Abstract:
BACKGROUND:A relationship may exist between body iron stores, endothelial dysfunction and overall cardiovascular risk. AIMS:To compare vascular compliance, biochemical endothelial function and antioxidant status between patients with homozygous hereditary haemochromatosis and healthy controls. METHODS:Haemochromatosis patients and healthy controls were recruited. Measures of vascular compliance were assessed by applanation tonometry. Serological markers of endothelial function (plasma lipid hydroperoxides, cell adhesion molecules), antioxidant levels (ascorbate, lipid soluble antioxidants) and high-sensitivity C-reactive protein (CRP) were also measured. RESULTS:Thirty-five hereditary haemochromatosis patients (ten females, mean age 54.6) and 36 controls (27 female, mean age 54.0) were recruited. Haemochromatosis patients had significantly higher systolic and diastolic blood pressures. Pulse wave velocity (PWV) was significantly higher in male haemochromatosis patients (9.90 vs. 8.65 m/s, p = 0.048). Following adjustment for age and blood pressure, male haemochromatosis patients continued to have a trend for higher PWVs (+1.37 m/s, p = 0.058). Haemochromatosis patients had significantly lower levels of ascorbate (46.11 vs. 72.68 μmol/L, p = 0.011), retinol (1.17 vs. 1.81 μmol/L, p = 0.001) and g-tocopherol (2.51 vs. 3.14 μmol/L, p = 0.011). However, there was no difference in lipid hydroperoxides (0.46 vs. 0.47 nmol/L, p = 0.94), cell adhesion molecule levels (ICAM: 348.12 vs. 308.03 ng/mL, p = 0.32 and VCAM: 472.78 vs. 461.31 ng/mL, p = 0.79) or high-sensitivity CRP (225.01 vs. 207.13 mg/L, p = 0.32). CONCLUSIONS:Haemochromatosis is associated with higher PWVs in males and diminished antioxidants across the sexes but no evidence of endothelial dysfunction or increased lipid peroxidation.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Cash WJ,O'Neill S,O'Donnell ME,McCance DR,Young IS,McEneny J,Cadden IS,McDougall NI,Callender MEdoi
10.1007/s11845-013-1010-2subject
Has Abstractpub_date
2014-06-01 00:00:00pages
303-9issue
2eissn
0021-1265issn
1863-4362journal_volume
183pub_type
杂志文章abstract:BACKGROUND:Data from randomized trials evaluating the efficacy of on- versus off-pump coronary artery bypass grafting remain inconclusive, particularly in high-risk populations. AIMS:The aim of this study is to compare the outcomes associated with on- versus off-pump coronary artery bypass grafting among high-risk pat...
journal_title:Irish journal of medical science
pub_type: 杂志文章,meta分析
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journal_title:Irish journal of medical science
pub_type: 杂志文章,meta分析
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Irish journal of medical science
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更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:The numbers of removals of patients from General Practitioner lists in Ireland is increasing and is a cause for some concern. AIMS:To examine the views of both general practitioners and patients toward removals of patients from general practitioner lists. METHODS:Questionnaire survey to general practitione...
journal_title:Irish journal of medical science
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journal_title:Irish journal of medical science
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更新日期:2014-12-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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abstract:AIMS:Imported childhood malaria has never been studied in Ireland. We aimed to document the incidence and species of malaria in children presenting to paediatric hospitals in Dublin and to examine management and outcome measures. METHODS:Subjects were identified through laboratory archives from the three paediatric ho...
journal_title:Irish journal of medical science
pub_type: 杂志文章
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942098
更新日期:1993-03-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Cosmetic outcomes and scar lengths remain important considerations in breast cancer surgery. Suturing techniques should decrease scar tissue formation and provide good cosmetic results. The use of an accordion suturing technique may result in decreased surgical wound lengths and better cosmetic outcomes. We ...
journal_title:Irish journal of medical science
pub_type: 杂志文章,随机对照试验
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更新日期:2018-11-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914547
更新日期:2004-10-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167689
更新日期:2000-07-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:Irish journal of medical science
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pub_type: 杂志文章
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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journal_title:Irish journal of medical science
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
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journal_title:Irish journal of medical science
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pub_type: 杂志文章,评审
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journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00