Abstract：
BACKGROUND:With the increasing incidence of breast cancer in patients over 70 years, there is interest in the best therapeutic approach. AIMS:To review the management of breast cancer in elderly women and to identify the factors involved in the decision to treat patients with tamoxifen as first line therapy. PATIENTS AND METHODS:Between 1986 and 1999, 302 female patients aged > or = 70 years presented with primary breast cancer, of whom 219 underwent surgery, 79 received tamoxifen as first line treatment and four received primary radiotherapy. A retrospective review was performed on these 79 patients and the outcome recorded. RESULTS:Of these 79 patients, data was available on 68. Follow-up ranged from one to 63 months (median 17 months). Co-morbidity was the principal reason for choosing first line tamoxifen therapy in 61% and patient preference in 11%. Tumour size was less than 5cm in 51%. In 25% tumour size decreased, in 24% it remained stable and in 27% it increased in size following tamoxifen therapy. Additional treatment was prescribed for 33% of patients. CONCLUSION:In the authors' experience, for those elderly patients suffering considerable co-morbidity or who refuse surgical intervention, tamoxifen is an acceptable alternative.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Hooper SB,Hill AD,Kennedy S,Dijkstra B,Kelly LM,McDermott EW,O'Higgins Ndoi
10.1007/BF03168937keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
28-30issue
1eissn
0021-1265issn
1863-4362journal_volume
171pub_type
杂志文章abstract：:Nasal intermittent positive pressure ventilation (NIPPV) represents a major advance in the management of respiratory failure. While its role in chronic respiratory failure is well documented, its use in acute respiratory failure is less well defined. We studied four patients with respiratory failure due to kyphoscolio...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02968110
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION:Pituitary tuberculosis is an uncommon cause of sellar mass [1]; the estimated prevalence worldwide is not known, and there have been no reports of the condition occurring in Ireland. Tuberculosis of the pituitary gland may present as a sellar mass or with symptoms of hypopituitarism. CASE PRESENTATION:A 4...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-017-1654-4
更新日期：2018-05-01 00:00:00
abstract：INTRODUCTION:Recent implementation of the European Working Time Directive in Ireland has resulted in a change from thetraditional model of patient care to a system characterised by shift work among clinicians. Effective handover ofpatient information is essential for transfer of responsibility between clinicians and ma...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1675-z
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The majority of patients presenting with oesophageal cancer have symptoms for more than three months and advanced disease at presentation. Most appear unaware of the significance of dysphagia as a symptom. Cancer awareness programmes focus on symptoms such as lumps and bleeding. AIM:To sample the level of p...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03167788
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:Understanding the impact of a publication by using bibliometric indices becomes an essential activity not only for universities and research institutes but also for individual academicians. This paper aims to provide a brief review of the current bibliometric tools used by authors and editors and proposes an...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-018-1936-5
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Attitudes have been shown to be important determinants of the quality and efficacy of medical care. There is little research on the education about, and assessment of, attitudes in undergraduate medical education. AIM:To describe the design and delivery of an attitude awareness workshop, and the associated ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03170282
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:In the last decades, the studies performed on the field of endothelial dysfunction confirmed the fact that the starting point of this pathology is the inflammation. Several inflammatory biomarkers had been discovered and studied, ones showing systemic inflammation, and others being more specific biomarkers a...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1580-5
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Venipuncture is one of the most painful events for children in hospitals. Valsalva maneuver (VM) decreases the incidence and severity of pain on venipuncture pain in adults. This study was designed to evaluate VM as compared with Eutectic Mixture of Local Anesthetic (EMLA(®)) cream for venipuncture pain in c...
journal_title：Irish journal of medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11845-013-1037-4
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:There have been many changes in number and place of trocars that have been described, since the first laparoscopic cholecystectomy (LC), but, in fact, all authors agree that laparoscopic procedure is accepted as gold standard. However, four trocars use in standard laparoscopic cholecystectomy, it has been ar...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-016-1493-8
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:To describe the relationship between parents with gender identity disorder (GID) and their child(ren) as described by the parent and to understand how being a parent affects transitioning from one gender to the other. METHODS:Fourteen parents with GID underwent a semi-structured interview and completed the I...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1003-1
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:The recent introduction of the General Data Protection Regulation and Health Research Regulations has been an area of significant concern for those engaged in clinical research. These European regulations, following subsequent interpretation by Ireland's Department of Health, now place Ireland in a unique po...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-019-01980-2
更新日期：2019-11-01 00:00:00
abstract：AIMS:The purpose of this study was to review indications, source of haemorrhage, method of embolisation and clinical outcome in patients referred to Interventional Radiology for the emergency management of acute arterial haemorrhage. METHODS:Retrospective review of patients undergoing emergency percutaneous embolisati...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0400-y
更新日期：2010-09-01 00:00:00
abstract：:It is widely acknowledged that there is interplay between physical and mental health, with causality in both directions. A common theme across countries is the uncertainty surrounding who should act as gatekeeper for physical health matters in psychiatry. Much of the metabolic monitoring is carried out by psychiatrist...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-014-1205-1
更新日期：2015-03-01 00:00:00
abstract：:Direct Antibiotic Sensitivity Testing (DST) is a rapid means of diagnosing urinary tract infection (UTI) and obtaining antibiotic sensitivity patterns of the infecting organisms. In this study 227 urine samples from general practice were analysed using this technique with those obtained using the standard laboratory m...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02937439
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Of over 20 different scoring systems to evaluate outcome following calcaneal fracture, the Maryland Foot Score has broad current acceptance. A general health survey, the Short Form 36 (SF 36) has also been used. AIMS:The study compared two scoring systems for assessing the outcome of open reduction and inte...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03166916
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Temporary ureteric stent insertion is an integral part of modern endo-urological practice. Delayed stent removal or forgotten stents are associated with increased patient morbidity and complications which are often difficult to manage. METHODS AND RESULTS:We prospectively audited our ureteric stent insertio...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-007-0043-9
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Tinnitus is a phenomenon that affects approximately 15% of the adult population. A minority of patients will experience chronic bothersome tinnitus that has a detrimental effect on their quality of life. Management of such tinnitus is challenging for healthcare practitioners. Primary care services are the fi...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02222-6
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Little is known about the economic impact of diabetic foot ulceration in the Irish healthcare setting. AIM:Audit of diabetic foot ulcer admissions in St James's Hospital between April 2001 and March 2002. METHODS:Hospital charts were reviewed and costs were calculated on the length of patients' hospital st...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02914564
更新日期：2004-04-01 00:00:00
abstract：:Menorrhagia affects 20-30% of healthy women, many of whom undergo hysterectomy. In recent years, transcervical resection of the endometrium (TCRE) has become an alternative surgical option. This observational study assesses patient satisfaction following TCRE. The case notes of 55 patients who had a TCRE in the Coombe...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02940244
更新日期：1996-07-01 00:00:00
abstract：:Early Warning Systems (EWS) track the physiological parameters of individual patients and trigger a response when the parameter threshold has been reached. The use of early warning scores in adult hospital medicine has been shown to be beneficial in facilitating the early recognition of the deteriorating patient, ther...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-019-02028-1
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Cognitive impairment (CI) is common in multiple sclerosis (MS), including newly diagnosed MS, where it is particularly underrecognised. Determining the presence of CI in the outpatient clinic often relies on patient-reported complaints, with limited time and resources in this setting. Prior studies have show...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02404-2
更新日期：2020-10-27 00:00:00
abstract：BACKGROUND:Injecting drug use is associated with increased morbidity and mortality. This is the first longitudinal study of a community-based population of injecting drug users (IDUs) in the Republic of Ireland. AIM:To establish the natural history of IDUs in a deprived Dublin community. METHODS:Eighty-two IDUs (hero...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-012-0814-9
更新日期：2012-12-01 00:00:00
abstract：:Sudden Infant Death Syndrome (SIDS) is any death occurring in an infant or young child which is unexpected by history and in which a thorough post mortem examination fails to demonstrate an adequate cause of death. The National Sudden Infant Death Register collects information on all sudden unexpected deaths in infant...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02944347
更新日期：1999-10-01 00:00:00
abstract：INTRODUCTION:Childhood obesity is associated with increased risk of adult obesity, cardiovascular disease, diabetes and cancer. Appropriate techniques for assessment of childhood adiposity are required to identify children at risk. The aim of this review was to examine core clinical measurements and more technical tool...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-014-1124-1
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:A congenital diaphragmatic hernia (Bochdalek's hernia) rarely presents in adulthood. CASE PRESENTATION:We present the case of a 21-year-old woman with thrombocytopenia secondary to hypersplenism due to left-sided (sinistral) portal hypertension. This portal hypertension was caused by strangulation of the sp...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0140-4
更新日期：2009-03-01 00:00:00
abstract：INTRODUCTION:Charles Lucas, apothecary, physician and MP, was instrumental in facilitating legislation in Ireland in 1765 that established a nationwide network of hospitals in Ireland. This legislation was unique in contemporary Europe, and by the end of the century, there was a hospital in every county in the country....
journal_title：Irish journal of medical science
pub_type： 传,历史文章,杂志文章
doi：10.1007/s11845-015-1255-z
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Patients' awareness of the increased cardiovascular risk associated with their diabetes is poorly documented. AIM:The aim of this study was to assess the awareness of diabetes complications among patients with diabetes in Ireland. METHODS:Patients attending diabetes outpatient clinics in two teaching hospi...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0301-0
更新日期：2009-12-01 00:00:00
abstract：AIM:This study aimed to investigate the impact of the 2014 safety warnings on use of domperidone, on subsequent prescribing patterns in Ireland. METHODS:The Irish HSE-PCRS pharmacy claims database was used to identify the study cohort (aged 18+), prescribed domperidone from Jan 2014 to Oct 2015. Dosage was available f...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1657-1
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Congenital cytomegalovirus (CMV) infection is the most important infectious cause of central nervous system disease and hearing loss in children. AIMS:In this study, we aimed to investigate the role of maternal screening in early diagnosis of congenital infection in highly immune populations. METHODS:A tot...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-014-1149-5
更新日期：2015-06-01 00:00:00
abstract：:Quality of life of out-of-hospital cardiac arrest (OHCA) survivors is believed to be as important as a factor in resuscitation outcome as the survival rate. The aim of this investigation is to assess the quality of life outcomes of survivors of out-of- hospital cardiac arrest in the Munster region. OHCAR was used to i...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02189-4
更新日期：2020-08-01 00:00:00
