Abstract:
:The management of breast cancer has evolved in the last 40 years to now encompass not only treating the cancer in the most effective way, but also to detect and treat cancers before they can pose a risk to patients. This evolution in therapy and diagnostics has moved away from treating patients with the maximum amount of therapy they can tolerate towards a new paradigm where patents receive the minimum treatment to be most efficacious.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Kell MRdoi
10.1007/s11845-014-1142-zsubject
Has Abstractpub_date
2015-03-01 00:00:00pages
77-80issue
1eissn
0021-1265issn
1863-4362journal_volume
184pub_type
杂志文章,评审abstract:BACKGROUND:Atrial fibrillation is the most common arrhythmia in clinical practice and is a major contributor to mortality. Recently, several studies have reported different results for treatments aimed at reducing the risk of postoperative AF. AIMS:The aim of this study was to evaluate the efficacy of beta-blockers (B...
journal_title:Irish journal of medical science
pub_type: 杂志文章,meta分析
doi:10.1007/s11845-016-1447-1
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Osteoid osteoma is a painful benign bone tumour. Previously the standard therapy was surgical excision. Image guided radiofrequency ablation can be clinically applied to ablate the tumour in a minimally invasive manner. AIMS:We present a case of an 18-year-old boy who presented with features of chronic left...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169159
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive illness that is mostly managed in the general practice setting. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines are the international gold standard, and it is important to understand how these are being applied in gene...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1651-7
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Coroners routinely enquire into suicide deaths and communicate with people bereaved by suicide. However, no research has been conducted into coroners' attitudes towards suicide and its prevention. AIMS:We assessed attitudes towards suicide among Irish coroners in order to determine their understanding of su...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0261-9
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Suicidal behaviour has become recognised as a major public health problem. AIM:To examine hospital-treated parasuicide and suicide in the Southern and Mid-Western Health Boards. METHODS:Parasuicide data were derived from independent data collection in general and psychiatric hospitals and prisons between 1...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914492
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Obtaining patient consent is a fundamental process in surgical practice and is integral in respecting and safeguarding patient autonomy. It has been reported that the task of consenting patients frequently lies with junior doctors, who have the least experience of the procedure. AIM:To examine the role of i...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1782-5
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:There is increasing concern that the use of second-generation antipsychotic medications in schizophrenia is associated with the development of metabolic syndrome. AIMS:This study assessed the prevalence and clinical associations of metabolic syndrome among patients receiving clozapine within the catchment a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0156-9
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:The recent introduction of the General Data Protection Regulation and Health Research Regulations has been an area of significant concern for those engaged in clinical research. These European regulations, following subsequent interpretation by Ireland's Department of Health, now place Ireland in a unique po...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-01980-2
更新日期:2019-11-01 00:00:00
abstract::We assessed the long term efficacy of Novopen as a form of insulin administration. Records were obtained on 48 patients who were treated with Novopen between January '86 and October '88. Six patients were excluded due to insufficient data. The study group of 42 patients comprised 22 females and 20 males of average age...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02948414
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Chronic anal fissures (CAF) are caused by anal sphincter hypertonia leading to an ischaemic ulcer. By inducing temporary sphincter relaxation, botulinum toxin (Botox) injection has been shown to heal CAF in approximately 73-96% of cases in clinical trials. AIM:This study looks at the efficacy of Botox clini...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914547
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Of over 20 different scoring systems to evaluate outcome following calcaneal fracture, the Maryland Foot Score has broad current acceptance. A general health survey, the Short Form 36 (SF 36) has also been used. AIMS:The study compared two scoring systems for assessing the outcome of open reduction and inte...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03166916
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To analyze the capability of four-dimensional surface rendering mode ultrasound (4D SRM USG) in the detection of fetal abnormalities, and also compare it with 2D USG. MATERIALS AND METHODS:A total of 1,379 pregnant women were enrolled in the study, and they all underwent 2D USG screening. In the same session...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1184-2
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:The aims of this investigation was to analyse the response to second and third postal invitations from a group of patients previously invited for mammographic screening and to identify any demographic differences between responders and non-responders. SUBJECTS:The subjects were females aged 50-64 yr resident...
journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
doi:10.1007/BF02939577
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Assess the association between the Society for Vascular Surgery/American Association for Vascular Surgery (SVS/AVSS) (Rutherford et al., J Vasc Surg 26: 517-38, 1997; Chaikof et al., J Vasc Surg 35:1061-6, 2002) medical comorbidity scoring scheme (MCS), and the global scoring system (GS) and major m...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02160-y
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:Surgical site infection (SSI) is one of the main causes of postoperative morbidity and mortality. Appendectomy for acute appendicitis is one of the most commonly performed surgical interventions worldwide. The use of ring retractors to protect the wound edge from contaminated intra-abdominal contents may b...
journal_title:Irish journal of medical science
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11845-015-1381-7
更新日期:2016-02-01 00:00:00
abstract::Liver failure resulting from deliberate or accidental paracetamol overdose continues to be an important reason for referral to liver transplant centres. Severe hepatic dysfunction often appears 72-96 h after overdose. Liver injury can be prevented by timely administration of the specific antidote, N-acetylcysteine. Un...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0783-4
更新日期:2012-09-01 00:00:00
abstract::Elective and emergent coronary interventions via transradial access (TRA) are been used increasingly as they carry a reduced risk of complications. Percutaneous coronary intervention via TRA may lead to radial artery spasms (RAS) that may result in prolonged procedure time, cross-over of access site, and other complic...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-020-02203-9
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Intravenous drug misuse, principally heroin, occurs primarily in the Greater Dublin area. Methadone maintenance treatment has been an important part of the response to opiate misuse in Dublin since 1992. AIMS:To determine the number of opiate-related deaths in Dublin City and County during 1999, to establis...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167718
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Maternity care in hospitals in the Republic of Ireland is funded by a hybrid of public finance and private health insurance. AIMS:The aim of this longitudinal observational study was to investigate the annual trends in maternity care from 2009 to 2017 during and after the Great Economic Recession. METHODS:...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02415-z
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Anal ulceration is uncommon. Patients are typically referred because of severe anal pain, bleeding, discharge, and ulceration. It is important to exclude anal carcinoma, and to consider more unusual causes. METHODS:A 74-year-old lady presented with severe anal pain and ulceration. This was subsequently note...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169175
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Surveillance of Clostridium difficile infection (CDI) is an essential component of a CDI preventative programme. AIMS:The aim of this study was to evaluate two methods of CDI surveillance. METHODS:Prevalence of CDI, antibiotic use and associated co-morbidity was assessed weekly on two wards over 6 weeks. I...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0798-x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze neuropathic pain (NeP) and its therapy in patients with Guillain-Barré syndrome (GBS) during a 6-month follow-up period. METHOD:This longitudinal multicenter study included 69 newly diagnosed adult GBS patients. NeP diagnosis was based on the criteria of Finnerup and conf...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02395-0
更新日期:2020-10-15 00:00:00
abstract::The aim of this paper is to assess the adequacy of the diet of individuals over 60 yr of age, participating in the 1990 Irish National Nutritional Survey. A nationwide random sample based on the most recently updated electoral register was used. Demographic information was collected. Anthropometric measurements were t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944238
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:To describe the shared care and outcomes of patients with periocular skin tumours who underwent Mohs micrographic surgery (MMS) performed by dermatologists, followed by oculoplastic reconstruction undertaken by ophthalmologists at two teaching and one private hospital in Ireland. RESEARCH DESIGN AND METHODS:...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1296-3
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:During recent years, there has been an exponential demand for joint arthroplasty, which has coincided with the global economic recession. In response, the management of patients following arthroplasty is continuously evolving, with the average inpatient length of stay decreasing from weeks to days, and more ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1641-9
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:Prostate cancer cells can switch from an androgen-dependent state to an androgen-independent state after a continuous androgen ablation therapy. However, the molecular mechanisms underlying this switch are still unclear. Therefore, we explored the change in androgen receptor (AR)-related gene expression du...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0714-4
更新日期:2011-12-01 00:00:00
abstract::A bioassay method for measuring parathyroid hormone (PTH) and other substances that influence bone metabolism is described. Monolayers of bone cells are culturedin vitro, then treated with the test material. Biological activity is determined by measuring the resulting rise in bone-cell adenosine 3',5'-monophosphate (c...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02938966
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Postoperative sore throat (POST) is a common complication following tracheal intubation. The effectiveness of prophylactic dexamethasone on POST needs further elucidation. AIMS:To evaluate the effectiveness and safety of intravenous dexamethasone for the prevention of POST in patients undergoing endotrachea...
journal_title:Irish journal of medical science
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11845-013-1057-0
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Vitamin D deficiency in pregnancy has important maternal and fetal implications, with increased risk of developing gestational diabetes, preeclampsia, preterm birth and small for gestational age birthweight. It is recommended that every pregnant woman should take 5 μg (200 IU) of vitamin D per day during pre...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1707-8
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Internationally, the number of computerised tomographic pulmonary angiographies (CTPAs) being performed to rule out pulmonary embolism (PE) has caused some concern. AIM:This study was performed to assess if the application of Pulmonary Embolism Rule-out Criteria (PERC) in an Irish Emergency Department (ED) ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02398-x
更新日期:2020-10-22 00:00:00