Abstract:
INTRODUCTION:The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been diversely studied. Its role associated with tumor development has attracted attention just in recent years. However, little is known about its regulation and functions in the tumorigenesis and progression of lung cancer. MATERIALS AND METHODS:We did a pioneer study to identify the function of FoxD3 in lung cancer by knocking down FoxD3 expression in lung adenocarcinoma cell lines. RESULTS:The result showed that silencing FoxD3 in lung cancer cell lines stimulated cell growth and inhibited cell apoptosis. Through quantified PCR analysis, we observed marked gene expression increase of insulin-like growth factor receptor 1 and BRAF under the condition of FoxD3 silencing. In contrast, cell cycle negative regulator P21 expression decreased after FoxD3 silencing. CONCLUSIONS:Our study is the first to identify the tumor suppressor function of FoxD3 in lung cancer.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Wang C,Huang Y,Dai Wdoi
10.1007/s11845-015-1297-2subject
Has Abstractpub_date
2016-08-01 00:00:00pages
547-553issue
3eissn
0021-1265issn
1863-4362pii
10.1007/s11845-015-1297-2journal_volume
185pub_type
杂志文章abstract:BACKGROUND:Cell-based tissue engineering has emerged as a potential therapy for intervertebral disc degeneration. However, propagating and maintaining high quantity and quality of the seed cells remains a challenge. AIMS:To investigate the feasibility of culturing human disc cells using a microcarrier bioreactor syste...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0537-8
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:This study aimed to investigate the occurrence and predictive factors of restenosis in coronary heart disease (CHD) patients underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stent (SES). METHODS:Demographic data, clinical features, and laboratory tests of 398 CHD patients underwent ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02176-9
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Rubella is caused by the rubella virus, a single-stranded RNA virus of the Togaviridae family. The most severe complications of rubella in adult women occur during pregnancy when infection can lead to miscarriage, stillbirth or congenital rubella syndrome. Antenatal rubella susceptibility screening is no lon...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1722-9
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The magnitude of effects of lean mass and fat mass on bone health is controversial, and this study is a contribution to understand its effects on skeletal composition. AIM:We explored the relationship of body fat and muscle parameters with bone mineral density (BMD) and age and observed if it changed when m...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02177-8
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:The purpose of this study is to introduce peer teaching of communication skills to first-year anaesthesia trainees in Ireland and to evaluate their perception of this teaching modality. METHODS:Seventy-nine first-year anaesthesia trainees participated in a novel peer-led communication skills programme over a 2...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1637-5
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:A relationship may exist between body iron stores, endothelial dysfunction and overall cardiovascular risk. AIMS:To compare vascular compliance, biochemical endothelial function and antioxidant status between patients with homozygous hereditary haemochromatosis and healthy controls. METHODS:Haemochromatosi...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1010-2
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Internal iliac artery (IIA) embolisation is commonly performed prior to endovascular aneurysm repair (EVAR) of aortoiliac aneurysms to prevent type 2 endoleaks via the internal iliac arteries. The safety of this procedure is controversial due to the high incidence of pelvic ischaemic complications. METHODS:We ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1384-4
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:Doctors' continuing medical educational and professional development (CME and CPD) needs are known to be strongly influenced by national and local contextual characteristics. A crucial step in the development of effective education and training programmes is the assessment of learner needs. METHODS:A nati...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02047-y
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Congenital cytomegalovirus (CMV) infection is the most important infectious cause of central nervous system disease and hearing loss in children. AIMS:In this study, we aimed to investigate the role of maternal screening in early diagnosis of congenital infection in highly immune populations. METHODS:A tot...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1149-5
更新日期:2015-06-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0532-0
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Hemoglobin (HB) and red cell distribution width (RDW) are known to be prognostic in many cancer types. The HB-RDW ratio (HRR) is a new biomarker that has been shown to be predictive in some cancer types. However, the prognostic significance of HRR in patients with gastric cancer (GC) is unknown. AIMS:In thi...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02153-x
更新日期:2020-02-01 00:00:00
abstract::Quality of life of out-of-hospital cardiac arrest (OHCA) survivors is believed to be as important as a factor in resuscitation outcome as the survival rate. The aim of this investigation is to assess the quality of life outcomes of survivors of out-of- hospital cardiac arrest in the Munster region. OHCAR was used to i...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02189-4
更新日期:2020-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02939026
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND:Wound botulism occurs as a consequence of inoculation of Clostridium botulinum spores into a wound. AIM:To describe such a case of wound botulism. RESULTS:A 23-year-old drug-injecting user presented with bulbar symptoms and progressive signs over a three-day period. The diagnosis of botulism was suspected ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914502
更新日期:2003-07-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168937
更新日期:2002-01-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-016-1493-8
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION AND AIM:Various techniques have been proposed for the repair of abdominal wall defects (AWD) with varying rates of success. Despite the development of new materials and modifications of surgical technique, no single approach has emerged as the optimum way to close large AWD. We report a method for repairin...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0776-3
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:When worn external Hip Protectors (EHP) reduce hip fracture but poor compliance results in reduced efficacy. AIMS:We determined the compliance with EHP therapy among a group of elderly people attending a day hospital. METHODS:Forty-five patients or their care-givers were interviewed a mean (sd) 334 (150) d...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168519
更新日期:2005-01-01 00:00:00
abstract::A questionnaire survey was carried out to estimate activity levels in a sample of 784 men and women aged 35 to 64 years in County Kilkenny, Ireland. Men were more likely to have sedentary, heavy or very heavy work activity while the majority of women had moderate activity during an average day. Only a small minority o...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02950440
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The numbers of removals of patients from General Practitioner lists in Ireland is increasing and is a cause for some concern. AIMS:To examine the views of both general practitioners and patients toward removals of patients from general practitioner lists. METHODS:Questionnaire survey to general practitione...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0062-6
更新日期:2007-09-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02961666
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Vitamin D deficiency in pregnancy has important maternal and fetal implications, with increased risk of developing gestational diabetes, preeclampsia, preterm birth and small for gestational age birthweight. It is recommended that every pregnant woman should take 5 μg (200 IU) of vitamin D per day during pre...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1707-8
更新日期:2018-08-01 00:00:00
abstract::The management of patients with suspected post laparotomy intra-abdominal sepsis poses a major therapeutic challenge to clinicians. The mortality is high and the optimal interventional modality remains ill-defined. We define the incidence, diagnostic methodology, pre- and postoperative findings and outcome of patients...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944195
更新日期:1997-04-01 00:00:00
abstract::Laparoscopy has been described as being safe and effective in the diagnosis and treatment of Meckel's Diverticulum. We describe the use of laparoscopy in the diagnosis and resection of a Meckel's diverticulum in a 13 year old girl. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942803
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:In 1996, Irish accident and emergency (A&E) departments had approximately 1.2 million visits. General practitioners (GPs) have been shown to work efficiently in A&E. AIM:This study aimed to describe the current A&E structures in Ireland and the potential contribution of general practice. METHOD:Questionnai...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03173524
更新日期:2000-10-01 00:00:00
abstract:INTRODUCTION:The "National Integrated Medical Imaging System" or NIMIS went live in 2011 and allows the movement of patient radiology imaging throughout the Irish health system. At the time of its launch, NIMIS was not only going to allow the filmless passage of patient radiology imaging but it was also envisaged that ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1900-4
更新日期:2019-05-01 00:00:00
abstract:AIM:This study aimed to investigate the impact of the 2014 safety warnings on use of domperidone, on subsequent prescribing patterns in Ireland. METHODS:The Irish HSE-PCRS pharmacy claims database was used to identify the study cohort (aged 18+), prescribed domperidone from Jan 2014 to Oct 2015. Dosage was available f...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1657-1
更新日期:2018-05-01 00:00:00
abstract::The aim of this paper is to assess the adequacy of the diet of individuals over 60 yr of age, participating in the 1990 Irish National Nutritional Survey. A nationwide random sample based on the most recently updated electoral register was used. Demographic information was collected. Anthropometric measurements were t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944238
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:To analyze the capability of four-dimensional surface rendering mode ultrasound (4D SRM USG) in the detection of fetal abnormalities, and also compare it with 2D USG. MATERIALS AND METHODS:A total of 1,379 pregnant women were enrolled in the study, and they all underwent 2D USG screening. In the same session...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1184-2
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Sport-related concussion (SRC) is a potential issue within Gaelic Football. Therefore, it is essential that concussion management guidelines are adhered to. HYPOTHESIS/PURPOSE:The aim of this study is to determine if potential concussive events (PCEs) in the Gaelic Athletic Association (GAA) National Footba...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02390-5
更新日期:2020-09-30 00:00:00