Abstract：
OBJECTIVE:The aim of this study was to analyze neuropathic pain (NeP) and its therapy in patients with Guillain-Barré syndrome (GBS) during a 6-month follow-up period. METHOD:This longitudinal multicenter study included 69 newly diagnosed adult GBS patients. NeP diagnosis was based on the criteria of Finnerup and confirmed by the PainDETECT Questionnaire (PD-Q). Severity of GBS was assessed by GBS disability scale (GDS). Patients were assessed: on day 14 (D14), day 28 (D28), month 3 (M3), and month 6 (M6) from the disease onset. RESULTS:At D14, pain was present in 85.5% of patients, while 26.4% had NeP. At M6, 72.5% of patients had pain, 20.0% of them NeP. In acute GBS, pain intensity was higher in patients with NeP compared to those with non-NeP (p < 0.01). Pain intensity in patients with NeP did not change during time, but it decreased in patients with non-NeP at M6 (p < 0.05). Around 20% of GBS patients were on specific NeP medication throughout the observed period. One quarter of patients with NeP were not on specific NeP drug in the acute phase. Up to one third of patients with NeP were on NeP medication but still had significant NeP. Pooled PD-Q score was in correlation with pooled GDS score (rho = + 0.43, p < 0.01). CONCLUSIONS:NeP is a common and potentially severe symptom in GBS that may persist for months. It is important to recognize NeP, start specific treatment on time, in adequate doses, and for prolonged period of time.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Vukojevic Z,Berisavac I,Bozovic I,Dominovic-Kovacevic A,Lavrnic D,Peric Sdoi
10.1007/s11845-020-02395-0subject
Has Abstractpub_date
2020-10-15 00:00:00eissn
0021-1265issn
1863-4362pii
10.1007/s11845-020-02395-0pub_type
杂志文章abstract：INTRODUCTION:The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been diversely studied. Its role associated with tumor development has attracted attention just in rece...
journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Irish journal of medical science
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journal_title：Irish journal of medical science
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journal_title：Irish journal of medical science
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journal_title：Irish journal of medical science
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journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：2006-07-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-016-1485-8
更新日期：2017-05-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 已发布勘误
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更新日期：2020-09-09 00:00:00
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journal_title：Irish journal of medical science
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更新日期：2001-01-01 00:00:00
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更新日期：2017-02-01 00:00:00
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journal_title：Irish journal of medical science
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更新日期：2016-08-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02960724
更新日期：1993-08-01 00:00:00
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journal_title：Irish journal of medical science
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更新日期：1991-08-01 00:00:00
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journal_title：Irish journal of medical science
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pub_type： 杂志文章,meta分析
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更新日期：2016-05-01 00:00:00
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更新日期：2016-11-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：1999-10-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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更新日期：2020-08-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：2002-10-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
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更新日期：2017-08-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02944248
更新日期：1997-10-01 00:00:00
