Abstract：
BACKGROUND:This study was to investigate the value of 10 serum inflammatory cytokines for predicting clinical response to celecoxib in ankylosing spondylitis (AS) patients. METHODS:Totally, 103 active AS patients who underwent celecoxib treatment for 12 weeks were enrolled. Then, pre-treatment serum TNF-α, IL-1β, IL-6, IL-8, IL-17A, IL-21, IL-23, IL-32, ICAM-1, and VEGF were detected by enzyme-linked immunosorbent assay. Besides, the ASAS 20 response was assessed at week 2 (W2), week 6 (W6), and week 12 (W12). Based on the ASAS 20 response at W12, patients were divided into responders and non-responders. RESULTS:After celecoxib treatment, 53 (51.3%), 58 (56.3%), and 60 (58.3%) patients achieved ASAS 20 response at W2, W6, and W12, respectively. Furthermore, IL-1β (P = 0.019), IL-6 (P = 0.004), and IL-17A (P = 0.007) levels were higher, while TNF-α (P = 0.086), IL-8 (P = 0.143), IL-21 (P = 0.687), IL-23 (P = 0.329), IL-32 (P = 0.216), ICAM-1 (P = 0.119), and VEGF (P = 0.732) levels were similar in responders compared with non-responders. Subsequent multivariate logistic regression analysis revealed that among these inflammatory cytokines, only IL-6 (P = 0.019) independently predicted higher ASAS 20 response to celecoxib at W12, and it had a fair value for predicting ASAS 20 response to celecoxib at W12 (area under the curve: 0.666, 95% confidence interval: 0.561-0.771) by receiver-operating characteristic curve analysis. CONCLUSION:Serum IL-1β, IL-6, and IL-17A serve as indicators for predicting clinical response to celecoxib in AS patients, which may assist with the optimization of personalized treatment.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Zhang Y,Ning C,Zhou H,Yan Y,Liu F,Huang Ydoi
10.1007/s11845-020-02366-5subject
Has Abstractpub_date
2020-09-21 00:00:00eissn
0021-1265issn
1863-4362pii
10.1007/s11845-020-02366-5pub_type
杂志文章abstract：BACKGROUND:Acute scrotal pain is a common urological emergency. Urgent exploration is the standard means of management, as no investigation can confidently exclude torsion of testis from the differential diagnoses. In our department, all patients up to the age of 40 years, presenting with acute scrotal pain undergo eme...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03173885
更新日期：2001-07-01 00:00:00
abstract：AIM:The aim of this study was to investigate the microbiology of secondary bacterial peritonitis due to appendicitis and the appropriateness of current antimicrobial practice in one institution. METHODS:A 14-year retrospective single-centre study of 69 consecutive paediatric patients (age 1-14 years) with appendicitis...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1055-2
更新日期：2014-12-01 00:00:00
abstract：:The management of breast cancer has evolved in the last 40 years to now encompass not only treating the cancer in the most effective way, but also to detect and treat cancers before they can pose a risk to patients. This evolution in therapy and diagnostics has moved away from treating patients with the maximum amount...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-014-1142-z
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02386-1
更新日期：2020-10-17 00:00:00
abstract：BACKGROUND:Adults ageing with HIV and on antiretroviral therapy have a greater burden of chronic diseases compared with adults without HIV as reported by Althoff et al. (Curr Opin HIV AIDS 11:527-36, 2016). Therefore, it is important in this clinically stable HIV+ population to monitor and evaluate their risk of chroni...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-019-02063-y
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Hypertension (HT) is a disease associated with endothelial dysfunction which is related to some adipokines and pro- and anti-inflammatory cytokines. AIMS:Our aim was to investigate roles of apelin, omentin-1, and vaspin in essential HT and to evaluate their relationships with other pro- and anti-inflammator...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02272-w
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:Assessment of non-cardiac chest pain places a considerable burden on healthcare resources. The current practice of serial electrocardiographs (ECGs), serum creatinine phosphokinase and by pre-discharge exercise electrocardiography gives an average in-hospital stay of 3.7 days. AIMS:This study assess the use...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03167689
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes. METHODS:A 79-year-old lady presented with frequent episodes of torsade de pointes following commencement of clari...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-007-0057-3
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To describe the relationship between parents with gender identity disorder (GID) and their child(ren) as described by the parent and to understand how being a parent affects transitioning from one gender to the other. METHODS:Fourteen parents with GID underwent a semi-structured interview and completed the I...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1003-1
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:The apolipoprotein (Apo) E gene, and thus its gene product, plays a central and pervasive role in lipid metabolism by serving as a ligand for lipoprotein receptors. Polymorphisms of this gene have been associated with variation in lipid phenotypes in some Caucasian and Asian populations, but not in others. N...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03170486
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Injuries to the cervical spine (C-spine) are among the most serious in rugby and are well documented. Front-row players are particularly at risk due to repetitive high-intensity collisions in the scrum. AIM:This study evaluates degenerative changes of the C-spine and associated symptomatology in front-row r...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0432-3
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:In 1996, Irish accident and emergency (A&E) departments had approximately 1.2 million visits. General practitioners (GPs) have been shown to work efficiently in A&E. AIM:This study aimed to describe the current A&E structures in Ireland and the potential contribution of general practice. METHOD:Questionnai...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03173524
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:To investigate whether topical application of hesperin affords protection to Balb/C mice epidermis from UVB-induced cyclobutane pyrimidine dimers (CPDs). METHODS:A DNA damage model of UVB irradiation-induced mice epidermis was established. The immunohistochemical staining and southwestern dot blotting were use...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-010-0503-5
更新日期：2011-09-01 00:00:00
abstract：:This paper analyses data on 2,226 cases of Hepatitis B virus (HBV) infection detected during the years 1970 to 1987. Of those where information on risk-group was available (1,301), infection among intravenous drug-abusers accounted for the largest proportion (49%). Most became infected during and since an outbreak of ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02943614
更新日期：1989-08-01 00:00:00
abstract：:Hepatic haemangiosarcoma is a rare condition although there are known carcinogens in 25%. This case reports hepatic haemangiosarcoma in a 59 year old man with psoriasis and Crohn's disease who had previously received combined treatment with psoralen and UVA light. ...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/BF02942382
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:Anal ulceration is uncommon. Patients are typically referred because of severe anal pain, bleeding, discharge, and ulceration. It is important to exclude anal carcinoma, and to consider more unusual causes. METHODS:A 74-year-old lady presented with severe anal pain and ulceration. This was subsequently note...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169175
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:During recent years, there has been an exponential demand for joint arthroplasty, which has coincided with the global economic recession. In response, the management of patients following arthroplasty is continuously evolving, with the average inpatient length of stay decreasing from weeks to days, and more ...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-017-1641-9
更新日期：2018-02-01 00:00:00
abstract：:Serum antibodies to Epstein-Barr virus (EBV) were measured in members of twenty-nine families in which two or more first degree relatives had rheumatoid arthritis (RA). These patients were assessed clinically for activity of disease and their treatment recorded. A higher proportion of seropositive individuals was foun...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02943612
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND:The incidence and prevalence of childhood chronic disease is increasing worldwide. Obesity, poor diet and lifestyle may be more prevalent in children with a chronic disease than in their healthier contemporaries. The Growing Up in Ireland (GUI) study is a nationally representative cohort study of children li...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1814-1
更新日期：2019-02-01 00:00:00
abstract：INTRODUCTION:Heparin-induced thrombocytopenia syndrome (HITS) is an infrequent complication of heparin anticoagulation. CASE REPORT:We present the case of a 44-year-old male who was admitted with acute ischaemia of his right lower limb. He was initially treated with unfractionated heparin and thrombolysis, but subsequ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-010-0531-1
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:The first Irish heart transplant was performed on the 10th of September 1985. Over the next 20 years, 229 transplants were performed in 228 recipients. AIMS:To evaluate the success of the first generation of cardiac transplantation in Ireland. METHODS:Analysis of clinical outcomes and survival statistics f...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03168991
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Whether developments in palliative care have impacted on where cancer patients die is unknown. We investigated time trends in place of death for colorectal cancer. METHODS:Details were abstracted on 10,175 colorectal cancer deaths during 1994-2004. Time trends were analysed by joinpoint regression. RESULTS...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-010-0607-y
更新日期：2011-03-01 00:00:00
abstract：:Collagen type I from rat tail was tested for its effect on wound healing of 6 male rabbits and on the regeneration of liver after partial hepatectomy in 15 male rats. It had a negligible effect on the rate of wound healing and a statistically significant acceleratory effect on regeneration of the rat liver. ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02942070
更新日期：1989-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to analyze neuropathic pain (NeP) and its therapy in patients with Guillain-Barré syndrome (GBS) during a 6-month follow-up period. METHOD:This longitudinal multicenter study included 69 newly diagnosed adult GBS patients. NeP diagnosis was based on the criteria of Finnerup and conf...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02395-0
更新日期：2020-10-15 00:00:00
abstract：INTRODUCTION:Emergency laparotomy (EL) is a commonly performed operation with increased morbidity and mortality. Currently, there is a lack of published outcomes following emergency laparotomy within an Irish population. The aim of this study was to assess our outcomes and compare these to predefined outcomes from NELA...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1759-4
更新日期：2018-11-01 00:00:00
abstract：INTRODUCTION:Recent implementation of the European Working Time Directive in Ireland has resulted in a change from thetraditional model of patient care to a system characterised by shift work among clinicians. Effective handover ofpatient information is essential for transfer of responsibility between clinicians and ma...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1675-z
更新日期：2018-05-01 00:00:00
abstract：:Quality of life of out-of-hospital cardiac arrest (OHCA) survivors is believed to be as important as a factor in resuscitation outcome as the survival rate. The aim of this investigation is to assess the quality of life outcomes of survivors of out-of- hospital cardiac arrest in the Munster region. OHCAR was used to i...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02189-4
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Perforation of the oesophagus is a life-threatening condition requiring early recognition and repair to prevent mediastinitis and death. Primary closure with mediastinal drainage is recognised as the treatment of choice for patients presenting within 24 hours. Many are frail, however, and unsuitable for majo...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03168953
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:A relationship may exist between body iron stores, endothelial dysfunction and overall cardiovascular risk. AIMS:To compare vascular compliance, biochemical endothelial function and antioxidant status between patients with homozygous hereditary haemochromatosis and healthy controls. METHODS:Haemochromatosi...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1010-2
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Data from randomized trials evaluating the efficacy of on- versus off-pump coronary artery bypass grafting remain inconclusive, particularly in high-risk populations. AIMS:The aim of this study is to compare the outcomes associated with on- versus off-pump coronary artery bypass grafting among high-risk pat...
journal_title：Irish journal of medical science
pub_type： 杂志文章,meta分析
doi：10.1007/s11845-017-1679-8
更新日期：2018-05-01 00:00:00
