Abstract:
:1. Rats were rendered hypoxic by maintaining them within silicone rubber membrane covered enclosures. In experiment one the inspired oxygen concentration was progressively reduced from 21 per cent to 7 per cent over a period of 13 days. In the second experiment the inspired oxygen was maintained at nine per cent for seven days. 2. The reticulocyte counts, haematocrit values and haemoglobin concentration of blood samples from control and hypoxic rats were measured. These results showed a significant increase in all three parameters in both experiments compared with the values from control rats. 3. The renin content of the kidneys of the rats was bioassayed by its hypertensive effect in bilaterally nephrectomised rats. There was no significant difference in renal renin content of the hypoxic rats of experiment one or two when compared with their controls. These results do not support the concept that the juxtaglomerular cell granule is a source of erythropoietin or its precursors in rats.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Bridges JB,Taylor ICdoi
10.1007/BF02939026subject
Has Abstractpub_date
1975-12-01 00:00:00pages
274-85issue
1eissn
0021-1265issn
1863-4362pii
10.1007/BF02939026journal_volume
144pub_type
杂志文章abstract:BACKGROUND:Assessment of non-cardiac chest pain places a considerable burden on healthcare resources. The current practice of serial electrocardiographs (ECGs), serum creatinine phosphokinase and by pre-discharge exercise electrocardiography gives an average in-hospital stay of 3.7 days. AIMS:This study assess the use...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167689
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Hereditary pancreatitis is an important cause of chronic pancreatitis, which may result in endocrine and exocrine failure. This may necessitate simultaneous pancreas and kidney transplant (SPK). Bladder drainage of the exocrine secretions may cause problems. AIM:To report one such case and its surgical corr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02915290
更新日期:2003-10-01 00:00:00
abstract::Analysis of the results of treatment of localised prostate cancer with radiation and surgery has identified patients who are at high risk of developing metastatic dissemination. High histologic grade, serum prostate specific antigen above 20 ng/ml, extension beyond the capsule of the prostate, and involvement of lymph...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937924
更新日期:1998-07-01 00:00:00
abstract:AIM:We report a case of a giant diverticulum of the sigmoid colon presenting as a mass in the left upper quadrant of the abdomen in an elderly man. METHODS:This report highlights a rare complication of diverticular disease. At operation, the giant cyst was situated in the supracolic compartment of the abdomen. The man...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0090-2
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Coeliac disease (CD) is more common in those with type 1 diabetes mellitus (T1DM) and may be asymptomatic despite the presence of intestinal histological changes. Optimal screening practice guidelines differ internationally. We undertook a retrospective audit to determine the efficacy of current scr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1831-0
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Our ability to maintain satisfactory levels of outcome after elective abdominal aortic aneurysm (AAA) surgery is increasingly strained by rising levels of co-morbidity in the presenting population. In this study we present a comparative outcome analysis of patients undergoing elective AAA surgery 18 months b...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169165
更新日期:2006-07-01 00:00:00
abstract:INTRODUCTION:We conducted a study at two main centres for paediatric surgery in the Republic of Ireland, Temple Street Children's University Hospital (TSCUH) and Our Lady's Children's Hospital Crumlin (OLCHC). AIM:The aim of the study was to assess doctors' opinions, frequency and methods of smartphone use in clinical...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1713-x
更新日期:2018-08-01 00:00:00
abstract:INTRODUCTION:Medullary carcinoma of the thyroid (MTC) is a rare tumour which occurs in both sporadic and hereditary forms. Mutations of the RET proto-oncogene have been identified in hereditary forms. The aim of our study was to confirm or exclude familial disease by examining for germline mutations in the RET proto-on...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937418
更新日期:1998-10-01 00:00:00
abstract:INTRODUCTION:The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been diversely studied. Its role associated with tumor development has attracted attention just in rece...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1297-2
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Although laparoscopic appendectomy (LA) is considered to be minimally invasive compared with open appendectomy (OA), there are few studies showing this in terms of cytokines and oxidative stress markers. AIM:LA and OA techniques have been compared in terms of different conditions such as operation time and ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02317-0
更新日期:2021-02-01 00:00:00
abstract::The case of a 27 month old male with a congenital midline nasal dermoid cyst is presented. The child attended the Ear, Nose and Throat outpatient's department in July 1995, with an external midline nasal swelling, which had been present at birth and was noted to be gradually increasing in size. Magnetic resonance imag...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02943594
更新日期:1997-07-01 00:00:00
abstract::A questionnaire survey was carried out to estimate activity levels in a sample of 784 men and women aged 35 to 64 years in County Kilkenny, Ireland. Men were more likely to have sedentary, heavy or very heavy work activity while the majority of women had moderate activity during an average day. Only a small minority o...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02950440
更新日期:1991-01-01 00:00:00
abstract:AIMS:Imported childhood malaria has never been studied in Ireland. We aimed to document the incidence and species of malaria in children presenting to paediatric hospitals in Dublin and to examine management and outcome measures. METHODS:Subjects were identified through laboratory archives from the three paediatric ho...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0343-3
更新日期:2009-09-01 00:00:00
abstract::DNA, extracted from tumours arising in 29 paediatric patients [14 neuroblastoma, 9 Wilms tumour (nephroblastoma), 6 miscellaneous] was investigated for evidence of N-myc amplification, using pNb-1, a recombinant plasmid containing a 1.0 Kb fragment homologous to the 5' end of the human N-myc gene. Within the neuroblas...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937236
更新日期:1990-06-01 00:00:00
abstract::In a prospective study designed to assess the effect of duration of antibiotic therapy on the helicobactericidal and ulcer healing efficacy of bismuth therapy, groups of patients, 10 in each group, with H. pylori-positive duodenal ulcer received a triple therapy regimen consisting of colloidal bismuth subcitrate 120 m...
journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
doi:10.1007/BF02939774
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Temporary ureteric stent insertion is an integral part of modern endo-urological practice. Delayed stent removal or forgotten stents are associated with increased patient morbidity and complications which are often difficult to manage. METHODS AND RESULTS:We prospectively audited our ureteric stent insertio...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0043-9
更新日期:2007-07-01 00:00:00
abstract::Previous studies have shown that up to 40 per cent of patients have symptoms after cholecystectomy or laparoscopic cholecystectomy (LC). There are concerns, however, that these symptoms reflect those of the general population and are not a specific post-operative phenomenon. Abdominal symptoms of 212 patients followin...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937544
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Tinnitus is a phenomenon that affects approximately 15% of the adult population. A minority of patients will experience chronic bothersome tinnitus that has a detrimental effect on their quality of life. Management of such tinnitus is challenging for healthcare practitioners. Primary care services are the fi...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02222-6
更新日期:2020-11-01 00:00:00
abstract::The evaluation of fetal health using ultrasound to establish a biophysical profile in the Rotunda Hospital in 1987 is reported. The corrected perinatal mortality rate fell from 10.0 in 1986 to 6.9 per 1,000 for babies over 500g and from 5.9 in 1986 to 3.4 for babies over 1,000g. This was achieved without significant a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02984636
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Whether developments in palliative care have impacted on where cancer patients die is unknown. We investigated time trends in place of death for colorectal cancer. METHODS:Details were abstracted on 10,175 colorectal cancer deaths during 1994-2004. Time trends were analysed by joinpoint regression. RESULTS...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0607-y
更新日期:2011-03-01 00:00:00
abstract::The management of breast cancer has evolved in the last 40 years to now encompass not only treating the cancer in the most effective way, but also to detect and treat cancers before they can pose a risk to patients. This evolution in therapy and diagnostics has moved away from treating patients with the maximum amount...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-014-1142-z
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:There is little known regarding how familiar parents are with the newborn bloodspot screening (NBS) test or how well parents of a child with a screen-detected condition understand that condition initially. AIM:The study aim was to examine parental NBS awareness and conditions screened. METHODS:Two studies ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1949-0
更新日期:2019-08-01 00:00:00
abstract::Nineteen patients underwent one stage surgical management of infected hip prostheses over a five year period. Thirteen were male and six were female. The mean age was 64 years (Range 49-82). The mean time interval between primary and revision surgery was 26 months (Range 6 months-16 years). One stage re-implantation w...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942793
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Anal ulceration is uncommon. Patients are typically referred because of severe anal pain, bleeding, discharge, and ulceration. It is important to exclude anal carcinoma, and to consider more unusual causes. METHODS:A 74-year-old lady presented with severe anal pain and ulceration. This was subsequently note...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169175
更新日期:2006-07-01 00:00:00
abstract::In 2006, Dutch authorities introduced a new health financing system of compulsory private for-profit insurance with strong government regulation. This system has recently attracted attention in Ireland. This paper assesses the theoretical arguments and evidence for applying the Dutch ideas to Ireland. In particular, t...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-009-0365-x
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The clinical spectrum of adult coeliac disease (ACD) is varied with limited Irish data. AIMS AND OBJECTIVES:The aim of this study was to analyse the presenting symptoms, associated conditions and complications in a consecutive series of patients with ACD. METHODS:Data were obtained from database on patient...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0788-z
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Cell-based tissue engineering has emerged as a potential therapy for intervertebral disc degeneration. However, propagating and maintaining high quantity and quality of the seed cells remains a challenge. AIMS:To investigate the feasibility of culturing human disc cells using a microcarrier bioreactor syste...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0537-8
更新日期:2010-12-01 00:00:00
abstract::Quality of life of out-of-hospital cardiac arrest (OHCA) survivors is believed to be as important as a factor in resuscitation outcome as the survival rate. The aim of this investigation is to assess the quality of life outcomes of survivors of out-of- hospital cardiac arrest in the Munster region. OHCAR was used to i...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02189-4
更新日期:2020-08-01 00:00:00
abstract::This study assessed the ability of biochemical tests and ultrasound to predict the presence of ductal calculi, and thereby refine the indications for ERCP, in patients before or after laparoscopic cholecystectomy. Thirteen of fifty-three patients investigated before laparoscopic cholecystectomy, and four of seventeen ...
journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
doi:10.1007/BF03022585
更新日期:1993-12-01 00:00:00
abstract:AIM:To examine the role of alcohol and alcohol-related cognitive impairment in the clinical presentation of adults in-patients less than 65 years who are 'hard to discharge' in a general hospital. METHOD:Retrospective medical file review of inpatients in CUH referred to the discharge coordinator between March and Sept...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0135-1
更新日期:2008-06-01 00:00:00