Abstract：
:Factors which can account for the poor correlation between whole blood and plasma Cyclosporine (CsA) levels in patients on CsA prophylaxis are evaluated. The study took account of the influence of plasma separation procedures, and the sample haematocrit on CsA distribution in the blood of renal transplant patients (n = 35). CsA was measured using both specific and non-specific CsA radioimmunoassays. Significant negative correlations occurred between CsA distribution and the haematocrit, independently of the plasma separation procedure or the specificity of the assay. All results were lower when using the specific assay but a significantly higher percentage of CsA was measured in the plasma by specific assay compared to nonspecific assay when plasma was separated at both 22 degrees C (t-test, p less than 0.02) and at 37 degrees C, p less than 0.01). This may relate to the selective binding of CsA and its analogues by blood cells. This study is a prelude to the development of more consistent plasma separation procedures in the monitoring of this drug.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Broin SO,Clarke E,McCann Sdoi
10.1007/BF02993609subject
Has Abstractpub_date
1990-09-01 00:00:00pages
269-71issue
9-12eissn
0021-1265issn
1863-4362journal_volume
159pub_type
杂志文章abstract：:STRIPS of bovine tracheal smooth muscle were subjected to changes in the gas tensions of the Krebs solution bathing them. Contractions were produced by 50 Hz sine-wave electrical field stimulation, either in single bursts, or repetitively throughout the experiment.Hypoxia (Po2 99, 55 or 22 mm Hg, pH 7.4) decreased the...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02939006
更新日期：1975-12-01 00:00:00
abstract：BACKGROUND:In recent decades the management of acute appendicitis has evolved significantly. Improved access to early imaging and better clinical scoring algorithms have resulted in less negative appendicectomy rates. In addition, non-operative management has become increasingly utilized. The aim of this study was to a...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02349-6
更新日期：2020-08-27 00:00:00
abstract：:In automobile accidents, the "seatbelt syndrome" (SBS) consists of a constellation of injuries, predominantly involving thoraco-lumbar vertebral fractures and intraabdominal organ injury. A recent amendment to Irish legislation has made the wearing of seatbelts mandatory for all rear seated passengers in an effort to ...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-008-0215-2
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:There is extensive focus on the rising costs of healthcare. However, for patients undergoing cancer treatment, there are additional personal costs, which are poorly characterised. AIM:To qualify indirect costs during anti-cancer therapy in a designated Irish cancer centre. METHODS:An anonymous questionnair...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-016-1483-x
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Cardiac arrest due to ischaemia is frequently the first manifestation of cardiovascular disease. We sought to describe the characteristics and outcomes of patients admitted to the Intensive Care Unit (ICU) with a diagnosis of cardiac arrest secondary to acute coronary syndrome (ACS). METHODS:We performed a ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-016-1422-x
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Acute scrotal pain is a common urological emergency. Urgent exploration is the standard means of management, as no investigation can confidently exclude torsion of testis from the differential diagnoses. In our department, all patients up to the age of 40 years, presenting with acute scrotal pain undergo eme...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03173885
更新日期：2001-07-01 00:00:00
abstract：:Two term infants suffering severe asphyxial events were found to have diffusely high attenuation of the cortical gyri on CT scanning within 12 days. The findings are consistent with haemorrhagic necrosis or microcalcification. This feature has rarely been described in the literature. The evolution of the CT appearance...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02937934
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Anaesthetists are at high risk from blood-borne pathogens. Universal Precautions (UP) include the routine use of appropriate barrier precautions and techniques to reduce the likelihood of exposure to blood, body fluids and tissues that may contain pathogens. The compliance of Irish anaesthetists with these p...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03167699
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula. The modification of diet in renal disease (MDRD) equation is now routinely available to estimate GFR (eGFR). METHODS:We performe...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0250-z
更新日期：2009-09-01 00:00:00
abstract：:Supervised machine learning (ML) is a class of algorithms that "learn" from existing input-output pairs, which is gaining popularity in pattern recognition for classification and prediction problems. In this scoping review, we examined the use of supervised ML algorithms for the prediction of long-term allograft survi...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-020-02332-1
更新日期：2020-08-06 00:00:00
abstract：BACKGROUND:The clinical spectrum of adult coeliac disease (ACD) is varied with limited Irish data. AIMS AND OBJECTIVES:The aim of this study was to analyse the presenting symptoms, associated conditions and complications in a consecutive series of patients with ACD. METHODS:Data were obtained from database on patient...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-011-0788-z
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To describe the relationship between parents with gender identity disorder (GID) and their child(ren) as described by the parent and to understand how being a parent affects transitioning from one gender to the other. METHODS:Fourteen parents with GID underwent a semi-structured interview and completed the I...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1003-1
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:It has been recognised for some time that mortality rates vary across social class groups, with lower rates in the higher social classes. Internationally, but particularly in Ireland, many studies on the topic of inequalities in mortality have been confined to men, partly because the most frequently used soc...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-014-1189-x
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:There is increasing concern that the use of second-generation antipsychotic medications in schizophrenia is associated with the development of metabolic syndrome. AIMS:This study assessed the prevalence and clinical associations of metabolic syndrome among patients receiving clozapine within the catchment a...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0156-9
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:In Ireland, the paediatric emergency department (PED) is tasked with acute healthcare provision to children and adolescents under 16 years of age. The population > 15 years attending the PED remains undescribed. AIMS:The objective of the study is to describe the presentations of patients > 15 years to the P...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02213-7
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:ADHD is the most frequent reason for attendance at Child and Adolescent Mental Health Services (CAMHS). General practitioners (GPs) play a key role in recognising symptoms, referring for assessment and supporting ongoing treatment. However, there is an ambiguous understanding of ADHD among GPs, and different...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1804-3
更新日期：2019-02-01 00:00:00
abstract：AIMS:The purpose of this study was to review indications, source of haemorrhage, method of embolisation and clinical outcome in patients referred to Interventional Radiology for the emergency management of acute arterial haemorrhage. METHODS:Retrospective review of patients undergoing emergency percutaneous embolisati...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0400-y
更新日期：2010-09-01 00:00:00
abstract：:Ninety-nine inguinal herniorrhaphies were performed under local anaesthetic blockade between 1980 and 1988. This represents 32% of this surgical teams herniorrhaphy operations. A follow-up interview was possible in 82 patients. Satisfaction was expressed by 77 patient (94%) although six of the interviewed patients (7....
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02942128
更新日期：1994-06-01 00:00:00
abstract：AIMS:Imported childhood malaria has never been studied in Ireland. We aimed to document the incidence and species of malaria in children presenting to paediatric hospitals in Dublin and to examine management and outcome measures. METHODS:Subjects were identified through laboratory archives from the three paediatric ho...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0343-3
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:The human body consists of water, proteins, lipids, carbohydrates, and minerals that build cells, tissues, and organs. In healthy people, the content of these molecules remains nearly constant. The body mass index (BMI) is commonly used to classify abnormal body composition among adults. According to the WHO...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02403-3
更新日期：2020-10-21 00:00:00
abstract：BACKGROUND:Laparoscopic cholecystectomy is the operation of choice for cholelithiasis. AIMS:The aims of our study were to assess the feasibility of day case laparoscopic cholecystectomy (DCLC) in selected patients. METHODS:DCLC was introduced in this unit in July 1999. The first 50 patients were prospectively evaluat...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03168818
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:Programmed cell death, or apoptosis, is a distinct, managed form of cell death. It is fundamentally different from necrosis. It is a genetically controlled, energy-dependent method of cellular deletion without inflammation. In the cardiovascular system, apoptosis occurs as a primary and secondary event in di...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/BF03168827
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:Attitudes have been shown to be important determinants of the quality and efficacy of medical care. There is little research on the education about, and assessment of, attitudes in undergraduate medical education. AIM:To describe the design and delivery of an attitude awareness workshop, and the associated ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03170282
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Inadequate medical documentation has been associated with a higher rate of adverse events and may have medicolegal consequences. An accurate admission note is critical as it is frequently referred to during inpatient stay, particularly when the patient is acutely unwell and during handover of care. AIM:We s...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02475-1
更新日期：2021-01-19 00:00:00
abstract：BACKGROUND:When worn external Hip Protectors (EHP) reduce hip fracture but poor compliance results in reduced efficacy. AIMS:We determined the compliance with EHP therapy among a group of elderly people attending a day hospital. METHODS:Forty-five patients or their care-givers were interviewed a mean (sd) 334 (150) d...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03168519
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Over the last decade there have been significant changes in the prescribing of antidiabetic therapies. It is of interest to know about these trends and variations in the Irish population so that future prescribing patterns can be estimated. AIMS:To examine the trends in prescribed antidiabetic treatments, i...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1011-1
更新日期：2014-06-01 00:00:00
abstract：:RADIOACTIVE fallout from the Chernobyl accident reached Ireland in May 1986 and caused serious concern with regard to its possible effects on health. Reports of a large scale American study claim an almost immediate effect of Chernobyl fallout in terms of increased mortality rates. A study of Irish mortality rates rep...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02943039
更新日期：1989-05-01 00:00:00
abstract：:This study assessed the ability of biochemical tests and ultrasound to predict the presence of ductal calculi, and thereby refine the indications for ERCP, in patients before or after laparoscopic cholecystectomy. Thirteen of fifty-three patients investigated before laparoscopic cholecystectomy, and four of seventeen ...
journal_title：Irish journal of medical science
pub_type： 临床试验,杂志文章
doi：10.1007/BF03022585
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Despite Ireland's temperate maritime climate, it has the third highest rate of malignant melanoma in the European Union, indicating the need to recognise tanning practices as a risky behaviour, especially amongst those most at risk (the younger population). AIM:To explore the factors associated with deliber...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-015-1389-z
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Tinnitus is a phenomenon that affects approximately 15% of the adult population. A minority of patients will experience chronic bothersome tinnitus that has a detrimental effect on their quality of life. Management of such tinnitus is challenging for healthcare practitioners. Primary care services are the fi...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02222-6
更新日期：2020-11-01 00:00:00
