Abstract：
BACKGROUND:Surveillance of Clostridium difficile infection (CDI) is an essential component of a CDI preventative programme. AIMS:The aim of this study was to evaluate two methods of CDI surveillance. METHODS:Prevalence of CDI, antibiotic use and associated co-morbidity was assessed weekly on two wards over 6 weeks. In addition, CDI incidence surveillance was performed on all new CDI cases over a 13-week period. Cases were assessed for CDI risk factors, disease severity, response to treatment and outcome at 6 months. RESULTS:Clostridium difficile infection prevalence was 3.5% (range 2.9-6.1%) on the medical ward and 1.1% (range 0-3.5%) on the surgical ward. Patients on the medical ward were older and more likely to be colonised with MRSA; however, recent antibiotic use was more prevalent among surgical patients. Sixty-one new CDI cases were audited. Patients were elderly (mean age 71 years) with significant co-morbidity (median age adjusted Charlson co-morbidity score 5). CDI ribotypes included 027 (29 cases) 078 (5) and 106 (4). Eight patients developed severe CDI, seven due to 027. Antibiotic use was common with 56% receiving three or more antibiotics in the preceding 8 weeks. Twenty-four patients had died at 6 months, five due to CDI. CONCLUSION:Clostridium difficile infection prevalence gives a broad overview of CDI and points to areas that require more detailed surveillance and requires little time. However, patient-based CDI incidence surveillance provides a more useful analysis of CDI risk factors, disease and outcome for planning preventative programmes and focusing antibiotic stewardship efforts.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Lavan AH,McCartan DP,Downes MM,Hill AD,Fitzpatrick Fdoi
10.1007/s11845-011-0798-xsubject
Has Abstractpub_date
2012-09-01 00:00:00pages
315-20issue
3eissn
0021-1265issn
1863-4362journal_volume
181pub_type
杂志文章abstract：INTRODUCTION:The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been diversely studied. Its role associated with tumor development has attracted attention just in rece...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-015-1297-2
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is associated with variable predisposing risk factors including preeclampsia and eclampsia since it proposed. However, studies of large case series focusing on pregnancy-related PRES are still limited. We performed a large retrospective study of patients wi...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1567-2
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Among many factors predisposing to monosymptomatic enuresis (MNE) disturbances in urinary electrolites excretion play an important role. Because of many controversies in this field there is a need to debate the role of hypercalciuria in MNE. The aim of our study was to determine the urinary calcium in childr...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-014-1217-x
更新日期：2015-12-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-015-1384-4
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Assess the association between the Society for Vascular Surgery/American Association for Vascular Surgery (SVS/AVSS) (Rutherford et al., J Vasc Surg 26: 517-38, 1997; Chaikof et al., J Vasc Surg 35:1061-6, 2002) medical comorbidity scoring scheme (MCS), and the global scoring system (GS) and major m...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-019-02160-y
更新日期：2020-08-01 00:00:00
abstract：:Susceptibility to metronidazole of 213 clinical strains of H. pylori from dyspeptic patients was determined by a plate dilution method. Seventy two (33.8%) of the strains were resistant to metronidazole (MIC > 8 mg/L), 20 of these were from 24 patients who had received previously metronidazole (83.3%), giving a primar...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02942098
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Wound botulism occurs as a consequence of inoculation of Clostridium botulinum spores into a wound. AIM:To describe such a case of wound botulism. RESULTS:A 23-year-old drug-injecting user presented with bulbar symptoms and progressive signs over a three-day period. The diagnosis of botulism was suspected ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02914502
更新日期：2003-07-01 00:00:00
abstract：:We assessed the long term efficacy of Novopen as a form of insulin administration. Records were obtained on 48 patients who were treated with Novopen between January '86 and October '88. Six patients were excluded due to insufficient data. The study group of 42 patients comprised 22 females and 20 males of average age...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02948414
更新日期：1991-09-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0171-x
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND AND AIMS:Coeliac disease (CD) is more common in those with type 1 diabetes mellitus (T1DM) and may be asymptomatic despite the presence of intestinal histological changes. Optimal screening practice guidelines differ internationally. We undertook a retrospective audit to determine the efficacy of current scr...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1831-0
更新日期：2019-02-01 00:00:00
abstract：INTRODUCTION:Prostate cancer cells can switch from an androgen-dependent state to an androgen-independent state after a continuous androgen ablation therapy. However, the molecular mechanisms underlying this switch are still unclear. Therefore, we explored the change in androgen receptor (AR)-related gene expression du...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-011-0714-4
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:The case report is the cornerstone of both medical teaching and writing. However, during recent years the value of the case report has been questioned, so much so that it has been abandoned by many journals. The aim of this study was to assess case reports published by the Irish Journal of Medical Science ...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-010-0649-1
更新日期：2011-06-01 00:00:00
abstract：:The improved survival of cystic fibrosis (CF) patients is partly due to intensive treatment for their chronic infections. Treatment usually includes intravenous and nebulised aminoglycoside antibiotics and they receive a large cumulative dose of these antibiotics over their lifetime. There is little information in the...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02961666
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:It has been recognised for some time that mortality rates vary across social class groups, with lower rates in the higher social classes. Internationally, but particularly in Ireland, many studies on the topic of inequalities in mortality have been confined to men, partly because the most frequently used soc...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-014-1189-x
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Nearly half of the Irish population is covered by private health insurance. In recent years, premium inflation has been significantly ahead of overall inflation and has been accelerating. This has contributing to a drop in the numbers insured since the peak in 2008. The fall in the numbers with private healt...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-013-0929-7
更新日期：2013-12-01 00:00:00
abstract：INTRODUCTION:Surgical site infection (SSI) is one of the main causes of postoperative morbidity and mortality. Appendectomy for acute appendicitis is one of the most commonly performed surgical interventions worldwide. The use of ring retractors to protect the wound edge from contaminated intra-abdominal contents may b...
journal_title：Irish journal of medical science
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11845-015-1381-7
更新日期：2016-02-01 00:00:00
abstract：:A ten year review (1980-1989) of 59 neonates presenting with congenital diaphragmatic hernia (CDH) to Our Lady's Hospital for Sick Children, the main referral centre for neonatal surgery in Ireland, is presented to determine the outcome and make suggestions for improvements. CDH was more common in males (34M, 25F). Th...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02984671
更新日期：1992-01-01 00:00:00
abstract：:We report a rare case of iatrogenic tracheal tear during a three-stage oesophagectomy in a 76-year-old woman and review current literature. The tear occurred due to trauma from a double lumen endotracheal tube. We used a novel technique of repairing the tear, which extended to the carina, avoiding a second thoracotomy...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0169-4
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Circumcision is one of the world's most common operations. Series describing a new technique involving the use of fibrin-based glue have become more apparent in the literature. Here we outline the first 100 such cases for 62 children and 38 adults in our practice describing complications and learning curve. ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-010-0545-8
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:In patients presenting with rapidly progressive dementia, prion disease may enter the differential diagnosis. The commonest malignancies masquerading as prion disease are primary CNS lymphoma and intravascular large B-cell lymphoma, both rare and difficult to diagnose without brain biopsy. CASE PRESENTATION...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-017-1653-5
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0298-4
更新日期：2012-06-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-007-0075-1
更新日期：2007-12-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02942793
更新日期：1996-01-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0404-7
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Acute appendicitis is the most common surgical emergency. Its management reflects the efficacy of acute care surgery. Limited theatre space is an escalating issue, especially without dedicated emergency theatre access. Pre-operative delays are associated with longer length of stay, higher costs and post-oper...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-019-02135-z
更新日期：2020-05-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-011-0768-3
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Perforation of the oesophagus is a life-threatening condition requiring early recognition and repair to prevent mediastinitis and death. Primary closure with mediastinal drainage is recognised as the treatment of choice for patients presenting within 24 hours. Many are frail, however, and unsuitable for majo...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03168953
更新日期：2002-04-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02939006
更新日期：1975-12-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-0900-7
更新日期：2013-09-01 00:00:00
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journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0140-4
更新日期：2009-03-01 00:00:00
