Abstract:
:Eighty-one epithelial lesions were studied immunohistologically for cytokeratin protein expression using three anticytokeratins CAM 5.2, NCL5D3 and RCK102. Consistent differences were noted between squamous and glandular neoplasms. Squamous and cutaneous carcinomas were found to preferentially express higher molecular weight cytokeratins than adenocarcinomas. In addition, tumours of similar morphology from different sites showed differences in expression of these markers. Differences in pattern were also found between benign and malignant lesions in the case of liver and urinary bladder. Thus the value of cytokeratin profile analysis in characterisation of epithelial neoplasms is confirmed and may be useful in distinguishing benign from malignant tumours in some instances.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Mortimer G,Jones DN,Assaf H,al-Ahmadi Tdoi
10.1007/BF02942094subject
Has Abstractpub_date
1993-03-01 00:00:00pages
77-81issue
3eissn
0021-1265issn
1863-4362journal_volume
162pub_type
杂志文章abstract:BACKGROUND:Despite Ireland's temperate maritime climate, it has the third highest rate of malignant melanoma in the European Union, indicating the need to recognise tanning practices as a risky behaviour, especially amongst those most at risk (the younger population). AIM:To explore the factors associated with deliber...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1389-z
更新日期:2016-11-01 00:00:00
abstract::It has been suggested in the literature that an eight hour period of distal oesophageal monitoring is adequate for the diagnosis of reflux in symptomatic patients. The aim of this study was to investigate whether 3 hour intra-oesophageal pH-metry could be substituted for the eight hour test period without loss of sens...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02947641
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Obtaining patient consent is a fundamental process in surgical practice and is integral in respecting and safeguarding patient autonomy. It has been reported that the task of consenting patients frequently lies with junior doctors, who have the least experience of the procedure. AIM:To examine the role of i...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1782-5
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Pre-pubertal varicocele can result in hypotrophy of testes, progressive deterioration of Sertoli cells and spermatogonia cell number, decrease in seminiferous diameter and cause to sperm damage. AIMS:Because of detrimental time-dependent effects of varicocele, this study describes the effects of varicocele ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1167-3
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The Health Service Executive introduced a generic prescription policy to reduce costs. Despite this, generic prescription rates remain low. AIM:To audit in-patient prescription practice in a single surgical department and identify potential savings which could be realised by adherence to the generic prescri...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-0900-7
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:We describe a case report and technique for using an ultrasound scanner and a linear transducer to guide serratus posterior superior (SPS) muscle injection. A 43-year-old female presented with chronic pain centered under the right upper portion of her scapula impacting her activities of daily living. METH...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1336-z
更新日期:2016-08-01 00:00:00
abstract::One hundred and forty-nine renal transplant patients attending 2 centres in Dublin were examined. Twelve patients (8.1%) were found to have cutaneous malignancy while dysplastic lesions (premalignant and/or malignant) were identified in 34 (22.8%). The prevalence of cutaneous malignancy in this study is substantially ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02983762
更新日期:1992-04-01 00:00:00
abstract::This paper analyses data on 2,226 cases of Hepatitis B virus (HBV) infection detected during the years 1970 to 1987. Of those where information on risk-group was available (1,301), infection among intravenous drug-abusers accounted for the largest proportion (49%). Most became infected during and since an outbreak of ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02943614
更新日期:1989-08-01 00:00:00
abstract:INTRODUCTION:Otitis externa (OE) is an extremely common dermatological condition that can affect social life and employment, but formal studies of its general health impact are lacking. OBJECTIVE:The aims of this study were two-folded, first to assess the impact of OE on various health determinants as measured by the ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0137-z
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:The intravenous infusion of atrial (ANP) and brain (BNP) natriuretic peptides have been shown to increase urinary albumin excretion in type 1 diabetes. AIMS:To measure plasma ANP and BNP concentrations in patients with type 1 diabetes and to examine the parameters associated with elevated plasma concentrati...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169149
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:Although good evidence exists regarding the clinical effectiveness of mechanical thrombectomy for people with acute ischaemic stroke, cost-effectiveness should also be considered. The aim of this study was to systematically review the evidence of cost-effectiveness of emergency endovascular therapy using mechan...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1946-3
更新日期:2019-08-01 00:00:00
abstract::Liver failure resulting from deliberate or accidental paracetamol overdose continues to be an important reason for referral to liver transplant centres. Severe hepatic dysfunction often appears 72-96 h after overdose. Liver injury can be prevented by timely administration of the specific antidote, N-acetylcysteine. Un...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0783-4
更新日期:2012-09-01 00:00:00
abstract::A new investigative modality, cervicography, has been advocated for cervical screening. In the first 51 patients referred for colposcopy because of an abnormal cervicogram, none had invasive cancer and 75% had preinvasive cancer. The cervicogram appears superior to cytology but inferior to colposcopy in the detection ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937249
更新日期:1990-02-01 00:00:00
abstract::Height, body weight, the thickness of triceps, biceps, subscapular and supra-iliac skinfolds and the six-minute run-walk test of aerobic endurance were measured on 1163 National school children between the ages of 7 and 13, who were attending rural or urban schools in counties Cork, Galway, Limerick, Mayo, Waterford a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942167
更新日期:1993-09-01 00:00:00
abstract:PURPOSE:Internal iliac artery (IIA) embolisation is commonly performed prior to endovascular aneurysm repair (EVAR) of aortoiliac aneurysms to prevent type 2 endoleaks via the internal iliac arteries. The safety of this procedure is controversial due to the high incidence of pelvic ischaemic complications. METHODS:We ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1384-4
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:Childhood obesity is associated with increased risk of adult obesity, cardiovascular disease, diabetes and cancer. Appropriate techniques for assessment of childhood adiposity are required to identify children at risk. The aim of this review was to examine core clinical measurements and more technical tool...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-014-1124-1
更新日期:2015-03-01 00:00:00
abstract::Deliberate and recurrent foreign body ingestion is a common problem among institutionalised patients. We review our experience with 36 cases of deliberate foreign body ingestion by prisoners or psychiatric patients, thirty of whom were institutionalised at the time of ingestion. Symptoms were frequently severe in the ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02943095
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Treatment of pilonidal sinus disease is controversial. Many claim policy of marsupialisation and healing by secondary intention. This is demanding in terms of nursing care and time lost from work. AIMS:To examine outcome of excision and primary closure of chronic pilonidal disease on recurrence rate and pat...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0532-0
更新日期:2011-03-01 00:00:00
abstract::Direct Antibiotic Sensitivity Testing (DST) is a rapid means of diagnosing urinary tract infection (UTI) and obtaining antibiotic sensitivity patterns of the infecting organisms. In this study 227 urine samples from general practice were analysed using this technique with those obtained using the standard laboratory m...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937439
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:Evaluate condylar, ramal, and condylar plus ramal vertical mandibular asymmetry in patients with unilateral posterior crossbite (UPCB) and in patients with unilateral cleft lip and palate (UCLP) compared with subjects having normal occlusion. DESIGN:This cross-sectional study evaluated panoramic radiographs ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1020-0
更新日期:2014-09-01 00:00:00
abstract::A questionnaire survey was carried out to estimate activity levels in a sample of 784 men and women aged 35 to 64 years in County Kilkenny, Ireland. Men were more likely to have sedentary, heavy or very heavy work activity while the majority of women had moderate activity during an average day. Only a small minority o...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02950440
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Among many factors predisposing to monosymptomatic enuresis (MNE) disturbances in urinary electrolites excretion play an important role. Because of many controversies in this field there is a need to debate the role of hypercalciuria in MNE. The aim of our study was to determine the urinary calcium in childr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1217-x
更新日期:2015-12-01 00:00:00
abstract::Two term infants suffering severe asphyxial events were found to have diffusely high attenuation of the cortical gyri on CT scanning within 12 days. The findings are consistent with haemorrhagic necrosis or microcalcification. This feature has rarely been described in the literature. The evolution of the CT appearance...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937934
更新日期:1998-07-01 00:00:00
abstract:INTRODUCTION:Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02386-1
更新日期:2020-10-17 00:00:00
abstract:BACKGROUND:Glycodelin plays an important role in normal and abnormal reproductive growth. The in vitro properties of glycodelin have been studied in K562 cells. The role of glycodelin in vivo in the peripheral circulation has not been determined. AIM:To determine if circulating leukocytes in normal subjects express th...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0019-9
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Hypertension (HT) is a disease associated with endothelial dysfunction which is related to some adipokines and pro- and anti-inflammatory cytokines. AIMS:Our aim was to investigate roles of apelin, omentin-1, and vaspin in essential HT and to evaluate their relationships with other pro- and anti-inflammator...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02272-w
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:Charles Lucas, apothecary, physician and MP, was instrumental in facilitating legislation in Ireland in 1765 that established a nationwide network of hospitals in Ireland. This legislation was unique in contemporary Europe, and by the end of the century, there was a hospital in every county in the country....
journal_title:Irish journal of medical science
pub_type: 传,历史文章,杂志文章
doi:10.1007/s11845-015-1255-z
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:There is increasing concern that the use of second-generation antipsychotic medications in schizophrenia is associated with the development of metabolic syndrome. AIMS:This study assessed the prevalence and clinical associations of metabolic syndrome among patients receiving clozapine within the catchment a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0156-9
更新日期:2008-09-01 00:00:00
abstract::Previous studies have shown that up to 40 per cent of patients have symptoms after cholecystectomy or laparoscopic cholecystectomy (LC). There are concerns, however, that these symptoms reflect those of the general population and are not a specific post-operative phenomenon. Abdominal symptoms of 212 patients followin...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937544
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Multiple primary neoplasms, a common clinical entity, can be classified as synchronous or metachronous. Renal cell carcinoma, in particular, is associated with a high rate of multiple primary neoplasms. METHODS:We report a case of a 67-year-old Caucasian woman, who was admitted with history of bleeding per ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0298-4
更新日期:2012-06-01 00:00:00