Abstract：
INTRODUCTION:Charles Lucas, apothecary, physician and MP, was instrumental in facilitating legislation in Ireland in 1765 that established a nationwide network of hospitals in Ireland. This legislation was unique in contemporary Europe, and by the end of the century, there was a hospital in every county in the country. MATERIALS AND METHODS:His work as an apothecary provided him with the knowledge to attempt to address the problems in the apothecaries' trade, and his 1741 pamphlet, Pharmacomastix, provided the framework for the 1761 Irish Apothecaries Act, which attempted to address these issues. It was, however, 1791 before nationwide regulation of the Irish apothecaries' trade was implemented following the establishment of the Apothecaries Hall, and this was 24 years before similar regulatory legislation was passed in Britain. Lucas sought enhanced regulation of the apothecaries' trade to provide better quality drugs and medicines for the general public, and he tried to ensure that untrained quacks did not practise as apothecaries, unbeknownst to their patients. He was aware that his proposals would meet with opposition, but he had the courage to pursue these without any element of personal gain. CONCLUSION:In medical terms, Charles Lucas was man ahead of his time.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Mullaney Sdoi
10.1007/s11845-015-1255-zsubject
Has Abstractpub_date
2015-09-01 00:00:00pages
555-6issue
3eissn
0021-1265issn
1863-4362journal_volume
184pub_type
传,历史文章,杂志文章abstract：BACKGROUND:Osteoid osteoma is a painful benign bone tumour. Previously the standard therapy was surgical excision. Image guided radiofrequency ablation can be clinically applied to ablate the tumour in a minimally invasive manner. AIMS:We present a case of an 18-year-old boy who presented with features of chronic left...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169159
更新日期：2005-07-01 00:00:00
abstract：INTRODUCTION:The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been diversely studied. Its role associated with tumor development has attracted attention just in rece...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-015-1297-2
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Most femoral neck fractures in younger patients have a different mechanism, treatment, and prognosis from those in elderly patients. AIMS:To evaluate the results of internal fixation of femoral neck fractures in patients aged between 20 and 60 years, and to determine reasons for failure. PATIENTS AND METHO...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03168981
更新日期：2005-10-01 00:00:00
abstract：AIMS:Many studies have suggested Cytomegalovirus infection might be implicated in steroid-refractory inflammatory bowel disease (IBD), in which situation management is extremely difficult. CMV infection being a potential cause of IBD have drawn great attention of clinicians, with insufficient evidence to reach conclusi...
journal_title：Irish journal of medical science
pub_type： 杂志文章,meta分析
doi：10.1007/s11845-018-1752-y
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Cardiac arrest due to ischaemia is frequently the first manifestation of cardiovascular disease. We sought to describe the characteristics and outcomes of patients admitted to the Intensive Care Unit (ICU) with a diagnosis of cardiac arrest secondary to acute coronary syndrome (ACS). METHODS:We performed a ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-016-1422-x
更新日期：2017-02-01 00:00:00
abstract：:A 48 year old patient with resistant coeliac disease developed prolonged unexplained pyrexia after surgery for small bowel volvulus. Despite extensive investigations and intensive antibiotic therapy, he deteriorated and died eight weeks postoperatively and significant isolated pulmonary valve endocarditis was discover...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02967092
更新日期：1994-11-01 00:00:00
abstract：:This study assessed the ability of biochemical tests and ultrasound to predict the presence of ductal calculi, and thereby refine the indications for ERCP, in patients before or after laparoscopic cholecystectomy. Thirteen of fifty-three patients investigated before laparoscopic cholecystectomy, and four of seventeen ...
journal_title：Irish journal of medical science
pub_type： 临床试验,杂志文章
doi：10.1007/BF03022585
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Platelets are involved in atherosclerosis. Mean platelet volume (MPV) could be a marker of platelet activation. We aim to determine whether MPV levels were correlated with the presence of atherosclerotic disease in carotid arteries of patients with stroke. METHODS:We recruited 215 patients with atherothromb...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-011-0755-8
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Internationally, the number of computerised tomographic pulmonary angiographies (CTPAs) being performed to rule out pulmonary embolism (PE) has caused some concern. AIM:This study was performed to assess if the application of Pulmonary Embolism Rule-out Criteria (PERC) in an Irish Emergency Department (ED) ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02398-x
更新日期：2020-10-22 00:00:00
abstract：BACKGROUND:ADHD is the most frequent reason for attendance at Child and Adolescent Mental Health Services (CAMHS). General practitioners (GPs) play a key role in recognising symptoms, referring for assessment and supporting ongoing treatment. However, there is an ambiguous understanding of ADHD among GPs, and different...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1804-3
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:A relationship may exist between body iron stores, endothelial dysfunction and overall cardiovascular risk. AIMS:To compare vascular compliance, biochemical endothelial function and antioxidant status between patients with homozygous hereditary haemochromatosis and healthy controls. METHODS:Haemochromatosi...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1010-2
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Gallbladder stone with symptom is an indication of cholecystectomy according to the current guideline. However, about 80% of gallstone patients are asymptomatic. The identification of gallbladder stone patients likely to develop symptomatic complications would be of benefit in clinical practice. AIMS:The ai...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-019-02161-x
更新日期：2020-08-01 00:00:00
abstract：:Reproductive surrogacy can be altruistic or commercial, each with complex ethical considerations that are complicated by heterogeneity in governing laws across jurisdictions. Surrogacy in Ireland is relatively new and largely unregulated, so this review aims to elucidate its current regulatory status and associated et...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-020-02402-4
更新日期：2020-10-31 00:00:00
abstract：:Eighty-one epithelial lesions were studied immunohistologically for cytokeratin protein expression using three anticytokeratins CAM 5.2, NCL5D3 and RCK102. Consistent differences were noted between squamous and glandular neoplasms. Squamous and cutaneous carcinomas were found to preferentially express higher molecular...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02942094
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Adults ageing with HIV and on antiretroviral therapy have a greater burden of chronic diseases compared with adults without HIV as reported by Althoff et al. (Curr Opin HIV AIDS 11:527-36, 2016). Therefore, it is important in this clinically stable HIV+ population to monitor and evaluate their risk of chroni...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-019-02063-y
更新日期：2020-02-01 00:00:00
abstract：AIM:We report a case of a giant diverticulum of the sigmoid colon presenting as a mass in the left upper quadrant of the abdomen in an elderly man. METHODS:This report highlights a rare complication of diverticular disease. At operation, the giant cyst was situated in the supracolic compartment of the abdomen. The man...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-007-0090-2
更新日期：2008-12-01 00:00:00
abstract：INTRODUCTION:The "National Integrated Medical Imaging System" or NIMIS went live in 2011 and allows the movement of patient radiology imaging throughout the Irish health system. At the time of its launch, NIMIS was not only going to allow the filmless passage of patient radiology imaging but it was also envisaged that ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1900-4
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Medication discrepancies at the time of hospital discharge are common and can result in error, patient/carer inconvenience or patient harm. Providing accurate medication information to the next care provider is necessary to prevent adverse events. AIMS:To investigate the quality and consistency of medicatio...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0142-2
更新日期：2008-06-01 00:00:00
abstract：INTRODUCTION:Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02386-1
更新日期：2020-10-17 00:00:00
abstract：OBJECTIVE:To analyze the capability of four-dimensional surface rendering mode ultrasound (4D SRM USG) in the detection of fetal abnormalities, and also compare it with 2D USG. MATERIALS AND METHODS:A total of 1,379 pregnant women were enrolled in the study, and they all underwent 2D USG screening. In the same session...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-014-1184-2
更新日期：2015-09-01 00:00:00
abstract：:This article was published online with an error. In Table 3, the name of the variable in the last row is missing. It just says 'mmHg'. The name to be written is 'MAP (mmHg)'. ...
journal_title：Irish journal of medical science
pub_type： 已发布勘误
doi：10.1007/s11845-020-02363-8
更新日期：2020-09-09 00:00:00
abstract：AIMS:Imported childhood malaria has never been studied in Ireland. We aimed to document the incidence and species of malaria in children presenting to paediatric hospitals in Dublin and to examine management and outcome measures. METHODS:Subjects were identified through laboratory archives from the three paediatric ho...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0343-3
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Rubella is caused by the rubella virus, a single-stranded RNA virus of the Togaviridae family. The most severe complications of rubella in adult women occur during pregnancy when infection can lead to miscarriage, stillbirth or congenital rubella syndrome. Antenatal rubella susceptibility screening is no lon...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1722-9
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Although laparoscopic appendectomy (LA) is considered to be minimally invasive compared with open appendectomy (OA), there are few studies showing this in terms of cytokines and oxidative stress markers. AIM:LA and OA techniques have been compared in terms of different conditions such as operation time and ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02317-0
更新日期：2021-02-01 00:00:00
abstract：INTRODUCTION:Heparin-induced thrombocytopenia syndrome (HITS) is an infrequent complication of heparin anticoagulation. CASE REPORT:We present the case of a 44-year-old male who was admitted with acute ischaemia of his right lower limb. He was initially treated with unfractionated heparin and thrombolysis, but subsequ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-010-0531-1
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats. METHODS:A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg(-1)), middle (30 mg kg(-1)), and high-dose diosgenin (90 mg k...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-015-1309-2
更新日期：2016-08-01 00:00:00
abstract：:The management of breast cancer has evolved in the last 40 years to now encompass not only treating the cancer in the most effective way, but also to detect and treat cancers before they can pose a risk to patients. This evolution in therapy and diagnostics has moved away from treating patients with the maximum amount...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-014-1142-z
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency in pregnancy has important maternal and fetal implications, with increased risk of developing gestational diabetes, preeclampsia, preterm birth and small for gestational age birthweight. It is recommended that every pregnant woman should take 5 μg (200 IU) of vitamin D per day during pre...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1707-8
更新日期：2018-08-01 00:00:00
abstract：:A case of foetal death with retroplacental haemorrhage at 24 weeks gestation is reported, where the placenta histologically showed diffuse severe chorioangiosis. The latter is an infrequently reported placental vascular anomaly, which recent studies have indicated to be an important sign of neonatal morbidity and mort...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02937381
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:Data from randomized trials evaluating the efficacy of on- versus off-pump coronary artery bypass grafting remain inconclusive, particularly in high-risk populations. AIMS:The aim of this study is to compare the outcomes associated with on- versus off-pump coronary artery bypass grafting among high-risk pat...
journal_title：Irish journal of medical science
pub_type： 杂志文章,meta分析
doi：10.1007/s11845-017-1679-8
更新日期：2018-05-01 00:00:00
