Patterns of cytokeratin expression by neoplastic and non-neoplastic epithelium.

Abstract:

:Eighty-one epithelial lesions were studied immunohistologically for cytokeratin protein expression using three anticytokeratins CAM 5.2, NCL5D3 and RCK102. Consistent differences were noted between squamous and glandular neoplasms. Squamous and cutaneous carcinomas were found to preferentially express higher molecular weight cytokeratins than adenocarcinomas. In addition, tumours of similar morphology from different sites showed differences in expression of these markers. Differences in pattern were also found between benign and malignant lesions in the case of liver and urinary bladder. Thus the value of cytokeratin profile analysis in characterisation of epithelial neoplasms is confirmed and may be useful in distinguishing benign from malignant tumours in some instances.

journal_name

Ir J Med Sci

authors

Mortimer G,Jones DN,Assaf H,al-Ahmadi T

doi

10.1007/BF02942094

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

77-81

issue

3

eissn

0021-1265

issn

1863-4362

journal_volume

162

pub_type

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