Abstract:
OBJECTIVE:We describe a case of Cushing's syndrome due to ectopic ACTH secretion, where the only potential source on conventional imaging was a tiny benign-appearing lung nodule, which failed to take up radiolabelled octreotide. DESIGN AND METHODS:To determine whether the patient might respond to therapeutic administration of octreotide, a test dose was given. RESULTS:Compared to ACTH and cortisol levels on a control day, the levels following the test dose of octreotide were lower. Subsequent therapeutic administration of subcutaneous octreotide normalised urine free cortisol, with symptomatic improvement, pending evaluation for surgery. Eventual resection of the lung nodule resulted in cure of hypercortisolism. Histological examination of the resected specimen confirmed bronchial carcinoid staining positive for ACTH. CONCLUSIONS:This is one of the few cases described where ectopic ACTH secretion secondary to bronchial carcinoid responded to somatostatin analogue therapy. The case was also unusual in that the tumour responded despite not taking up radiolabelled octreotide.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
McDermott JH,Thabit H,Hickey N,Thompson C,Gaffney E,Young V,Sreenan Sdoi
10.1007/s11845-008-0171-xsubject
Has Abstractpub_date
2008-09-01 00:00:00pages
269-72issue
3eissn
0021-1265issn
1863-4362journal_volume
177pub_type
杂志文章abstract:BACKGROUND:Increasing prevalence of overweight and obese children in developed countries poses a substantial threat to long-term health. One well-described factor is the amount of time spent watching television, with exposure to food advertising a known influence on food preferences and consumption patterns. AIMS:Foll...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-014-1088-1
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Wound botulism occurs as a consequence of inoculation of Clostridium botulinum spores into a wound. AIM:To describe such a case of wound botulism. RESULTS:A 23-year-old drug-injecting user presented with bulbar symptoms and progressive signs over a three-day period. The diagnosis of botulism was suspected ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914502
更新日期:2003-07-01 00:00:00
abstract::Two term infants suffering severe asphyxial events were found to have diffusely high attenuation of the cortical gyri on CT scanning within 12 days. The findings are consistent with haemorrhagic necrosis or microcalcification. This feature has rarely been described in the literature. The evolution of the CT appearance...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937934
更新日期:1998-07-01 00:00:00
abstract::We identified 51 patients from pathology and operative records who were treated in the Royal Victoria Eye and Ear Hospital with malignant sinonasal tumours between January 1980 and December 1991. Complete follow up was available in 43 patients. There were 30 males, mean age 50 years, range (10-80) and 13 females, mean...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02973281
更新日期:1995-04-01 00:00:00
abstract::A bioassay method for measuring parathyroid hormone (PTH) and other substances that influence bone metabolism is described. Monolayers of bone cells are culturedin vitro, then treated with the test material. Biological activity is determined by measuring the resulting rise in bone-cell adenosine 3',5'-monophosphate (c...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02938966
更新日期:1976-12-01 00:00:00
abstract::Hepatic haemangiosarcoma is a rare condition although there are known carcinogens in 25%. This case reports hepatic haemangiosarcoma in a 59 year old man with psoriasis and Crohn's disease who had previously received combined treatment with psoralen and UVA light. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/BF02942382
更新日期:1992-12-01 00:00:00
abstract:PURPOSE:Internal iliac artery (IIA) embolisation is commonly performed prior to endovascular aneurysm repair (EVAR) of aortoiliac aneurysms to prevent type 2 endoleaks via the internal iliac arteries. The safety of this procedure is controversial due to the high incidence of pelvic ischaemic complications. METHODS:We ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1384-4
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Pancreatic tumours are most frequently primary, with lesions secondary to metastasis uncommon. METHODS:This report describes the case of a 61-year-old man who underwent resection of a right thigh leiomyosarcoma 2 years prior to presentation with obstructive jaundice. Subsequent CT and endoscopic ultrasound ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0447-9
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abstract:BACKGROUND:The regulatory body responsible for the registration of Irish pre-hospital practitioners, the Pre-Hospital Emergency Care Council (PHECC), identified the need to implement a continuing professional competence (CPC) framework. The first cycle of CPC (focused on emergency medical technicians) commenced in Nove...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-016-1412-z
更新日期:2016-05-01 00:00:00
abstract::Direct Antibiotic Sensitivity Testing (DST) is a rapid means of diagnosing urinary tract infection (UTI) and obtaining antibiotic sensitivity patterns of the infecting organisms. In this study 227 urine samples from general practice were analysed using this technique with those obtained using the standard laboratory m...
journal_title:Irish journal of medical science
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更新日期:1990-04-01 00:00:00
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journal_title:Irish journal of medical science
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更新日期:1999-07-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To describe the shared care and outcomes of patients with periocular skin tumours who underwent Mohs micrographic surgery (MMS) performed by dermatologists, followed by oculoplastic reconstruction undertaken by ophthalmologists at two teaching and one private hospital in Ireland. RESEARCH DESIGN AND METHODS:...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1296-3
更新日期:2016-11-01 00:00:00
abstract::It is widely acknowledged that there is interplay between physical and mental health, with causality in both directions. A common theme across countries is the uncertainty surrounding who should act as gatekeeper for physical health matters in psychiatry. Much of the metabolic monitoring is carried out by psychiatrist...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-014-1205-1
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Our ability to maintain satisfactory levels of outcome after elective abdominal aortic aneurysm (AAA) surgery is increasingly strained by rising levels of co-morbidity in the presenting population. In this study we present a comparative outcome analysis of patients undergoing elective AAA surgery 18 months b...
journal_title:Irish journal of medical science
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更新日期:2006-07-01 00:00:00
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journal_title:Irish journal of medical science
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doi:10.1007/BF02943588
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Surveillance of Clostridium difficile infection (CDI) is an essential component of a CDI preventative programme. AIMS:The aim of this study was to evaluate two methods of CDI surveillance. METHODS:Prevalence of CDI, antibiotic use and associated co-morbidity was assessed weekly on two wards over 6 weeks. I...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0798-x
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION AND AIM:Various techniques have been proposed for the repair of abdominal wall defects (AWD) with varying rates of success. Despite the development of new materials and modifications of surgical technique, no single approach has emerged as the optimum way to close large AWD. We report a method for repairin...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0776-3
更新日期:2012-06-01 00:00:00
abstract::Susceptibility to metronidazole of 213 clinical strains of H. pylori from dyspeptic patients was determined by a plate dilution method. Seventy two (33.8%) of the strains were resistant to metronidazole (MIC > 8 mg/L), 20 of these were from 24 patients who had received previously metronidazole (83.3%), giving a primar...
journal_title:Irish journal of medical science
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journal_title:Irish journal of medical science
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journal_title:Irish journal of medical science
pub_type: 杂志文章,meta分析,评审
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abstract:BACKGROUND:The recent introduction of the General Data Protection Regulation and Health Research Regulations has been an area of significant concern for those engaged in clinical research. These European regulations, following subsequent interpretation by Ireland's Department of Health, now place Ireland in a unique po...
journal_title:Irish journal of medical science
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更新日期:2019-11-01 00:00:00
abstract::Anxiety, depression, self-esteem, behavioural deviance and prosocial behaviour were studied in children attending a normal school in a disadvantaged urban area, using self-rated and teacher-rated questionnaires. The prevalence of depression was rated as 5%. 15% described frequent suicidal thoughts. 40% scored as behav...
journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
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abstract::Over a four year period, 20 segments in 16 patients were treated by lengthening by callotasis or chondrodiastasis. The indications for treatment were leg length discrepancy in 13 patients and short stature in three. Patients with leg length discrepancy were all treated by femoral lengthening; the mean length gained wa...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02960724
更新日期:1993-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章,meta分析
doi:10.1007/s11845-018-1752-y
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:The American College of Cardiology Foundation (ACCF) with other professional societies developed appropriate use criteria (AUC) for diagnostic coronary angiography. This study aims to examine the appropriate use of elective coronary angiography for patients with suspected stable coronary artery disease in ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1953-4
更新日期:2019-08-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2020-09-18 00:00:00
abstract:BACKGROUND:Adults ageing with HIV and on antiretroviral therapy have a greater burden of chronic diseases compared with adults without HIV as reported by Althoff et al. (Curr Opin HIV AIDS 11:527-36, 2016). Therefore, it is important in this clinically stable HIV+ population to monitor and evaluate their risk of chroni...
journal_title:Irish journal of medical science
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abstract::The evaluation of fetal health using ultrasound to establish a biophysical profile in the Rotunda Hospital in 1987 is reported. The corrected perinatal mortality rate fell from 10.0 in 1986 to 6.9 per 1,000 for babies over 500g and from 5.9 in 1986 to 3.4 for babies over 1,000g. This was achieved without significant a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02984636
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