults in our practice describing complications and learning curve. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0545-8
更新日期:2011-03-01 00:00:00