Abstract:
:Analysis of the results of treatment of localised prostate cancer with radiation and surgery has identified patients who are at high risk of developing metastatic dissemination. High histologic grade, serum prostate specific antigen above 20 ng/ml, extension beyond the capsule of the prostate, and involvement of lymph nodes are highly predictive of metastatic risk. Antiandrogen therapy has high rates of activity in the treatment of overt metastatic disease prompting its assessment as an adjuvant treatment added to radiation therapy. There are now major prospective randomized trials which have been completed. The current evidence indicates that a large survival benefit ensues when antiandrogen therapy is added to radiation for appropriately selected patients. This adjuvant approach is likely to become the standard of care. Strategies for further enhancement of adjuvant therapy are discussed.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Armstrong Jdoi
10.1007/BF02937924subject
Has Abstractpub_date
1998-07-01 00:00:00pages
138-44issue
3eissn
0021-1265issn
1863-4362journal_volume
167pub_type
杂志文章abstract:BACKGROUND:Patients' awareness of the increased cardiovascular risk associated with their diabetes is poorly documented. AIM:The aim of this study was to assess the awareness of diabetes complications among patients with diabetes in Ireland. METHODS:Patients attending diabetes outpatient clinics in two teaching hospi...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0301-0
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Dysphagia affects up to 30% of hospitalized patients, and it is associated with numerous complications. AIMS:Assess the impact of a 24/7 dysphagia screening protocol in an Internal Medicine Unit regarding respiratory complications (such as aspiration pneumonia) as the primary outcome. Length of stay and dis...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02371-8
更新日期:2020-09-22 00:00:00
abstract:INTRODUCTION:Recent reports show increased failure rates in hip resurfacings that display >10 % neck narrowing. The etiology of neck narrowing remains unknown. METHODS:We assessed 80 hip resurfacings at mean 3.5 years follow-up. RESULTS:The overall rate of significant narrowing was 11.25 %. Neck narrowing occurred in...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-012-0857-y
更新日期:2013-06-01 00:00:00
abstract::Changes in endothelial cell (EC) morphology occur at sites of physiological lymphocyte traffic and in areas of chronic inflammation. Previous studies have shown that EC shape changes also occur in vitro following exposure of EC monolayers to peripheral blood mononuclear cell (PBMC)-derived conditioned media (CM). In t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942828
更新日期:1994-08-01 00:00:00
abstract::von Willebrand's disease (vWD) is the commonest inherited bleeding disorder in man with an estimated incidence of 1 per thousand of the population. Acquired von Willebrand's disease (AvWD) is rare with less than 70 cases reported. AvWD is usually associated with autoimmune or clonal proliferation disorders and whilst ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937942
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To describe the relationship between parents with gender identity disorder (GID) and their child(ren) as described by the parent and to understand how being a parent affects transitioning from one gender to the other. METHODS:Fourteen parents with GID underwent a semi-structured interview and completed the I...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1003-1
更新日期:2014-06-01 00:00:00
abstract::Nineteen patients underwent one stage surgical management of infected hip prostheses over a five year period. Thirteen were male and six were female. The mean age was 64 years (Range 49-82). The mean time interval between primary and revision surgery was 26 months (Range 6 months-16 years). One stage re-implantation w...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942793
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To investigate whether topical application of hesperin affords protection to Balb/C mice epidermis from UVB-induced cyclobutane pyrimidine dimers (CPDs). METHODS:A DNA damage model of UVB irradiation-induced mice epidermis was established. The immunohistochemical staining and southwestern dot blotting were use...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0503-5
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Pain is one of the primary motivations for patients to seek medical advice. Pain location is one element in the process of formulating a diagnosis. AIMS:The purpose of the study is to determine if there is a correlation between the location of pain and the location of pathology in the knees of patients with...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-0965-3
更新日期:2014-03-01 00:00:00
abstract::The aim of this study is to investigate David Healy's hypothesis that the development of weighing technologies significantly contributes to the development of anorexia nervosa. A newly developed questionnaire and the EAT-26 were used to investigate these ideas. The key results from this study are that a positive corre...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1047-2
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Gaming is a growing area and there are conflicting reports on its harms and benefits. There is also increasing interest in the use of gaming clinically. AIMS:This research aims to enhance our understanding of video and smartphone game use, and perceptions, among outpatients attending an Irish general adult ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02016-5
更新日期:2019-11-01 00:00:00
abstract::In a prospective study designed to assess the effect of duration of antibiotic therapy on the helicobactericidal and ulcer healing efficacy of bismuth therapy, groups of patients, 10 in each group, with H. pylori-positive duodenal ulcer received a triple therapy regimen consisting of colloidal bismuth subcitrate 120 m...
journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
doi:10.1007/BF02939774
更新日期:1997-01-01 00:00:00
abstract::Early Warning Systems (EWS) track the physiological parameters of individual patients and trigger a response when the parameter threshold has been reached. The use of early warning scores in adult hospital medicine has been shown to be beneficial in facilitating the early recognition of the deteriorating patient, ther...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-019-02028-1
更新日期:2020-02-01 00:00:00
abstract::Liver failure resulting from deliberate or accidental paracetamol overdose continues to be an important reason for referral to liver transplant centres. Severe hepatic dysfunction often appears 72-96 h after overdose. Liver injury can be prevented by timely administration of the specific antidote, N-acetylcysteine. Un...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0783-4
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Chronic anal fissures (CAF) are caused by anal sphincter hypertonia leading to an ischaemic ulcer. By inducing temporary sphincter relaxation, botulinum toxin (Botox) injection has been shown to heal CAF in approximately 73-96% of cases in clinical trials. AIM:This study looks at the efficacy of Botox clini...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914547
更新日期:2004-10-01 00:00:00
abstract::Advocates of transhiatal oesophagectomy warn of the danger of tracheal injury resulting from the blind dissection of tumours of the upper and middle thirds of the oesophagus when the tumour has invaded the membranous part of the trachea. We report an unusual cause of tracheal injury at transhiatal oesophagectomy due t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02947266
更新日期:1991-03-01 00:00:00
abstract:AIMS:Imported childhood malaria has never been studied in Ireland. We aimed to document the incidence and species of malaria in children presenting to paediatric hospitals in Dublin and to examine management and outcome measures. METHODS:Subjects were identified through laboratory archives from the three paediatric ho...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0343-3
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Congenital cytomegalovirus (CMV) infection is the most important infectious cause of central nervous system disease and hearing loss in children. AIMS:In this study, we aimed to investigate the role of maternal screening in early diagnosis of congenital infection in highly immune populations. METHODS:A tot...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1149-5
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:The impact of a change in service delivery in a psychogeriatric service, moving from a consultation model to liaison model of care, was examined in a naturalistic study. METHODS:The study period was divided into two phases, defined by the change in service delivery. The impact of the change on (1) referral r...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02470-6
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:The regulatory body responsible for the registration of Irish pre-hospital practitioners, the Pre-Hospital Emergency Care Council (PHECC), identified the need to implement a continuing professional competence (CPC) framework. The first cycle of CPC (focused on emergency medical technicians) commenced in Nove...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-016-1412-z
更新日期:2016-05-01 00:00:00
abstract::Reproductive surrogacy can be altruistic or commercial, each with complex ethical considerations that are complicated by heterogeneity in governing laws across jurisdictions. Surrogacy in Ireland is relatively new and largely unregulated, so this review aims to elucidate its current regulatory status and associated et...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-020-02402-4
更新日期:2020-10-31 00:00:00
abstract:OBJECTIVE:Evaluate condylar, ramal, and condylar plus ramal vertical mandibular asymmetry in patients with unilateral posterior crossbite (UPCB) and in patients with unilateral cleft lip and palate (UCLP) compared with subjects having normal occlusion. DESIGN:This cross-sectional study evaluated panoramic radiographs ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1020-0
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:Charles Lucas, apothecary, physician and MP, was instrumental in facilitating legislation in Ireland in 1765 that established a nationwide network of hospitals in Ireland. This legislation was unique in contemporary Europe, and by the end of the century, there was a hospital in every county in the country....
journal_title:Irish journal of medical science
pub_type: 传,历史文章,杂志文章
doi:10.1007/s11845-015-1255-z
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:The magnitude of effects of lean mass and fat mass on bone health is controversial, and this study is a contribution to understand its effects on skeletal composition. AIM:We explored the relationship of body fat and muscle parameters with bone mineral density (BMD) and age and observed if it changed when m...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02177-8
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes. METHODS:A 79-year-old lady presented with frequent episodes of torsade de pointes following commencement of clari...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0057-3
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Our ability to maintain satisfactory levels of outcome after elective abdominal aortic aneurysm (AAA) surgery is increasingly strained by rising levels of co-morbidity in the presenting population. In this study we present a comparative outcome analysis of patients undergoing elective AAA surgery 18 months b...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169165
更新日期:2006-07-01 00:00:00
abstract:INTRODUCTION:Medullary carcinoma of the thyroid (MTC) is a rare tumour which occurs in both sporadic and hereditary forms. Mutations of the RET proto-oncogene have been identified in hereditary forms. The aim of our study was to confirm or exclude familial disease by examining for germline mutations in the RET proto-on...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937418
更新日期:1998-10-01 00:00:00
abstract::Susceptibility to metronidazole of 213 clinical strains of H. pylori from dyspeptic patients was determined by a plate dilution method. Seventy two (33.8%) of the strains were resistant to metronidazole (MIC > 8 mg/L), 20 of these were from 24 patients who had received previously metronidazole (83.3%), giving a primar...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942098
更新日期:1993-03-01 00:00:00
abstract:INTRODUCTION:2013 is the tercentenary of the death of Sir Patrick Dun. When Dun died in 1713, he left the proceeds of his estate to enhance medical education in Dublin by funding chairs in medicine. He showed remarkable innovation, but it took 95 years, five Acts of Parliament, two House of Commons enquiries and a Hous...
journal_title:Irish journal of medical science
pub_type: 传,历史文章,杂志文章
doi:10.1007/s11845-014-1082-7
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Hypertension (HT) is a disease associated with endothelial dysfunction which is related to some adipokines and pro- and anti-inflammatory cytokines. AIMS:Our aim was to investigate roles of apelin, omentin-1, and vaspin in essential HT and to evaluate their relationships with other pro- and anti-inflammator...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02272-w
更新日期:2021-02-01 00:00:00