Abstract:
BACKGROUND:Hemoglobin (HB) and red cell distribution width (RDW) are known to be prognostic in many cancer types. The HB-RDW ratio (HRR) is a new biomarker that has been shown to be predictive in some cancer types. However, the prognostic significance of HRR in patients with gastric cancer (GC) is unknown. AIMS:In this study, we aimed to demonstrate the prognostic importance of HRR in GC patients treated with neoadjuvant fluorouracil, leucovorin, oxaliplatin, docetaxel (FLOT). METHODS:Eighty-five GC patients who were treated with neoadjuvant FLOT in our center were included in the study, retrospectively. Associations between clinical and histopathological parameters with disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier curves and compared by the log-rank test. The optimal cutoff values were determined by a receiver operating characteristic (ROC) curve analysis. Neutrophil-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and HRR were grouped based on a cutoff points 3.05, 802, and 0.89, respectively. Univariate and multivariate analyses were used to assess their prognostic values for DFS and OS. RESULTS:Low NLR, low SII, and high HRR were found to be associated with longer DFS/OS. In univariate analysis, Eastern Cooperative Oncology Group performance status, grade, stage, response to neoadjuvant treatment, NLR, SII, and HRR were found to be significantly associated with DFS and OS. But in multivariate analysis, only HRR was demonstrated as an independent prognostic factor for DFS/OS (p 0.001, p 0.037, respectively). CONCLUSIONS:HRR is a new biomarker that can predict DFS and OS in GC patients treated with neoadjuvant FLOT.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Yılmaz A,Mirili C,Tekin SB,Bilici Mdoi
10.1007/s11845-019-02153-xsubject
Has Abstractpub_date
2020-02-01 00:00:00pages
91-102issue
1eissn
0021-1265issn
1863-4362pii
10.1007/s11845-019-02153-xjournal_volume
189pub_type
杂志文章abstract:BACKGROUND:Since their original description in 1687, aneurysms of the extracranial internal carotid artery (ICA) remain rare and account for less than 2% of all carotid operations (Zwolak et al. in: J Vasc Surg 1:415-422, 1984; El-Sabrout, Cooley in: J Vasc Surg 31:702-712, 2000). Cerebrovascular morbidity and mortalit...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-009-0353-1
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND/AIMS:To describe the epidemiology, outcomes, and prognostic factors of intraocular foreign body (IOFB) injuries at a tertiary ophthalmic referral centre in Cork University Hospital, Ireland. METHODS:A retrospective review of 23 eyes with IOFB that presented to Cork University Hospital (CUH) from January 200...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02443-9
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Surgery for perforated peptic ulcer disease is one of the most common emergency procedures carried out in the western world. The role of postoperative empiric Helicobacter Pylori eradication therapy is controversial. METHODS:The clinical, operative and postoperative surveillance details of 84 consecutive pa...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167950
更新日期:2006-04-01 00:00:00
abstract:AIM:This study aimed to investigate the impact of the 2014 safety warnings on use of domperidone, on subsequent prescribing patterns in Ireland. METHODS:The Irish HSE-PCRS pharmacy claims database was used to identify the study cohort (aged 18+), prescribed domperidone from Jan 2014 to Oct 2015. Dosage was available f...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1657-1
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Warfarin is the mainstay of anticoagulation therapy worldwide. CYP2C9 and VKORC1 are two major genetic factors associated with inter-individual and inter-ethnic variability in the warfarin dose. AIM:This study aims to assess the impact of VKORC1-1639G>A polymorphism and the most common CYP2C9 variant allele...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-0978-y
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Low birth weight (LBW) is a leading cause of infant mortality and morbidity, and a specific risk for the development of neuro-developmental and academic problems. AIM:To examine the medical, cognitive and academic outcomes of VLBW (<1,500 g) children, born in one maternity hospital in Dublin between 1995 an...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1040-9
更新日期:2014-12-01 00:00:00
abstract::Percutaneous tracheostomy (PCT) facilitates easy, bedside insertion of a tracheostomy tube. The percutaneous approach to tracheostomy is used in some parts of the world. This is the first report of a PCT method, in Ireland. The percutaneous technique appears to have advantages over conventional, surgical tracheostomy....
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02996321
更新日期:1993-10-01 00:00:00
abstract:INTRODUCTION:Childhood obesity is associated with increased risk of adult obesity, cardiovascular disease, diabetes and cancer. Appropriate techniques for assessment of childhood adiposity are required to identify children at risk. The aim of this review was to examine core clinical measurements and more technical tool...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-014-1124-1
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Intravenous drug misuse, principally heroin, occurs primarily in the Greater Dublin area. Methadone maintenance treatment has been an important part of the response to opiate misuse in Dublin since 1992. AIMS:To determine the number of opiate-related deaths in Dublin City and County during 1999, to establis...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167718
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Cell-based tissue engineering has emerged as a potential therapy for intervertebral disc degeneration. However, propagating and maintaining high quantity and quality of the seed cells remains a challenge. AIMS:To investigate the feasibility of culturing human disc cells using a microcarrier bioreactor syste...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0537-8
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Although screw breakage or loosening are rarely encountered, they were reported to occur after instability of the internal fixation. METHODS:A man with a history of traumatic pelvic fracture 6 months ago presented to our clinic with inability to void. An anterior urethral meatotomy was made and a calcified ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0232-1
更新日期:2010-09-01 00:00:00
abstract::Ninety-nine inguinal herniorrhaphies were performed under local anaesthetic blockade between 1980 and 1988. This represents 32% of this surgical teams herniorrhaphy operations. A follow-up interview was possible in 82 patients. Satisfaction was expressed by 77 patient (94%) although six of the interviewed patients (7....
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942128
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVE:Evaluate condylar, ramal, and condylar plus ramal vertical mandibular asymmetry in patients with unilateral posterior crossbite (UPCB) and in patients with unilateral cleft lip and palate (UCLP) compared with subjects having normal occlusion. DESIGN:This cross-sectional study evaluated panoramic radiographs ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-1020-0
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Sport-related concussion (SRC) is a potential issue within Gaelic Football. Therefore, it is essential that concussion management guidelines are adhered to. HYPOTHESIS/PURPOSE:The aim of this study is to determine if potential concussive events (PCEs) in the Gaelic Athletic Association (GAA) National Footba...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02390-5
更新日期:2020-09-30 00:00:00
abstract:BACKGROUND:Circumcision is one of the world's most common operations. Series describing a new technique involving the use of fibrin-based glue have become more apparent in the literature. Here we outline the first 100 such cases for 62 children and 38 adults in our practice describing complications and learning curve. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0545-8
更新日期:2011-03-01 00:00:00
abstract::Self-instruction programmes comprise audio tapes and a variety of visual materials ranging from photographs to models. The use of such programmes in an anatomy course is described and illustrated. They are an effective ancillary in teaching and are applicable to other medical teaching disciplines. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02938052
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:The Structure of Irish General Practice over 23 years was the third in a series of national studies that examined the development of general practice in 1982, 1992, and 2005. AIMS:This study analysed specific data from the 2005 survey to determine the types of services offered by GPs, and to examine the cha...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0006-1
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:There is increasing concern that the use of second-generation antipsychotic medications in schizophrenia is associated with the development of metabolic syndrome. AIMS:This study assessed the prevalence and clinical associations of metabolic syndrome among patients receiving clozapine within the catchment a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0156-9
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:When worn external Hip Protectors (EHP) reduce hip fracture but poor compliance results in reduced efficacy. AIMS:We determined the compliance with EHP therapy among a group of elderly people attending a day hospital. METHODS:Forty-five patients or their care-givers were interviewed a mean (sd) 334 (150) d...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168519
更新日期:2005-01-01 00:00:00
abstract::The establishment of the Dublin Hospitals Initiative and the Efficiency Review Group as first steps in an "action" plan was based on the report in 1989 of the Commission of Health Funding which suggested that "the solution to the problem facing the Irish health services...(lies) primarily...in the way that services ar...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02973395
更新日期:1991-08-01 00:00:00
abstract::All the biopsies of pulmonary mass lesions obtained by percutaneous needle aspiration over a seven year period were reviewed. Emphasis is laid upon the differences in cell typing of malignant tumours when two types of preparation of the same tissue, cytological smears and tissue sections are examined. Some problems in...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942112
更新日期:1989-04-01 00:00:00
abstract:PURPOSE:Recombinant parathyroid hormone (rPTH) increases bone mineral density (BMD). However, certain other potential effects of rPTH remain to be studied. The aim of this study is to identify whether bone turnover markers, relevant biochemical parameters or total body fat and muscle composition affect the response to ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1875-1
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Acute scrotal pain is a common urological emergency. Urgent exploration is the standard means of management, as no investigation can confidently exclude torsion of testis from the differential diagnoses. In our department, all patients up to the age of 40 years, presenting with acute scrotal pain undergo eme...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03173885
更新日期:2001-07-01 00:00:00
abstract::Approximately one-third of patients with Crohn's disease have a distinct fibrostenosing phenotype predisposing them to recurrent intestinal stricture formation. The intestinal fibroblast was thought to play a critical role in the abnormal wound healing which ends in stricture formation. Recognising this, a laboratory-...
journal_title:Irish journal of medical science
pub_type: 传,历史文章,杂志文章,评审
doi:10.1007/s11845-018-1850-x
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:With the increasing incidence of breast cancer in patients over 70 years, there is interest in the best therapeutic approach. AIMS:To review the management of breast cancer in elderly women and to identify the factors involved in the decision to treat patients with tamoxifen as first line therapy. PATIENTS...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168937
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Eclampsia is rare in molar pregnancy. Sudden cortical blindness in eclampsia is an uncommon but very dramatic experience for the patient. Because of its rarity, blindness associated with eclampsia may pose a significant problem for the obstetrician. CASE REPORT:We describe cortical blindness and posterior r...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0370-0
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Little is known about the economic impact of diabetic foot ulceration in the Irish healthcare setting. AIM:Audit of diabetic foot ulcer admissions in St James's Hospital between April 2001 and March 2002. METHODS:Hospital charts were reviewed and costs were calculated on the length of patients' hospital st...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914564
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:While considerable changes are happening in primary care in Ireland and considerable potential exists in intelligence derived from practice-based data to inform these changes, relatively few large-scale general morbidity surveys have been published. AIMS:To examine the most common reasons why people attend ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1367-5
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Solitary adenomas have been shown to be responsible for almost 90% of cases of primary hyperparathyroidism. AIM:The purpose of this study was to determine the utility of sestamibi scanning pre-operatively to guide minimally invasive video-assisted (MIVA) parathyroidectomy. METHODS:We reviewed 40 patients w...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0075-1
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Surveillance of Clostridium difficile infection (CDI) is an essential component of a CDI preventative programme. AIMS:The aim of this study was to evaluate two methods of CDI surveillance. METHODS:Prevalence of CDI, antibiotic use and associated co-morbidity was assessed weekly on two wards over 6 weeks. I...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0798-x
更新日期:2012-09-01 00:00:00